[Effect of prodigiozan on immune reactivity in patients with steroid-dependent bronchial asthma]. / Vliianie prodigiozana na immunnuiu reaktivnost' bol'nykh steroidzavisimoi bronkhial'noi astmoi.

An optimum scheme of prodigiosan therapy was developed for patients with steroid-dependent bronchial asthma taking account of the hormonal and immunological status. First the drug was administered at a dose of 0.1 ml of 0.005% solution, then in 3-4 days the dose was increased (in good tolerance) up to 0.2-0.4-0.8-1.0 ml. After the first administration of the drug at a dose exceeding 0.1 ml herpes virus could be activated in the body. Course therapy producing a stimulating effect on the immune system, inhibited the occurrence of autoimmune manifestations, prolonged bronchial asthma remission, permitted the reduction of retention of a maintenance dose of glucocorticoids.

[The effect of injectable leukinferon on the immune reactivity of patients with steroid-dependent bronchial asthma]. / O vliianii leikinferona dlia in''ektsii na immunoreaktivnost' bol'nykh steroidozavisimoi bronkhial'noi astmoi.

The authors provide the results of the treatment with leukinferon for injections of 25 patients with steroid-dependent bronchial asthma. It is the authors' belief that leukinferon for injections may be recommended for introduction into multimodality schedules of the treatment of patients with the above-indicated pathology. The drug is tolerated well, without any phenomena of sensitization, when administered by inhalation in the form of aqueous aerosol in a dose of 10,000 IU/day. As a result of 6 to 8 injections, immunoreactivity showed a positive time-course of changes, the patients' clinical status improved, and the maintenance doses of glucocorticosteroids could be noticeably reduced.

[Pathogenesis of the cytopenia syndrome in patients with cirrhosis of the liver complicated by portal hypertension]. / Patogenez tsitopenicheskogo sindroma u bol'nykh tsirrozom pecheni, oslozhennym portal'noi gipertenziei.

One of the main causes of cytopenia and cellular immunodeficiency in patients with cirrhosis of the liver and portal hypertension is increased portal pressure, which, in turn, induces increased storage of formed elements in the spleen. Shunting operations producing a stable decompressive effect correct cytopenia similar to splenectomy but at the same time are devoid of the menacing postoperative complications characteristic of splenectomy.

[The theophylline test in the evaluation of the state of cellular immunity in children with different clinical courses of systemic lupus erythematosus]. / Teofillinovyi test v otsenke sostoianiia kletochnogo immuniteta u detei s razlichnym klinicheskim techeniem sistemnoi krasnoi volchanki.

An inverse reaction of T-lymphocytes to theophylline is sometimes observed in children with systemic lupus erythematosus. In this case the disease runs a more benign course and is less resistant to prednisolone therapy. The theophylline test is recommended for the prediction of the disease course.

[Comparative studies of immunologic characteristics in plasmapheresis and hemosorption in patients with purulent diseases of the lungs and pleura]. / Sravnitel'naia kharakteristika immunologicheskikh pokazatelei pri plazmafereze i gemosorbtsii u bol'nykh gnoinymi zaboleva- niiami legkikh i plevry.

The article deals with the comparative characteristics of the changes in immunological indices in 40 patients with non-specific purulent diseases of the lungs and pleura when plasmapheresis and hemosorption were included in the complex of therapeutic measures. The changes were found to be hetero-directional in character: a non-specific effect of immunostimulation in hemosorption, and immunodepression, particularly marked in the first 24 hours, in plasmapheresis. The post-aggressive reaction after plasmapheresis is either absent or delayed significantly, which makes it possible to conduct detoxification in extremely grave conditions of the patients without making the mechanisms of the post-aggressive reaction operative, as observed in performance of hemosorption.