1.
Am J Vet Res
; 42(6): 996-1001, 1981 Jun.
Article
in English
| MEDLINE
| ID: mdl-7283250
ABSTRACT
Serial blood samples were obtained from 12 healthy adult dogs given equivalent subcutaneous and oral doses of the antibacterial combination, trimethoprim-sulfadiazine (1:5). By using a 1-compartment open model, pharmacokinetic parameters for both drugs were estimated from the mean serum concentration data after oral administration. Trimethoprim and sulfadiazine were rapidly absorbed, reaching maximum concentrations in 1 and 4 hours with serum elimination half-lives of 2.5 and 9.9 hours, respectively. After a single oral dose (30 mg/kg, combined ingredients) was given, both drugs were present in urine for up to 24 hours at concentrations exceeding the minimum inhibitory concentrations for common pathogenic bacteria.
Subject(s)
Dogs/metabolism , Sulfadiazine/metabolism , Trimethoprim/metabolism , Administration, Oral , Animals , Kinetics , Male , Sulfadiazine/administration & dosage , Sulfadiazine/urine , Trimethoprim/administration & dosage , Trimethoprim/urine
2.
J Am Optom Assoc
; 40(6): 603-6, 1969 Jun.
Article
in English
| MEDLINE
| ID: mdl-5789179