ABSTRACT
Ocular mucous membrane pemphigoid (MMP) is a chronic autoimmune blistering disease that usually affects elderly patients being extremely rare in pediatric population. Despite aggressive immunosuppressive therapy, ocular MMP may progress causing significant morbidity. Herein, we describe a toddler with ocular MMP successfully treated with rituximab.
Subject(s)
Immunologic Factors/therapeutic use , Pemphigoid, Benign Mucous Membrane/drug therapy , Rituximab/therapeutic use , Child, Preschool , Humans , MaleSubject(s)
Glossalgia/etiology , Syphilis/complications , Adult , Anti-Bacterial Agents/therapeutic use , Female , Glossalgia/diagnosis , Glossalgia/drug therapy , Glossalgia/pathology , Humans , Syphilis/diagnosis , Syphilis/drug therapy , Syphilis/pathology , Syphilis Serodiagnosis , Tongue/pathology , Treatment OutcomeABSTRACT
Aim: To investigate the efficacy and tolerability of a cream (Rilastil Xerolact PB) containing a mixture of prebiotics and postbiotics, and to validate the PRURISCORE itch scale in the management of atopic dermatitis.Methods: The study is based on 396 subjects of both sexes in three age groups (i.e., infants, children, adults) suffering from mild/moderate Atopic Dermatitis, recruited from 8 European countries and followed for 3 months.Results: The product demonstrated good efficacy combined with good/very good tolerability in all age groups. In particular, SCORAD, PRURISCORE and IGA scores decreased significantly over the course of the study. The PRURISCORE was preferred to VAS by the vast majority of patients.Conclusion: Even though the role of prebiotics and postbiotics was not formally demonstrated since these substances were part of a complex formulation, it can be reasonably stated that prebiotics and postbiotics have safety and standardization features that probiotics do not have. In addition they are authorized by regulatory authorities, whereas topical probiotics are not.
Subject(s)
Dermatitis, Atopic , Probiotics , Child , Male , Infant , Adult , Female , Humans , Dermatitis, Atopic/drug therapy , Prebiotics , Probiotics/therapeutic use , Pruritus , Emollients , Severity of Illness IndexABSTRACT
Standards in post-surgery wound care management require a rapid healing process in order to prevent and minimize abnormal scarring. For the healing process to start as early as possible, the ideal dressing should be applied directly on the open wound and perfectly adapt to it. The authors report a case study series regarding the efficacy of a flexible film-forming wound dressing in the form of a gel (Stratamed®, Stratpharma AG, Switzerland) that is approved for the use on open wounds and injured skin. Evidence from the current study shows that, while remaining safe to use, the dressing was efficacious in promoting epithelialization and accelerated wound healing of areas in which skin integrity had been compromised, and at the same time prevented the formation of abnormal scars. Results were observed across a broad range of dermatologic surgical procedures. All treated conditions showed a beneficial outcome, as well as an overall favorable patient treatment perception.