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Org Biomol Chem
; 16(46): 8940-8943, 2018 11 28.
Article
in English
| MEDLINE
| ID: mdl-30451259
ABSTRACT
An effective asymmetric α-phenylation of methyl ketones with triphenylaluminium in the presence of (+)-benzopyranoisoxazolidine has been developed. The reaction proceeds via the in situ formation of a chiral N-alkoxyenamine and the subsequent diastereoselective nucleophilic phenylation to provide α-phenylated products in moderate to good yields, with high enantioselectivities.