Search | Virtual Health Library

1.

The JAK-STAT pathway at 30: Much learned, much more to do.

Philips, Rachael L; Wang, Yuxin; Cheon, HyeonJoo; Kanno, Yuka; Gadina, Massimo; Sartorelli, Vittorio; Horvath, Curt M; Darnell, James E; Stark, George R; O'Shea, John J.

Cell ; 185(21): 3857-3876, 2022 10 13.

Article in English | MEDLINE | ID: mdl-36240739

2.

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.

Oda, Hirotsugu; Manthiram, Kalpana; Chavan, Pallavi Pimpale; Rieser, Eva; Veli, Önay; Kaya, Öykü; Rauch, Charles; Nakabo, Shuichiro; Kuehn, Hye Sun; Swart, Mariël; Wang, Yanli; Çelik, Nisa Ilgim; Molitor, Anne; Ziaee, Vahid; Movahedi, Nasim; Shahrooei, Mohammad; Parvaneh, Nima; Alipour-Olyei, Nasrin; Carapito, Raphael; Xu, Qin; Preite, Silvia; Beck, David B; Chae, Jae Jin; Nehrebecky, Michele; Ombrello, Amanda K; Hoffmann, Patrycja; Romeo, Tina; Deuitch, Natalie T; Matthíasardóttir, Brynja; Mullikin, James; Komarow, Hirsh; Stoddard, Jennifer; Niemela, Julie; Dobbs, Kerry; Sweeney, Colin L; Anderton, Holly; Lawlor, Kate E; Yoshitomi, Hiroyuki; Yang, Dan; Boehm, Manfred; Davis, Jeremy; Mudd, Pamela; Randazzo, Davide; Tsai, Wanxia Li; Gadina, Massimo; Kaplan, Mariana J; Toguchida, Junya; Mayer, Christian T; Rosenzweig, Sergio D; Notarangelo, Luigi D.

Nat Immunol ; 25(5): 764-777, 2024 May.

Article in English | MEDLINE | ID: mdl-38609546

3.

SnapShot: Jak-STAT Signaling II.

Villarino, Alejandro V; Gadina, Massimo; O'Shea, John J; Kanno, Yuka.

Cell ; 181(7): 1696-1696.e1, 2020 06 25.

Article in English | MEDLINE | ID: mdl-32589961

4.

Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery.

Clement, Cristina C; Nanaware, Padma P; Yamazaki, Takahiro; Negroni, Maria Pia; Ramesh, Karthik; Morozova, Kateryna; Thangaswamy, Sangeetha; Graves, Austin; Kim, Hei Jung; Li, Tsai Wanxia; Vigano', Marco; Soni, Rajesh K; Gadina, Massimo; Tse, Harley Y; Galluzzi, Lorenzo; Roche, Paul A; Denzin, Lisa K; Stern, Lawrence J; Santambrogio, Laura.

Immunity ; 54(4): 721-736.e10, 2021 04 13.

Article in English | MEDLINE | ID: mdl-33725478

5.

Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome.

Baghdassarian, Hratch; Blackstone, Sarah A; Clay, Owen S; Philips, Rachael; Matthiasardottir, Brynja; Nehrebecky, Michele; Hua, Vivian K; McVicar, Rachael; Liu, Yang; Tucker, Suzanne M; Randazzo, Davide; Deuitch, Natalie; Rosenzweig, Sofia; Mark, Adam; Sasik, Roman; Fisch, Kathleen M; Pimpale Chavan, Pallavi; Eren, Elif; Watts, Norman R; Ma, Chi A; Gadina, Massimo; Schwartz, Daniella M; Sanyal, Anwesha; Werner, Giffin; Murdock, David R; Horita, Nobuyuki; Chowdhury, Shimul; Dimmock, David; Jepsen, Kristen; Remmers, Elaine F; Goldbach-Mansky, Raphaela; Gahl, William A; O'Shea, John J; Milner, Joshua D; Lewis, Nathan E; Chang, Johanna; Kastner, Daniel L; Torok, Kathryn; Oda, Hirotsugu; Putnam, Christopher D; Broderick, Lori.

N Engl J Med ; 388(24): 2241-2252, 2023 Jun 15.

Article in English | MEDLINE | ID: mdl-37256972

6.

Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation.

Scarno, Gianluca; Mazej, Julija; Laffranchi, Mattia; Di Censo, Chiara; Mattiola, Irene; Candelotti, Arianna M; Pietropaolo, Giuseppe; Stabile, Helena; Fionda, Cinzia; Peruzzi, Giovanna; Brooks, Stephen R; Tsai, Wanxia Li; Mikami, Yohei; Bernardini, Giovanni; Gismondi, Angela; Sozzani, Silvano; Di Santo, James P; Vosshenrich, Christian A J; Diefenbach, Andreas; Gadina, Massimo; Santoni, Angela; Sciumè, Giuseppe.

Proc Natl Acad Sci U S A ; 120(40): e2306761120, 2023 10 03.

Article in English | MEDLINE | ID: mdl-37756335

7.

Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story.

Bonelli, Michael; Kerschbaumer, Andreas; Kastrati, Kastriot; Ghoreschi, Kamran; Gadina, Massimo; Heinz, Leonhard X; Smolen, Josef S; Aletaha, Daniel; O'Shea, John; Laurence, Arian.

Ann Rheum Dis ; 83(2): 139-160, 2024 Jan 11.

Article in English | MEDLINE | ID: mdl-37923366

8.

Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu's arteritis, ANCA-associated vasculitis and giant cell arteritis.

Gutierrez-Rodrigues, Fernanda; Wells, Kristina V; Jones, Adrianna I; Hironaka, Dalton; Rankin, Cameron; Gadina, Massimo; Sikora, Keith A; Alemu, Lemlem; Calado, Rodrigo T; Quinn, Kaitlin A; Patel, Bhavisha; Young, Neal S; Grayson, Peter C.

Ann Rheum Dis ; 83(4): 508-517, 2024 Mar 12.

Article in English | MEDLINE | ID: mdl-38049983

9.

Interrupting an IFN-Î³-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne.

Lee, Wonyong; Stone, Deborah L; Hoffmann, Patrycja; Rosenzweig, Sofia; Tsai, Wanxia Li; Gadina, Massimo; Romeo, Tina; Lee, Chyi-Chia Richard; Randazzo, Davide; Pimpale Chavan, Pallavi; Manthiram, Kalpana; Canna, Scott; Park, Yong Hwan; Ombrello, Amanda K; Aksentijevich, Ivona; Kastner, Daniel L; Chae, Jae Jin.

Ann Rheum Dis ; 83(6): 787-798, 2024 May 15.

Article in English | MEDLINE | ID: mdl-38408849

10.

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

Beck, David B; Ferrada, Marcela A; Sikora, Keith A; Ombrello, Amanda K; Collins, Jason C; Pei, Wuhong; Balanda, Nicholas; Ross, Daron L; Ospina Cardona, Daniela; Wu, Zhijie; Patel, Bhavisha; Manthiram, Kalpana; Groarke, Emma M; Gutierrez-Rodrigues, Fernanda; Hoffmann, Patrycja; Rosenzweig, Sofia; Nakabo, Shuichiro; Dillon, Laura W; Hourigan, Christopher S; Tsai, Wanxia L; Gupta, Sarthak; Carmona-Rivera, Carmelo; Asmar, Anthony J; Xu, Lisha; Oda, Hirotsugu; Goodspeed, Wendy; Barron, Karyl S; Nehrebecky, Michele; Jones, Anne; Laird, Ryan S; Deuitch, Natalie; Rowczenio, Dorota; Rominger, Emily; Wells, Kristina V; Lee, Chyi-Chia R; Wang, Weixin; Trick, Megan; Mullikin, James; Wigerblad, Gustaf; Brooks, Stephen; Dell'Orso, Stefania; Deng, Zuoming; Chae, Jae J; Dulau-Florea, Alina; Malicdan, May C V; Novacic, Danica; Colbert, Robert A; Kaplan, Mariana J; Gadina, Massimo; Savic, Sinisa.

N Engl J Med ; 383(27): 2628-2638, 2020 12 31.

Article in English | MEDLINE | ID: mdl-33108101

11.

JAK inhibitors: Ten years after.

Spinelli, Francesca Romana; Meylan, Françoise; O'Shea, John J; Gadina, Massimo.

Eur J Immunol ; 51(7): 1615-1627, 2021 07.

Article in English | MEDLINE | ID: mdl-33930196

12.

Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver.

Di Censo, Chiara; Marotel, Marie; Mattiola, Irene; Müller, Lena; Scarno, Gianluca; Pietropaolo, Giuseppe; Peruzzi, Giovanna; Laffranchi, Mattia; Mazej, Julija; Hasim, Mohamed Shaad; Asif, Sara; Russo, Eleonora; Tomaipitinca, Luana; Stabile, Helena; Lee, Seung-Hwan; Vian, Laura; Gadina, Massimo; Gismondi, Angela; Shih, Han-Yu; Mikami, Yohei; Capuano, Cristina; Bernardini, Giovanni; Bonelli, Michael; Sozzani, Silvano; Diefenbach, Andreas; Ardolino, Michele; Santoni, Angela; Sciumè, Giuseppe.

Eur J Immunol ; 51(11): 2568-2575, 2021 11.

Article in English | MEDLINE | ID: mdl-34347289

13.

Peroxisome proliferator activated receptor-Î³ agonist pioglitazone improves vascular and metabolic dysfunction in systemic lupus erythematosus.

Hasni, Sarfaraz; Temesgen-Oyelakin, Yenealem; Davis, Michael; Chu, Jun; Poncio, Elaine; Naqi, Mohammad; Gupta, Sarthak; Wang, Xinghao; Oliveira, Christopher; Claybaugh, Dillon; Dey, Amit; Lu, Shajia; Carlucci, Philip; Purmalek, Monica; Manna, Zerai G; Shi, Yinghui; Ochoa-Navas, Isabel; Chen, Jinguo; Mukherjee, Amrita; Han, Kyu Lee; Cheung, Foo; Koroleva, Galina; Belkaid, Yasmine; Tsang, John S; Apps, Richard; Thomas, Donald E; Heller, Theo; Gadina, Massimo; Playford, Martin P; Li, Xiaobai; Mehta, Nehal N; Kaplan, Mariana J.

Ann Rheum Dis ; 2022 Aug 01.

Article in English | MEDLINE | ID: mdl-35914929

14.

Translating JAKs to Jakinibs.

Gadina, Massimo; Chisolm, Danielle A; Philips, Rachael L; McInness, Iain B; Changelian, Paul S; O'Shea, John J.

J Immunol ; 204(8): 2011-2020, 2020 04 15.

Article in English | MEDLINE | ID: mdl-32253269

15.

JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition.

Luo, Yiming; Alexander, Madison; Gadina, Massimo; O'Shea, John J; Meylan, Francoise; Schwartz, Daniella M.

J Allergy Clin Immunol ; 148(4): 911-925, 2021 10.

Article in English | MEDLINE | ID: mdl-34625141

16.

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians.

Stabile, Helena; Scarno, Gianluca; Fionda, Cinzia; Gismondi, Angela; Santoni, Angela; Gadina, Massimo; Sciumè, Giuseppe.

Immunol Rev ; 286(1): 148-159, 2018 11.

Article in English | MEDLINE | ID: mdl-30294965

17.

JAK1: Number one in the family; number one in inflammation?

Spinelli, Francesca Romana; Colbert, Robert A; Gadina, Massimo.

Rheumatology (Oxford) ; 60(Suppl 2): ii3-ii10, 2021 05 05.

Article in English | MEDLINE | ID: mdl-33950229

18.

Super-enhancers delineate disease-associated regulatory nodes in T cells.

Vahedi, Golnaz; Kanno, Yuka; Furumoto, Yasuko; Jiang, Kan; Parker, Stephen C J; Erdos, Michael R; Davis, Sean R; Roychoudhuri, Rahul; Restifo, Nicholas P; Gadina, Massimo; Tang, Zhonghui; Ruan, Yijun; Collins, Francis S; Sartorelli, Vittorio; O'Shea, John J.

Nature ; 520(7548): 558-62, 2015 Apr 23.

Article in English | MEDLINE | ID: mdl-25686607

19.

Tofacitinib inhibits the development of experimental autoimmune uveitis and reduces the proportions of Th1 but not of Th17 cells.

Bing, So Jin; Lyu, Cancan; Xu, Biying; Wandu, Wambui S; Hinshaw, Samuel J; Furumoto, Yasuko; Caspi, Rachel R; Gadina, Massimo; Gery, Igal.

Mol Vis ; 26: 641-651, 2020.

Article in English | MEDLINE | ID: mdl-33088168

20.

Type 2 immunity in the skin and lungs.

Akdis, Cezmi A; Arkwright, Peter D; Brüggen, Marie-Charlotte; Busse, William; Gadina, Massimo; Guttman-Yassky, Emma; Kabashima, Kenji; Mitamura, Yasutaka; Vian, Laura; Wu, Jianni; Palomares, Oscar.

Allergy ; 75(7): 1582-1605, 2020 07.

Article in English | MEDLINE | ID: mdl-32319104

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