ABSTRACT
The article presents data concerning assessment of content of such components of carbohydrate metabolism as lactate and pyruvate and their ration in patients with diabetes mellitus type I, representatives of Mongoloids and Caucasians. The decreased concentration of the given metabolites in mongoloids is established. The intensive cumulation of lactate and ration lactate/pyruvate in Caucasians can promote development of hypoxemic occurrences and as a result decrease course and prognosis of disease. The given differences require differentiated approach to tactics of treatment of the mentioned category of patients.
ABSTRACT
The peculiarities of HLA class II profile and lipid metabolism were examined in Buryat and Russian ethnic groups of patients with diabetes mellitus type 1. The incidence of type 1 haplotypes in HLA class II gene family was lower in Buryats than that in Russians. In comparison with Russians, the course of diabetes mellitus type 1 in Buryat patients was characterized with a lower content of total lipids, triacylglycerols, total cholesterol, and LDL, which probably explains a more favorable course of the disease in Buryat population.
Subject(s)
Diabetes Mellitus, Type 1/genetics , Diabetes Mellitus, Type 1/metabolism , Histocompatibility Antigens Class II/genetics , Adult , Ethnicity/genetics , Female , Humans , Male , Russia , White People/geneticsABSTRACT
Here we performed individual evaluation of the oxidative stress index that serves as an integral criterion for the balance of LPO-antioxidant defense system in women with endocrine pathology (type 1 diabetes mellitus and infertility with hyperprolactinemia). The state of the LPO-antioxidant defense system was estimated from blood levels of LPO substrates with conjugated double bonds, conjugated dienes, ketodienes, conjugated trienes, thiobarbituric acid-reactive substances, retinol, α-tocopherol, reduced and oxidized glutathione, and SOD activity. The use of this oxidative stress index allowed us to diagnose oxidative stress in female patients with endocrine pathology.