Search | Virtual Health Library

1.

BET bromodomains mediate transcriptional pause release in heart failure.

Anand, Priti; Brown, Jonathan D; Lin, Charles Y; Qi, Jun; Zhang, Rongli; Artero, Pedro Calderon; Alaiti, M Amer; Bullard, Jace; Alazem, Kareem; Margulies, Kenneth B; Cappola, Thomas P; Lemieux, Madeleine; Plutzky, Jorge; Bradner, James E; Haldar, Saptarsi M.

Cell ; 154(3): 569-82, 2013 Aug 01.

Article in English | MEDLINE | ID: mdl-23911322

2.

A transcriptional switch governs fibroblast activation in heart disease.

Alexanian, Michael; Przytycki, Pawel F; Micheletti, Rudi; Padmanabhan, Arun; Ye, Lin; Travers, Joshua G; Gonzalez-Teran, Barbara; Silva, Ana Catarina; Duan, Qiming; Ranade, Sanjeev S; Felix, Franco; Linares-Saldana, Ricardo; Li, Li; Lee, Clara Youngna; Sadagopan, Nandhini; Pelonero, Angelo; Huang, Yu; Andreoletti, Gaia; Jain, Rajan; McKinsey, Timothy A; Rosenfeld, Michael G; Gifford, Casey A; Pollard, Katherine S; Haldar, Saptarsi M; Srivastava, Deepak.

Nature ; 595(7867): 438-443, 2021 07.

Article in English | MEDLINE | ID: mdl-34163071

3.

Transcription factors KLF15 and PPARÎ´ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle.

Fan, Liyan; Sweet, David R; Fan, Erica K; Prosdocimo, Domenick A; Madera, Annmarie; Jiang, Zhen; Padmanabhan, Roshan; Haldar, Saptarsi M; Vinayachandran, Vinesh; Jain, Mukesh K.

J Biol Chem ; 298(6): 101926, 2022 06.

Article in English | MEDLINE | ID: mdl-35413288

4.

Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction.

Hahn, Virginia S; Knutsdottir, Hildur; Luo, Xin; Bedi, Kenneth; Margulies, Kenneth B; Haldar, Saptarsi M; Stolina, Marina; Yin, Jun; Khakoo, Aarif Y; Vaishnav, Joban; Bader, Joel S; Kass, David A; Sharma, Kavita.

Circulation ; 143(2): 120-134, 2021 01 12.

Article in English | MEDLINE | ID: mdl-33118835

5.

KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice.

Massopust, Ryan; Juros, Devin; Shapiro, Dillon; Lopes, Mikayla; Haldar, Saptarsi M; Taetzsch, Thomas; Valdez, Gregorio.

Neurobiol Dis ; 162: 105583, 2022 01.

Article in English | MEDLINE | ID: mdl-34902552

6.

Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs.

George, Matthew R; Duan, Qiming; Nagle, Abigail; Kathiriya, Irfan S; Huang, Yu; Rao, Kavitha; Haldar, Saptarsi M; Bruneau, Benoit G.

Development ; 146(23)2019 12 09.

Article in English | MEDLINE | ID: mdl-31784461

7.

A New Therapeutic Framework for Atrial Fibrillation Drug Development.

Ang, Yen-Sin; Rajamani, Sridharan; Haldar, Saptarsi M; Hüser, Jörg.

Circ Res ; 127(1): 184-201, 2020 06 19.

Article in English | MEDLINE | ID: mdl-32717173

8.

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.

Padmanabhan, Arun; Alexanian, Michael; Linares-Saldana, Ricardo; González-Terán, Bárbara; Andreoletti, Gaia; Huang, Yu; Connolly, Andrew J; Kim, Wonho; Hsu, Austin; Duan, Qiming; Winchester, Sarah A B; Felix, Franco; Perez-Bermejo, Juan A; Wang, Qiaohong; Li, Li; Shah, Parisha P; Haldar, Saptarsi M; Jain, Rajan; Srivastava, Deepak.

Circulation ; 142(24): 2338-2355, 2020 12 15.

Article in English | MEDLINE | ID: mdl-33094644

9.

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.

Stratton, Matthew S; Bagchi, Rushita A; Felisbino, Marina B; Hirsch, Rachel A; Smith, Harrison E; Riching, Andrew S; Enyart, Blake Y; Koch, Keith A; Cavasin, Maria A; Alexanian, Michael; Song, Kunhua; Qi, Jun; Lemieux, Madeleine E; Srivastava, Deepak; Lam, Maggie P Y; Haldar, Saptarsi M; Lin, Charles Y; McKinsey, Timothy A.

Circ Res ; 125(7): 662-677, 2019 09 13.

Article in English | MEDLINE | ID: mdl-31409188

10.

BET bromodomain proteins regulate enhancer function during adipogenesis.

Brown, Jonathan D; Feldman, Zachary B; Doherty, Sean P; Reyes, Jaime M; Rahl, Peter B; Lin, Charles Y; Sheng, Quanhu; Duan, Qiong; Federation, Alexander J; Kung, Andrew L; Haldar, Saptarsi M; Young, Richard A; Plutzky, Jorge; Bradner, James E.

Proc Natl Acad Sci U S A ; 115(9): 2144-2149, 2018 02 27.

Article in English | MEDLINE | ID: mdl-29444854

11.

Drugging transcription in heart failure.

Padmanabhan, Arun; Haldar, Saptarsi M.

J Physiol ; 598(14): 3005-3014, 2020 07.

Article in English | MEDLINE | ID: mdl-30927446

12.

The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.

Mahabeleshwar, Ganapati H; Kawanami, Daiji; Sharma, Nikunj; Takami, Yoichi; Zhou, Guangjin; Shi, Hong; Nayak, Lalitha; Jeyaraj, Darwin; Grealy, Robert; White, Mary; McManus, Ross; Ryan, Thomas; Leahy, Patrick; Lin, Zhiyong; Haldar, Saptarsi M; Atkins, G Brandon; Wong, Hector R; Lingrel, Jerry B; Jain, Mukesh K.

Immunity ; 34(5): 715-28, 2011 May 27.

Article in English | MEDLINE | ID: mdl-21565532

13.

Epigenetic therapies in heart failure.

Alexanian, Michael; Padmanabhan, Arun; McKinsey, Timothy A; Haldar, Saptarsi M.

J Mol Cell Cardiol ; 130: 197-204, 2019 05.

Article in English | MEDLINE | ID: mdl-30991033

14.

S-Nitrosylation at the interface of autophagy and disease.

Haldar, Saptarsi M; Stamler, Jonathan S.

Mol Cell ; 43(1): 1-3, 2011 Jul 08.

Article in English | MEDLINE | ID: mdl-21726803

15.

Circadian rhythms govern cardiac repolarization and arrhythmogenesis.

Jeyaraj, Darwin; Haldar, Saptarsi M; Wan, Xiaoping; McCauley, Mark D; Ripperger, Jürgen A; Hu, Kun; Lu, Yuan; Eapen, Betty L; Sharma, Nikunj; Ficker, Eckhard; Cutler, Michael J; Gulick, James; Sanbe, Atsushi; Robbins, Jeffrey; Demolombe, Sophie; Kondratov, Roman V; Shea, Steven A; Albrecht, Urs; Wehrens, Xander H T; Rosenbaum, David S; Jain, Mukesh K.

Nature ; 483(7387): 96-9, 2012 Feb 22.

Article in English | MEDLINE | ID: mdl-22367544

16.

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.

Morrison-Nozik, Alexander; Anand, Priti; Zhu, Han; Duan, Qiming; Sabeh, Mohamad; Prosdocimo, Domenick A; Lemieux, Madeleine E; Nordsborg, Nikolai; Russell, Aaron P; MacRae, Calum A; Gerber, Anthony N; Jain, Mukesh K; Haldar, Saptarsi M.

Proc Natl Acad Sci U S A ; 112(49): E6780-9, 2015 Dec 08.

Article in English | MEDLINE | ID: mdl-26598680

17.

Differential role of an NF-κB transcriptional response element in endothelial versus intimal cell VCAM-1 expression.

Milstone, David S; Ilyama, Motoi; Chen, Mian; O'Donnell, Peter; Davis, Vannessa M; Plutzky, Jorge; Brown, Jonathan D; Haldar, Saptarsi M; Siu, Allan; Lau, Andrew C; Zhu, Su-Ning; Basheer, Mayada F; Collins, Tucker; Jongstra-Bilen, Jenny; Cybulsky, Myron I.

Circ Res ; 117(2): 166-77, 2015 Jul 03.

Article in English | MEDLINE | ID: mdl-26034041

18.

Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning.

Duan, Qiming; Madan, Namrata D; Wu, Jian; Kalisz, Jennifer; Doshi, Krunal Y; Haldar, Saptarsi M; Liu, Lijun; Pierre, Sandrine V.

J Mol Cell Cardiol ; 80: 114-25, 2015 Mar.

Article in English | MEDLINE | ID: mdl-25575882

19.

Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism.

Prosdocimo, Domenick A; Anand, Priti; Liao, Xudong; Zhu, Han; Shelkay, Shamanthika; Artero-Calderon, Pedro; Zhang, Lilei; Kirsh, Jacob; Moore, D'Vesharronne; Rosca, Mariana G; Vazquez, Edwin; Kerner, Janos; Akat, Kemal M; Williams, Zev; Zhao, Jihe; Fujioka, Hisashi; Tuschl, Thomas; Bai, Xiaodong; Schulze, P Christian; Hoppel, Charles L; Jain, Mukesh K; Haldar, Saptarsi M.

J Biol Chem ; 289(9): 5914-24, 2014 Feb 28.

Article in English | MEDLINE | ID: mdl-24407292

20.

The Cardiac Myofibroblast.

Alexanian, Michael; Haldar, Saptarsi M.

Circ Res ; 123(12): 1258-1260, 2018 12 07.

Article in English | MEDLINE | ID: mdl-30566054

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