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1.
Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals.
Xenobiotica
; 51(10): 1155-1180, 2021 Oct.
Article
in English
| MEDLINE | ID: mdl-34496722
2.
Application of an in Vitro Blood-Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington's Disease.
Mol Pharm
; 16(5): 2069-2082, 2019 05 06.
Article
in English
| MEDLINE | ID: mdl-30916978
3.
Validation of LC-MS/MS methods for quantitative analysis of kynurenine pathway metabolites in human plasma and cerebrospinal fluid.
Bioanalysis
; 15(11): 637-651, 2023 Jun.
Article
in English
| MEDLINE | ID: mdl-37170582
4.
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.
J Med Chem
; 66(1): 641-656, 2023 01 12.
Article
in English
| MEDLINE | ID: mdl-36548390
5.
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.
J Med Chem
; 66(18): 13205-13246, 2023 Sep 28.
Article
in English
| MEDLINE | ID: mdl-37712656
6.
Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators.
Bioorg Med Chem Lett
; 21(20): 6170-5, 2011 Oct 15.
Article
in English
| MEDLINE | ID: mdl-21889339
7.
Benzobistriazinones and related heterocyclic ring systems as potent, orally bioavailable positive allosteric AMPA receptor modulators.
Bioorg Med Chem Lett
; 21(24): 7455-9, 2011 Dec 15.
Article
in English
| MEDLINE | ID: mdl-22056742
8.
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins.
J Med Chem
; 64(16): 12003-12021, 2021 08 26.
Article
in English
| MEDLINE | ID: mdl-34351166
9.
Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System.
Cells
; 9(4)2020 04 16.
Article
in English
| MEDLINE | ID: mdl-32316221
10.
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand.
J Med Chem
; 63(15): 8608-8633, 2020 08 13.
Article
in English
| MEDLINE | ID: mdl-32662649
11.
A single-run liquid chromatography mass spectrometry method to quantify neuroactive kynurenine pathway metabolites in rat plasma.
J Pharm Biomed Anal
; 107: 426-31, 2015 Mar 25.
Article
in English
| MEDLINE | ID: mdl-25668794
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