1.
Acta Pol Pharm
; 52(6): 477-82, 1995.
Article
in English
| MEDLINE
| ID: mdl-8960266
ABSTRACT
Hydrolysis of 1-acetoxyethyl ester of cefuroxime [I] in blood was studied in vitro and in vivo. In vitro [I] hydrolyzes to biological active cefuroxime [II] and at the same time it undergoes isomerization to isomer delta 2 of 1-acetoxyethyl ester of cefuroxime [IV] and next hydrolyzes to biological inactive isomer delta 2 of cefuroxime [V]. As a result of hydrolysis [I] in vivo only [II] is formed.
Subject(s)
Blood/metabolism , Cefuroxime/analogs & derivatives , Cephalosporins/metabolism , Prodrugs/metabolism , Cefuroxime/metabolism , Humans
2.
Acta Pol Pharm
; 33(5): 665-6, 1976.
Article
in English
| MEDLINE
| ID: mdl-998321
3.
Acta Pol Pharm
; 35(1): 125, 1978.
Article
in English
| MEDLINE
| ID: mdl-645387
4.
Acta Pol Pharm
; 42(2): 205-8, 1985.
Article
in Polish
| MEDLINE
| ID: mdl-4083056