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A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging We gratefully acknowledge financial support from Pfizer Global Research and Development, the University of Ferrara (Italy, Postdoctoral Fellowship to A.M.), the EU (Marie Curie Fellowship to F.R.), and a Novartis Research Fellowship (to S.V.L.).

Ley, Steven V.; Massi, Alessandro; Rodríguez, Félix; Horwell, David C.; Lewthwaite, Russell A.; Pritchard, Martyn C.; Reid, Alison M..

Angew Chem Int Ed Engl ; 40(6): 1053-1055, 2001 Mar 16.

Article in English | MEDLINE | ID: mdl-11268070

Syntheses of novel heterocycles as anticancer agents.

Chauhan, Prem M S; Martins, Cristina J A; Horwell, David C.

Bioorg Med Chem ; 13(10): 3513-8, 2005 May 16.

Article in English | MEDLINE | ID: mdl-15848764

ABSTRACT

Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCI-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as novel templates for the anticancer chemotherapy and can serve as new leads in cancer chemotherapy.

Subject(s)

Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/pharmacology , Cell Proliferation/drug effects , Pteridines/chemical synthesis , Pteridines/pharmacology , Antineoplastic Agents/chemistry , Drug Screening Assays, Antitumor , Humans , Inhibitory Concentration 50 , Molecular Structure , Pteridines/chemistry , Structure-Activity Relationship , Tumor Cells, Cultured

ABSTRACT

Subject(s)

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