Search | Virtual Health Library

1.

Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.

Hu, Chunyi; Myers, Mason T; Zhou, Xufei; Hou, Zhonggang; Lozen, Macy L; Nam, Ki Hyun; Zhang, Yan; Ke, Ailong.

Mol Cell ; 84(3): 463-475.e5, 2024 Feb 01.

Article in English | MEDLINE | ID: mdl-38242128

2.

Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems.

Tan, Renke; Krueger, Ryan K; Gramelspacher, Max J; Zhou, Xufei; Xiao, Yibei; Ke, Ailong; Hou, Zhonggang; Zhang, Yan.

Mol Cell ; 82(4): 852-867.e5, 2022 02 17.

Article in English | MEDLINE | ID: mdl-35051351

3.

Epigenomic analysis of multilineage differentiation of human embryonic stem cells.

Xie, Wei; Schultz, Matthew D; Lister, Ryan; Hou, Zhonggang; Rajagopal, Nisha; Ray, Pradipta; Whitaker, John W; Tian, Shulan; Hawkins, R David; Leung, Danny; Yang, Hongbo; Wang, Tao; Lee, Ah Young; Swanson, Scott A; Zhang, Jiuchun; Zhu, Yun; Kim, Audrey; Nery, Joseph R; Urich, Mark A; Kuan, Samantha; Yen, Chia-an; Klugman, Sarit; Yu, Pengzhi; Suknuntha, Kran; Propson, Nicholas E; Chen, Huaming; Edsall, Lee E; Wagner, Ulrich; Li, Yan; Ye, Zhen; Kulkarni, Ashwinikumar; Xuan, Zhenyu; Chung, Wen-Yu; Chi, Neil C; Antosiewicz-Bourget, Jessica E; Slukvin, Igor; Stewart, Ron; Zhang, Michael Q; Wang, Wei; Thomson, James A; Ecker, Joseph R; Ren, Bing.

Cell ; 153(5): 1134-48, 2013 May 23.

Article in English | MEDLINE | ID: mdl-23664764

4.

Snapshots of a tiny ancestral nuclease of Cas9.

Hou, Zhonggang; Tan, Renke; Zhang, Yan.

Trends Biochem Sci ; 48(1): 9-10, 2023 01.

Article in English | MEDLINE | ID: mdl-36100522

5.

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas.

Dolan, Adam E; Hou, Zhonggang; Xiao, Yibei; Gramelspacher, Max J; Heo, Jaewon; Howden, Sara E; Freddolino, Peter L; Ke, Ailong; Zhang, Yan.

Mol Cell ; 74(5): 936-950.e5, 2019 06 06.

Article in English | MEDLINE | ID: mdl-30975459

6.

Insights into a Mysterious CRISPR Adaptation Factor, Cas4.

Hou, Zhonggang; Zhang, Yan.

Mol Cell ; 70(5): 757-758, 2018 06 07.

Article in English | MEDLINE | ID: mdl-29883600

7.

Programmable RNA Cleavage and Recognition by a Natural CRISPR-Cas9 System from Neisseria meningitidis.

Rousseau, Beth A; Hou, Zhonggang; Gramelspacher, Max J; Zhang, Yan.

Mol Cell ; 69(5): 906-914.e4, 2018 03 01.

Article in English | MEDLINE | ID: mdl-29456189

8.

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

Ordureau, Alban; Paulo, Joao A; Zhang, Wei; Ahfeldt, Tim; Zhang, Jiuchun; Cohn, Erin F; Hou, Zhonggang; Heo, Jin-Mi; Rubin, Lee L; Sidhu, Sachdev S; Gygi, Steven P; Harper, J Wade.

Mol Cell ; 70(2): 211-227.e8, 2018 04 19.

Article in English | MEDLINE | ID: mdl-29656925

9.

Biochemical characterization of RNA-guided ribonuclease activities for CRISPR-Cas9 systems.

Gramelspacher, Max J; Hou, Zhonggang; Zhang, Yan.

Methods ; 172: 32-41, 2020 02 01.

Article in English | MEDLINE | ID: mdl-31228550

10.

Functional characterization of human pluripotent stem cell-derived arterial endothelial cells.

Zhang, Jue; Chu, Li-Fang; Hou, Zhonggang; Schwartz, Michael P; Hacker, Timothy; Vickerman, Vernella; Swanson, Scott; Leng, Ning; Nguyen, Bao Kim; Elwell, Angela; Bolin, Jennifer; Brown, Matthew E; Stewart, Ron; Burlingham, William J; Murphy, William L; Thomson, James A.

Proc Natl Acad Sci U S A ; 114(30): E6072-E6078, 2017 07 25.

Article in English | MEDLINE | ID: mdl-28696312

11.

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.

Schwartz, Michael P; Hou, Zhonggang; Propson, Nicholas E; Zhang, Jue; Engstrom, Collin J; Santos Costa, Vitor; Jiang, Peng; Nguyen, Bao Kim; Bolin, Jennifer M; Daly, William; Wang, Yu; Stewart, Ron; Page, C David; Murphy, William L; Thomson, James A.

Proc Natl Acad Sci U S A ; 112(40): 12516-21, 2015 Oct 06.

Article in English | MEDLINE | ID: mdl-26392547

12.

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis.

Hou, Zhonggang; Zhang, Yan; Propson, Nicholas E; Howden, Sara E; Chu, Li-Fang; Sontheimer, Erik J; Thomson, James A.

Proc Natl Acad Sci U S A ; 110(39): 15644-9, 2013 Sep 24.

Article in English | MEDLINE | ID: mdl-23940360

13.

MPBind: a Meta-motif-based statistical framework and pipeline to Predict Binding potential of SELEX-derived aptamers.

Jiang, Peng; Meyer, Susanne; Hou, Zhonggang; Propson, Nicholas E; Soh, H Tom; Thomson, James A; Stewart, Ron.

Bioinformatics ; 30(18): 2665-7, 2014 Sep 15.

Article in English | MEDLINE | ID: mdl-24872422

14.

Phosphorylation regulates human OCT4.

Brumbaugh, Justin; Hou, Zhonggang; Russell, Jason D; Howden, Sara E; Yu, Pengzhi; Ledvina, Aaron R; Coon, Joshua J; Thomson, James A.

Proc Natl Acad Sci U S A ; 109(19): 7162-8, 2012 May 08.

Article in English | MEDLINE | ID: mdl-22474382

15.

Chemically defined conditions for human iPSC derivation and culture.

Chen, Guokai; Gulbranson, Daniel R; Hou, Zhonggang; Bolin, Jennifer M; Ruotti, Victor; Probasco, Mitchell D; Smuga-Otto, Kimberly; Howden, Sara E; Diol, Nicole R; Propson, Nicholas E; Wagner, Ryan; Lee, Garrett O; Antosiewicz-Bourget, Jessica; Teng, Joyce M C; Thomson, James A.

Nat Methods ; 8(5): 424-9, 2011 May.

Article in English | MEDLINE | ID: mdl-21478862

16.

Integrated module and gene-specific regulatory inference implicates upstream signaling networks.

Roy, Sushmita; Lagree, Stephen; Hou, Zhonggang; Thomson, James A; Stewart, Ron; Gasch, Audrey P.

PLoS Comput Biol ; 9(10): e1003252, 2013.

Article in English | MEDLINE | ID: mdl-24146602

17.

Thermal stability of fibroblast growth factor protein is a determinant factor in regulating self-renewal, differentiation, and reprogramming in human pluripotent stem cells.

Chen, Guokai; Gulbranson, Daniel R; Yu, Pengzhi; Hou, Zhonggang; Thomson, James A.

Stem Cells ; 30(4): 623-30, 2012 Apr.

Article in English | MEDLINE | ID: mdl-22213113

18.

Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications.

Hu, Chunyi; Myers, Mason T; Zhou, Xufei; Hou, Zhonggang; Lozen, Macy L; Zhang, Yan; Ke, Ailong.

bioRxiv ; 2023 Aug 06.

Article in English | MEDLINE | ID: mdl-37577534

19.

The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication.

Shor, Erika; Warren, Christopher L; Tietjen, Joshua; Hou, Zhonggang; Müller, Ulrika; Alborelli, Ilaria; Gohard, Florence H; Yemm, Adrian I; Borisov, Lev; Broach, James R; Weinreich, Michael; Nieduszynski, Conrad A; Ansari, Aseem Z; Fox, Catherine A.

PLoS Genet ; 5(12): e1000755, 2009 Dec.

Article in English | MEDLINE | ID: mdl-19997491

20.

Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3.

Hou, Zhonggang; Hu, Chunyi; Ke, Ailong; Zhang, Yan.

Curr Protoc ; 2(2): e361, 2022 Feb.

Article in English | MEDLINE | ID: mdl-35129865

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