Search | Virtual Health Library

1.

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.

Burrows, Natalie; Bashford-Rogers, Rachael J M; Bhute, Vijesh J; Peñalver, Ana; Ferdinand, John R; Stewart, Benjamin J; Smith, Joscelin E G; Deobagkar-Lele, Mukta; Giudice, Girolamo; Connor, Thomas M; Inaba, Akimichi; Bergamaschi, Laura; Smith, Sam; Tran, Maxine G B; Petsalaki, Evangelia; Lyons, Paul A; Espeli, Marion; Huntly, Brian J P; Smith, Kenneth G C; Cornall, Richard J; Clatworthy, Menna R; Maxwell, Patrick H.

Nat Immunol ; 21(11): 1408-1420, 2020 11.

Article in English | MEDLINE | ID: mdl-32868930

2.

Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.

Gong, Chun; Krupka, Joanna A; Gao, Jie; Grigoropoulos, Nicholas F; Giotopoulos, George; Asby, Ryan; Screen, Michael; Usheva, Zelvera; Cucco, Francesco; Barrans, Sharon; Painter, Daniel; Zaini, Nurmahirah Binte Mohammed; Haupl, Björn; Bornelöv, Susanne; Ruiz De Los Mozos, Igor; Meng, Wei; Zhou, Peixun; Blain, Alex E; Forde, Sorcha; Matthews, Jamie; Khim Tan, Michelle Guet; Burke, G A Amos; Sze, Siu Kwan; Beer, Philip; Burton, Cathy; Campbell, Peter; Rand, Vikki; Turner, Suzanne D; Ule, Jernej; Roman, Eve; Tooze, Reuben; Oellerich, Thomas; Huntly, Brian J; Turner, Martin; Du, Ming-Qing; Samarajiwa, Shamith A; Hodson, Daniel J.

Mol Cell ; 81(19): 4059-4075.e11, 2021 10 07.

Article in English | MEDLINE | ID: mdl-34437837

3.

Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.

Burrows, Natalie; Bashford-Rogers, Rachael J M; Bhute, Vijesh J; Peñalver, Ana; Ferdinand, John R; Stewart, Benjamin J; Smith, Joscelin E G; Deobagkar-Lele, Mukta; Giudice, Girolamo; Connor, Thomas M; Inaba, Akimichi; Bergamaschi, Laura; Smith, Sam; Tran, Maxine G B; Petsalaki, Evangelia; Lyons, Paul A; Espeli, Marion; Huntly, Brian J P; Smith, Kenneth G C; Cornall, Richard J; Clatworthy, Menna R; Maxwell, Patrick H.

Nat Immunol ; 22(11): 1465, 2021 Nov.

Article in English | MEDLINE | ID: mdl-34522040

4.

Molecular, clinical and therapeutic determinants of outcome in NPM1 mutated AML.

Othman, Jad; Potter, Nicola; Ivey, Adam; Tazi, Yanis; Papaemmanuil, Elli; Jovanovic, Jelena; Freeman, Sylvie D; Gilkes, Amanda Frances; Gale, Rosemary E; Rapoz-D'Silva, Tanya; Runglall, Manohursingh; Kleeman, Michelle; Dhami, Pawan; Thomas, Ian; Johnson, Sean; Canham, Joanna; Cavenagh, James Durrell; Kottaridis, Panagiotis; Arnold, Claire; Ommen, Hans Beier; Overgaard, Ulrik Malthe; Dennis, Mike; Burnett, Alan Kenneth; Wilhelm-Benartzi, Charlotte S; Huntly, Brian Jp; Russell, Nigel H; Dillon, Richard James.

Blood ; 2024 May 01.

Article in English | MEDLINE | ID: mdl-38691678

5.

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia.

Agrawal-Singh, Shuchi; Bagri, Jaana; Giotopoulos, George; Azazi, Dhoyazan M A; Horton, Sarah J; Lopez, Cecile K; Anand, Shubha; Bach, Anne-Sophie; Stedham, Frances; Antrobus, Robin; Houghton, Jack W; Vassiliou, George S; Sasca, Daniel; Yun, Haiyang; Whetton, Anthony D; Huntly, Brian J P.

Blood ; 141(14): 1737-1754, 2023 04 06.

Article in English | MEDLINE | ID: mdl-36577137

6.

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma.

Anderson, Georgina S F; Ballester-Beltran, Jose; Giotopoulos, George; Guerrero, Jose A; Surget, Sylvanie; Williamson, James C; So, Tsz; Bloxham, David; Aubareda, Anna; Asby, Ryan; Walker, Ieuan; Jenkinson, Lesley; Soilleux, Elizabeth J; Roy, James P; Teodósio, Ana; Ficken, Catherine; Officer-Jones, Leah; Nasser, Sara; Skerget, Sheri; Keats, Jonathan J; Greaves, Peter; Tai, Yu-Tzu; Anderson, Kenneth C; MacFarlane, Marion; Thaventhiran, James E; Huntly, Brian J P; Lehner, Paul J; Chapman, Michael A.

Blood ; 139(16): 2471-2482, 2022 04 21.

Article in English | MEDLINE | ID: mdl-35134130

7.

Population dynamics of normal human blood inferred from somatic mutations.

Lee-Six, Henry; Øbro, Nina Friesgaard; Shepherd, Mairi S; Grossmann, Sebastian; Dawson, Kevin; Belmonte, Miriam; Osborne, Robert J; Huntly, Brian J P; Martincorena, Inigo; Anderson, Elizabeth; O'Neill, Laura; Stratton, Michael R; Laurenti, Elisa; Green, Anthony R; Kent, David G; Campbell, Peter J.

Nature ; 561(7724): 473-478, 2018 09.

Article in English | MEDLINE | ID: mdl-30185910

8.

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.

Sciacovelli, Marco; Gonçalves, Emanuel; Johnson, Timothy Isaac; Zecchini, Vincent Roberto; da Costa, Ana Sofia Henriques; Gaude, Edoardo; Drubbel, Alizee Vercauteren; Theobald, Sebastian Julian; Abbo, Sandra Riekje; Tran, Maxine Gia Binh; Rajeeve, Vinothini; Cardaci, Simone; Foster, Sarah; Yun, Haiyang; Cutillas, Pedro; Warren, Anne; Gnanapragasam, Vincent; Gottlieb, Eyal; Franze, Kristian; Huntly, Brian; Maher, Eamonn Richard; Maxwell, Patrick Henry; Saez-Rodriguez, Julio; Frezza, Christian.

Nature ; 537(7621): 544-547, 2016 08 31.

Article in English | MEDLINE | ID: mdl-27580029

9.

Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.

Lu, Yongxu; Stuart, Jennifer H; Talbot-Cooper, Callum; Agrawal-Singh, Shuchi; Huntly, Brian; Smid, Andrei I; Snowden, Joseph S; Dupont, Liane; Smith, Geoffrey L.

Proc Natl Acad Sci U S A ; 116(24): 11997-12006, 2019 06 11.

Article in English | MEDLINE | ID: mdl-31127039

10.

Sialic acid-binding immunoglobulin-like lectin (Sigelac)-15 is a rapidly internalised cell-surface antigen expressed by acute myeloid leukaemia cells.

Cao, Huan; Neerincx, Andreas; de Bono, Bernard; Lakner, Ursula; Huntington, Catherine; Elvin, John; Gudgin, Emma; Pridans, Clare; Vickers, Mark A; Huntly, Brian; Trowsdale, John; Barrow, Alexander D.

Br J Haematol ; 193(5): 946-950, 2021 06.

Article in English | MEDLINE | ID: mdl-33951750

11.

Real-world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study.

Milojkovic, Dragana; Cross, Nicholas C P; Ali, Sahra; Byrne, Jenny; Campbell, Gavin; Dignan, Fiona L; Drummond, Mark; Huntly, Brian; Marshall, Scott; McMullin, Mary Frances; Neelakantan, Pratap; Raghavan, Manoj; Sivakumaran, Muttuswamy; Tighe, Jane; Wandroo, Farooq; Willis, Fenella; Glen, Fiona; Fildes, Louise; Collington, Sarah J; Ryan, Jacqueline; Clark, Richard E; Mead, Adam J.

Br J Haematol ; 192(1): 62-74, 2021 01.

Article in English | MEDLINE | ID: mdl-32449159

12.

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.

Sasca, Daniel; Yun, Haiyang; Giotopoulos, George; Szybinski, Jakub; Evan, Theo; Wilson, Nicola K; Gerstung, Moritz; Gallipoli, Paolo; Green, Anthony R; Hills, Robert; Russell, Nigel; Osborne, Cameron S; Papaemmanuil, Elli; Göttgens, Berthold; Campbell, Peter; Huntly, Brian J P.

Blood ; 134(24): 2195-2208, 2019 12 12.

Article in English | MEDLINE | ID: mdl-31515253

13.

BET inhibitor resistance emerges from leukaemia stem cells.

Fong, Chun Yew; Gilan, Omer; Lam, Enid Y N; Rubin, Alan F; Ftouni, Sarah; Tyler, Dean; Stanley, Kym; Sinha, Devbarna; Yeh, Paul; Morison, Jessica; Giotopoulos, George; Lugo, Dave; Jeffrey, Philip; Lee, Stanley Chun-Wei; Carpenter, Christopher; Gregory, Richard; Ramsay, Robert G; Lane, Steven W; Abdel-Wahab, Omar; Kouzarides, Tony; Johnstone, Ricky W; Dawson, Sarah-Jane; Huntly, Brian J P; Prinjha, Rab K; Papenfuss, Anthony T; Dawson, Mark A.

Nature ; 525(7570): 538-42, 2015 Sep 24.

Article in English | MEDLINE | ID: mdl-26367796

14.

Glutaminolysis is a metabolic dependency in FLT3^ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.

Gallipoli, Paolo; Giotopoulos, George; Tzelepis, Konstantinos; Costa, Ana S H; Vohra, Shabana; Medina-Perez, Paula; Basheer, Faisal; Marando, Ludovica; Di Lisio, Lorena; Dias, Joao M L; Yun, Haiyang; Sasca, Daniel; Horton, Sarah J; Vassiliou, George; Frezza, Christian; Huntly, Brian J P.

Blood ; 131(15): 1639-1653, 2018 04 12.

Article in English | MEDLINE | ID: mdl-29463564

15.

Molecular Landscape of Acute Myeloid Leukemia: Prognostic and Therapeutic Implications.

Marando, Ludovica; Huntly, Brian J P.

Curr Oncol Rep ; 22(6): 61, 2020 06 01.

Article in English | MEDLINE | ID: mdl-32476069

16.

Novel epigenetic therapies in hematological malignancies: Current status and beyond.

Gallipoli, Paolo; Huntly, Brian J P.

Semin Cancer Biol ; 51: 198-210, 2018 08.

Article in English | MEDLINE | ID: mdl-28782607

17.

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance.

Grimwade, David; Ivey, Adam; Huntly, Brian J P.

Blood ; 127(1): 29-41, 2016 Jan 07.

Article in English | MEDLINE | ID: mdl-26660431

18.

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.

McKerrell, Thomas; Moreno, Thaidy; Ponstingl, Hannes; Bolli, Niccolo; Dias, João M L; Tischler, German; Colonna, Vincenza; Manasse, Bridget; Bench, Anthony; Bloxham, David; Herman, Bram; Fletcher, Danielle; Park, Naomi; Quail, Michael A; Manes, Nicla; Hodkinson, Clare; Baxter, Joanna; Sierra, Jorge; Foukaneli, Theodora; Warren, Alan J; Chi, Jianxiang; Costeas, Paul; Rad, Roland; Huntly, Brian; Grove, Carolyn; Ning, Zemin; Tyler-Smith, Chris; Varela, Ignacio; Scott, Mike; Nomdedeu, Josep; Mustonen, Ville; Vassiliou, George S.

Blood ; 128(1): e1-9, 2016 07 07.

Article in English | MEDLINE | ID: mdl-27121471

19.

CML: new tools to answer old questions.

Giotopoulos, George; Huntly, Brian J P.

Blood ; 135(26): 2327-2328, 2020 06 25.

Article in English | MEDLINE | ID: mdl-32585023

20.

Corrigendum: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition.