1.
Bioorg Med Chem Lett
; 20(9): 2968-73, 2010 May 01.
Article
in English
| MEDLINE
| ID: mdl-20347591
ABSTRACT
We describe the structure-activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.
Subject(s)
Antiviral Agents/chemistry , Enzyme Inhibitors/chemistry , Indoles/chemistry , Pyrans/chemistry , Viral Nonstructural Proteins/antagonists & inhibitors , Antiviral Agents/chemical synthesis , Antiviral Agents/pharmacology , Binding Sites , Crystallography, X-Ray , Drug Discovery , Enzyme Inhibitors/chemical synthesis , Enzyme Inhibitors/pharmacology , Indoles/chemical synthesis , Indoles/pharmacology , Pyrans/chemical synthesis , Pyrans/pharmacology , Structure-Activity Relationship , Viral Nonstructural Proteins/metabolism
2.
ChemMedChem
; 3(10): 1508-15, 2008 Oct.
Article
in English
| MEDLINE
| ID: mdl-18729128