Paternal involvement in infant care and developmental milestone outcomes at age 3 years: the Japan Environment and Children's Study (JECS).

BACKGROUND: In developed countries, the time fathers spend on childcare has increased steadily in recent decades. However, studies on the relationship between paternal care and child outcomes remain scarce. Thus, we examined the association between paternal involvement in childcare and children's developmental outcomes. METHODS: We used Japan's largest birth cohort data, the Japan Environment and Children's Study, to examine the relationship between paternal involvement in childcare at the child's age of 6 months and developmental milestone outcomes at the child's age of 3 years (n = 28,050). Developmental delays were assessed with Ages and Stages Questionnaire. Potential mediation by maternal parenting stress at the child's age of 1.5 years was also examined. We used log-binomial regression analyses to estimate risk ratios. RESULTS: Fathers' high involvement in childcare was associated with a lower risk of developmental delay in gross-motor, fine-motor, problem solving, and personal-social domains compared with low involvement, adjusting for potential confounders. For example, the risk ratio with 95% confidence intervals was 0.76 [0.67, 0.86] for the gross-motor domain. We also observed that the associations were partially mediated by maternal parenting stress. CONCLUSIONS: Fathers' active involvement in childcare during infancy may promote young children's development, partially by reducing maternal parenting stress. IMPACT: Using Japan's largest birth cohort data (Japan Environment and Children's Study), we showed that paternal involvement in infant care might benefit young children's development. Fathers' active involvement in infant care was associated with a lower risk of developmental delays in gross-motor, fine-motor, problem solving, and personal-social domains. Maternal parenting stress may mediate the association between paternal involvement in infant care and child development outcomes at 3 years.

Visual attention across cultures: Similarities and differences in child development and maternal attention styles.

Previous cross-cultural research has described two different attention styles: a holistic style, characterized by context-sensitive processing, generally associated with interdependent cultural contexts, and an analytic style, a higher focus on salient objects, generally found in independent cultural contexts. Though a general assumption in the field is that attention styles are gradually socialized in culture-specific interactions in childhood, empirical evidence for the proximal mechanisms underlying this development is scarce. This study aimed to document the emergence of cross-cultural differences in attention styles in three cultural contexts differing in social orientations, namely in urban middle-class families from Münster, Germany (i.e., more independent context), and Kyoto, Japan, and Indigenous-heritage families from Cotacachi, Ecuador (i.e., more interdependent contexts). Furthermore, to test the assumption that caregivers' attention guidance is one of the forces driving differential development, we investigated how caregivers guide children's attention. In total, 270 children between 4 and 9 years of age and their mothers participated in three tasks: an eye-tracking task, a picture description task and a forced-choice recognition task. Results indicate a mixed pattern of findings: While some tasks revealed the expected cultural differences, namely a higher object focus in Münster compared to Kyoto and Cotacachi, others did not. Regarding caregivers' attention guidance, we found that mothers in Münster more strongly emphasized the focal object than mothers in Kyoto and Cotacachi. The results are discussed in terms of culture-specific developmental trajectories and the generalizability of attentional processes across tasks and cultural contexts. RESEARCH HIGHLIGHTS: We investigated visual attention styles in 4- to 9-year-old children and their mothers from urban Germany, urban Japan, and rural Ecuador in three different tasks. Special emphasis lied on mothers' verbal attention guidance toward their children as a proximal mechanism underlying the emergence of culture-specific attention styles. Mothers from urban Germany guided their children's attention in more analytic ways than mothers from urban Japan and rural Ecuador. The relevance of verbal attention guidance in the development of culture-specific attention styles has been demonstrated beyond the East-West dichotomy.

Impact of prior bevacizumab therapy on the incidence of ramucirumab-induced proteinuria in colorectal cancer: a multi-institutional cohort study.

BACKGROUND: The association between prior bevacizumab (BEV) therapy and ramucirumab (RAM)-induced proteinuria is not known. We aimed to investigate this association in patients with metastatic colorectal cancer (mCRC). METHODS: mCRC patients who received folinic acid, fluorouracil, and irinotecan (FOLFIRI) plus RAM were divided into with and without prior BEV treatment groups. The cumulative incidence of grade 2-3 proteinuria and rate of RAM discontinuation within 6 months (6M) after RAM initiation were compared between the two groups. RESULTS: We evaluated 245 patients. In the Fine-Gray subdistribution hazard model including prior BEV, age, sex, comorbidities, eGFR, proteinuria ≥ 2 + at baseline, and later line of RAM, prior BEV treatment contributed to proteinuria onset (P < 0.01). A shorter interval between final BEV and initial RAM increased the proteinuria risk; the adjusted odds ratios (95% confidence intervals) for the intervals of < 28 days, 28-55 days, and > 55 days (referring to prior BEV absence) were 2.60 (1.23-5.51), 1.51 (1.01-2.27), and 1.04 (0.76-1.44), respectively. The rate of RAM discontinuation for ≤ 6M due to anti-VEGF toxicities was significantly higher in the prior BEV treatment group compared with that in the no prior BEV treatment group (18% vs. 6%, P = 0.02). Second-line RAM discontinuation for ≤ 6M without progression resulted in shorter overall survival of 132 patients with prior BEV treatment (P < 0.01). CONCLUSION: Sequential FOLFIRI plus RAM after BEV failure, especially within 55 days, may exacerbate proteinuria. Its escalated anti-VEGF toxicity may negatively impact the overall survival.

Memory Monitoring and Control in Japanese and German Preschoolers.

Prior studies explored the early development of memory monitoring and control. However, little work has examined cross-cultural similarities and differences in metacognitive development in early childhood. In the present research, we investigated a total of 100 Japanese and German preschool-aged children's memory monitoring and control in a visual perception task. After seeing picture items, some of which were repeated, children were presented with picture pairs, one of which had been presented earlier and the other was a novel item. They then were asked to identify the previously presented picture. Children were also asked to evaluate their confidence about their selection, and to sort the responses to be used for being awarded with a prize at the end of the test. Both groups similarly expressed more confidence in the accurately remembered items than in the inaccurately remembered items, and their sorting decision was based on their subjective confidence. Japanese children's sorting more closely corresponded to memory accuracy than German children's sorting, however. These findings were further confirmed by a hierarchical Bayesian estimation of metacognitive efficiency. The present findings therefore suggest that early memory monitoring and control have both culturally similar and diverse aspects. The findings are discussed in light of broader sociocultural influences on metacognition.

Source memory and social exchange in young children.

Reciprocal interactions require memories of social exchanges; however, little is known about how we remember social partner actions, especially during childhood when we start forming peer-to-peer relationships. This study examined if the expectation-violation effect, which has been observed in adults' source memory, exists among 5-6-year-old children. Forty participants played a coin collection game where they either received or lost coins after being shown an individual with a smiling or angry expression. This set-up generated congruent (smiling-giver and angry-taker) versus incongruent (smiling-taker and angry-giver) conditions. In the subsequent tasks, the children were asked to recall which actions accompanied each individual. The children considered the person with incongruent conditions as being stranger than the person with congruent conditions, suggesting that the former violated the children's emotion-based expectations. However, no heightened source memory was found for the incongruent condition. Instead, children seem to better recognise the action of angry individuals than smiling individuals, suggesting that angry facial expressions are more salient for children's source memory in a social exchange.

Metacognition and mindreading in young children: A cross-cultural study.

Prior studies document cross cultural variation in the developmental onset of mindreading. In particular, Japanese children are reported to pass a standard false belief task later than children from Western countries. By contrast, we know little about cross-cultural variation in young children's metacognitive abilities. Moreover, one prominent theoretical discussion in developmental psychology focuses on the relation between metacognition and mindreading. Here we investigated the relation between mindreading and metacognition (both implicit and explicit) by testing 4-year-old Japanese and German children. We found no difference in metacognition between the two cultural groups. By contrast, Japanese children showed lower performance than German children replicating cultural differences in mindreading. Finally, metacognition and mindreading were not related in either group. We discuss the findings in light of the existing theoretical accounts of the relation between metacognition and mindreading.

Physiological arousal predicts gaze following in infants.

According to the natural pedagogy theory, infant gaze following is based on an understanding of the communicative intent of specific ostensive cues. However, it has remained unclear how eye contact affects this understanding and why it induces gaze following behaviour. In this study, we examined infant arousal in different gaze following contexts and whether arousal levels during eye contact predict gaze following. Twenty-five infants, ages 9-10 months participated in this study. They watched a video of an actress gazing towards one of two objects and then either looking directly into the camera to make eye contact or not showing any communicative intent. We found that eye contact led to an elevation in the infants' heart rates (HRs) and that HR during eye contact was predictive of later gaze following. Furthermore, increases in HR predicted gaze following whether it was accompanied by communicative cues or not. These findings suggest that infant gaze following behaviour is associated with both communicative cues and physiological arousal.

From understanding others' needs to prosocial action: Motor and social abilities promote infants' helping.

In the present study, we test the main hypothesis that infants' understanding of others' needs translates into helping behavior, when critical motor and social competencies have emerged, early in the second year. We assessed the understanding of others' needs in an eye-tracking paradigm and the helping behavior of 10- (n = 41) and 16-month-olds (n = 37). Furthermore, we assessed the motor and social abilities of 16-month-olds. Critically, while infants understood others' needs already at 10 months, fine motor and social interaction skills moderated the link between infants' prosocial understanding and helping behavior at 16 months. This provides first evidence that infants' helping behavior relates to their understanding of others' needs. Furthermore, we found that fine motor, gross motor, and social interaction skills predicted early helping behavior by themselves. These findings highlight that the emergence of infants' helping behavior is the result of a developmental system that includes infants' understanding of others' needs and also their motor and social competencies. The link between infants' understanding of others' needs and their early helpful actions provide further support for the prosocial nature of early helping behavior.

Effects of attentional behaviours on infant visual preferences and object choice.

Many developmental studies have examined the effects of joint attention. However, it has been difficult to compare effects of initiating joint attention and responding to joint attention in infants. Here, we compared the effects of initiating joint attention and responding joint attention on object information processing, object preference, and facial preferences in infants. Thirty-seven infants (10 to 12 months of age) were shown stimuli in which a female gazed towards or away from an object. Participants were assigned to initiating joint attention condition or responding joint attention condition. Results suggest that initiating joint attention promoted object information processing, whereas responding joint attention did not. Both joint attention conditions affected the facial preference for the person who engaged joint attention. In addition, after initiating joint attention, infants chose objects gazed by other person more often than after responding joint attention. It appears that attentional behaviours that precede the perception of certain stimuli affect infants' cognitive responses to those stimuli.

Causal Information Over Facial Expression: Modulation of Facial Expression Processing by Congruency and Causal Factor of the Linguistic Cues in 5-Year-Old Japanese Children.

It is unknown whether linguistic cues influence preschoolers' recognition of facial expression when the emotion of the face is incongruent with the linguistic cues and what type of linguistic cue is influential in the modulation of facial expression. In a priming task, we presented 5-year-old children three types of linguistic information conveying happy or sad emotion (simple label, label with rich causal explanation of emotion, and label with poor causal explanation of emotion) prior to the presentation of a happy or a sad face. We asked participants to recognize emotion of facial expression and examined whether they follow linguistic information than the facial expression when the emotions of linguistic information and face were incongruent. As a result, children who were presented the label with rich causal explanation judged emotion of face according to the linguistic information, whereas children who were presented the simple label or the label with poor causal explanation followed the emotions of facial expression. This result indicated that children's autonomic reliance on situational cues depends on the emotional causality and the concreteness of emotional state conveyed by the linguistic cues. This finding contributes to our understanding of the face inferiority effect on children's developing notion of emotions.

Oral mucositis associated with anti-EGFR therapy in colorectal cancer: single institutional retrospective cohort study.

BACKGROUND: Chemotherapy-induced oral mucositis impairs the quality of life. The difference in severity of oral mucositis between different anti-epidermal growth factor receptor (EGFR) antibodies combined with cytotoxic drugs in colorectal cancer is unclear. The aim of this study was to investigate the differences in oral mucositis between panitumumab (Pmab) and cetuximab (Cmab) combined with 5-fluorouracil (5-FU). METHODS: We conducted a retrospective cohort study. A total of 75 colorectal cancer outpatients treated with an anti-EGFR antibody combined with FOLFOX, FOLFIRI, or 5-FU/leucovorin as the first- to third-line treatment were included. The primary endpoint was the incidence of grade 2-3 oral mucositis. The secondary endpoint was the time to onset of oral mucositis. We also compared the incidence of toxicities of interest, skin toxicity, hypomagnesaemia and neutropenia, and time to treatment failure (TTF) between the two groups. RESULTS: Thirty-two patients treated with Pmab and 43 patients treated with Cmab were evaluated. Patient characteristics were similar between the two groups. The incidence of grade 2-3 oral mucositis was significantly higher with Pmab than with Cmab (31.3% vs 9.3%, P < 0.05). Moreover, the incidence of grade 3 oral mucositis was significantly higher in patients treated with Pmab (18.8% vs 0%, P < 0.01). The mean (SD) cycles to onset of the worst oral mucositis was 3.0 (2.9) in the Pmab group and 2.3 (1.7) in the Cmab group (P = 0.29). Oral mucositis was characterized by glossitis and cheilitis. The incidences of other toxicities were the following (Pmab vs Cmab): grade 2-3 skin toxicity: 68.8% vs 74.4% (P = 0.61), grade 2-3 hypomagnesaemia: 9.3% vs 7.0% (P = 1.00), grade 3-4 neutropenia: 28.1% vs 37.2% (P = 0.46). The median TTF was not significantly different, i.e., 223 days vs 200 days (P = 0.39) for Pmab vs Cmab. CONCLUSIONS: Pmab-based chemotherapy resulted in significantly higher grades of oral mucositis compared with Cmab-based chemotherapy. The oral condition should be monitored carefully and early supportive care should be provided for patients treated with Pmab-based chemotherapy.

Narrowing in face and speech perception in infancy: Developmental change in the relations between domains.

Although prior research has established that perceptual narrowing reflects the influence of experience on the development of face and speech processing, it is unclear whether narrowing in the two domains is related. A within-participant design (N = 72) was used to investigate discrimination of own- and other-race faces and native and non-native speech sounds in 3-, 6-, 9-, and 12-month-old infants. For face and speech discrimination, whereas 3-month-olds discriminated own-race faces and native speech sounds as well as other-race faces and non-native speech sounds, older infants discriminated only own-race faces and native speech sounds. Narrowing in face and narrowing in speech were not correlated at 6 months, negatively correlated at 9 months, and positively correlated at 12 months. The findings reveal dynamic developmental changes in the relation between modalities during the first year of life.

[Twelve-month-old infants show social preferences for native-dialect speakers].

Recent research demonstrates that social preferences for native language speakers emerge early in development, indicating that infants prefer speakers from their own society. Dialect may also be a reliable cue to group membership because it provides information about an individual's social and ethnic identity. We investigated whether infants showed social preferences toward native-dialect speakers over those with unfamiliar dialects. Infants at 9 and 12 months of age were shown videos in which two adults (a native-dialect speaker and an unfamiliar-dialect speaker) each spoke to and then offered an identical toy to the participating infants. Next, two real versions of the toys were presented to the infants in person. The 12-month-old infants preferentially reached for the toy offered by the native-dialect speaker. The 9-month-old infants also showed a preference for native-dialect speakers but this finding was not statistically significant. Our results suggest that dialects may be a reliable cue to group membership, and that infants' orientation toward members of their native community may guide their social and cultural learning.

Relationship between maternal grit and effortful control among 18-21-month-old toddlers.

Grit is known to be effective for long-term academic and social success. However, few studies have focused on the role of grit in parenting and its effect on the development of grit in children. Therefore, this study investigated the effect of maternal grit on children's effortful control (EC), which is thought to be a precursor to grit, using parenting as a mediating factor. Participants in the current study were 412 children (age range: 18-21 months, M = 34.67 months, SD = 4.51 months) and their mothers. We assessed maternal grit, parenting style, maternal EC, and child EC, and found that maternal grit, maternal EC, and parenting style were positively correlated with child EC. Furthermore, maternal grit was related to EC in children not only directly, but also indirectly through responsive parenting. Additionally, maternal grit was found to be directly related to child EC only when assessed separately from maternal EC. The current study's findings suggest that maternal grit is directly related to EC in children in a way that differs from the mother's EC in child-rearing situations.

The infant-doctor relationship: an examination of infants' distress reactions in the presence of a doctor.

Fear of doctors is a common source of distress among infants; however, the underlying sources of this distress are unknown. To investigate the doctor-infant relationship, the behaviors of 61 healthy infants (176-617 days old) were observed in a simulated examination room. Their behaviors and electrocardiograms were recorded. Two groups of infants were analyzed: those who cried and those who did not. When an experimenter dressed in the doctor's attire entered the room, all 9 infants who were crying (14.8% of all infants) stopped crying, all infants gazed at the experimenter, and their mean heart rate (HR) decreased. After the auscultation started, 29.5% of all infants cried, and the HRs of infants who cried were higher than those of infants who did not cry. During the auscultation, 80.0% of infants who cried averted from the experimenter, while 34.4% of infants who did not cry. Within 5 s of gazing at the stethoscope, the number of infants who cried increased from 3 to 12, and their mean HR also increased. Our findings suggest that the fear of doctors is not due to the appearance of doctors but rather to specific actions performed by doctors, such as auscultation. Infants may regard a doctor's appearance as a source of interest. Furthermore, a stethoscope is a possible trigger for infants' crying. These behavioral observations suggest the potential for patient-centered care for infants.

Brain structure variation and individual differences in theory of mind among older adults.

The theory of mind (ToM) is not substantially influenced by aging, suggesting the emergence of various compensatory mechanisms. To identify brain regions subserving ToM in older adults, we investigated the associations of individual differences in brain structure with performance on the Reading the Mind in the Eyes Test (RMET), a widely used measure of ToM, using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). In contrast to findings obtained from young adults, where multiple cortical regions are implicated in ToM, VBM analysis revealed a significant positive correlation between RMET score and gray matter (GM) volume only in the right middle temporal gyrus, a region implicated in social cognition. Alternatively, TBSS revealed significant positive correlations between RMET score and the fractional anisotropy (FA) values in widespread white matter (WM) tracts, including the bilateral uncinate fasciculus, a region previously linked to RMET performance in young adults. We speculate that individual differences in WM integrity are strong influences on ToM among older adults, whereas the impact of individual differences in GM volumes is relatively limited.

Mealtime conversations between parents and their 2-year-old children in five cultural contexts.

Children all over the world learn language, yet the contexts in which they do so vary substantially. This variation needs to be systematically quantified to build robust and generalizable theories of language acquisition. We compared communicative interactions between parents and their 2-year-old children (N = 99 families) during mealtime across five cultural settings (Brazil, Ecuador, Argentina, Germany, and Japan) and coded the amount of talk and gestures as well as their conversational embedding (interlocutors, function, and themes). We found a comparable pattern of communicative interactions across cultural settings, which were modified in ways that are consistent with local norms and values. These results suggest that children encounter similarly structured communicative environments across diverse cultural contexts and will inform theories of language learning. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

East-West cultural differences in context-sensitivity are evident in early childhood.

Accumulating evidence suggests that North Americans tend to focus on central objects whereas East Asians tend to pay more attention to contextual information in a visual scene. Although it is generally believed that such culturally divergent attention tendencies develop through socialization, existing evidence largely depends on adult samples. Moreover, no past research has investigated the relation between context-sensitivity and other domains of cognitive development. The present study examined children in the United States and Japan (N = 175, age 4-9 years) to investigate the developmental pattern in context-sensitivity and its relation to executive function. The study found that context-sensitivity increased with age across cultures. Nevertheless, Japanese children showed significantly greater context-sensitivity than American children. Also, context-sensitivity fully mediated the cultural difference in a set-shifting executive function task, which might help explain past findings that East Asian children outperformed their American counterparts on executive function.

Three- and 4-year-old children's response tendencies to various interviewers.

Unlike young preschoolers, older preschoolers may exhibit a response bias under social pressure from authoritative interviewers. To examine this, 3- and 4-year-old preschoolers were asked yes-no questions about familiar and unfamiliar objects in three conditions. In one condition an adult asked them questions in a live interaction, in a second condition an adult asked questions via video, and in a third condition a robot asked questions via video. The 3-year-olds exhibited a yes bias-a tendency to say "yes"-in nearly all conditions. The only exception was when they were asked questions about unfamiliar objects by the human interviewer via video, where they did not respond in a biased manner. The 4-year-olds exhibited a yes bias in only one condition-when they were questioned by a live human interviewer about both objects. They also exhibited a nay-saying bias when asked questions about unfamiliar objects in both video conditions, and they did not show any response bias in other conditions. The results suggest that the social pressure from an authoritative adult in a live interaction is problematic.

Infants understand the referential nature of human gaze but not robot gaze.

Infants can acquire much information by following the gaze direction of others. This type of social learning is underpinned by the ability to understand the relationship between gaze direction and a referent object (i.e., the referential nature of gaze). However, it is unknown whether human gaze is a privileged cue for information that infants use. Comparing human gaze with nonhuman (robot) gaze, we investigated whether infants' understanding of the referential nature of looking is restricted to human gaze. In the current study, we developed a novel task that measured by eye-tracking infants' anticipation of an object from observing an agent's gaze shift. Results revealed that although 10- and 12-month-olds followed the gaze direction of both a human and a robot, only 12-month-olds predicted the appearance of objects from referential gaze information when the agent was the human. Such a prediction for objects reflects an understanding of referential gaze. Our study demonstrates that by 12 months of age, infants hold referential expectations specifically from the gaze shift of humans. These specific expectations from human gaze may enable infants to acquire various information that others convey in social learning and social interaction.