Search | Virtual Health Library

1.

Gut microbial carbohydrate metabolism contributes to insulin resistance.

Takeuchi, Tadashi; Kubota, Tetsuya; Nakanishi, Yumiko; Tsugawa, Hiroshi; Suda, Wataru; Kwon, Andrew Tae-Jun; Yazaki, Junshi; Ikeda, Kazutaka; Nemoto, Shino; Mochizuki, Yoshiki; Kitami, Toshimori; Yugi, Katsuyuki; Mizuno, Yoshiko; Yamamichi, Nobutake; Yamazaki, Tsutomu; Takamoto, Iseki; Kubota, Naoto; Kadowaki, Takashi; Arner, Erik; Carninci, Piero; Ohara, Osamu; Arita, Makoto; Hattori, Masahira; Koyasu, Shigeo; Ohno, Hiroshi.

Nature ; 621(7978): 389-395, 2023 Sep.

Article in English | MEDLINE | ID: mdl-37648852

2.

Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation.

Toda, Gotaro; Soeda, Kotaro; Okazaki, Yukiko; Kobayashi, Naoki; Masuda, Yukari; Arakawa, Naoko; Suwanai, Hirotsugu; Masamoto, Yosuke; Izumida, Yoshihiko; Kamei, Nozomu; Sasako, Takayoshi; Suzuki, Ryo; Kubota, Tetsuya; Kubota, Naoto; Kurokawa, Mineo; Tobe, Kazuyuki; Noda, Tetsuo; Honda, Kenya; Accili, Domenico; Yamauchi, Toshimasa; Kadowaki, Takashi; Ueki, Kohjiro.

Mol Cell ; 79(1): 43-53.e4, 2020 07 02.

Article in English | MEDLINE | ID: mdl-32464093

3.

Empagliflozin in Patients with Chronic Kidney Disease.

Herrington, William G; Staplin, Natalie; Wanner, Christoph; Green, Jennifer B; Hauske, Sibylle J; Emberson, Jonathan R; Preiss, David; Judge, Parminder; Mayne, Kaitlin J; Ng, Sarah Y A; Sammons, Emily; Zhu, Doreen; Hill, Michael; Stevens, Will; Wallendszus, Karl; Brenner, Susanne; Cheung, Alfred K; Liu, Zhi-Hong; Li, Jing; Hooi, Lai Seong; Liu, Wen; Kadowaki, Takashi; Nangaku, Masaomi; Levin, Adeera; Cherney, David; Maggioni, Aldo P; Pontremoli, Roberto; Deo, Rajat; Goto, Shinya; Rossello, Xavier; Tuttle, Katherine R; Steubl, Dominik; Petrini, Michaela; Massey, Dan; Eilbracht, Jens; Brueckmann, Martina; Landray, Martin J; Baigent, Colin; Haynes, Richard.

N Engl J Med ; 388(2): 117-127, 2023 01 12.

Article in English | MEDLINE | ID: mdl-36331190

4.

NFIA in adipocytes reciprocally regulates mitochondrial and inflammatory gene program to improve glucose homeostasis.

Hiraike, Yuta; Saito, Kaede; Oguchi, Misato; Wada, Takahito; Toda, Gotaro; Tsutsumi, Shuichi; Bando, Kana; Sagawa, Junji; Nagano, Gaku; Ohno, Haruya; Kubota, Naoto; Kubota, Tetsuya; Aburatani, Hiroyuki; Kadowaki, Takashi; Waki, Hironori; Yanagimoto, Shintaro; Yamauchi, Toshimasa.

Proc Natl Acad Sci U S A ; 120(31): e2308750120, 2023 08.

Article in English | MEDLINE | ID: mdl-37487068

5.

Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation.

Masamoto, Yosuke; Arai, Shunya; Sato, Tomohiko; Yoshimi, Akihide; Kubota, Naoto; Takamoto, Iseki; Iwakura, Yoichiro; Yoshimura, Akihiko; Kadowaki, Takashi; Kurokawa, Mineo.

Immunity ; 44(6): 1422-33, 2016 06 21.

Article in English | MEDLINE | ID: mdl-27317261

6.

Genetic Reduction of Insulin Signaling Mitigates Amyloid-ß Deposition by Promoting Expression of Extracellular Matrix Proteins in the Brain.

Sano, Toshiharu; Ochiai, Toshitaka; Nagayama, Takeru; Nakamura, Ayaka; Kubota, Naoto; Kadowaki, Takashi; Wakabayashi, Tomoko; Iwatsubo, Takeshi.

J Neurosci ; 43(43): 7226-7241, 2023 10 25.

Article in English | MEDLINE | ID: mdl-37699718

7.

Effects of empagliflozin in patients with chronic kidney disease from Japan: exploratory analyses from EMPA-KIDNEY.

Nangaku, Masaomi; Herrington, William G; Goto, Shinya; Maruyama, Shoichi; Kashihara, Naoki; Ueki, Kohjiro; Wada, Jun; Watada, Hirotaka; Nakashima, Eitaro; Lee, Ryonfa; Massey, Dan; Mayne, Kaitlin J; Tomita, Aiko; Haynes, Richard; Hauske, Sibylle J; Kadowaki, Takashi.

Clin Exp Nephrol ; 28(6): 588-595, 2024 Jun.

Article in English | MEDLINE | ID: mdl-38643286

8.

Genome-wide association studies identify two novel loci conferring susceptibility to diabetic retinopathy in Japanese patients with type 2 diabetes.

Imamura, Minako; Takahashi, Atsushi; Matsunami, Masatoshi; Horikoshi, Momoko; Iwata, Minoru; Araki, Shin-Ichi; Toyoda, Masao; Susarla, Gayatri; Ahn, Jeeyun; Park, Kyu Hyung; Kong, Jinhwa; Moon, Sanghoon; Sobrin, Lucia; Yamauchi, Toshimasa; Tobe, Kazuyuki; Maegawa, Hiroshi; Kadowaki, Takashi; Maeda, Shiro.

Hum Mol Genet ; 30(8): 716-726, 2021 05 17.

Article in English | MEDLINE | ID: mdl-33607655

9.

Randomized, double-blind, placebo-controlled phase 3 study of bardoxolone methyl in patients with diabetic kidney disease: design and baseline characteristics of the AYAME study.

Nangaku, Masaomi; Takama, Hirotaka; Ichikawa, Tomohiro; Mukai, Kazuya; Kojima, Masahiro; Suzuki, Yusuke; Watada, Hirotaka; Wada, Takashi; Ueki, Kohjiro; Narita, Ichiei; Kashihara, Naoki; Kadowaki, Takashi; Hase, Hiroki; Akizawa, Tadao.

Nephrol Dial Transplant ; 38(5): 1204-1216, 2023 05 04.

Article in English | MEDLINE | ID: mdl-36002026

10.

Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men.

Nakagawa-Nagahama, Yoshiko; Igarashi, Masaki; Miura, Masaomi; Kashiwabara, Kosuke; Yaku, Keisuke; Fukamizu, Yuichiro; Sato, Toshiya; Sakurai, Takanobu; Nakagawa, Takashi; Kadowaki, Takashi; Yamauchi, Toshimasa.

BMC Geriatr ; 23(1): 97, 2023 02 15.

Article in English | MEDLINE | ID: mdl-36792992

11.

Comparison of bleeding complications after pediatric kidney biopsy between intravenous sedation and general anesthesia: a nationwide cohort study.

Okada, Akira; Ikeda Kurakawa, Kayo; Harita, Yutaka; Shimizu, Akira; Yamaguchi, Satoko; Aso, Shotaro; Ono, Sachiko; Hashimoto, Yohei; Kumazawa, Ryosuke; Michihata, Nobuaki; Jo, Taisuke; Matsui, Hiroki; Fushimi, Kiyohide; Nangaku, Masaomi; Yamauchi, Toshimasa; Yasunaga, Hideo; Kadowaki, Takashi.

BMC Pediatr ; 23(1): 33, 2023 01 20.

Article in English | MEDLINE | ID: mdl-36670403

12.

NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentiation.

Hiraike, Yuta; Waki, Hironori; Miyake, Kana; Wada, Takahito; Oguchi, Misato; Saito, Kaede; Tsutsumi, Shuichi; Aburatani, Hiroyuki; Yamauchi, Toshimasa; Kadowaki, Takashi.

PLoS Genet ; 16(9): e1009044, 2020 09.

Article in English | MEDLINE | ID: mdl-32991581

13.

LPL/AQP7/GPD2 promotes glycerol metabolism under hypoxia and prevents cardiac dysfunction during ischemia.

Ishihama, Sohta; Yoshida, Satoya; Yoshida, Tatsuya; Mori, Yu; Ouchi, Noriyuki; Eguchi, Shunsuke; Sakaguchi, Teruhiro; Tsuda, Takuma; Kato, Katsuhiro; Shimizu, Yuuki; Ohashi, Koji; Okumura, Takahiro; Bando, Yasuko K; Yagyu, Hiroaki; Wettschureck, Nina; Kubota, Naoto; Offermanns, Stefan; Kadowaki, Takashi; Murohara, Toyoaki; Takefuji, Mikito.

FASEB J ; 35(12): e22048, 2021 12.

Article in English | MEDLINE | ID: mdl-34807469

14.

Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan.

Kadowaki, Takashi; Maegawa, Hiroshi; Watada, Hirotaka; Yabe, Daisuke; Node, Koichi; Murohara, Toyoaki; Wada, Jun.

Diabetes Obes Metab ; 24(12): 2283-2296, 2022 12.

Article in English | MEDLINE | ID: mdl-35929483

15.

Cost of healthcare utilization associated with incident cardiovascular and renal disease in individuals with type 2 diabetes: A multinational, observational study across 12 countries.

Norhammar, Anna; Bodegard, Johan; Eriksson, Jan W; Haller, Hermann; Linssen, Gerard C M; Banerjee, Amitava; Karasik, Avraham; Mamouris, Pavlos; Tangri, Navdeep; Taveira-Gomes, Tiago; Maggioni, Aldo P; Botana, Manuel; Thuresson, Marcus; Okami, Suguru; Yajima, Toshitaka; Kadowaki, Takashi; Birkeland, Kåre I.

Diabetes Obes Metab ; 24(7): 1277-1287, 2022 07.

Article in English | MEDLINE | ID: mdl-35322567

16.

Major complications after percutaneous biopsy of native or transplanted liver in pediatric patients: a nationwide inpatient database study in Japan.

Kurakawa, Kayo Ikeda; Okada, Akira; Bessho, Kazuhiko; Jo, Taisuke; Ono, Sachiko; Michihata, Nobuaki; Kumazawa, Ryosuke; Matsui, Hiroki; Fushimi, Kiyohide; Yamaguchi, Satoko; Yamauchi, Toshimasa; Nangaku, Masaomi; Kadowaki, Takashi; Yasunaga, Hideo.

BMC Gastroenterol ; 22(1): 395, 2022 Aug 24.

Article in English | MEDLINE | ID: mdl-36002811

17.

SnapShot: physiology of insulin signaling.

Kadowaki, Takashi; Kubota, Naoto; Ueki, Kohjiro; Yamauchi, Toshimasa.

Cell ; 148(4): 834-834.e1, 2012 Feb 17.

Article in English | MEDLINE | ID: mdl-22341452

18.

SnapShot: Insulin signaling pathways.

Kadowaki, Takashi; Ueki, Kohjiro; Yamauchi, Toshimasa; Kubota, Naoto.

Cell ; 148(3): 624, 624.e1, 2012 Feb 03.

Article in English | MEDLINE | ID: mdl-22304926

19.

Elucidating exercise-induced skeletal muscle signaling pathways and applying relevant findings to preemptive therapy for lifestyle-related diseases.

Iwabu, Masato; Okada-Iwabu, Miki; Kadowaki, Takashi; Yamauchi, Toshimasa.

Endocr J ; 69(1): 1-8, 2022 Jan 28.

Article in English | MEDLINE | ID: mdl-34511589

20.

Impact of body mass index on in-hospital mortality in older patients hospitalized for bacterial pneumonia with non-dialysis-dependent chronic kidney disease.

Okada, Akira; Yamaguchi, Satoko; Jo, Taisuke; Yokota, Isao; Ono, Sachiko; Ikeda Kurakawa, Kayo; Nangaku, Masaomi; Yamauchi, Toshimasa; Kadowaki, Takashi.

BMC Geriatr ; 22(1): 950, 2022 12 09.

Article in English | MEDLINE | ID: mdl-36494609

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