Search | Virtual Health Library

1.

ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.

Maxwell, Matthew B; Hom-Tedla, Marianne S; Yi, Jawoon; Li, Shitian; Rivera, Samuel A; Yu, Jingting; Burns, Mannix J; McRae, Helen M; Stevenson, Braden T; Coakley, Katherine E; Ho, Josephine; Gastelum, Kameneff Bojorquez; Bell, Joshua C; Jones, Alexander C; Eskander, Ramez N; Dykhuizen, Emily C; Shadel, Gerald S; Kaech, Susan M; Hargreaves, Diana C.

Cell ; 2024 May 09.

Article in English | MEDLINE | ID: mdl-38754421

2.

SnapShot: Cancer immunoediting.

Varanasi, Siva Karthik; Kaech, Susan M; Bui, Jack D.

Cell ; 185(21): 4038-4038.e1, 2022 10 13.

Article in English | MEDLINE | ID: mdl-36240741

3.

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence.

Harel, Michal; Ortenberg, Rona; Varanasi, Siva Karthik; Mangalhara, Kailash Chandra; Mardamshina, Mariya; Markovits, Ettai; Baruch, Erez N; Tripple, Victoria; Arama-Chayoth, May; Greenberg, Eyal; Shenoy, Anjana; Ayasun, Ruveyda; Knafo, Naama; Xu, Shihao; Anafi, Liat; Yanovich-Arad, Gali; Barnabas, Georgina D; Ashkenazi, Shira; Besser, Michal J; Schachter, Jacob; Bosenberg, Marcus; Shadel, Gerald S; Barshack, Iris; Kaech, Susan M; Markel, Gal; Geiger, Tamar.

Cell ; 179(1): 236-250.e18, 2019 09 19.

Article in English | MEDLINE | ID: mdl-31495571

4.

CD8⁺ T cells in the cancer-immunity cycle.

Giles, Josephine R; Globig, Anna-Maria; Kaech, Susan M; Wherry, E John.

Immunity ; 56(10): 2231-2253, 2023 10 10.

Article in English | MEDLINE | ID: mdl-37820583

5.

Canonical BAF complex activity shapes the enhancer landscape that licenses CD8⁺ T cell effector and memory fates.

McDonald, Bryan; Chick, Brent Y; Ahmed, Nasiha S; Burns, Mannix; Ma, Shixin; Casillas, Eduardo; Chen, Dan; Mann, Thomas H; O'Connor, Carolyn; Hah, Nasun; Hargreaves, Diana C; Kaech, Susan M.

Immunity ; 56(6): 1303-1319.e5, 2023 06 13.

Article in English | MEDLINE | ID: mdl-37315534

6.

CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma.

Chen, Dan; Varanasi, Siva Karthik; Hara, Toshiro; Traina, Kacie; Sun, Ming; McDonald, Bryan; Farsakoglu, Yagmur; Clanton, Josh; Xu, Shihao; Garcia-Rivera, Lizmarie; Mann, Thomas H; Du, Victor; Chung, H Kay; Xu, Ziyan; Tripple, Victoria; Casillas, Eduardo; Ma, Shixin; O'Connor, Carolyn; Yang, Qiyuan; Zheng, Ye; Hunter, Tony; Lemke, Greg; Kaech, Susan M.

Immunity ; 56(9): 2086-2104.e8, 2023 09 12.

Article in English | MEDLINE | ID: mdl-37572655

7.

Metabolic Instruction of Immunity.

Buck, Michael D; Sowell, Ryan T; Kaech, Susan M; Pearce, Erika L.

Cell ; 169(4): 570-586, 2017 05 04.

Article in English | MEDLINE | ID: mdl-28475890

8.

Probing the Diversity of T Cell Dysfunction in Cancer.

Sowell, Ryan T; Kaech, Susan M.

Cell ; 166(6): 1362-1364, 2016 Sep 08.

Article in English | MEDLINE | ID: mdl-27610560

9.

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

Xu, Shihao; Chaudhary, Omkar; Rodríguez-Morales, Patricia; Sun, Xiaoli; Chen, Dan; Zappasodi, Roberta; Xu, Ziyan; Pinto, Antonio F M; Williams, April; Schulze, Isabell; Farsakoglu, Yagmur; Varanasi, Siva Karthik; Low, Jun Siong; Tang, Wenxi; Wang, Haiping; McDonald, Bryan; Tripple, Victoria; Downes, Michael; Evans, Ronald M; Abumrad, Nada A; Merghoub, Taha; Wolchok, Jedd D; Shokhirev, Maxim N; Ho, Ping-Chih; Witztum, Joseph L; Emu, Brinda; Cui, Guoliang; Kaech, Susan M.

Immunity ; 54(7): 1561-1577.e7, 2021 07 13.

Article in English | MEDLINE | ID: mdl-34102100

10.

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity.

Cui, Guoliang; Staron, Matthew M; Gray, Simon M; Ho, Ping-Chih; Amezquita, Robert A; Wu, Jingxia; Kaech, Susan M.

Cell ; 161(4): 750-61, 2015 May 07.

Article in English | MEDLINE | ID: mdl-25957683

11.

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

Ho, Ping-Chih; Bihuniak, Jessica Dauz; Macintyre, Andrew N; Staron, Matthew; Liu, Xiaojing; Amezquita, Robert; Tsui, Yao-Chen; Cui, Guoliang; Micevic, Goran; Perales, Jose C; Kleinstein, Steven H; Abel, E Dale; Insogna, Karl L; Feske, Stefan; Locasale, Jason W; Bosenberg, Marcus W; Rathmell, Jeffrey C; Kaech, Susan M.

Cell ; 162(6): 1217-28, 2015 Sep 10.

Article in English | MEDLINE | ID: mdl-26321681

12.

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Perry, Rachel J; Camporez, João-Paulo G; Kursawe, Romy; Titchenell, Paul M; Zhang, Dongyan; Perry, Curtis J; Jurczak, Michael J; Abudukadier, Abulizi; Han, Myoung Sook; Zhang, Xian-Man; Ruan, Hai-Bin; Yang, Xiaoyong; Caprio, Sonia; Kaech, Susan M; Sul, Hei Sook; Birnbaum, Morris J; Davis, Roger J; Cline, Gary W; Petersen, Kitt Falk; Shulman, Gerald I.

Cell ; 160(4): 745-758, 2015 Feb 12.

Article in English | MEDLINE | ID: mdl-25662011

13.

The ß₁-adrenergic receptor links sympathetic nerves to T cell exhaustion.

Globig, Anna-Maria; Zhao, Steven; Roginsky, Jessica; Maltez, Vivien I; Guiza, Juan; Avina-Ochoa, Natalia; Heeg, Maximilian; Araujo Hoffmann, Filipe; Chaudhary, Omkar; Wang, Jiawei; Senturk, Gokhan; Chen, Dan; O'Connor, Carolyn; Pfaff, Samuel; Germain, Ronald N; Schalper, Kurt A; Emu, Brinda; Kaech, Susan M.

Nature ; 622(7982): 383-392, 2023 Oct.

Article in English | MEDLINE | ID: mdl-37731001

14.

A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.

Xin, Annie; Masson, Frederick; Liao, Yang; Preston, Simon; Guan, Tianxia; Gloury, Renee; Olshansky, Moshe; Lin, Jian-Xin; Li, Peng; Speed, Terence P; Smyth, Gordon K; Ernst, Matthias; Leonard, Warren J; Pellegrini, Marc; Kaech, Susan M; Nutt, Stephen L; Shi, Wei; Belz, Gabrielle T; Kallies, Axel.

Nat Immunol ; 17(4): 422-32, 2016 Apr.

Article in English | MEDLINE | ID: mdl-26950239

15.

T Cell Metabolism in a State of Flux.

Varanasi, Siva Karthik; Ma, Shixin; Kaech, Susan M.

Immunity ; 51(5): 783-785, 2019 11 19.

Article in English | MEDLINE | ID: mdl-31747577

16.

Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.

Laidlaw, Brian J; Cui, Weiguo; Amezquita, Robert A; Gray, Simon M; Guan, Tianxia; Lu, Yisi; Kobayashi, Yasushi; Flavell, Richard A; Kleinstein, Steven H; Craft, Joe; Kaech, Susan M.

Nat Immunol ; 16(8): 871-9, 2015 Aug.

Article in English | MEDLINE | ID: mdl-26147684

17.

KLRG1⁺ Effector CD8⁺ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

Herndler-Brandstetter, Dietmar; Ishigame, Harumichi; Shinnakasu, Ryo; Plajer, Valerie; Stecher, Carmen; Zhao, Jun; Lietzenmayer, Melanie; Kroehling, Lina; Takumi, Akiko; Kometani, Kohei; Inoue, Takeshi; Kluger, Yuval; Kaech, Susan M; Kurosaki, Tomohiro; Okada, Takaharu; Flavell, Richard A.

Immunity ; 48(4): 716-729.e8, 2018 04 17.

Article in English | MEDLINE | ID: mdl-29625895

18.

Tick-TOX, it's time for T cell exhaustion.

Mann, Thomas H; Kaech, Susan M.

Nat Immunol ; 20(9): 1092-1094, 2019 09.

Article in English | MEDLINE | ID: mdl-31427776

19.

A central role for Notch in effector CD8(+) T cell differentiation.

Backer, Ronald A; Helbig, Christina; Gentek, Rebecca; Kent, Andrew; Laidlaw, Brian J; Dominguez, Claudia X; de Souza, Yevan S; van Trierum, Stella E; van Beek, Ruud; Rimmelzwaan, Guus F; ten Brinke, Anja; Willemsen, A Marcel; van Kampen, Antoine H C; Kaech, Susan M; Blander, J Magarian; van Gisbergen, Klaas; Amsen, Derk.

Nat Immunol ; 15(12): 1143-51, 2014 Dec.

Article in English | MEDLINE | ID: mdl-25344724

20.

Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8⁺ T Cell Terminal Differentiation and Loss of Multipotency.

Gray, Simon M; Amezquita, Robert A; Guan, Tianxia; Kleinstein, Steven H; Kaech, Susan M.

Immunity ; 46(4): 596-608, 2017 04 18.

Article in English | MEDLINE | ID: mdl-28410989

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