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[Trypanocidal structure- activity relationship in 9-thioalkylacridines]. / Relations structure-activité trypanocide chez les 9-thioalkylacridines.
Bsiri, N; Johnson, C; Kayirere, M; Galy, A M; Galy, J P; Barbe, J; Osuna, A; Mesa-Valle, M C; Castilla Calvente, J J; Rodriguez-Cabezas, M N.
Ann Pharm Fr ; 54(1): 27-33, 1996.
Article in French | MEDLINE | ID: mdl-8702191

ABSTRACT

A set of 9-thioalkylacridinones, has been prepared and investigated "in vitro" against T. cruzi. Structure-antiparasitic activity relationships are detailed with a view to identify the major structural parameters for the activity under consideration.


Subject(s)
Acridines/pharmacology , Trypanocidal Agents/pharmacology , Trypanosoma cruzi/drug effects , Acridines/chemistry , Acridines/classification , Animals , Antiprotozoal Agents , In Vitro Techniques , Mice , Structure-Activity Relationship , Trypanocidal Agents/chemistry
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