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1.
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors.
Bioorg Med Chem Lett
; 56: 128463, 2022 01 15.
Article
in English
| MEDLINE | ID: mdl-34838652
2.
Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity.
J Pharmacol Exp Ther
; 377(1): 11-19, 2021 04.
Article
in English
| MEDLINE | ID: mdl-33509901
3.
BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain.
Brain
; 143(12): 3816-3826, 2020 12 01.
Article
in English
| MEDLINE | ID: mdl-33253354
4.
fMRI study of olfactory processing in mice under three anesthesia protocols: Insight into the effect of ketamine on olfactory processing.
Neuroimage
; 213: 116725, 2020 06.
Article
in English
| MEDLINE | ID: mdl-32173412
5.
Extending a Systems Model of the APP Pathway: Separation of ß- and γ-Secretase Sequential Cleavage Steps of APP.
J Pharmacol Exp Ther
; 365(3): 507-518, 2018 06.
Article
in English
| MEDLINE | ID: mdl-29563326
6.
Verubecestat for Prodromal Alzheimer's Disease. Reply.
N Engl J Med
; 381(4): 389, 2019 07 25.
Article
in English
| MEDLINE | ID: mdl-31340106
7.
Systems Pharmacology Analysis of the Amyloid Cascade after ß-Secretase Inhibition Enables the Identification of an Aß42 Oligomer Pool.
J Pharmacol Exp Ther
; 357(1): 205-16, 2016 Apr.
Article
in English
| MEDLINE | ID: mdl-26826190
8.
CNS amyloid-ß, soluble APP-α and -ß kinetics during BACE inhibition.
J Neurosci
; 34(24): 8336-46, 2014 Jun 11.
Article
in English
| MEDLINE | ID: mdl-24920637
9.
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
J Pharmacol Exp Ther
; 355(3): 397-409, 2015 Dec.
Article
in English
| MEDLINE | ID: mdl-26407721
10.
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.
J Neurochem
; 130(1): 4-28, 2014 Jul.
Article
in English
| MEDLINE | ID: mdl-24646365
11.
Microglial roles in Alzheimer's disease: An agent-based model to elucidate microglial spatiotemporal response to beta-amyloid.
CPT Pharmacometrics Syst Pharmacol
; 13(3): 449-463, 2024 Mar.
Article
in English
| MEDLINE | ID: mdl-38078626
12.
The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130.
Mol Neurodegener
; 18(1): 13, 2023 02 21.
Article
in English
| MEDLINE | ID: mdl-36810097
13.
Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease.
NPJ Parkinsons Dis
; 9(1): 74, 2023 May 11.
Article
in English
| MEDLINE | ID: mdl-37169750
14.
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
J Med Chem
; 66(21): 14912-14927, 2023 11 09.
Article
in English
| MEDLINE | ID: mdl-37861679
15.
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg Med Chem Lett
; 22(7): 2444-9, 2012 Apr 01.
Article
in English
| MEDLINE | ID: mdl-22390835
16.
The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method.
Sci Rep
; 12(1): 14985, 2022 Sep 02.
Article
in English
| MEDLINE | ID: mdl-36056033
17.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Article
in English
| MEDLINE | ID: mdl-36475697
18.
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
J Med Chem
; 65(1): 838-856, 2022 01 13.
Article
in English
| MEDLINE | ID: mdl-34967623
19.
Pharmacological BACE Inhibition Improves Axonal Regeneration in Nerve Injury and Disease Models.
Neurotherapeutics
; 17(3): 973-988, 2020 07.
Article
in English
| MEDLINE | ID: mdl-32236823
20.
Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings.
Sci Transl Med
; 12(570)2020 11 18.
Article
in English
| MEDLINE | ID: mdl-33208500