ABSTRACT
Feline infectious peritonitis (FIP) is a common, fatal, systemic disease of cats. This case report describes the antemortem diagnosis of FIP in a 2-year-old spayed female Sphinx cat that presented with a bilateral panuveitis and multiple papular cutaneous lesions. Histopathologically, the skin lesions were characterized by perivascular infiltrates of macrophages, neutrophils, with fewer plasma cells, mast cells, and small lymphocytes in the mid- to deep dermis. Immunohistochemistry for intracellular feline coronavirus (FeCoV) antigen demonstrated positive staining in dermal macrophages providing an antemortem diagnosis of a moderate, nodular to diffuse, pyogranulomatous perivascular dermatitis due to FIP infection. Obtaining an antemortem diagnosis of FIP can be a challenge and cutaneous lesions are rare in the disease. Recognition and biopsy of any cutaneous lesions in cats with panuveitis and suspected FIP can help establish an antemortem diagnosis of the disease.
Subject(s)
Coronavirus, Feline/immunology , Feline Infectious Peritonitis/pathology , Panuveitis/veterinary , Animals , Anti-Inflammatory Agents/therapeutic use , Antiviral Agents/therapeutic use , Cats , Coronavirus, Feline/classification , Feline Infectious Peritonitis/drug therapy , Female , Interferon-alpha/therapeutic use , Panuveitis/drug therapy , Panuveitis/pathology , Panuveitis/virology , Prednisolone/therapeutic useABSTRACT
Co-expression of cytokeratin and vimentin has been traditionally associated with a few select tumors. However, this phenomenon is being recognized in a wider range of tumors. Twenty-one canine primary pulmonary epithelial neoplasms were evaluated for the co-expression of cytokeratin and vimentin. The histologic pattern and grade, and an immunohistochemical grade for cytokeratin and vimentin staining, were determined for each neoplasm. Adenocarcinomas predominated, and histologically, most tumors were grade II. All of the neoplasms stained positive for cytokeratin, while only 8 (38%) stained positive for both vimentin and cytokeratin. Papillary adenocarcinomas were consistently vimentin negative. The anaplastic histologic pattern had significantly more vimentin staining than the other histologic patterns. There was no significant difference in histologic grade or grading criteria between those tumors that stained with vimentin and those that did not. The present study established that cytokeratin and vimentin co-expression occurs in canine primary pulmonary epithelial tumors at a similar frequency to human pulmonary neoplasms. Further investigation will be needed to characterize the significance of this finding, particularly with respect to prognosis.
Subject(s)
Dog Diseases/genetics , Keratins/genetics , Lung Neoplasms/veterinary , Vimentin/genetics , Adenocarcinoma/genetics , Adenocarcinoma/metabolism , Adenocarcinoma/veterinary , Animals , Dog Diseases/metabolism , Dog Diseases/pathology , Dogs , Humans , Immunohistochemistry , Keratins/metabolism , Lung Neoplasms/genetics , Lung Neoplasms/pathology , Necrosis , Vimentin/metabolismABSTRACT
An adult golden retriever was presented for progressive neurologic dysfunction. Clinical examination suggested brainstem disease. Blastomycosis was diagnosed based on fine-needle aspiration cytology of a normal sized lymph node and a positive blastomycosis urine antigen test. Systemic blastomycosis with neurologic involvement was confirmed at necropsy.
Subject(s)
Blastomycosis/veterinary , Central Nervous System Fungal Infections/veterinary , Dog Diseases/diagnosis , Animals , Antifungal Agents/therapeutic use , Biopsy, Fine-Needle/veterinary , Blastomycosis/diagnosis , Blastomycosis/drug therapy , Blastomycosis/pathology , Central Nervous System Fungal Infections/diagnosis , Central Nervous System Fungal Infections/drug therapy , Central Nervous System Fungal Infections/pathology , Dog Diseases/drug therapy , Dog Diseases/pathology , Dogs , Fatal Outcome , Female , Itraconazole/therapeutic useABSTRACT
An 8-year-old rottweiler, diagnosed with multiple myeloma and multiple sites of cutaneous involvement, was treated with chemotherapy and radiation therapy. The diagnostic criteria for canine multiple myeloma, limitations of diagnostic testing for light chain proteinuria in dogs, and the role of radiation therapy in multiple myeloma patients is discussed.