Search | Virtual Health Library

1.

Tracking chromatin state changes using nanoscale photo-proximity labelling.

Seath, Ciaran P; Burton, Antony J; Sun, Xuemeng; Lee, Gihoon; Kleiner, Ralph E; MacMillan, David W C; Muir, Tom W.

Nature ; 616(7957): 574-580, 2023 04.

Article in English | MEDLINE | ID: mdl-37020029

2.

Bumping up kinase activity with an ATP-derived neo-substrate.

Kleiner, Ralph E; Kapoor, Tarun M.

Cell ; 154(4): 716-8, 2013 Aug 15.

Article in English | MEDLINE | ID: mdl-23953104

3.

Profiling dynamic RNA-protein interactions using small-molecule-induced RNA editing.

Seo, Kyung W; Kleiner, Ralph E.

Nat Chem Biol ; 19(11): 1361-1371, 2023 Nov.

Article in English | MEDLINE | ID: mdl-37349582

4.

Chemoproteomic Approaches to Studying RNA Modification-Associated Proteins.

Dai, Wei; Yu, Nathan J; Kleiner, Ralph E.

Acc Chem Res ; 56(19): 2726-2739, 2023 10 03.

Article in English | MEDLINE | ID: mdl-37733063

5.

Chemoproteomic Profiling of 8-Oxoguanosine-Sensitive RNA-Protein Interactions.

Villers, Jennifer; McCann Smith, Eliana; DeLiberto, Amanda N; Arguello, A Emilia; Nyaanga, Joy; Kleiner, Ralph E.

Biochemistry ; 62(23): 3411-3419, 2023 12 05.

Article in English | MEDLINE | ID: mdl-38010074

6.

Global Discovery of Covalent Modulators of Ribonucleoprotein Granules.

Ciancone, Anthony M; Seo, Kyung W; Chen, Miaomiao; Borne, Adam L; Libby, Adam H; Bai, Dina L; Kleiner, Ralph E; Hsu, Ku-Lung.

J Am Chem Soc ; 145(20): 11056-11066, 2023 05 24.

Article in English | MEDLINE | ID: mdl-37159397

7.

Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation.

Dai, Wei; Li, Ang; Yu, Nathan J; Nguyen, Thao; Leach, Robert W; Wühr, Martin; Kleiner, Ralph E.

Nat Chem Biol ; 17(11): 1178-1187, 2021 11.

Article in English | MEDLINE | ID: mdl-34556860

8.

Live-Cell RNA Imaging with Metabolically Incorporated Fluorescent Nucleosides.

Wang, Danyang; Shalamberidze, Ana; Arguello, A Emilia; Purse, Byron W; Kleiner, Ralph E.

J Am Chem Soc ; 144(32): 14647-14656, 2022 08 17.

Article in English | MEDLINE | ID: mdl-35930766

9.

Mechanisms of epitranscriptomic gene regulation.

Seo, Kyung W; Kleiner, Ralph E.

Biopolymers ; 112(1): e23403, 2021 Jan.

Article in English | MEDLINE | ID: mdl-33001446

10.

Cell- and Polymerase-Selective Metabolic Labeling of Cellular RNA with 2'-Azidocytidine.

Wang, Danyang; Zhang, Yu; Kleiner, Ralph E.

J Am Chem Soc ; 142(34): 14417-14421, 2020 08 26.

Article in English | MEDLINE | ID: mdl-32786764

11.

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.

Maianti, Juan Pablo; McFedries, Amanda; Foda, Zachariah H; Kleiner, Ralph E; Du, Xiu Quan; Leissring, Malcolm A; Tang, Wei-Jen; Charron, Maureen J; Seeliger, Markus A; Saghatelian, Alan; Liu, David R.

Nature ; 511(7507): 94-8, 2014 Jul 03.

Article in English | MEDLINE | ID: mdl-24847884

12.

In Vitro Selection with a Site-Specifically Modified RNA Library Reveals the Binding Preferences of N⁶-Methyladenosine Reader Proteins.

Arguello, A Emilia; Leach, Robert W; Kleiner, Ralph E.

Biochemistry ; 58(31): 3386-3395, 2019 08 06.

Article in English | MEDLINE | ID: mdl-31287290

13.

A Metabolic Engineering Approach to Incorporate Modified Pyrimidine Nucleosides into Cellular RNA.

Zhang, Yu; Kleiner, Ralph E.

J Am Chem Soc ; 141(8): 3347-3351, 2019 02 27.

Article in English | MEDLINE | ID: mdl-30735369

14.

RNA Chemical Proteomics Reveals the N⁶-Methyladenosine (m⁶A)-Regulated Protein-RNA Interactome.

Arguello, A Emilia; DeLiberto, Amanda N; Kleiner, Ralph E.

J Am Chem Soc ; 139(48): 17249-17252, 2017 12 06.

Article in English | MEDLINE | ID: mdl-29140688

15.

Chemical proteomics reveals a Î³H2AX-53BP1 interaction in the DNA damage response.

Kleiner, Ralph E; Verma, Priyanka; Molloy, Kelly R; Chait, Brian T; Kapoor, Tarun M.

Nat Chem Biol ; 11(10): 807-14, 2015 Oct.

Article in English | MEDLINE | ID: mdl-26344695

16.

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.

Georghiou, George; Kleiner, Ralph E; Pulkoski-Gross, Michael; Liu, David R; Seeliger, Markus A.

Nat Chem Biol ; 8(4): 366-74, 2012 Feb 19.

Article in English | MEDLINE | ID: mdl-22344177

17.

Sequence- and Structure-Specific tRNA Dihydrouridylation by hDUS2.

Ji, Jingwei; Yu, Nathan J; Kleiner, Ralph E.

ACS Cent Sci ; 10(4): 803-812, 2024 Apr 24.

Article in English | MEDLINE | ID: mdl-38680565

18.

Introduction to 'The Epitranscriptome'.

Kleiner, Ralph E; Höbartner, Claudia; Jia, Guifang.

RSC Chem Biol ; 5(4): 271-272, 2024 Apr 03.

Article in English | MEDLINE | ID: mdl-38576727

19.

The impact of epitranscriptomic modifications on liver disease.

Berggren, Keith A; Schwartz, Robert E; Kleiner, Ralph E; Ploss, Alexander.

Trends Endocrinol Metab ; 35(4): 331-346, 2024 Apr.

Article in English | MEDLINE | ID: mdl-38212234

20.

Reading the RNA Code.

Kleiner, Ralph E.

Biochemistry ; 57(1): 11-12, 2018 01 09.

Article in English | MEDLINE | ID: mdl-28937209

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