Search | Virtual Health Library

1.

Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle.

Cheng, Wan-Chen; Tsui, Yao-Chen; Ragusa, Simone; Koelzer, Viktor H; Mina, Marco; Franco, Fabien; Läubli, Heinz; Tschumi, Benjamin; Speiser, Daniel; Romero, Pedro; Zippelius, Alfred; Petrova, Tatiana V; Mertz, Kirsten; Ciriello, Giovanni; Ho, Ping-Chih.

Nat Immunol ; 20(2): 206-217, 2019 02.

Article in English | MEDLINE | ID: mdl-30664764

2.

Publisher Correction: Uncoupling protein 2 reprograms the tumor microenvironment to support the anti-tumor immune cycle.

Cheng, Wan-Chen; Tsui, Yao-Chen; Ragusa, Simone; Koelzer, Viktor H; Mina, Marco; Franco, Fabien; Läubli, Heinz; Tschumi, Benjamin; Speiser, Daniel; Romero, Pedro; Zippelius, Alfred; Petrova, Tatiana V; Mertz, Kirsten; Ciriello, Giovanni; Ho, Ping-Chih.

Nat Immunol ; 20(4): 515-516, 2019 Apr.

Article in English | MEDLINE | ID: mdl-30862953

3.

High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity.

Vazquez-Lombardi, Rodrigo; Jung, Johanna S; Schlatter, Fabrice S; Mei, Anna; Mantuano, Natalia Rodrigues; Bieberich, Florian; Hong, Kai-Lin; Kucharczyk, Jakub; Kapetanovic, Edo; Aznauryan, Erik; Weber, Cédric R; Zippelius, Alfred; Läubli, Heinz; Reddy, Sai T.

Immunity ; 55(10): 1953-1966.e10, 2022 10 11.

Article in English | MEDLINE | ID: mdl-36174557

4.

Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade.

Wyss, Nina; Berner, Fiamma; Walter, Vincent; Jochum, Ann-Kristin; Purde, Mette T; Abdou, Marie-Therese; Sinnberg, Tobias; Hofmeister, Kathrin; Pop, Oltin T; Hasan Ali, Omar; Bauer, Jens; Cheng, Hung-Wei; Lütge, Mechthild; Klümper, Niklas; Diem, Stefan; Kosaloglu-Yalcin, Zeynep; Zhang, Yizheng; Sellmer, Laura; Macek, Boris; Karbach, Julia; König, David; Läubli, Heinz; Zender, Lars; Meyer, Britta S; Driessen, Christoph; Schürch, Christian M; Jochum, Wolfram; Amaral, Teresa; Heinzerling, Lucie; Cozzio, Antonio; Hegazy, Ahmed N; Schneider, Tino; Brutsche, Martin H; Sette, Alessandro; Lenz, Tobias L; Walz, Juliane; Rammensee, Hans-Georg; Früh, Martin; Jäger, Elke; Becher, Burkhard; Tufman, Amanda; Nuñez, Nicolas; Joerger, Markus; Flatz, Lukas.

Am J Respir Crit Care Med ; 2024 Apr 16.

Article in English | MEDLINE | ID: mdl-38626354

5.

A phase Ib/II randomized, open-label drug repurposing trial of glutamate signaling inhibitors in combination with chemoradiotherapy in patients with newly diagnosed glioblastoma: the GLUGLIO trial protocol.

Mastall, Maximilian; Roth, Patrick; Bink, Andrea; Fischer Maranta, Angela; Läubli, Heinz; Hottinger, Andreas Felix; Hundsberger, Thomas; Migliorini, Denis; Ochsenbein, Adrian; Seystahl, Katharina; Imbach, Lukas; Hortobagyi, Tibor; Held, Leonhard; Weller, Michael; Wirsching, Hans-Georg.

BMC Cancer ; 24(1): 82, 2024 Jan 15.

Article in English | MEDLINE | ID: mdl-38225589

6.

Real-world outcomes using PD-1 antibodies and BRAF + MEK inhibitors for adjuvant melanoma treatment from 39 skin cancer centers in Germany, Austria and Switzerland.

Schumann, Katharina; Mauch, Cornelia; Klespe, Kai-Christian; Loquai, Carmen; Nikfarjam, Ulrike; Schlaak, Max; Akçetin, Larissa; Kölblinger, Peter; Hoellwerth, Magdalena; Meissner, Markus; Mengi, Guelcin; Braun, Andreas Dominik; Mengoni, Miriam; Dummer, Reinhard; Mangana, Joanna; Sindrilaru, Mihaela-Anca; Radmann, Dan; Hafner, Christine; Freund, Johann; Rappersberger, Klemens; Weihsengruber, Felix; Meiss, Frank; Reinhardt, Lydia; Meier, Friedegund; Rainer, Barbara; Richtig, Erika; Ressler, Julia Maria; Höller, Christoph; Eigentler, Thomas; Amaral, Teresa; Peitsch, Wiebke K; Hillen, Uwe; Harth, Wolfgang; Ziller, Fabian; Schatton, Kerstin; Gambichler, Thilo; Susok, Laura; Maul, Lara Valeska; Läubli, Heinz; Debus, Dirk; Weishaupt, Carsten; Börger, Sevil; Sievers, Katharina; Haferkamp, Sebastian; Zenderowski, Veronika; Nguyen, Van Anh; Wanner, Marina; Gutzmer, Ralf; Terheyden, Patrick; Kähler, Katharina.

J Eur Acad Dermatol Venereol ; 37(5): 894-906, 2023 May.

Article in English | MEDLINE | ID: mdl-36433688

7.

[Cellular immunotherapies for malignancies - How do they work and what are the side effects?]

Läubli, Heinz.

Ther Umsch ; 80(8): 348-352, 2023 Oct.

Article in German | MEDLINE | ID: mdl-37971524

8.

Tetra- and Hexavalent Siglec-8 Ligands Modulate Immune Cell Activation.

Conti, Gabriele; Bärenwaldt, Anne; Rabbani, Said; Mühlethaler, Tobias; Sarcevic, Mirza; Jiang, Xiaohua; Schwardt, Oliver; Ricklin, Daniel; Pieters, Roland J; Läubli, Heinz; Ernst, Beat.

Angew Chem Int Ed Engl ; 62(52): e202314280, 2023 Dec 21.

Article in English | MEDLINE | ID: mdl-37947772

9.

Glycosaminoglycans in cancer therapy.

Wieboldt, Ronja; Läubli, Heinz.

Am J Physiol Cell Physiol ; 322(6): C1187-C1200, 2022 06 01.

Article in English | MEDLINE | ID: mdl-35385322

10.

Targeted glycan degradation potentiates the anticancer immune response in vivo.

Gray, Melissa A; Stanczak, Michal A; Mantuano, Natália R; Xiao, Han; Pijnenborg, Johan F A; Malaker, Stacy A; Miller, Caitlyn L; Weidenbacher, Payton A; Tanzo, Julia T; Ahn, Green; Woods, Elliot C; Läubli, Heinz; Bertozzi, Carolyn R.

Nat Chem Biol ; 16(12): 1376-1384, 2020 12.

Article in English | MEDLINE | ID: mdl-32807964

11.

Larotrectinib Response in NTRK3 Fusion-Driven Diffuse High-Grade Glioma.

König, David; Hench, Jürgen; Frank, Stephan; Dima, Laura; Bratic Hench, Ivana; Läubli, Heinz.

Pharmacology ; 107(7-8): 433-438, 2022.

Article in English | MEDLINE | ID: mdl-35526519

12.

Unraveling the impact of a glyco-immune checkpoint in bone metastasis.

Läubli, Heinz.

Proc Natl Acad Sci U S A ; 121(9): e2400499121, 2024 Feb 27.

Article in English | MEDLINE | ID: mdl-38377217

13.

Tumor mutational burden assessed by targeted NGS predicts clinical benefit from immune checkpoint inhibitors in non-small cell lung cancer.

Alborelli, Ilaria; Leonards, Katharina; Rothschild, Sacha I; Leuenberger, Laura P; Savic Prince, Spasenija; Mertz, Kirsten D; Poechtrager, Severin; Buess, Martin; Zippelius, Alfred; Läubli, Heinz; Haegele, Jasmin; Tolnay, Markus; Bubendorf, Lukas; Quagliata, Luca; Jermann, Philip.

J Pathol ; 250(1): 19-29, 2020 01.

Article in English | MEDLINE | ID: mdl-31471895

14.

Sialic acid-binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses.

Läubli, Heinz; Varki, Ajit.

Cell Mol Life Sci ; 77(4): 593-605, 2020 Feb.

Article in English | MEDLINE | ID: mdl-31485715

15.

Mechanisms of Immune-Related Complications in Cancer Patients Treated with Immune Checkpoint Inhibitors.

König, David; Läubli, Heinz.

Pharmacology ; 106(3-4): 123-136, 2021.

Article in English | MEDLINE | ID: mdl-32721966

16.

PD-1⁺ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade.

Trefny, Marcel P; Kaiser, Monika; Stanczak, Michal A; Herzig, Petra; Savic, Spasenija; Wiese, Mark; Lardinois, Didier; Läubli, Heinz; Uhlenbrock, Franziska; Zippelius, Alfred.

Cancer Immunol Immunother ; 69(8): 1505-1517, 2020 Aug.

Article in English | MEDLINE | ID: mdl-32296919

17.

Targeting sialic acid-Siglec interactions to reverse immune suppression in cancer.

Adams, Olivia Joan; Stanczak, Michal A; von Gunten, Stephan; Läubli, Heinz.

Glycobiology ; 28(9): 640-647, 2018 09 01.

Article in English | MEDLINE | ID: mdl-29309569

18.

The multi-receptor inhibitor axitinib reverses tumor-induced immunosuppression and potentiates treatment with immune-modulatory antibodies in preclinical murine models.

Läubli, Heinz; Müller, Philipp; D'Amico, Lucia; Buchi, Mélanie; Kashyap, Abhishek S; Zippelius, Alfred.

Cancer Immunol Immunother ; 67(5): 815-824, 2018 05.

Article in English | MEDLINE | ID: mdl-29487979

19.

A red meat-derived glycan promotes inflammation and cancer progression.

Samraj, Annie N; Pearce, Oliver M T; Läubli, Heinz; Crittenden, Alyssa N; Bergfeld, Anne K; Banda, Kalyan; Gregg, Christopher J; Bingman, Andrea E; Secrest, Patrick; Diaz, Sandra L; Varki, Nissi M; Varki, Ajit.

Proc Natl Acad Sci U S A ; 112(2): 542-7, 2015 Jan 13.

Article in English | MEDLINE | ID: mdl-25548184

20.

Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies.

Pearce, Oliver M T; Läubli, Heinz; Verhagen, Andrea; Secrest, Patrick; Zhang, Jiquan; Varki, Nissi M; Crocker, Paul R; Bui, Jack D; Varki, Ajit.

Proc Natl Acad Sci U S A ; 111(16): 5998-6003, 2014 Apr 22.

Article in English | MEDLINE | ID: mdl-24711415

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