Prospects for high gain inertial fusion energy: an introduction to the second edition.

Part II of this special edition contains the remaining 11 papers arising from a Hooke discussion meeting held in March 2020 devoted to exploring the current status of inertial confinement fusion research worldwide and its application to electrical power generation in the future, via the development of an international inertial fusion energy programme. It builds upon increased coordination within Europe over the past decade by researchers supported by the EUROFusion Enabling Research grants, as well as collaborations that have arisen naturally with some of America's and Asia's leading researchers, both in the universities and national laboratories. The articles are devoted to informing an update to the European roadmap for an inertial fusion energy demonstration reactor, building upon the commonalities between the magnetic and inertial fusion communities' approaches to fusion energy. A number of studies devoted to understanding the physics barriers to ignition on current facilities are then presented. The special issue concludes with four state-of-the-art articles describing recent significant advances in fast ignition inertial fusion research. This article is part of a discussion meeting issue 'Prospects for high gain inertial fusion energy (part 2)'.

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

Apo2L/TRAIL stimulates cancer cell death through the proapoptotic receptors DR4 and DR5, but the determinants of tumor susceptibility to this ligand are not fully defined. mRNA expression of the peptidyl O-glycosyltransferase GALNT14 correlated with Apo2L/TRAIL sensitivity in pancreatic carcinoma, non-small-cell lung carcinoma and melanoma cell lines, and up to 30% of samples from various human malignancies showed GALNT14 overexpression. RNA interference of GALNT14 reduced cellular Apo2L/TRAIL sensitivity, whereas overexpression increased responsiveness. Biochemical analysis of DR5 identified several ectodomain O-(N-acetyl galactosamine-galactose-sialic acid) structures. Sequence comparison predicted conserved extracellular DR4 and DR5 O-glycosylation sites; progressive mutation of the DR5 sites attenuated apoptotic signaling. O-glycosylation promoted ligand-stimulated clustering of DR4 and DR5, which mediated recruitment and activation of the apoptosis-initiating protease caspase-8. These results uncover a new link between death-receptor O-glycosylation and apoptotic signaling, providing potential predictive biomarkers for Apo2L/TRAIL-based cancer therapy.

Picosecond optical parametric chirped pulse amplifier as a preamplifier to generate high-energy seed pulses for contrast enhancement.

We present the design, implementation, and testing of a novel picosecond optical parametric preamplifier system to generate high-energy seed pulses for the Vulcan laser facility. The preamplifier amplifies 100 fs pulses stretched to 3 ps pulses from 10 pJ to 70 µJ in a single stage of amplification before the pulses are further amplified in the Vulcan high-power Nd:glass laser facility to the petawatt power level. This increased seed energy has led to an improvement of the nanosecond amplified spontaneous emission contrast intensity to 10(-10) of the main pulse, without degrading the output of the laser system.

Characterization of the backscattered radiation from petawatt laser matter interactions.

The development of high peak power and energy laser systems require the assurance that any backscattered radiation will not lead to damage of the laser system. We present the characterization of the backscattered radiation for different target types and conditions at petawatt power levels and intensities (>10(20)W/cm2). We observe that radiation is generated between 700 and 900 nm, as well as the expected self emission and laser fundamental. The percentage of the incident light backscattered reduces as a function of the incident energy and is typically <1% for petawatt laser interactions.