ABSTRACT
PURPOSE: To evaluate the health-related quality of life (QOL) in patients with major salivary gland carcinoma (MSGC). METHODS: 45 patients with MSGC completed the University of Washington Quality of Life (UWQOL) questionnaire. Results and factors influencing quality of life were analyzed using Mann-Whitney U test. RESULTS: 24 patients were male, 21 patients were female, and median age was 57 years. 33 patients presented with early stage (UICC stage I or II) cancer. All patients had surgery as initial therapy. The UWQOL domains with the worst results were 'appearance', 'activity' and 'anxiety'. Factors influencing QOL were sex, tumor stage, comorbidities, follow-up time, tumor grade, postoperative radiation therapy and facial nerve dysfunction. CONCLUSIONS: Diagnosis and treatment of MSGC has influence on overall QOL. Postoperative radiation has the greatest impact on QOL. This is one of the largest study evaluating QOL in patients with salivary gland carcinoma using the UWQOL.
Subject(s)
Carcinoma , Quality of Life , Salivary Gland Neoplasms , Adult , Aged , Carcinoma/epidemiology , Carcinoma/pathology , Carcinoma/psychology , Carcinoma/therapy , Female , Germany/epidemiology , Humans , Male , Middle Aged , Neoplasm Grading , Neoplasm Staging , Radiotherapy/statistics & numerical data , Salivary Gland Neoplasms/epidemiology , Salivary Gland Neoplasms/pathology , Salivary Gland Neoplasms/psychology , Salivary Gland Neoplasms/therapy , Salivary Glands/pathology , Sex Factors , Statistics, Nonparametric , Surgical Procedures, Operative/statistics & numerical data , Surveys and QuestionnairesSubject(s)
Cochlear Diseases , Psychoses, Substance-Induced , Tinnitus , Cochlear Diseases/diagnosis , Cochlear Diseases/drug therapy , Humans , Male , Middle Aged , Prednisolone/adverse effects , Prednisolone/therapeutic use , Psychoses, Substance-Induced/diagnosis , Psychoses, Substance-Induced/physiopathology , Tinnitus/diagnosis , Tinnitus/drug therapyABSTRACT
INTRODUCTION: To evaluate the influence of comorbidities and anemia on outcome and survival in patients with sinonasal carcinomas. MATERIALS AND METHODS: Review of medical records of 121 patients with carcinoma treated at a single quaternary medical care and cancer center between 2002 and 2015. Comorbidities were classified according to the age-adjusted Charlson comorbidity index (ACCI) scoring system. RESULTS: 71 patients were male, 50 were female. Median age was 65 years, and the median interval between tumor diagnosis and date of study inclusion was 71 months. The most common histological subtype was squamous cell carcinoma (n = 64). The median ACCI score was 2 and the most frequent ACCI score was 0 (n = 26). Mean overall survival was 52.2 months (ACCI 0-2) and 39.5 months (ACCI ≥ 3), respectively (p < 0.0001). Mean disease-free survival was 52.9 months (ACCI 0-2) and 45.5 months (ACCI ≥ 3), respectively (p = 0.026). Mean overall survival in patients without anemia was 49.5 months, compared with 39.8 months in patients with anemia (p = 0.043). CONCLUSION: Comorbidity is an independent risk factor on overall, disease-free and disease-specific survival in patients with sinonasal carcinoma. Anemia is associated with shorter overall survival. This is the first study evaluating comorbidity using the ACCI scoring system and focusing on patients with sinonasal carcinoma.