Search | Virtual Health Library

1.

Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation.

Scholz, Nicole; Dahse, Anne-Kristin; Kemkemer, Marguerite; Bormann, Anne; Auger, Genevieve M; Vieira Contreras, Fernando; Ernst, Lucia F; Staake, Hauke; Körner, Marek B; Buhlan, Max; Meyer-Mölck, Amelie; Chung, Yin Kwan; Blanco-Redondo, Beatriz; Klose, Franziska; Jarboui, Mohamed Ali; Ljaschenko, Dmitrij; Bigl, Marina; Langenhan, Tobias.

Nature ; 615(7954): 945-953, 2023 03.

Article in English | MEDLINE | ID: mdl-36890234

2.

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.

Beliu, Gerti; Altrichter, Steffen; Guixà-González, Ramon; Hemberger, Mareike; Brauer, Ina; Dahse, Anne-Kristin; Scholz, Nicole; Wieduwild, Robert; Kuhlemann, Alexander; Batebi, Hossein; Seufert, Florian; Pérez-Hernández, Guillermo; Hildebrand, Peter W; Sauer, Markus; Langenhan, Tobias.

Mol Cell ; 81(5): 905-921.e5, 2021 03 04.

Article in English | MEDLINE | ID: mdl-33497605

3.

7TM domain structures of adhesion GPCRs: what's new and what's missing?

Seufert, Florian; Chung, Yin Kwan; Hildebrand, Peter W; Langenhan, Tobias.

Trends Biochem Sci ; 48(8): 726-739, 2023 08.

Article in English | MEDLINE | ID: mdl-37349240

4.

Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs.

Fu, Chaoyu; Huang, Wenmao; Tang, Qingnan; Niu, Minghui; Guo, Shiwen; Langenhan, Tobias; Song, Gaojie; Yan, Jie.

Nano Lett ; 23(20): 9179-9186, 2023 10 25.

Article in English | MEDLINE | ID: mdl-37831892

5.

The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release.

Paul, Mila M; Dannhäuser, Sven; Morris, Lydia; Mrestani, Achmed; Hübsch, Martha; Gehring, Jennifer; Hatzopoulos, Georgios N; Pauli, Martin; Auger, Genevieve M; Bornschein, Grit; Scholz, Nicole; Ljaschenko, Dmitrij; Müller, Martin; Sauer, Markus; Schmidt, Hartmut; Kittel, Robert J; DiAntonio, Aaron; Vakonakis, Ioannis; Heckmann, Manfred; Langenhan, Tobias.

Brain ; 145(11): 3787-3802, 2022 11 21.

Article in English | MEDLINE | ID: mdl-35022694

6.

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.

Mathiasen, Signe; Palmisano, Tiago; Perry, Nicole A; Stoveken, Hannah M; Vizurraga, Alex; McEwen, Dyke P; Okashah, Najeah; Langenhan, Tobias; Inoue, Asuka; Lambert, Nevin A; Tall, Gregory G; Javitch, Jonathan A.

Nat Chem Biol ; 16(12): 1343-1350, 2020 12.

Article in English | MEDLINE | ID: mdl-32778842

7.

Publisher Correction: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.

Mathiasen, Signe; Palmisano, Tiago; Perry, Nicole A; Stoveken, Hannah M; Vizurraga, Alex; McEwen, Dyke P; Okashah, Najeah; Langenhan, Tobias; Inoue, Asuka; Lambert, Nevin A; Tall, Gregory G; Javitch, Jonathan A.

Nat Chem Biol ; 16(12): 1440, 2020 Dec.

Article in English | MEDLINE | ID: mdl-32807971

8.

Adhesion G protein-coupled receptors in nervous system development and disease.

Langenhan, Tobias; Piao, Xianhua; Monk, Kelly R.

Nat Rev Neurosci ; 17(9): 550-61, 2016 09.

Article in English | MEDLINE | ID: mdl-27466150

9.

Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila.

Blanco-Redondo, Beatriz; Nuwal, Nidhi; Kneitz, Susanne; Nuwal, Tulip; Halder, Partho; Liu, Yiting; Ehmann, Nadine; Scholz, Nicole; Mayer, Annika; Kleber, Jörg; Kähne, Thilo; Schmitt, Dominique; Sadanandappa, Madhumala K; Funk, Natalja; Albertova, Viera; Helfrich-Förster, Charlotte; Ramaswami, Mani; Hasan, Gaiti; Kittel, Robert J; Langenhan, Tobias; Gerber, Bertram; Buchner, Erich.

J Exp Biol ; 222(Pt 19)2019 10 08.

Article in English | MEDLINE | ID: mdl-31488622

10.

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.

Hamann, Jörg; Aust, Gabriela; Araç, Demet; Engel, Felix B; Formstone, Caroline; Fredriksson, Robert; Hall, Randy A; Harty, Breanne L; Kirchhoff, Christiane; Knapp, Barbara; Krishnan, Arunkumar; Liebscher, Ines; Lin, Hsi-Hsien; Martinelli, David C; Monk, Kelly R; Peeters, Miriam C; Piao, Xianhua; Prömel, Simone; Schöneberg, Torsten; Schwartz, Thue W; Singer, Kathleen; Stacey, Martin; Ushkaryov, Yuri A; Vallon, Mario; Wolfrum, Uwe; Wright, Mathew W; Xu, Lei; Langenhan, Tobias; Schiöth, Helgi B.

Pharmacol Rev ; 67(2): 338-67, 2015.

Article in English | MEDLINE | ID: mdl-25713288

11.

Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications.

Dawydow, Alexej; Gueta, Ronnie; Ljaschenko, Dmitrij; Ullrich, Sybille; Hermann, Moritz; Ehmann, Nadine; Gao, Shiqiang; Fiala, André; Langenhan, Tobias; Nagel, Georg; Kittel, Robert J.

Proc Natl Acad Sci U S A ; 111(38): 13972-7, 2014 Sep 23.

Article in English | MEDLINE | ID: mdl-25201989

12.

Effects of transgenic expression of botulinum toxins in Drosophila.

Backhaus, Philipp; Langenhan, Tobias; Neuser, Kirsa.

J Neurogenet ; 30(1): 22-31, 2016 03.

Article in English | MEDLINE | ID: mdl-27276193

13.

Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors.

Scholz, Nicole; Monk, Kelly R; Kittel, Robert J; Langenhan, Tobias.

Handb Exp Pharmacol ; 234: 221-247, 2016.

Article in English | MEDLINE | ID: mdl-27832490

14.

Control of Adhesion GPCR Function Through Proteolytic Processing.

Nieberler, Matthias; Kittel, Robert J; Petrenko, Alexander G; Lin, Hsi-Hsien; Langenhan, Tobias.

Handb Exp Pharmacol ; 234: 83-109, 2016.

Article in English | MEDLINE | ID: mdl-27832485

15.

Adhesion G Protein-Coupled Receptors: From In Vitro Pharmacology to In Vivo Mechanisms.

Monk, Kelly R; Hamann, Jörg; Langenhan, Tobias; Nijmeijer, Saskia; Schöneberg, Torsten; Liebscher, Ines.

Mol Pharmacol ; 88(3): 617-23, 2015 Sep.

Article in English | MEDLINE | ID: mdl-25956432

16.

Model Organisms in G Protein-Coupled Receptor Research.

Langenhan, Tobias; Barr, Maureen M; Bruchas, Michael R; Ewer, John; Griffith, Leslie C; Maiellaro, Isabella; Taghert, Paul H; White, Benjamin H; Monk, Kelly R.

Mol Pharmacol ; 88(3): 596-603, 2015 Sep.

Article in English | MEDLINE | ID: mdl-25979002

17.

Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster.

Buhlan, Max; Ljaschenko, Dmitrij; Scholz, Nicole; Langenhan, Tobias.

Nat Protoc ; 19(1): 113-126, 2024 Jan.

Article in English | MEDLINE | ID: mdl-37945792

18.

The adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila.

Vieira Contreras, Fernando; Auger, Genevieve M; Müller, Lena; Richter, Vincent; Huetteroth, Wolf; Seufert, Florian; Hildebrand, Peter W; Scholz, Nicole; Thum, Andreas S; Ljaschenko, Dmitrij; Blanco-Redondo, Beatriz; Langenhan, Tobias.

Cell Rep ; 43(1): 113640, 2024 01 23.

Article in English | MEDLINE | ID: mdl-38180839

19.

Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse.

Prömel, Simone; Waller-Evans, Helen; Dixon, John; Zahn, Dirk; Colledge, William H; Doran, Joanne; Carlton, Mark B L; Grosse, Johannes; Schöneberg, Torsten; Russ, Andreas P; Langenhan, Tobias.

Dev Dyn ; 241(10): 1591-602, 2012 Oct.

Article in English | MEDLINE | ID: mdl-22837050

20.

Adhesion GPCRs in glioblastoma revisited.

Langenhan, Tobias.

Cell Rep ; 42(12): 113474, 2023 12 26.

Article in English | MEDLINE | ID: mdl-37995190

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