Search | Virtual Health Library

1.

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.

Oda, Hirotsugu; Manthiram, Kalpana; Chavan, Pallavi Pimpale; Rieser, Eva; Veli, Önay; Kaya, Öykü; Rauch, Charles; Nakabo, Shuichiro; Kuehn, Hye Sun; Swart, Mariël; Wang, Yanli; Çelik, Nisa Ilgim; Molitor, Anne; Ziaee, Vahid; Movahedi, Nasim; Shahrooei, Mohammad; Parvaneh, Nima; Alipour-Olyei, Nasrin; Carapito, Raphael; Xu, Qin; Preite, Silvia; Beck, David B; Chae, Jae Jin; Nehrebecky, Michele; Ombrello, Amanda K; Hoffmann, Patrycja; Romeo, Tina; Deuitch, Natalie T; Matthíasardóttir, Brynja; Mullikin, James; Komarow, Hirsh; Stoddard, Jennifer; Niemela, Julie; Dobbs, Kerry; Sweeney, Colin L; Anderton, Holly; Lawlor, Kate E; Yoshitomi, Hiroyuki; Yang, Dan; Boehm, Manfred; Davis, Jeremy; Mudd, Pamela; Randazzo, Davide; Tsai, Wanxia Li; Gadina, Massimo; Kaplan, Mariana J; Toguchida, Junya; Mayer, Christian T; Rosenzweig, Sergio D; Notarangelo, Luigi D.

Nat Immunol ; 25(5): 764-777, 2024 May.

Article in English | MEDLINE | ID: mdl-38609546

2.

Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases.

Lawlor, Kate E; Murphy, James M; Vince, James E.

Immunity ; 57(3): 429-445, 2024 Mar 12.

Article in English | MEDLINE | ID: mdl-38479360

3.

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.

Speir, Mary; Nowell, Cameron J; Chen, Alyce A; O'Donnell, Joanne A; Shamie, Isaac S; Lakin, Paul R; D'Cruz, Akshay A; Braun, Roman O; Babon, Jeff J; Lewis, Rowena S; Bliss-Moreau, Meghan; Shlomovitz, Inbar; Wang, Shu; Cengia, Louise H; Stoica, Anca I; Hakem, Razq; Kelliher, Michelle A; O'Reilly, Lorraine A; Patsiouras, Heather; Lawlor, Kate E; Weller, Edie; Lewis, Nathan E; Roberts, Andrew W; Gerlic, Motti; Croker, Ben A.

Nat Immunol ; 21(1): 54-64, 2020 01.

Article in English | MEDLINE | ID: mdl-31819256

4.

Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.

Erlich, Ziv; Shlomovitz, Inbar; Edry-Botzer, Liat; Cohen, Hadar; Frank, Daniel; Wang, Hanqing; Lew, Andrew M; Lawlor, Kate E; Zhan, Yifan; Vince, James E; Gerlic, Motti.

Nat Immunol ; 20(4): 397-406, 2019 04.

Article in English | MEDLINE | ID: mdl-30742078

5.

Interferon-Î³ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.

Simpson, Daniel S; Pang, Jiyi; Weir, Ashley; Kong, Isabella Y; Fritsch, Melanie; Rashidi, Maryam; Cooney, James P; Davidson, Kathryn C; Speir, Mary; Djajawi, Tirta M; Hughes, Sebastian; Mackiewicz, Liana; Dayton, Merle; Anderton, Holly; Doerflinger, Marcel; Deng, Yexuan; Huang, Allan Shuai; Conos, Stephanie A; Tye, Hazel; Chow, Seong H; Rahman, Arfatur; Norton, Raymond S; Naderer, Thomas; Nicholson, Sandra E; Burgio, Gaetan; Man, Si Ming; Groom, Joanna R; Herold, Marco J; Hawkins, Edwin D; Lawlor, Kate E; Strasser, Andreas; Silke, John; Pellegrini, Marc; Kashkar, Hamid; Feltham, Rebecca; Vince, James E.

Immunity ; 55(3): 423-441.e9, 2022 03 08.

Article in English | MEDLINE | ID: mdl-35139355

6.

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard, James A; O'Donnell, Joanne A; Evans, Joseph M; Lalaoui, Najoua; Poh, Ashleigh R; Rogers, TeWhiti; Vince, James E; Lawlor, Kate E; Ninnis, Robert L; Anderton, Holly; Hall, Cathrine; Spall, Sukhdeep K; Phesse, Toby J; Abud, Helen E; Cengia, Louise H; Corbin, Jason; Mifsud, Sandra; Di Rago, Ladina; Metcalf, Donald; Ernst, Matthias; Dewson, Grant; Roberts, Andrew W; Alexander, Warren S; Murphy, James M; Ekert, Paul G; Masters, Seth L; Vaux, David L; Croker, Ben A; Gerlic, Motti; Silke, John.

Cell ; 157(5): 1175-88, 2014 May 22.

Article in English | MEDLINE | ID: mdl-24813849

7.

Sugar Fix Keeps RIPK3 at Bay.

Giogha, Cristina; Lawlor, Kate E.

Immunity ; 50(3): 539-541, 2019 03 19.

Article in English | MEDLINE | ID: mdl-30893581

8.

Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1ß release in X-linked inhibitor of apoptosis (XIAP) deficiency.

Hughes, Sebastian A; Lin, Meng; Weir, Ashley; Huang, Bing; Xiong, Liya; Chua, Ngee Kiat; Pang, Jiyi; Santavanond, Jascinta P; Tixeira, Rochelle; Doerflinger, Marcel; Deng, Yexuan; Yu, Chien-Hsiung; Silke, Natasha; Conos, Stephanie A; Frank, Daniel; Simpson, Daniel S; Murphy, James M; Lawlor, Kate E; Pearson, Jaclyn S; Silke, John; Pellegrini, Marc; Herold, Marco J; Poon, Ivan K H; Masters, Seth L; Li, Mingsong; Tang, Qin; Zhang, Yuxia; Rashidi, Maryam; Geng, Lanlan; Vince, James E.

EMBO J ; 42(5): e110468, 2023 03 01.

Article in English | MEDLINE | ID: mdl-36647737

9.

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease.

Lalaoui, Najoua; Boyden, Steven E; Oda, Hirotsugu; Wood, Geryl M; Stone, Deborah L; Chau, Diep; Liu, Lin; Stoffels, Monique; Kratina, Tobias; Lawlor, Kate E; Zaal, Kristien J M; Hoffmann, Patrycja M; Etemadi, Nima; Shield-Artin, Kristy; Biben, Christine; Tsai, Wanxia Li; Blake, Mary D; Kuehn, Hye Sun; Yang, Dan; Anderton, Holly; Silke, Natasha; Wachsmuth, Laurens; Zheng, Lixin; Moura, Natalia Sampaio; Beck, David B; Gutierrez-Cruz, Gustavo; Ombrello, Amanda K; Pinto-Patarroyo, Gineth P; Kueh, Andrew J; Herold, Marco J; Hall, Cathrine; Wang, Hongying; Chae, Jae Jin; Dmitrieva, Natalia I; McKenzie, Mark; Light, Amanda; Barham, Beverly K; Jones, Anne; Romeo, Tina M; Zhou, Qing; Aksentijevich, Ivona; Mullikin, James C; Gross, Andrew J; Shum, Anthony K; Hawkins, Edwin D; Masters, Seth L; Lenardo, Michael J; Boehm, Manfred; Rosenzweig, Sergio D; Pasparakis, Manolis.

Nature ; 577(7788): 103-108, 2020 01.

Article in English | MEDLINE | ID: mdl-31827281

10.

A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation.

Speir, Mary; Tye, Hazel; Gottschalk, Timothy A; Simpson, Daniel S; Djajawi, Tirta M; Deo, Pankaj; Ambrose, Rebecca L; Conos, Stephanie A; Emery, Jack; Abraham, Gilu; Pascoe, Ashlyn; Hughes, Sebastian A; Weir, Ashley; Hawkins, Edwin D; Kong, Isabella; Herold, Marco J; Pearson, Jaclyn S; Lalaoui, Najoua; Naderer, Thomas; Vince, James E; Lawlor, Kate E.

EMBO Rep ; 24(11): e56865, 2023 11 06.

Article in English | MEDLINE | ID: mdl-37846472

11.

RIP-roaring inflammation: RIPK1 and RIPK3 driven NLRP3 inflammasome activation and autoinflammatory disease.

Speir, Mary; Lawlor, Kate E.

Semin Cell Dev Biol ; 109: 114-124, 2021 01.

Article in English | MEDLINE | ID: mdl-32771377

12.

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

Vince, James E; Wong, W Wei-Lynn; Gentle, Ian; Lawlor, Kate E; Allam, Ramanjaneyulu; O'Reilly, Lorraine; Mason, Kylie; Gross, Olaf; Ma, Stephen; Guarda, Greta; Anderton, Holly; Castillo, Rosa; Häcker, Georg; Silke, John; Tschopp, Jürg.

Immunity ; 36(2): 215-27, 2012 Feb 24.

Article in English | MEDLINE | ID: mdl-22365665

13.

Cutting Edge: Blockade of Inhibitor of Apoptosis Proteins Sensitizes Neutrophils to TNF- but Not Lipopolysaccharide-Mediated Cell Death and IL-1ß Secretion.

Chen, Kaiwen W; Lawlor, Kate E; von Pein, Jessica B; Boucher, Dave; Gerlic, Motti; Croker, Ben A; Bezbradica, Jelena S; Vince, James E; Schroder, Kate.

J Immunol ; 200(10): 3341-3346, 2018 05 15.

Article in English | MEDLINE | ID: mdl-29661823

14.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos, Stephanie A; Chen, Kaiwen W; De Nardo, Dominic; Hara, Hideki; Whitehead, Lachlan; Núñez, Gabriel; Masters, Seth L; Murphy, James M; Schroder, Kate; Vaux, David L; Lawlor, Kate E; Lindqvist, Lisa M; Vince, James E.

Proc Natl Acad Sci U S A ; 114(6): E961-E969, 2017 02 07.

Article in English | MEDLINE | ID: mdl-28096356

15.

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.

Campbell, Ian K; Leong, David; Edwards, Kirsten M; Rayzman, Veronika; Ng, Milica; Goldberg, Gabrielle L; Wilson, Nicholas J; Scalzo-Inguanti, Karen; Mackenzie-Kludas, Charley; Lawlor, Kate E; Wicks, Ian P; Brown, Lorena E; Baz Morelli, Adriana; Panousis, Con; Wilson, Michael J; Nash, Andrew D; McKenzie, Brent S; Andrews, Arna E.

J Immunol ; 197(11): 4392-4402, 2016 12 01.

Article in English | MEDLINE | ID: mdl-27807194

16.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

Wong, W Wei-Lynn; Vince, James E; Lalaoui, Najoua; Lawlor, Kate E; Chau, Diep; Bankovacki, Aleksandra; Anderton, Holly; Metcalf, Donald; O'Reilly, Lorraine; Jost, Philipp J; Murphy, James M; Alexander, Warren S; Strasser, Andreas; Vaux, David L; Silke, John.

Blood ; 123(16): 2562-72, 2014 Apr 17.

Article in English | MEDLINE | ID: mdl-24497535

17.

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam, Ramanjaneyulu; Lawlor, Kate E; Yu, Eric Chi-Wang; Mildenhall, Alison L; Moujalled, Donia M; Lewis, Rowena S; Ke, Francine; Mason, Kylie D; White, Michael J; Stacey, Katryn J; Strasser, Andreas; O'Reilly, Lorraine A; Alexander, Warren; Kile, Benjamin T; Vaux, David L; Vince, James E.

EMBO Rep ; 15(9): 982-90, 2014 Sep.

Article in English | MEDLINE | ID: mdl-24990442

18.

Ambiguities in NLRP3 inflammasome regulation: is there a role for mitochondria?

Lawlor, Kate E; Vince, James E.

Biochim Biophys Acta ; 1840(4): 1433-40, 2014 Apr.

Article in English | MEDLINE | ID: mdl-23994495

19.

RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation.

Tran, Hong Tri; Kratina, Tobias; Coutansais, Auriane; Michalek, Dominika; Hogan, Benjamin M; Lawlor, Kate E; Vince, James E; Silke, John; Lalaoui, Najoua.

Cell Death Differ ; 31(5): 662-671, 2024 May.

Article in English | MEDLINE | ID: mdl-38514849

20.

Murine norovirus infection of macrophages induces intrinsic apoptosis as the major form of programmed cell death.

Deerain, Joshua M; Aktepe, Turgut E; Trenerry, Alice M; Ebert, Gregor; Hyde, Jennifer L; Charry, Katelyn; Edgington-Mitchell, Laura; Xu, Banyan; Ambrose, Rebecca L; Sarvestani, Soroush T; Lawlor, Kate E; Pearson, Jaclyn S; White, Peter A; Mackenzie, Jason M.

Virology ; 589: 109921, 2024 01.

Article in English | MEDLINE | ID: mdl-37939648

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