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1.
BJOG ; 126(6): 770-777, 2019 May.
Article in English | MEDLINE | ID: mdl-30506800

ABSTRACT

OBJECTIVE: To examine the relationship between gender and a career in academic medicine. DESIGN: Mixed-methods study. SETTING: Obstetrics-gynaecology postgraduate training programme in Paris, France. SAMPLE: Postgraduate trainees in obstetrics-gynaecology (n = 204). METHODS: Statistical analysis of quantitative survey data, thematic analysis of qualitative interview data and integrative analysis. MAIN OUTCOME MEASURES: Women's aspirations and obstacles related to their decision about a career in academic medicine. RESULTS: A career in academic medicine was envisaged by 13% of the women residents and 27% of the men (P = 0.01). Women reported receiving advice from a mentor less often than men (38.8% versus 52.9%, P = 0.002). Overall, 40.6% of women and 2.9% of men reported experiencing gender discrimination (P < 0.001). In response to the question 'Do you have doubts about your ability to pursue or succeed at an academic career?', 62.4% of the women and only 17.7% of the men answered yes (P < 0.001). The global analysis identified the following obstacles: persistent gender stereotypes that produce everyday sexism, lack of identification with male role models, lack of mentors, perceived discrimination, an ideal of professional excellence that is difficult to attain, constraining professional organisational norms, inequality between men and women in the domestic and family spheres, and finally self-censorship and important doubts about their ability to combine a demanding career and a fulfilling personal life. CONCLUSIONS: Women reported the desire to follow a career in academic medicine half as often as men. Improving the presence and visibility of role models for residents and combating workplace discrimination will address some of the barriers to women choosing a career in academic medicine. TWEETABLE ABSTRACT: Women obstetric trainees in France are only half as likely as men to envisage following an academic path.


Subject(s)
Career Choice , Education, Medical, Continuing , Gynecology/education , Obstetrics/education , Physicians, Women , Sexism , Adult , Education, Medical, Continuing/methods , Education, Medical, Continuing/standards , Education, Medical, Continuing/statistics & numerical data , Female , France , Humans , Internship and Residency/methods , Internship and Residency/standards , Male , Physicians, Women/psychology , Physicians, Women/statistics & numerical data , Qualitative Research , Sexism/prevention & control , Sexism/psychology , Teaching/standards
2.
BJOG ; 126(8): 1033-1041, 2019 07.
Article in English | MEDLINE | ID: mdl-30801948

ABSTRACT

OBJECTIVE: To investigate the association between in vitro fertilisation IVF and severe maternal morbidity (SMM) and to explore the role of multiple pregnancy as an intermediate factor. DESIGN: Population-based cohort-nested case-control study. SETTING: Six French regions in 2012/13. POPULATION: Cases were 2540 women with SMM according to the EPIMOMS definition; controls were 3651 randomly selected women who gave birth without SMM. METHODS: Analysis of the associations between IVF and SMM with multivariable logistic regression models, differentiating IVF with autologous oocytes (IVF-AO) from IVF with oocyte donation (IVF-OD). The contribution of multiple pregnancy as an intermediate factor was assessed by path analysis. MAIN OUTCOME MEASURES: Severe maternal morbidity overall and SMM according to its main underlying causal condition and by severity (near misses). RESULTS: The risk of SMM was significantly higher in women with IVF (adjusted OR = 2.5, 95% CI 1.8-3.3). The risk of SMM was significantly higher with IVF-AO, for all-cause SMM (aOR = 2.0, 95% CI 1.5-2.7), for near misses (aOR = 1.9, 95% CI 1.3-2.8), and for intra/postpartum haemorrhages (aOR = 2.3, 95% CI 1.6-3.2). The risk of SMM was significantly higher with IVF-OD, for all-cause SMM (aOR = 18.6, 95% CI 4.4-78.5), for near misses (aOR = 18.1, 95% CI 4.0-82.3), for SMM due to hypertensive disorders (aOR = 16.7, 95% CI 3.3-85.4) and due to intra/postpartum haemorrhages (aOR = 18.0, 95% CI 4.2-77.8). Path-analysis estimated that 21.6% (95% CI 10.1-33.0) of the risk associated with IVF-OD was mediated by multiple pregnancy, and 49.6% (95% CI 24.0-75.1) of the SMM risk associated with IVF-AO. CONCLUSION: The risk of SMM is higher in IVF pregnancies after adjustment for confounders. Exploratory results suggest higher risks among women with IVF-OD; however, confidence intervals were wide, so this finding needs to be confirmed. A large part of the association between IVF-AO and SMM appears to be mediated by multiple pregnancy. TWEETABLE ABSTRACT: The risk of severe maternal morbidity is higher in IVF-conceived pregnancies than in pregnancies conceived by other means.


Subject(s)
Fertilization in Vitro/adverse effects , Near Miss, Healthcare/statistics & numerical data , Pregnancy Complications/epidemiology , Pregnancy Complications/etiology , Adult , Case-Control Studies , Female , Humans , Hypertension, Pregnancy-Induced/etiology , Logistic Models , Multivariate Analysis , Odds Ratio , Oocytes/transplantation , Postpartum Hemorrhage/etiology , Pregnancy , Pregnancy, Multiple , Risk Factors
3.
BJOG ; 123(13): 2191-2197, 2016 12.
Article in English | MEDLINE | ID: mdl-26615965

ABSTRACT

OBJECTIVE: To estimate the rate of elective inductions in France and the proportion of them that were maternally requested, and to study the factors associated with elective inductions that were or were not requested by women. DESIGN: Cross-sectional population-based study. SETTING: All maternity units in France. POPULATION: About 14 681 women from the 2010 French National Perinatal Survey of a representative sample of births. METHODS: Inductions were classified as elective based on their indications and maternal and fetal characteristics, collected from medical records. Elective inductions requested by women were identified from the mother's postpartum interviews. Polytomous logistic regression analysis was used to study the determinants of inductions that were or were not maternally requested. Women with spontaneous labour served as the comparison group. MAIN OUTCOME MEASURE: Rate of elective inductions. RESULTS: The induction rate was 22.6, 13.9% elective. Among elective inductions, 47.3% were requested by women. The characteristics of mothers, pregnancies, and maternity units were similar in both groups of elective inductions. The main associated factors were parity 2 or more [adjusted odds ratio (OR) 4.7, 95% confidence interval (CI) 3.1-7.2 for maternally requested inductions and aOR of 1.8 (95% CI1.2-2.7) for unrequested inductions, compared with parity 0] and private hospital status [aOR 4.5 95% (CI 3.3-6.0) for maternally requested inductions and aOR 3.7 (95% CI 2.8-4.9) for inductions not requested by the mother]. We found no association between maternal social characteristics and type of elective induction. CONCLUSION: Parity and organisational factors appear to influence the decision about elective inductions. It would be interesting to determine how obstetricians and women make this decision and for what reasons. TWEETABLE ABSTRACT: About 13.9% of inductions of labour were elective in France, 47.3% of these requested by women.


Subject(s)
Elective Surgical Procedures/statistics & numerical data , Labor, Induced/statistics & numerical data , Patient Preference/statistics & numerical data , Adult , Cross-Sectional Studies , Female , France , Humans , Pregnancy , Young Adult
4.
BJOG ; 122(5): 690-9, 2015 Apr.
Article in English | MEDLINE | ID: mdl-25412695

ABSTRACT

OBJECTIVE: Caesarean rate increased in France between 1995 and 2003, but remained stable between 2003 and 2010. Our objective was to analyse these trends by identifying the groups of women who contributed to the increase and those who contributed to the stabilisation. DESIGN: Cross-sectional population-based study from the French national perinatal surveys. SETTING: All maternity units in France. POPULATION: Representative samples of women delivering in 1995 (n = 13 147), 2003 (n = 14 482), and 2010 (n = 14 681). METHODS: Robson classification, based on pregnancy and delivery characteristics, was used for each group. MAIN OUTCOME MEASURES: Caesarean rate for each group, its contribution to the overall caesarean rate, and the differences (Δ) in these contributions between 1995 and 2003 and between 2003 and 2010. RESULTS: Overall caesarean rates were 15.4% in 1995, 19.7% in 2003 and 20.5% in 2010. Between 1995 and 2003, the contribution to the overall caesarean rate of all groups but one rose. Between 2003 and 2010, the contribution of all groups but three stabilised or decreased: nulliparous women in spontaneous labour with singleton cephalic fetuses at term (Δ = + 0.5%, 95% CI 0.1-0.9%), an increase explained by their higher caesarean rate; nulliparous women with induced labour at term (Δ = + 1.1%, 95% CI 0.8-1.4%) caused by an increase in both the caesarean rate and the relative size of this group; and women with previous caesarean (Δ = + 0.8%, 95% CI 0.3-1.3%), because of the growing size of this group. CONCLUSION: Proposing and evaluating interventions for improving the management of labour in nulliparous women could help to maintain caesarean rates and mitigate increases among multiparous women in the future.


Subject(s)
Cesarean Section/statistics & numerical data , Hospitals, Maternity/statistics & numerical data , Adult , Body Mass Index , Cesarean Section/trends , Cross-Sectional Studies , Decision Making , Educational Status , Female , France/epidemiology , Health Services Needs and Demand , Humans , Infant, Newborn , Parity , Pregnancy , Pregnancy Outcome
5.
J Gynecol Obstet Hum Reprod ; 52(6): 102589, 2023 Jun.
Article in English | MEDLINE | ID: mdl-37059300

ABSTRACT

OBJECTIVE: The objective of this study was to compare two strategies for passive second stage management: three-hour vs two-hour delayed pushing after the diagnosis of full cervical dilation on mode of delivery and perinatal outcomes. STUDY DESIGN: This retrospective observational study included low-risk nulliparous women who reatched full cervical dilation under epidural analgesia with a single term fetus in cephalic presentation and normal fetal heart rate, between September and December 2016. Mode of delivery (spontaneous vaginal delivery versus operative delivery including cesarean section and instrumental vaginal delivery) and perinatal outcomes (post-partum hemorrhage, perineal lacerations, 5-min Apgar score, umbilical cord pH and transfer to neonatal intensive care unit) were compared between two maternity units: maternity unit A, where women could have up to a three-hour delayed pushing period after full cervical dilation diagnosis, and maternity unit B, where the delayed pushing period was a maximum of 2 h. Outcomes were compared using univariate and multivariable analyses. Adjusted odds ratios (aOR) were estimated using a logistic regression multivariable model that included potential cofounders. RESULTS: During the study period, 614 women were included, 305 in maternity unit A and 309 in maternity unit B. Women's pre-existing characteristics were comparable between the two maternity units. Women delivering in the maternity unit A had significantly lower risks of having an operative delivery compared to women delivering in the maternity unit B (respectively 18.4 vs 26.9%; aOR = 0.64; 95%CI [0.43 - 0.96]). Perinatal outcomes were comparable in the two maternity units, particularly in terms of post-partum hemorrhage rates (7.4 vs 7.8%; aOR = 1,19 [0.65 - 2.19]). CONCLUSION: Increasing the possible length of the delayed pushing period from 2 to 3 h after the diagnosis of full cervical dilation in low-risk nulliparous women appears to reduce operative deliveries without adverse effects on maternal or neonatal morbidity.


Subject(s)
Cesarean Section , Postpartum Hemorrhage , Infant, Newborn , Pregnancy , Female , Humans , Delivery, Obstetric , Postpartum Hemorrhage/epidemiology , Logistic Models , Parity , Observational Studies as Topic
6.
Gynecol Obstet Fertil Senol ; 51(9): 393-399, 2023 09.
Article in French | MEDLINE | ID: mdl-37295716

ABSTRACT

OBJECTIVES: To evaluate the use of simulation among French Obstetrics and Gynecology residency programs. METHODS: A survey was conducted with all 28 French residency program directors. The questionnaire covered equipment and human resources, training programs, types of simulation tools and time spent. RESULTS: Of the cities hosting a residency program, 93% (26/28) responded regarding equipment and human resources, and 75% (21/28) responded regarding training program details. All respondents declared having at least one structure dedicated to simulation. A formal training program was reported by 81% (21/26) of cities. This training program was mandatory in 73% of the cases. There was a median number of seven senior trainers involved, three of whom had received a specific training in medical education. Most of declared simulation activities concerned technical skills in obstetrics and surgery. Simulations to practice breaking bad news were offered by 62% (13/21) of cities. The median number of half-days spent annually on simulation training was 55 (IQR: 38-83). CONCLUSION: Simulation training is now widely available among French residency programs. There remains heterogeneity between centers regarding equipment, time spent and content of simulation curricula. The French College of Teachers of Gynecology and Obstetrics has proposed a roadmap for the content of simulation-based training based on the results of this survey. An inventory of all existing "train the trainers" simulation programs in France is also provided.


Subject(s)
Gynecology , Internship and Residency , Obstetrics , Simulation Training , Female , Pregnancy , Humans , Obstetrics/education , Gynecology/education , Surveys and Questionnaires
7.
Hum Reprod ; 27(3): 896-901, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22252087

ABSTRACT

BACKGROUND: Although older maternal age is a risk factor for pregnancy complications, an increasing number of women delay conception until the age of 40, and some must resort to IVF with oocyte donation. Our objective was to study the association between IVF, both with and without oocyte donation, and maternal and perinatal outcomes in a population of older women. METHODS: This retrospective study covered all women, aged 43 or more, who gave birth between 2008 and 2010. Univariate and multivariate analyses with logistic regression models were used to compare maternal and perinatal outcomes as a function of mode of conception: without IVF, with IVF using own oocytes or with IVF and oocyte donation. RESULTS: The study included 380 women, including 40 who had IVF without oocyte donation (10.5%) and 104 who had both (27.4%). There were 326 singleton and 54 multiple pregnancies. Overall, the complication rate was high: 8.7% pre-eclampsia, 6.1% gestational diabetes, 20.2% preterm delivery and 8.2% very preterm delivery (before 33 weeks), 44.8% Cesarean sections and 7.4% severe post-partum hemorrhage (PPH). The pre-eclampsia rate differed significantly between the groups (3.8% after no IVF, 10.0% after IVF only and 19.2% after IVF with oocyte donation, P< 0.001). After adjustment, the risk of pre-eclampsia was significantly higher in women with donated oocytes compared with pregnant women without IVF [adjusted OR = 3.3 (1.2-8.9)]. The rate of twin pregnancy was significantly higher in women with IVF and oocyte donation (39.4 versus 15.0% with IVF only and 2.5% without IVF, P< 0.001). Twin pregnancy was significantly associated with the risk of preterm delivery [adjusted OR = 8.9 (4.0-19.9)] and PPH [adjusted OR = 3.5 (1.3-9.5)]. CONCLUSION: In women aged 43 years or older, pregnancies obtained by IVF with oocyte donation are associated with higher rates of pre-eclampsia and twin pregnancies than those obtained without IVF or with IVF using their own oocytes.


Subject(s)
Maternal Age , Oocyte Donation , Pregnancy Complications/epidemiology , Adult , Female , Fertilization in Vitro , Humans , Logistic Models , Middle Aged , Multivariate Analysis , Pregnancy , Pregnancy Outcome , Retrospective Studies , Risk Assessment , Risk Factors
8.
J Gynecol Obstet Hum Reprod ; 51(2): 102284, 2022 Feb.
Article in English | MEDLINE | ID: mdl-34906693

ABSTRACT

INTRODUCTION: The "en caul" technique, i.e. delivery with intact membranes, may reduce the risk of obstetric trauma in vaginal breech delivery of extreme preterm infants. We aimed at comparing perinatal mortality and morbidity among extremely preterm breech vaginal deliveries between infants delivered "en caul" and those with "ruptured membranes". MATERIAL AND METHODS: We performed a fourteen-year retrospective study in a tertiary university center. All vaginal deliveries of singleton breech live infants with an antenatal decision of active resuscitation between 24 weeks and 27+6 weeks were included. Perinatal outcomes were compared between the "en caul" group, with intact membranes at the onset of pushing efforts and the "ruptured membranes" group, with ruptured membranes at the onset of pushing efforts. The primary outcome was perinatal mortality defined by intrapartum or neonatal death. The secondary outcomes were fetal extraction difficulties, arterial pH and 5 min Apgar score. RESULTS: We included 52 infants in the "en caul" group and 71 in the "ruptured membranes" group. The perinatal mortality rate did not differ between the two groups (19.2% in the "en caul" group versus 28.2% in the "ruptured membranes" group, p = 0.25). The mean arterial pH at birth was higher in the « en caul ¼ group (7.32 ± 0.1 vs 7.24 ± 0.1, p = 0.001). There were no differences between the groups for fetal extraction difficulties, especially fetal head entrapment (9.6% versus 9.9%). CONCLUSION: Even though the "en caul" technique does not seem to decrease the perinatal mortality rate, it remains a simple technique, which could improve neonatal morbidity.


Subject(s)
Breech Presentation , Delivery, Obstetric/methods , Infant, Extremely Premature , Adult , Female , Humans , Infant, Newborn , Perinatal Death , Pregnancy , Pregnancy Outcome , Retrospective Studies
9.
J Gynecol Obstet Hum Reprod ; 49(9): 101821, 2020 Nov.
Article in English | MEDLINE | ID: mdl-32474192

ABSTRACT

OBJECTIVE: The Society of Maternal Fetal Medicine (SMFM) and the Amniotic Fluid Embolism Foundation have recently proposed four diagnostic criteria for amniotic fluid embolism (AFE): presence of (1) sudden cardiac arrest or both respiratory and hemodynamic collapse, and (2) biological disseminated intravascular coagulopathy (DIC), and (3) absence of fever, and (4) clinical onset during labor or within 30 min of delivery. The objectives of our study were to describe the clinical presentation of women with a strong suspicion of AFE and to assess the validity of the four criteria proposed for AFE definition. MATERIAL AND METHODS: We performed a retrospective study including all patients with a strong suspicion of AFE who delivered between 2006 and 2018 at the Port Royal maternity unit, Paris. Strong suspicion of AFE was defined by a clinical presentation in favor of AFE associated with a biological pattern and/or autopsy result supporting AFE. The mention of AFE in files was essential to include the patients in our study. We estimated the incidence and mortality rate of AFE. Then, the presence of each of the four diagnosis criteria of the SMFM score was described, as well as the clinical and biological patterns. RESULTS: Among the 54 140 women who delivered during the study period, 14 had a strong suspicion of AFE (0.03 %), accounting for 25.9/100 000 deliveries (95 %CI (12.3-39.5/100,000)). All women had biological tests or autopsy supporting the diagnosis of AFE. Six of 14 patients (43 %) presented with all the four diagnostic criteria of the SMFM definition. All 14 women presented a hemodynamic collapse, but respiratory symptoms were lacking in 8 patients (57 %); 71 % fulfilled the criterion of biological DIC, and all patients had a clinical coagulopathy and a massive postpartum hemorrhage. Absence of fever was lacking in three women. In addition, all patients presented premonitory symptoms such as neurological disorders or irreversible and inaugural fetal bradycardia. CONCLUSION: The four SMFM diagnostic criteria were present in less than half of the women with a strong suspicion of AFE. We propose an alternative clinical and pragmatic definition to diagnose AFE, which has to be validated in the future. Early diagnosis of AFE based solely on clinical criteria can help clinicians anticipate the severity of the situation and optimize care.


Subject(s)
Embolism, Amniotic Fluid/diagnosis , Adult , Diagnostic Errors , Diagnostic Techniques and Procedures/statistics & numerical data , Embolism, Amniotic Fluid/mortality , Embolism, Amniotic Fluid/physiopathology , Female , France , Heart Arrest , Humans , Hypotension , Middle Aged , Perinatology , Postpartum Hemorrhage , Pregnancy , Reproducibility of Results , Retrospective Studies
10.
Arch Pediatr ; 27(4): 227-232, 2020 May.
Article in English | MEDLINE | ID: mdl-32278588

ABSTRACT

BACKGROUND: The rate of premature births in France is 6% and is increasing, as is the rate of extremely premature births. Morbidity and mortality rates in this population remain high despite significant medical progress. We aimed to evaluate the morbidity and mortality rate in preterm neonates weighing<750g and to evaluate their outcome at 2 years' corrected age (CA). METHODS: This was a retrospective monocentric study including babies born between May 2011 and April 2013 who were preterm and weighed<750g. We evaluated mortality and morbidity in the neonatal period. At 2 years' CA, we focused on developmental quotient (DQ) with the Brunet-Lézine test, on neurosensory assessment (sleeping/behavior), and growth evaluation. RESULTS: Among the 107 infants included, 29 (27%) died in the neonatal period. Mean gestational age was 25.6 weeks' gestation. Female sex and higher birth weight were independent predictors of survival. A total of 61 (78.2%) infants showed extra-uterine growth retardation at 36 weeks' postmenstrual age. At 2 years' CA, 57 children were followed up; 38 were evaluated using the Brunet-Lézine test, 20 (52.6%) had a DQc<85, and none had a severe developmental delay (DQc<50). Six (10%) children had cerebral palsy and 22 of 56 (39.2%) showed language delay. Growth retardation persisted in 15 of 52 (28.8%) children. CONCLUSION: Our results confirm the acute fragility of extremely low-birth-weight babies with a high rate of morbidity and mortality. At 2 years' CA, this population still shows a considerable rate of mild difficulties, whose long-term evolution needs to be followed.


Subject(s)
Infant, Extremely Low Birth Weight , Infant, Extremely Premature , Infant, Premature, Diseases/epidemiology , Child, Preschool , Female , Follow-Up Studies , France/epidemiology , Humans , Infant, Newborn , Infant, Premature, Diseases/diagnosis , Infant, Premature, Diseases/therapy , Male , Prognosis , Retrospective Studies
11.
J Gynecol Obstet Biol Reprod (Paris) ; 38(2): 188-94, 2009 Apr.
Article in French | MEDLINE | ID: mdl-19282112

ABSTRACT

In North America, postdoctoral fellowships are proposed to physicians and surgeons after their residency to obtain an expertise in a specific domain of their speciality. In obstetrics and gynecology, three fellowship programs are accredited by the Royal College of Physicians and Surgeons of Canada: maternal fetal medicine, gynaecological oncology and reproductive endocrinology and infertility. A two-year fellowship in Canada provides a great professional and personal experience. We present here the organization of these programs and the conditions to be admitted in a fellowship program in Canada.


Subject(s)
Fellowships and Scholarships/organization & administration , Gynecology/education , Obstetrics/education , Canada , Humans
12.
Gynecol Obstet Fertil Senol ; 47(6): 510-515, 2019 06.
Article in French | MEDLINE | ID: mdl-30959187

ABSTRACT

OBJECTIVE: Compare the professional aspiration and obstacles in gynecology and obstetrics residents careers between Lille and Paris. METHODS: We conducted a cross-sectional survey, using questionnaires sent by e-mail to residents in obstetrics and gynecology in Lille. An analysis by genre was made, and those results were compared to results obtained in a same study with Parisian residents. RESULTS: Among the 73 residents in training in Lille, 63 responded (86.3%), of them 53 those were women and 10 were men. No woman answered wanting to start an academic career, however 50% of men did (P=0.001). The global analysis found obstacles to an academic career in defined areas such as: lack of mentors, lack of identification in a same sex role model or women doubting more than men in their abilities to achieve this career. The comparison between the two cities shown a greater gap between women and men in Lille: women in Lille were most reluctant to engage in academic careers and have not the prerequisites (diplomas, mobility or publications) that seem necessary for this type of career. CONCLUSIONS: Women were less expecting to have academic careers in Lille than in Paris. Many barriers have been identified as difficulties for them to follow this career path. It is important to develop strategies to encourage women in gynecology and obstetrics to find their place in research and teaching, since they are most present in this specialty.


Subject(s)
Career Choice , Gynecology/education , Internship and Residency/statistics & numerical data , Obstetrics/education , Adult , Cross-Sectional Studies , Faculty, Medical , Female , France , Humans , Male , Mentors , Paris , Research Personnel , Sex Factors , Surveys and Questionnaires
13.
J Gynecol Obstet Hum Reprod ; 48(5): 309-314, 2019 May.
Article in English | MEDLINE | ID: mdl-30796984

ABSTRACT

The incidence of maternal cardiac arrest ranges from 1/55,000 to 1/12,000 births. It is due most frequently to cardiovascular, hemorrhagic, and anesthesia-related causes, as well as to amniotic fluid embolism. The basic principles of resuscitation remain applicable in this situation, but the physiological modifications of pregnancy must be taken into account, in particular, the aortocaval compression syndrome. After 24 weeks of gestation, a salvage cesarean delivery must be performed immediately, without transfer to the operating room, if resuscitation maneuvers have failed 4 min after arrest, because this interval conditions the mother's neurological prognosis and improves neonatal survival.


Subject(s)
Heart Arrest/therapy , Hospitalization , Pregnancy Complications, Cardiovascular/therapy , Advanced Cardiac Life Support , Cardiopulmonary Resuscitation , Cesarean Section , Embolism, Amniotic Fluid , Extracorporeal Membrane Oxygenation , Female , Heart Arrest/etiology , Humans , Incidence , Parturition , Pregnancy , Prognosis , Risk Factors
14.
Diabetes Metab ; 45(2): 191-196, 2019 04.
Article in English | MEDLINE | ID: mdl-29776801

ABSTRACT

AIM: This study assessed pregnancy outcomes in women with type 1 diabetes (T1D) over the last 15 years and identified modifiable factors associated with good perinatal outcomes. METHODS: Pregnancy outcomes were prospectively assessed in this cohort study of 588 singleton pregnancies (441 women) managed by standardized care from 2000 to 2014. A good perinatal outcome was defined as the uncomplicated delivery of a normally formed, non-macrosomic, full-term infant with no neonatal morbidity. Factors associated with good perinatal outcomes were identified by logistic regression. RESULTS: The rate of severe congenital malformations was 1.5%, and 0.7% for perinatal mortality. The most frequent perinatal complications were macrosomia (41%), preterm delivery (16%) and neonatal hypoglycaemia (11%). Shoulder dystocia occurred in 2.6% of cases, but without sequelae. Perinatal outcomes were good in 254 (44%) pregnancies, and were associated with lower maternal HbA1c values at delivery [adjusted odds ratio (aOR): 2.78, 95% CI: 2.04-3.70, for each 1% (11mmol/mol) absolute decrease], lower gestational weight gains (aOR: 1.06, 95% CI: 1.02-1.10) and absence of preeclampsia (aOR: 2.63, 95% CI: 1.09-6.25). The relationship between HbA1c at delivery and a good perinatal outcome was continuous, with no discrimination threshold. CONCLUSION: In our study, rates of severe congenital malformations and perinatal mortality were similar to those of the general population. Less severe complications, mainly macrosomia and late preterm delivery, persisted. Also, our study identified modifiable risk factors that could be targeted to further improve the prognosis of pregnancy in T1D.


Subject(s)
Diabetes Mellitus, Type 1/epidemiology , Pregnancy Outcome/epidemiology , Pregnancy in Diabetics/epidemiology , Adult , Cohort Studies , Congenital Abnormalities/epidemiology , Diabetes Mellitus, Type 1/complications , Diabetes, Gestational/epidemiology , Female , Fetal Macrosomia/epidemiology , France/epidemiology , Humans , Infant, Newborn , Pre-Eclampsia/epidemiology , Pregnancy , Pregnancy Rate , Premature Birth/epidemiology , Risk Factors
15.
Eur J Obstet Gynecol Reprod Biol ; 237: 68-73, 2019 Jun.
Article in English | MEDLINE | ID: mdl-31022655

ABSTRACT

OBJECTIVE: To assess the risk of cesarean delivery after induction of labor in twin compared with singleton pregnancies. STUDY DESIGN: This retrospective multicenter study compared data from two nationwide prospective cohorts: one of twin pregnancies established from February 2014 through March 2015 (JUMODA cohort), and the other of singleton pregnancies in November and December 2015 (MEDIP cohort). This study includes all women in both cohorts who had labor induced at ≥ 35 weeks of gestation, with a live fetus in cephalic presentation (Twin 1 for the twin pregnancies). Multivariate analyses with multilevel logistic regression models were used to study twin pregnancy as an independent risk factor for cesarean delivery, overall and stratified for parity and Bishop score. RESULTS: The outcomes of 1995 twin births after induction of labor were compared to those of 2771 induced singleton births. The cesarean rate differed significantly between the two populations and was higher in twins (23% in twins vs 19.4% in singletons, P = 0.002). After adjustment for factors associated with cesareans, twin pregnancy was independently associated with it (aOR = 1.8, 95% CI 1.4-2.2). CONCLUSION: Twin pregnancy appears to be an independent risk factor for cesarean births after induction of labor, but more than three-quarters of inductions culminated in vaginal delivery.


Subject(s)
Cesarean Section , Labor, Induced/adverse effects , Female , Humans , Pregnancy , Pregnancy Outcome , Pregnancy, Twin , Retrospective Studies , Risk Factors
16.
J Gynecol Obstet Hum Reprod ; 48(7): 455-460, 2019 Sep.
Article in English | MEDLINE | ID: mdl-30553051

ABSTRACT

INTRODUCTION: The objective of these clinical practice guidelines was to analyse all of the interventions during pregnancy and childbirth that might prevent obstetric anal sphincter injuries (OASIS) and postnatal pelvic floor symptoms. MATERIAL AND METHODS: These guidelines were developed in accordance with the methods prescribed by the French Health Authority (HAS). RESULTS: A prenatal clinical examination of the perineum is recommended for women with a history of Crohn's disease, OASIS, genital mutilation, or perianal lesions (professional consensus). Just after delivery, a perineal examination is recommended to check for OASIS (Grade B); if there is doubt about the diagnosis, a second opinion should be requested (Grade C). In case of OASIS, the injuries (including their severity) and the technique for their repair should be described in detail (Grade C). Perineal massage during pregnancy must be encouraged among women who want it (Grade B). No intervention conducted before the start of the active phase of the second stage of labour has been shown to be effective in reducing the risk of perineal injury. The crowning of the baby's head should be manually controlled and the posterior perineum manually supported to reduce the risk of OASIS (Grade C). The performance of an episiotomy during normal deliveries is not recommended to reduce the risk of OASIS (Grade A). In instrumental deliveries, episiotomy may be indicated to avoid OASIS (Grade C). When an episiotomy is performed, a mediolateral incision is recommended (Grade B). The indication for episiotomy should be explained to the woman, and she should consent before its performance. Advising women to have a caesarean delivery for primary prevention of postnatal urinary or anal incontinence is not recommended (Grade B). During pregnancy and again in the labour room, obstetrics professionals should focus on the woman's expectations and inform her about the modes of delivery.


Subject(s)
Anal Canal/injuries , Delivery, Obstetric/adverse effects , Delivery, Obstetric/methods , Lacerations/prevention & control , Perineum/injuries , Anal Canal/pathology , Anal Canal/surgery , Episiotomy/methods , Episiotomy/rehabilitation , Female , Gynecology/methods , Gynecology/organization & administration , Gynecology/standards , Humans , Infant, Newborn , Obstetrics/methods , Obstetrics/organization & administration , Obstetrics/standards , Parturition/physiology , Perineum/pathology , Perineum/surgery , Pregnancy , Risk Factors , Societies, Medical/standards
17.
Gynecol Obstet Fertil Senol ; 47(7-8): 555-561, 2019.
Article in French | MEDLINE | ID: mdl-31153953

ABSTRACT

OBJECTIVE: To describe induction of labor practices in France and to identify factors associated with the use of different methods. METHODS: The data came from the French prospective population-based cohort MEDIP (MEthodes de Déclenchement et Issues Périnatales), including consecutively during one month in 2015 all women with induction of labor and a live fetus in 7 perinatal networks. The characteristics of women, maternity units, gestational age, Bishop's score, decision mode, indication and methods of labor induction were described. Factors associated with the use of different methods were sought in univariate analyzes. RESULTS: The rate of induction of labor during the study was 21% and 3042 women were included (95.9% participation rate). The two main indications were prolonged pregnancy (28.7%) and premature rupture of the membranes (25.4%). More than one-third of women received intravenous oxytocin in first method, 57.3% prostaglandins, 4.5% balloon catheter and 1.4% another method. Among the prostaglandins, the vaginal device of dinoprostone was the most used (71.6%) then the gel (20.7%) and the vaginal misoprostol (6.7%). Women with a balloon were more often of higher body mass index and multiparous with scarred uterus. The balloon and misoprostol were mainly used in university public hospitals. CONCLUSIONS: The evolution of induction of labor methods, due to new data from the literature and the development of new drugs or devices, invites to regularly repeat population-based studies on induction of labor.


Subject(s)
Labor, Induced/methods , Practice Patterns, Physicians' , Cohort Studies , Dinoprostone/administration & dosage , Female , Fetal Membranes, Premature Rupture/therapy , France , Gestational Age , Humans , Labor, Induced/statistics & numerical data , Misoprostol/administration & dosage , Oxytocin/administration & dosage , Pregnancy , Pregnancy, Prolonged/therapy , Prospective Studies
18.
J Gynecol Obstet Biol Reprod (Paris) ; 37(4): 325-8, 2008 Jun.
Article in French | MEDLINE | ID: mdl-18406074

ABSTRACT

French guidelines recommend performing an assisted delivery after 30min pushing, even if the fetal heart rate is reassuring. A literature review shows that international practices differ from French recommendations; primiparous women usually push on average one hour. Specific data about duration of the active second stage are scarce. Therefore, there is no evidence that maternal and neonatal outcome would be improved by an early-assisted delivery as compared to pushing efforts prolonged after 30min.


Subject(s)
Labor Stage, Third , Extraction, Obstetrical , Female , Humans , Infant, Newborn , Posture , Practice Patterns, Physicians' , Pregnancy , Time Factors
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