ABSTRACT
BACKGROUND AND OBJECTIVE: To report a unique case series of diffuse unilateral subacute neuroretinitis (DUSN) patients imaged with optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: In this retrospective case series, multimodal imaging was performed in four patients with DUSN at the time of patient visit. The study patients underwent standard clinical treatment for DUSN. RESULTS: The clinical findings were consistent with the diagnosis of DUSN. Cross-sectional OCT showed disruption of outer retinal layers in the foveal area and an irregular structure of the outer plexiform layer. En face OCT revealed hyperreflective spots and a large hyperreflective lesion in the foveal area correspondent to the outer retina disruption seen on cross-sectional OCT. OCTA demonstrated decreased vascular perfusion in both the superficial and deep retinal capillary plexuses along with choriocapillaris preservation. CONCLUSION: OCTA may provide a more detailed assessment of the retinal microvascular changes, allowing a more precise anatomical-functional correlation in DUSN. [Ophthalmic Surg Lasers Imaging Retina. 2020;51:76-83.].
Subject(s)
Eye Infections, Parasitic/diagnosis , Fluorescein Angiography , Retinal Vessels/pathology , Retinitis/diagnosis , Tomography, Optical Coherence , Acute Disease , Administration, Oral , Adolescent , Adult , Albendazole/therapeutic use , Antiprotozoal Agents/therapeutic use , Child , Cross-Sectional Studies , Eye Infections, Parasitic/drug therapy , Eye Infections, Parasitic/parasitology , Female , Humans , Male , Multimodal Imaging , Retinal Vessels/drug effects , Retinitis/drug therapy , Retinitis/parasitology , Retrospective Studies , Visual Acuity/physiology , Young AdultABSTRACT
PURPOSE: To evaluate histopathologic signs of conjunctival inflammation in patients with conjunctival hyperemia induced by bimatoprost treatment. DESIGN: Prospective interventional study. METHODS: The study included 15 eyes of 15 patients scheduled for cataract surgery. Patients in the treatment group (n = 9) exhibited trace to moderate conjunctival hyperemia when treated with bimatoprost 0.03% every day for 15 to 30 days before surgery. The control group (n = 6) included untreated patients with no ocular disease other than cataract. Conjunctival biopsies were obtained for histologic evaluation with light microscopy. RESULTS: Vascular congestion was observed in biopsies from 7 patients (78%) in the bimatoprost group and 5 patients (83%) in the control group. Signs of inflammation were found in biopsies from 2 patients (22%) in the bimatoprost group and 2 patients (33%) in the control group. CONCLUSIONS: Histopathologic signs of inflammation were no more frequent in conjunctival specimens from bimatoprost-treated patients with trace to moderate hyperemia than in those from untreated control subjects.
Subject(s)
Antihypertensive Agents/adverse effects , Conjunctivitis/chemically induced , Hyperemia/chemically induced , Lipids/adverse effects , Amides , Antihypertensive Agents/therapeutic use , Bimatoprost , Cataract Extraction , Cloprostenol/analogs & derivatives , Conjunctiva/blood supply , Conjunctiva/pathology , Conjunctivitis/pathology , Glaucoma, Open-Angle/drug therapy , Humans , Hyperemia/pathology , Intraocular Pressure/drug effects , Lipids/therapeutic use , Prospective StudiesABSTRACT
The purpose of this study was to compare the IOP fluctuations in the daytime tension curves of glaucoma patients under ocular hypotensive therapy with those of patients previously submitted to trabeculectomy. We also evaluated the IOP peaks and fluctuations for the same patients in response to the water-drinking test (WDT). The study included 30 primary open-angle glaucoma (POAG) patients using ocular hypotensive medications and with no history of previous intraocular surgery (medical group), and 30 POAG patients previously submitted to one or more trabeculectomies though taking no medication at the time of the study (surgical group). All patients were submitted to a diurnal tension curve--DTC (8:30-17:00/3-hour intervals) followed by the WDT. The IOP peak and IOP fluctuation during the diurnal tension curve were significantly greater in the medical group than in the surgical group. The same was observed following the WDT. From an overall baseline IOP of 10.6 mmHg, the mean IOP change following the WDT was 13% in the surgical group and 40% in the medical group. Patients submitted to trabeculectomy have less TOP fluctuations during the diurnal tension curve and following a water-drinking provocative test. This effect could represent an additional benefit of surgery in controlling the intraocular pressure of glaucomatous patients.