Propofol combined with alfentanil for general anesthesia in vocal cord polypectomy under suspension laryngoscopy.

OBJECTIVE: To investigate the clinical effect of propofol combined with alfentanil in vocal cord polypectomy under suspension laryngoscopy. METHODS: A total of 308 patients undergoing vocal cord polypectomy under suspension laryngoscopy in the First Affiliated Hospital of Nanchang University were included in this prospective study, and the patients were randomly divided into an observation group and a control group. Patients in the observation group received alfentanil combined with propofol, while those in the control group were anesthetized with sufentanil combined with propofol. The heart rate (HR), mean arterial pressure (MAP), real portfolio project (RPP), and Steward postanesthetic recovery scores were compared between the two groups before anesthesia induction (T0), at intubation (T1), 5 min after intubation (T2), at the time of placing suspension laryngoscopy (T3), 1 min after placing the suspension laryngoscopy (T4), 1 min after extraction of support laryngoscope (T5), and 1 min after extubation (T6). In addition, the propofol dosage and peripheral plasma levels of epinephrine (E) and norepinephrine (NE) were also compared between the groups. RESULTS: The MAP, HR, and RPP of the patients in the observation group were higher than those in the control group at T1-T5 (all P<0.05), while there was no statistical difference at T0 and T6 (all P>0.05). The Steward postanesthetic recovery scores and the propofol dosage in the observation group were lower than those in the control group. In addition, there was a statistically significant difference in the E and NE levels between the two groups after surgery (P<0.001). There was also an interaction effect between the groups and among the time points (both P<0.001). CONCLUSION: Alfentanil can reduce the fluctuation of hemodynamics during vocal cord polypectomy under suspension laryngoscopy, and therefore improve anesthesia effect. Simultaneously, the usage of propofol was reduced, as well as the stress levels. CLINICAL TRIAL NUMBER: ChiCTR2100054186.

[Analysis of the contents of K, Na, Ca, Mg, Zn, Cu, Fe and Mn in serum of middle and old-aged hypertension patients].

Atomic absorption method was used to detect the contents of K, Na, Ca, Mg, Zn, Cu, Fe and Mn in serum of 48 hypertension patients and 52 healthy people. The results show that the contents of Na, Mg, Zn, Fe and Mn in hypertension were higher than healthy control, while K, Ca and Cu were lower. Na/K were higher, but Ca/Mg and Cu/Zn were lower, than healthy control. These suggested that we should add K, Ca, Mg and Cu properly, reduce Na, scientifically control the increase of Zn, Fe and Mn, pay attention to the balance relation of Na/K, Ca/Mg and Cu/Zn, reduce Na/K, raise Cu/Zn, and add Ca with Mg properly. This can be useful for preventing and treating hypertension.

[Analysis of the contents of Zn, Cu, Fe, Mn, Co and Ni in thymopeptide and transfer factor biological injections].

Thymopeptide and transfer factor are two common clinic biological preparations, which are used to cure immunodeficiency, low immunofunction or infectious disease caused by virus or fungi owing to their functions of increasing body immunity. In order to discuss the relationship between trace elements and those related diseases, to coordinate sound clinic use of the preparations and to provide productive data on them, atomic absorption spectrophotometry was used to detect the contents of Zn, Cu, Fe, Mn, Co and Ni in thymopeptide and transfer factor biological preparations. Respective contents of detected elements were compared in a statistical way. Results show that Zn and Co contents in thymopeptide were lower than in transfer factor; the contents of Cu, Fe, Mn and Ni, in thymopeptide were higher than in transfer factor. For Zn, Cu, Mn and Co, there was a significant difference between the two biologicam preparations (P<0.01). For Fe and Ni there was a great difference (Q<0.05). The results can provide useful data for sound clinic biological injection to promote immune function, and for increasing or decreasing certain trace elements in preparation.