Search | Virtual Health Library

1.

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

Caeiro, Lucas D; Nakata, Yuichiro; Borges, Rodrigo L; Zha, Mengsheng; Garcia-Martinez, Liliana; Bañuelos, Carolina P; Stransky, Stephanie; Liu, Tong; Chan, Ho Lam; Brabson, John; Domínguez, Diana; Zhang, Yusheng; Lewis, Peter W; Aznar Benitah, Salvador; Cimmino, Luisa; Bilbao, Daniel; Sidoli, Simone; Wang, Zheng; Verdun, Ramiro E; Morey, Lluis.

Genes Dev ; 38(1-2): 46-69, 2024 Feb 13.

Article in English | MEDLINE | ID: mdl-38286657

2.

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.

Black, Joshua C; Manning, Amity L; Van Rechem, Capucine; Kim, Jaegil; Ladd, Brendon; Cho, Juok; Pineda, Cristiana M; Murphy, Nancy; Daniels, Danette L; Montagna, Cristina; Lewis, Peter W; Glass, Kimberly; Allis, C David; Dyson, Nicholas J; Getz, Gad; Whetstine, Johnathan R.

Cell ; 154(3): 541-55, 2013 Aug 01.

Article in English | MEDLINE | ID: mdl-23871696

3.

H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.

Jain, Siddhant U; Rashoff, Andrew Q; Krabbenhoft, Samuel D; Hoelper, Dominik; Do, Truman J; Gibson, Tyler J; Lundgren, Stefan M; Bondra, Eliana R; Deshmukh, Shriya; Harutyunyan, Ashot S; Juretic, Nikoleta; Jabado, Nada; Harrison, Melissa M; Lewis, Peter W.

Mol Cell ; 80(4): 726-735.e7, 2020 11 19.

Article in English | MEDLINE | ID: mdl-33049227

4.

Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation.

McDaniel, Stephen L; Gibson, Tyler J; Schulz, Katharine N; Fernandez Garcia, Meilin; Nevil, Markus; Jain, Siddhant U; Lewis, Peter W; Zaret, Kenneth S; Harrison, Melissa M.

Mol Cell ; 74(1): 185-195.e4, 2019 04 04.

Article in English | MEDLINE | ID: mdl-30797686

5.

Distinct factors control histone variant H3.3 localization at specific genomic regions.

Goldberg, Aaron D; Banaszynski, Laura A; Noh, Kyung-Min; Lewis, Peter W; Elsaesser, Simon J; Stadler, Sonja; Dewell, Scott; Law, Martin; Guo, Xingyi; Li, Xuan; Wen, Duancheng; Chapgier, Ariane; DeKelver, Russell C; Miller, Jeffrey C; Lee, Ya-Li; Boydston, Elizabeth A; Holmes, Michael C; Gregory, Philip D; Greally, John M; Rafii, Shahin; Yang, Chingwen; Scambler, Peter J; Garrick, David; Gibbons, Richard J; Higgs, Douglas R; Cristea, Ileana M; Urnov, Fyodor D; Zheng, Deyou; Allis, C David.

Cell ; 140(5): 678-91, 2010 Mar 05.

Article in English | MEDLINE | ID: mdl-20211137

6.

Human spliceosomal snRNA sequence variants generate variant spliceosomes.

Mabin, Justin W; Lewis, Peter W; Brow, David A; Dvinge, Heidi.

RNA ; 27(10): 1186-1203, 2021 10.

Article in English | MEDLINE | ID: mdl-34234030

7.

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.

Jain, Siddhant U; Khazaei, Sima; Marchione, Dylan M; Lundgren, Stefan M; Wang, Xiaoshi; Weinberg, Daniel N; Deshmukh, Shriya; Juretic, Nikoleta; Lu, Chao; Allis, C David; Garcia, Benjamin A; Jabado, Nada; Lewis, Peter W.

Proc Natl Acad Sci U S A ; 117(44): 27354-27364, 2020 11 03.

Article in English | MEDLINE | ID: mdl-33067396

8.

Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase.

Jani, Krupa S; Jain, Siddhant U; Ge, Eva J; Diehl, Katharine L; Lundgren, Stefan M; Müller, Manuel M; Lewis, Peter W; Muir, Tom W.

Proc Natl Acad Sci U S A ; 116(17): 8295-8300, 2019 04 23.

Article in English | MEDLINE | ID: mdl-30967505

9.

A goldilocks amount of H3K27me3.

Reich, Tyler J; Lewis, Peter W.

Nat Chem Biol ; 19(9): 1046-1047, 2023 Sep.

Article in English | MEDLINE | ID: mdl-36973441

10.

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.

Strekalova, Elena; Malin, Dmitry; Weisenhorn, Erin M M; Russell, Jason D; Hoelper, Dominik; Jain, Aayushi; Coon, Joshua J; Lewis, Peter W; Cryns, Vincent L.

Breast Cancer Res Treat ; 175(1): 39-50, 2019 May.

Article in English | MEDLINE | ID: mdl-30712196

11.

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.

Jayaram, Hariharan; Hoelper, Dominik; Jain, Siddhant U; Cantone, Nico; Lundgren, Stefan M; Poy, Florence; Allis, C David; Cummings, Richard; Bellon, Steven; Lewis, Peter W.

Proc Natl Acad Sci U S A ; 113(22): 6182-7, 2016 May 31.

Article in English | MEDLINE | ID: mdl-27185940

12.

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.

Elsässer, Simon J; Huang, Hongda; Lewis, Peter W; Chin, Jason W; Allis, C David; Patel, Dinshaw J.

Nature ; 491(7425): 560-5, 2012 Nov 22.

Article in English | MEDLINE | ID: mdl-23075851

13.

ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.

Noh, Kyung-Min; Maze, Ian; Zhao, Dan; Xiang, Bin; Wenderski, Wendy; Lewis, Peter W; Shen, Li; Li, Haitao; Allis, C David.

Proc Natl Acad Sci U S A ; 112(22): 6820-7, 2015 Jun 02.

Article in English | MEDLINE | ID: mdl-25538301

14.

Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.

Brown, Zachary Z; Müller, Manuel M; Kong, Ha Eun; Lewis, Peter W; Muir, Tom W.

Angew Chem Int Ed Engl ; 54(22): 6457-61, 2015 May 26.

Article in English | MEDLINE | ID: mdl-25873363

15.

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2.

Brown, Zachary Z; Müller, Manuel M; Jain, Siddhant U; Allis, C David; Lewis, Peter W; Muir, Tom W.

J Am Chem Soc ; 136(39): 13498-501, 2014 Oct 01.

Article in English | MEDLINE | ID: mdl-25180930

16.

A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.

Venneti, Sriram; Santi, Mariarita; Felicella, Michelle Madden; Yarilin, Dmitry; Phillips, Joanna J; Sullivan, Lisa M; Martinez, Daniel; Perry, Arie; Lewis, Peter W; Thompson, Craig B; Judkins, Alexander R.

Acta Neuropathol ; 128(5): 743-53, 2014 Nov.

Article in English | MEDLINE | ID: mdl-25200322

17.

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas.

Bechet, Denise; Gielen, Gerrit G H; Korshunov, Andrey; Pfister, Stefan M; Rousso, Caterina; Faury, Damien; Fiset, Pierre-Olivier; Benlimane, Naciba; Lewis, Peter W; Lu, Chao; David Allis, C; Kieran, Mark W; Ligon, Keith L; Pietsch, Torsten; Ellezam, Benjamin; Albrecht, Steffen; Jabado, Nada.

Acta Neuropathol ; 128(5): 733-41, 2014 Nov.

Article in English | MEDLINE | ID: mdl-25200321

18.

Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing.

Jensvold, Zena D; Christenson, Anna E; Flood, Julia R; Lewis, Peter W.

bioRxiv ; 2024 Feb 01.

Article in English | MEDLINE | ID: mdl-38313255

19.

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.

Lewis, Peter W; Elsaesser, Simon J; Noh, Kyung-Min; Stadler, Sonja C; Allis, C David.

Proc Natl Acad Sci U S A ; 107(32): 14075-80, 2010 Aug 10.

Article in English | MEDLINE | ID: mdl-20651253

20.

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

Caeiro, Lucas D; Nakata, Yuichiro; Borges, Rodrigo L; Garcia-Martinez, Liliana; Bañuelos, Carolina P; Stransky, Stephanie; Chan, Ho Lam; Brabson, John; Domínguez, Diana; Zhang, Yusheng; Lewis, Peter W; Aznar-Benitah, Salvador; Cimmino, Luisa; Bilbao, Daniel; Sidoli, Simone; Verdun, Ramiro E; Morey, Lluis.

bioRxiv ; 2023 Nov 06.

Article in English | MEDLINE | ID: mdl-38076924

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Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.

H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.

Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation.

Distinct factors control histone variant H3.3 localization at specific genomic regions.

Human spliceosomal snRNA sequence variants generate variant spliceosomes.

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.

Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase.

A goldilocks amount of H3K27me3.

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.

ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.

Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2.

A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas.

Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing.

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.