Search | Virtual Health Library

1.

Pancreatic cancer: Advances and challenges.

Halbrook, Christopher J; Lyssiotis, Costas A; Pasca di Magliano, Marina; Maitra, Anirban.

Cell ; 186(8): 1729-1754, 2023 04 13.

Article in English | MEDLINE | ID: mdl-37059070

2.

Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology.

Fujiwara, Hideaki; Seike, Keisuke; Brooks, Michael D; Mathew, Anna V; Kovalenko, Ilya; Pal, Anupama; Lee, Ho-Joon; Peltier, Daniel; Kim, Stephanie; Liu, Chen; Oravecz-Wilson, Katherine; Li, Lu; Sun, Yaping; Byun, Jaeman; Maeda, Yoshinobu; Wicha, Max S; Saunders, Thomas L; Rehemtulla, Alnawaz; Lyssiotis, Costas A; Pennathur, Subramaniam; Reddy, Pavan.

Nat Immunol ; 22(11): 1440-1451, 2021 11.

Article in English | MEDLINE | ID: mdl-34686860

3.

Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.

Hu, Hai; Juvekar, Ashish; Lyssiotis, Costas A; Lien, Evan C; Albeck, John G; Oh, Doogie; Varma, Gopal; Hung, Yin Pun; Ullas, Soumya; Lauring, Josh; Seth, Pankaj; Lundquist, Mark R; Tolan, Dean R; Grant, Aaron K; Needleman, Daniel J; Asara, John M; Cantley, Lewis C; Wulf, Gerburg M.

Cell ; 164(3): 433-46, 2016 Jan 28.

Article in English | MEDLINE | ID: mdl-26824656

4.

An unexpected pathway to polyamines in pancreatic cancer.

Awad, Dominik; Lyssiotis, Costas A.

Mol Cell ; 83(11): 1765-1766, 2023 06 01.

Article in English | MEDLINE | ID: mdl-37267902

5.

Acetate fuels the cancer engine.

Lyssiotis, Costas A; Cantley, Lewis C.

Cell ; 159(7): 1492-4, 2014 Dec 18.

Article in English | MEDLINE | ID: mdl-25525870

6.

Uridine-derived ribose fuels glucose-restricted pancreatic cancer.

Nwosu, Zeribe C; Ward, Matthew H; Sajjakulnukit, Peter; Poudel, Pawan; Ragulan, Chanthirika; Kasperek, Steven; Radyk, Megan; Sutton, Damien; Menjivar, Rosa E; Andren, Anthony; Apiz-Saab, Juan J; Tolstyka, Zachary; Brown, Kristee; Lee, Ho-Joon; Dzierozynski, Lindsey N; He, Xi; Ps, Hari; Ugras, Julia; Nyamundanda, Gift; Zhang, Li; Halbrook, Christopher J; Carpenter, Eileen S; Shi, Jiaqi; Shriver, Leah P; Patti, Gary J; Muir, Alexander; Pasca di Magliano, Marina; Sadanandam, Anguraj; Lyssiotis, Costas A.

Nature ; 618(7963): 151-158, 2023 Jun.

Article in English | MEDLINE | ID: mdl-37198494

7.

The biological underpinnings of therapeutic resistance in pancreatic cancer.

Beatty, Gregory L; Werba, Gregor; Lyssiotis, Costas A; Simeone, Diane M.

Genes Dev ; 35(13-14): 940-962, 2021 07 01.

Article in English | MEDLINE | ID: mdl-34117095

8.

ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer.

Purohit, Vinee; Wang, Lidong; Yang, Huibin; Li, Jiufeng; Ney, Gina M; Gumkowski, Erica R; Vaidya, Akash J; Wang, Annie; Bhardwaj, Amit; Zhao, Ende; Dolgalev, Igor; Zamperone, Andrea; Abel, Ethan V; Magliano, Marina Pasca Di; Crawford, Howard C; Diolaiti, Daniel; Papagiannakopoulos, Thales Y; Lyssiotis, Costas A; Simeone, Diane M.

Genes Dev ; 35(3-4): 218-233, 2021 02 01.

Article in English | MEDLINE | ID: mdl-33446568

9.

A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.

Zhu, Lingxin; Tang, Yi; Li, Xiao-Yan; Kerk, Samuel A; Lyssiotis, Costas A; Feng, Wenqing; Sun, Xiaoyue; Hespe, Geoffrey E; Wang, Zijun; Stemmler, Marc P; Brabletz, Simone; Brabletz, Thomas; Keller, Evan T; Ma, Jun; Cho, Jung-Sun; Yang, Jingwen; Weiss, Stephen J.

EMBO J ; 42(7): e111148, 2023 04 03.

Article in English | MEDLINE | ID: mdl-36843552

10.

SIRT6 puts cancer metabolism in the driver's seat.

Lyssiotis, Costas A; Cantley, Lewis C.

Cell ; 151(6): 1155-6, 2012 Dec 07.

Article in English | MEDLINE | ID: mdl-23217699

11.

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Ying, Haoqiang; Kimmelman, Alec C; Lyssiotis, Costas A; Hua, Sujun; Chu, Gerald C; Fletcher-Sananikone, Eliot; Locasale, Jason W; Son, Jaekyoung; Zhang, Hailei; Coloff, Jonathan L; Yan, Haiyan; Wang, Wei; Chen, Shujuan; Viale, Andrea; Zheng, Hongwu; Paik, Ji-hye; Lim, Carol; Guimaraes, Alexander R; Martin, Eric S; Chang, Jeffery; Hezel, Aram F; Perry, Samuel R; Hu, Jian; Gan, Boyi; Xiao, Yonghong; Asara, John M; Weissleder, Ralph; Wang, Y Alan; Chin, Lynda; Cantley, Lewis C; DePinho, Ronald A.

Cell ; 149(3): 656-70, 2012 Apr 27.

Article in English | MEDLINE | ID: mdl-22541435

12.

Iron regulates the quiescence of naive CD4 T cells by controlling mitochondria and cellular metabolism.

Kumar, Ajay; Ye, Chenxian; Nkansah, Afia; Decoville, Thomas; Fogo, Garrett M; Sajjakulnukit, Peter; Reynolds, Mack B; Zhang, Li; Quaye, Osbourne; Seo, Young-Ah; Sanderson, Thomas H; Lyssiotis, Costas A; Chang, Cheong-Hee.

Proc Natl Acad Sci U S A ; 121(17): e2318420121, 2024 Apr 23.

Article in English | MEDLINE | ID: mdl-38621136

13.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer.

He, Tongchen; Cheng, Caleb; Qiao, Yuanyuan; Cho, Hanbyul; Young, Eleanor; Mannan, Rahul; Mahapatra, Somnath; Miner, Stephanie J; Zheng, Yang; Kim, NamHoon; Zeng, Victoria Z; Wisniewski, Jasmine P; Hou, Siyu; Jackson, Bailey; Cao, Xuhong; Su, Fengyun; Wang, Rui; Chang, Yu; Kuila, Bilash; Mukherjee, Subhendu; Dukare, Sandeep; Aithal, Kiran B; D S, Samiulla; Abbineni, Chandrasekhar; Vaishampayan, Ulka; Lyssiotis, Costas A; Parolia, Abhijit; Xiao, Lanbo; Chinnaiyan, Arul M.

Proc Natl Acad Sci U S A ; 121(15): e2322563121, 2024 Apr 09.

Article in English | MEDLINE | ID: mdl-38557192

14.

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.

Kumar, Roshan; Vitvitsky, Victor; Sethaudom, Apichaya; Singhal, Rashi; Solanki, Sumeet; Alibeckoff, Sydney; Hiraki, Harrison L; Bell, Hannah N; Andren, Anthony; Baker, Brendon M; Lyssiotis, Costas A; Shah, Yatrik M; Banerjee, Ruma.

Nat Chem Biol ; 2024 Mar 20.

Article in English | MEDLINE | ID: mdl-38509349

15.

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.

Bian, Yingjie; Li, Wei; Kremer, Daniel M; Sajjakulnukit, Peter; Li, Shasha; Crespo, Joel; Nwosu, Zeribe C; Zhang, Li; Czerwonka, Arkadiusz; Pawlowska, Anna; Xia, Houjun; Li, Jing; Liao, Peng; Yu, Jiali; Vatan, Linda; Szeliga, Wojciech; Wei, Shuang; Grove, Sara; Liu, J Rebecca; McLean, Karen; Cieslik, Marcin; Chinnaiyan, Arul M; Zgodzinski, Witold; Wallner, Grzegorz; Wertel, Iwona; Okla, Karolina; Kryczek, Ilona; Lyssiotis, Costas A; Zou, Weiping.

Nature ; 585(7824): 277-282, 2020 09.

Article in English | MEDLINE | ID: mdl-32879489

16.

PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool.

Chen, Brandon; Das, Nupur K; Talukder, Indrani; Singhal, Rashi; Castillo, Cristina; Andren, Anthony; Mancias, Joseph D; Lyssiotis, Costas A; Shah, Yatrik M.

J Biol Chem ; 299(5): 104691, 2023 05.

Article in English | MEDLINE | ID: mdl-37037306

17.

Targeting allosteric regulation of cancer metabolism.

Kremer, Daniel M; Lyssiotis, Costas A.

Nat Chem Biol ; 18(5): 441-450, 2022 05.

Article in English | MEDLINE | ID: mdl-35484254

18.

Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer.

Halbrook, Christopher J; Wahl, Daniel R; Lyssiotis, Costas A.

Trends Biochem Sci ; 44(12): 991-993, 2019 12.

Article in English | MEDLINE | ID: mdl-31699584

19.

Metabolic regulation of ferroptosis in the tumor microenvironment.

Mbah, Nneka E; Lyssiotis, Costas A.

J Biol Chem ; 298(3): 101617, 2022 03.

Article in English | MEDLINE | ID: mdl-35065965

20.

A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H₂S oxidation.

Kumar, Roshan; Landry, Aaron P; Guha, Arkajit; Vitvitsky, Victor; Lee, Ho Joon; Seike, Keisuke; Reddy, Pavan; Lyssiotis, Costas A; Banerjee, Ruma.

J Biol Chem ; 298(1): 101435, 2022 01.

Article in English | MEDLINE | ID: mdl-34808207

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