Search | Virtual Health Library

1.

Necroptosis and Inflammation.

Newton, Kim; Manning, Gerard.

Annu Rev Biochem ; 85: 743-63, 2016 Jun 02.

Article in English | MEDLINE | ID: mdl-26865533

2.

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

Jones, Alexander C; Kornev, Alexandr P; Weng, Jui-Hung; Manning, Gerard; Taylor, Susan S; Newton, Alexandra C.

Biochem J ; 480(16): 1299-1316, 2023 08 30.

Article in English | MEDLINE | ID: mdl-37551632

3.

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

Daemen, Anneleen; Manning, Gerard.

Breast Cancer Res ; 20(1): 8, 2018 01 30.

Article in English | MEDLINE | ID: mdl-29382369

4.

RPN-6 determines C. elegans longevity under proteotoxic stress conditions.

Vilchez, David; Morantte, Ianessa; Liu, Zheng; Douglas, Peter M; Merkwirth, Carsten; Rodrigues, Ana P C; Manning, Gerard; Dillin, Andrew.

Nature ; 489(7415): 263-8, 2012 Sep 13.

Article in English | MEDLINE | ID: mdl-22922647

5.

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.

Ngaki, Micheline N; Louie, Gordon V; Philippe, Ryan N; Manning, Gerard; Pojer, Florence; Bowman, Marianne E; Li, Ling; Larsen, Elise; Wurtele, Eve Syrkin; Noel, Joseph P.

Nature ; 485(7399): 530-3, 2012 May 13.

Article in English | MEDLINE | ID: mdl-22622584

6.

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Daemen, Anneleen; Peterson, David; Sahu, Nisebita; McCord, Ron; Du, Xiangnan; Liu, Bonnie; Kowanetz, Katarzyna; Hong, Rebecca; Moffat, John; Gao, Min; Boudreau, Aaron; Mroue, Rana; Corson, Laura; O'Brien, Thomas; Qing, Jing; Sampath, Deepak; Merchant, Mark; Yauch, Robert; Manning, Gerard; Settleman, Jeffrey; Hatzivassiliou, Georgia; Evangelista, Marie.

Proc Natl Acad Sci U S A ; 112(32): E4410-7, 2015 Aug 11.

Article in English | MEDLINE | ID: mdl-26216984

7.

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.

Mair, William; Morantte, Ianessa; Rodrigues, Ana P C; Manning, Gerard; Montminy, Marc; Shaw, Reuben J; Dillin, Andrew.

Nature ; 470(7334): 404-8, 2011 Feb 17.

Article in English | MEDLINE | ID: mdl-21331044

8.

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

Zhang, You-Wei; Brognard, John; Coughlin, Chris; You, Zhongsheng; Dolled-Filhart, Marisa; Aslanian, Aaron; Manning, Gerard; Abraham, Robert T; Hunter, Tony.

Mol Cell ; 35(4): 442-53, 2009 Aug 28.

Article in English | MEDLINE | ID: mdl-19716789

9.

The Amphimedon queenslandica genome and the evolution of animal complexity.

Srivastava, Mansi; Simakov, Oleg; Chapman, Jarrod; Fahey, Bryony; Gauthier, Marie E A; Mitros, Therese; Richards, Gemma S; Conaco, Cecilia; Dacre, Michael; Hellsten, Uffe; Larroux, Claire; Putnam, Nicholas H; Stanke, Mario; Adamska, Maja; Darling, Aaron; Degnan, Sandie M; Oakley, Todd H; Plachetzki, David C; Zhai, Yufeng; Adamski, Marcin; Calcino, Andrew; Cummins, Scott F; Goodstein, David M; Harris, Christina; Jackson, Daniel J; Leys, Sally P; Shu, Shengqiang; Woodcroft, Ben J; Vervoort, Michel; Kosik, Kenneth S; Manning, Gerard; Degnan, Bernard M; Rokhsar, Daniel S.

Nature ; 466(7307): 720-6, 2010 Aug 05.

Article in English | MEDLINE | ID: mdl-20686567

10.

Key challenges for the creation and maintenance of specialist protein resources.

Holliday, Gemma L; Bairoch, Amos; Bagos, Pantelis G; Chatonnet, Arnaud; Craik, David J; Finn, Robert D; Henrissat, Bernard; Landsman, David; Manning, Gerard; Nagano, Nozomi; O'Donovan, Claire; Pruitt, Kim D; Rawlings, Neil D; Saier, Milton; Sowdhamini, Ramanathan; Spedding, Michael; Srinivasan, Narayanaswamy; Vriend, Gert; Babbitt, Patricia C; Bateman, Alex.

Proteins ; 83(6): 1005-13, 2015 Jun.

Article in English | MEDLINE | ID: mdl-25820941

11.

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer.

Gnad, Florian; Doll, Sophia; Manning, Gerard; Arnott, David; Zhang, Zemin.

BMC Genomics ; 16 Suppl 8: S5, 2015.

Article in English | MEDLINE | ID: mdl-26110843

12.

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

Murphy, James M; Zhang, Qingwei; Young, Samuel N; Reese, Michael L; Bailey, Fiona P; Eyers, Patrick A; Ungureanu, Daniela; Hammaren, Henrik; Silvennoinen, Olli; Varghese, Leila N; Chen, Kelan; Tripaydonis, Anne; Jura, Natalia; Fukuda, Koichi; Qin, Jun; Nimchuk, Zachary; Mudgett, Mary Beth; Elowe, Sabine; Gee, Christine L; Liu, Ling; Daly, Roger J; Manning, Gerard; Babon, Jeffrey J; Lucet, Isabelle S.

Biochem J ; 457(2): 323-34, 2014 Jan 15.

Article in English | MEDLINE | ID: mdl-24107129

13.

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica.

Teh, Phildrich G; Chen, Mark J; Engel, James L; Worby, Carolyn A; Manning, Gerard; Dixon, Jack E; Zhang, Ji.

J Biol Chem ; 288(7): 5176-85, 2013 Feb 15.

Article in English | MEDLINE | ID: mdl-23293031

14.

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.

King, Nicole; Westbrook, M Jody; Young, Susan L; Kuo, Alan; Abedin, Monika; Chapman, Jarrod; Fairclough, Stephen; Hellsten, Uffe; Isogai, Yoh; Letunic, Ivica; Marr, Michael; Pincus, David; Putnam, Nicholas; Rokas, Antonis; Wright, Kevin J; Zuzow, Richard; Dirks, William; Good, Matthew; Goodstein, David; Lemons, Derek; Li, Wanqing; Lyons, Jessica B; Morris, Andrea; Nichols, Scott; Richter, Daniel J; Salamov, Asaf; Sequencing, J G I; Bork, Peer; Lim, Wendell A; Manning, Gerard; Miller, W Todd; McGinnis, William; Shapiro, Harris; Tjian, Robert; Grigoriev, Igor V; Rokhsar, Daniel.

Nature ; 451(7180): 783-8, 2008 Feb 14.

Article in English | MEDLINE | ID: mdl-18273011

15.

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.

Xiao, Junyu; Engel, James L; Zhang, Ji; Chen, Mark J; Manning, Gerard; Dixon, Jack E.

Proc Natl Acad Sci U S A ; 108(29): 11860-5, 2011 Jul 19.

Article in English | MEDLINE | ID: mdl-21730175

16.

Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Gnad, Florian; Baucom, Albion; Mukhyala, Kiran; Manning, Gerard; Zhang, Zemin.

BMC Genomics ; 14 Suppl 3: S7, 2013.

Article in English | MEDLINE | ID: mdl-23819521

17.

Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).

Stajich, Jason E; Wilke, Sarah K; Ahrén, Dag; Au, Chun Hang; Birren, Bruce W; Borodovsky, Mark; Burns, Claire; Canbäck, Björn; Casselton, Lorna A; Cheng, C K; Deng, Jixin; Dietrich, Fred S; Fargo, David C; Farman, Mark L; Gathman, Allen C; Goldberg, Jonathan; Guigó, Roderic; Hoegger, Patrick J; Hooker, James B; Huggins, Ashleigh; James, Timothy Y; Kamada, Takashi; Kilaru, Sreedhar; Kodira, Chinnapa; Kües, Ursula; Kupfer, Doris; Kwan, H S; Lomsadze, Alexandre; Li, Weixi; Lilly, Walt W; Ma, Li-Jun; Mackey, Aaron J; Manning, Gerard; Martin, Francis; Muraguchi, Hajime; Natvig, Donald O; Palmerini, Heather; Ramesh, Marilee A; Rehmeyer, Cathy J; Roe, Bruce A; Shenoy, Narmada; Stanke, Mario; Ter-Hovhannisyan, Vardges; Tunlid, Anders; Velagapudi, Rajesh; Vision, Todd J; Zeng, Qiandong; Zolan, Miriam E; Pukkila, Patricia J.

Proc Natl Acad Sci U S A ; 107(26): 11889-94, 2010 Jun 29.

Article in English | MEDLINE | ID: mdl-20547848

18.

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

Jones, Alexander C; Kornev, Alexandr P; Weng, Jui-Hung; Manning, Gerard; Taylor, Susan S; Newton, Alexandra C.

bioRxiv ; 2023 Mar 16.

Article in English | MEDLINE | ID: mdl-36993163

19.

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities.

Mattoo, Seema; Durrant, Eric; Chen, Mark J; Xiao, Junyu; Lazar, Cheri S; Manning, Gerard; Dixon, Jack E; Worby, Carolyn A.

J Biol Chem ; 286(37): 32834-42, 2011 Sep 16.

Article in English | MEDLINE | ID: mdl-21795713

20.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

Hutt, Darren M; Herman, David; Rodrigues, Ana P C; Noel, Sabrina; Pilewski, Joseph M; Matteson, Jeanne; Hoch, Ben; Kellner, Wendy; Kelly, Jeffery W; Schmidt, Andre; Thomas, Philip J; Matsumura, Yoshihiro; Skach, William R; Gentzsch, Martina; Riordan, John R; Sorscher, Eric J; Okiyoneda, Tsukasa; Yates, John R; Lukacs, Gergely L; Frizzell, Raymond A; Manning, Gerard; Gottesfeld, Joel M; Balch, William E.

Nat Chem Biol ; 6(1): 25-33, 2010 Jan.

Article in English | MEDLINE | ID: mdl-19966789

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Necroptosis and Inflammation.

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors.

RPN-6 determines C. elegans longevity under proteotoxic stress conditions.

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis.

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress.

The Amphimedon queenslandica genome and the evolution of animal complexity.

Key challenges for the creation and maintenance of specialist protein resources.

Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer.

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica.

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans.

Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis.

Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.