ABSTRACT
High-performance liquid chromatography was used for separation, identification and purification of synthetic analogues of prostaglandin E, about 30 various samples being analysed. Basing on the data obtained, recommendation are given on the preparative HPLC separation (up to 300 mg scale) of structural isomers and epimers of synthetic prostaglandins.
Subject(s)
Chromatography, High Pressure Liquid , Prostaglandins E, Synthetic/analysis , Chemical Phenomena , Chemistry , IsomerismABSTRACT
11-Deoxymisoprostol showed gastroprotector activity on the acute models of ulcers induced by acetylsalicylic acid and ethanol and produced curative effect on the chronic ulceration model induced by acetic acid. The positive effect is manifested by a decrease in the number of destructions and in the total area of chronic damage in the mucous membrane of the stomach. In addition, 11-deoxymisoprostol showed antiphlogistic activity on the acute edema models induced by carrageenan and formalin, by decreasing the model foot edema growth in experimental animals. The drug also decreased the level of lipid peroxidation in the rat blood serum on the background of acute ethanol ulceration.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Anti-Ulcer Agents/pharmacology , Misoprostol/pharmacology , Stomach Ulcer/prevention & control , Animals , Edema/chemically induced , Edema/prevention & control , Female , Lipid Peroxidation/drug effects , Male , Malondialdehyde/blood , Mice , Misoprostol/analogs & derivatives , Rats , Stomach Ulcer/chemically inducedABSTRACT
The results of studies on the biological activity of seven synthetic analogues of prostaglandins are presented. All the analogues under study possess uterotonic, antiulcer and anti-inflammatory activity; all the compounds except S1 induce diarrhea. The synthetic analogues studied decrease transiently and slightly the arterial blood pressure.