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Biochem Soc Trans
; 46(5): 1325-1332, 2018 10 19.
Article
in English
| MEDLINE
| ID: mdl-30287508
ABSTRACT
RAS proteins are small GTPases that regulate signalling networks that control cellular proliferation and survival. They are frequently mutated in cancer and a commonly occurring group of developmental disorders called RASopathies. We discuss recent findings describing how RAS isoforms and different activating mutations differentially contribute to normal and disease-associated biology and the mechanisms that have been proposed to underpin this.