Search | Virtual Health Library

1.

The cellular architecture of the antimicrobial response network in human leprosy granulomas.

Ma, Feiyang; Hughes, Travis K; Teles, Rosane M B; Andrade, Priscila R; de Andrade Silva, Bruno J; Plazyo, Olesya; Tsoi, Lam C; Do, Tran; Wadsworth, Marc H; Oulee, Aislyn; Ochoa, Maria Teresa; Sarno, Euzenir N; Iruela-Arispe, M Luisa; Klechevsky, Eynav; Bryson, Bryan; Shalek, Alex K; Bloom, Barry R; Gudjonsson, Johann E; Pellegrini, Matteo; Modlin, Robert L.

Nat Immunol ; 22(7): 839-850, 2021 07.

Article in English | MEDLINE | ID: mdl-34168371

2.

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy.

Madigan, Cressida A; Cambier, C J; Kelly-Scumpia, Kindra M; Scumpia, Philip O; Cheng, Tan-Yun; Zailaa, Joseph; Bloom, Barry R; Moody, D Branch; Smale, Stephen T; Sagasti, Alvaro; Modlin, Robert L; Ramakrishnan, Lalita.

Cell ; 170(5): 973-985.e10, 2017 Aug 24.

Article in English | MEDLINE | ID: mdl-28841420

3.

Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies.

Hughes, Travis K; Wadsworth, Marc H; Gierahn, Todd M; Do, Tran; Weiss, David; Andrade, Priscila R; Ma, Feiyang; de Andrade Silva, Bruno J; Shao, Shuai; Tsoi, Lam C; Ordovas-Montanes, Jose; Gudjonsson, Johann E; Modlin, Robert L; Love, J Christopher; Shalek, Alex K.

Immunity ; 53(4): 878-894.e7, 2020 10 13.

Article in English | MEDLINE | ID: mdl-33053333

4.

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Meller, Stephan; Di Domizio, Jeremy; Voo, Kui S; Friedrich, Heike C; Chamilos, Georgios; Ganguly, Dipyaman; Conrad, Curdin; Gregorio, Josh; Le Roy, Didier; Roger, Thierry; Ladbury, John E; Homey, Bernhard; Watowich, Stanley; Modlin, Robert L; Kontoyiannis, Dimitrios P; Liu, Yong-Jun; Arold, Stefan T; Gilliet, Michel.

Nat Immunol ; 16(9): 970-9, 2015 Sep.

Article in English | MEDLINE | ID: mdl-26168081

5.

Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab.

Ma, Feiyang; Gharaee-Kermani, Mehrnaz; Tsoi, Lam C; Plazyo, Olesya; Chaskar, Prasad; Harms, Paul; Patrick, Matthew T; Xing, Xianying; Hile, Grace; Piketty, Christophe; Lazzari, Anne; Van Delm, Wouter; Maverakis, Emanual; Nakamura, Mio; Modlin, Robert L; Kahlenberg, J Michelle; Billi, Allison C; Julia, Valerie; Krishnaswamy, Jayendra Kumar; Gudjonsson, Johann E.

J Allergy Clin Immunol ; 153(1): 146-160, 2024 01.

Article in English | MEDLINE | ID: mdl-37506977

6.

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.

Parvatiyar, Kislay; Zhang, Zhiqiang; Teles, Rosane M; Ouyang, Songying; Jiang, Yan; Iyer, Shankar S; Zaver, Shivam A; Schenk, Mirjam; Zeng, Shang; Zhong, Wenwan; Liu, Zhi-Jie; Modlin, Robert L; Liu, Yong-jun; Cheng, Genhong.

Nat Immunol ; 13(12): 1155-61, 2012 Dec.

Article in English | MEDLINE | ID: mdl-23142775

7.

IL-1ß Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells.

Weiss, David I; Ma, Feiyang; Merleev, Alexander A; Maverakis, Emanual; Gilliet, Michel; Balin, Samuel J; Bryson, Bryan D; Ochoa, Maria Teresa; Pellegrini, Matteo; Bloom, Barry R; Modlin, Robert L.

J Immunol ; 203(4): 911-921, 2019 08 15.

Article in English | MEDLINE | ID: mdl-31235553

8.

IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth.

Yang, Rui; Yang, Enzhuo; Shen, Ling; Modlin, Robert L; Shen, Hongbo; Chen, Zheng W.

J Immunol ; 200(7): 2405-2417, 2018 04 01.

Article in English | MEDLINE | ID: mdl-29453279

9.

Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network.

Keegan, Caroline; Krutzik, Stephan; Schenk, Mirjam; Scumpia, Philip O; Lu, Jing; Pang, Yan Ling Joy; Russell, Brandon S; Lim, Kok Seong; Shell, Scarlet; Prestwich, Erin; Su, Dan; Elashoff, David; Hershberg, Robert M; Bloom, Barry R; Belisle, John T; Fortune, Sarah; Dedon, Peter C; Pellegrini, Matteo; Modlin, Robert L.

J Immunol ; 200(9): 3244-3258, 2018 05 01.

Article in English | MEDLINE | ID: mdl-29610140

10.

Plasticity of antimicrobial and phagocytic programs in human macrophages.

Montoya, Dennis; Mehta, Manali; Ferguson, Benjamin G; Teles, Rosane M B; Krutzik, Stephan R; Cruz, Daniel; Pellegrini, Matteo; Modlin, Robert L.

Immunology ; 156(2): 164-173, 2019 02.

Article in English | MEDLINE | ID: mdl-30357820

11.

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.

Scumpia, Philip O; Botten, Giovanni A; Norman, Joshua S; Kelly-Scumpia, Kindra M; Spreafico, Roberto; Ruccia, Amber R; Purbey, Prabhat K; Thomas, Brandon J; Modlin, Robert L; Smale, Stephen T.

PLoS Pathog ; 13(7): e1006496, 2017 Jul.

Article in English | MEDLINE | ID: mdl-28704551

12.

Jagged1 Instructs Macrophage Differentiation in Leprosy.

Kibbie, Jon; Teles, Rosane M B; Wang, Zhiming; Hong, Patrick; Montoya, Dennis; Krutzik, Stephan; Lee, Seung; Kwon, Ohyun; Modlin, Robert L; Cruz, Daniel.

PLoS Pathog ; 12(8): e1005808, 2016 08.

Article in English | MEDLINE | ID: mdl-27532668

13.

S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages.

Realegeno, Susan; Kelly-Scumpia, Kindra M; Dang, Angeline Tilly; Lu, Jing; Teles, Rosane; Liu, Philip T; Schenk, Mirjam; Lee, Ernest Y; Schmidt, Nathan W; Wong, Gerard C L; Sarno, Euzenir N; Rea, Thomas H; Ochoa, Maria T; Pellegrini, Matteo; Modlin, Robert L.

PLoS Pathog ; 12(6): e1005705, 2016 06.

Article in English | MEDLINE | ID: mdl-27355424

14.

Complete genomic sequences of Propionibacterium freudenreichii phages from Swiss cheese reveal greater diversity than Cutibacterium (formerly Propionibacterium) acnes phages.

Cheng, Lucy; Marinelli, Laura J; Grosset, Noël; Fitz-Gibbon, Sorel T; Bowman, Charles A; Dang, Brian Q; Russell, Daniel A; Jacobs-Sera, Deborah; Shi, Baochen; Pellegrini, Matteo; Miller, Jeff F; Gautier, Michel; Hatfull, Graham F; Modlin, Robert L.

BMC Microbiol ; 18(1): 19, 2018 03 01.

Article in English | MEDLINE | ID: mdl-29490612

15.

TLR2 looks at lipoproteins.

Schenk, Mirjam; Belisle, John T; Modlin, Robert L.

Immunity ; 31(6): 847-9, 2009 Dec 18.

Article in English | MEDLINE | ID: mdl-20064441

16.

Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette-Guérin in Glucocorticoid-Treated Human Macrophages.

Steiger, Julia; Stephan, Alexander; Inkeles, Megan S; Realegeno, Susan; Bruns, Heiko; Kröll, Philipp; de Castro Kroner, Juliana; Sommer, Andrea; Batinica, Marina; Pitzler, Lena; Kalscheuer, Rainer; Hartmann, Pia; Plum, Georg; Stenger, Steffen; Pellegrini, Matteo; Brachvogel, Bent; Modlin, Robert L; Fabri, Mario.

J Immunol ; 197(1): 222-32, 2016 07 01.

Article in English | MEDLINE | ID: mdl-27233968

17.

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity.

Demaria, Olivier; De Gassart, Aude; Coso, Sanja; Gestermann, Nicolas; Di Domizio, Jeremy; Flatz, Lukas; Gaide, Olivier; Michielin, Olivier; Hwu, Patrick; Petrova, Tatiana V; Martinon, Fabio; Modlin, Robert L; Speiser, Daniel E; Gilliet, Michel.

Proc Natl Acad Sci U S A ; 112(50): 15408-13, 2015 Dec 15.

Article in English | MEDLINE | ID: mdl-26607445

18.

SaVanT: a web-based tool for the sample-level visualization of molecular signatures in gene expression profiles.

Lopez, David; Montoya, Dennis; Ambrose, Michael; Lam, Larry; Briscoe, Leah; Adams, Claire; Modlin, Robert L; Pellegrini, Matteo.

BMC Genomics ; 18(1): 824, 2017 Oct 25.

Article in English | MEDLINE | ID: mdl-29070035

19.

Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis.

Busch, Martin; Herzmann, Christian; Kallert, Stephanie; Zimmermann, Andreas; Höfer, Christoph; Mayer, Daniel; Zenk, Sebastian F; Muche, Rainer; Lange, Christoph; Bloom, Barry R; Modlin, Robert L; Stenger, Steffen.

Am J Respir Crit Care Med ; 194(3): 345-55, 2016 08 01.

Article in English | MEDLINE | ID: mdl-26882070

20.

Human NOD2 Recognizes Structurally Unique Muramyl Dipeptides from Mycobacterium leprae.

Schenk, Mirjam; Mahapatra, Sebabrata; Le, Phuonganh; Kim, Hee Jin; Choi, Aaron W; Brennan, Patrick J; Belisle, John T; Modlin, Robert L.

Infect Immun ; 84(9): 2429-38, 2016 09.

Article in English | MEDLINE | ID: mdl-27297389

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