Search | Virtual Health Library

1.

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.

Moroishi, Toshiro; Hayashi, Tomoko; Pan, Wei-Wei; Fujita, Yu; Holt, Matthew V; Qin, Jun; Carson, Dennis A; Guan, Kun-Liang.

Cell ; 167(6): 1525-1539.e17, 2016 Dec 01.

Article in English | MEDLINE | ID: mdl-27912060

2.

Alternative Wnt Signaling Activates YAP/TAZ.

Park, Hyun Woo; Kim, Young Chul; Yu, Bo; Moroishi, Toshiro; Mo, Jung-Soon; Plouffe, Steven W; Meng, Zhipeng; Lin, Kimberly C; Yu, Fa-Xing; Alexander, Caroline M; Wang, Cun-Yu; Guan, Kun-Liang.

Cell ; 162(4): 780-94, 2015 Aug 13.

Article in English | MEDLINE | ID: mdl-26276632

3.

Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.

Horiguchi, Haruki; Kadomatsu, Tsuyoshi; Kurahashi, Ryoma; Hara, Chiaki; Miyata, Keishi; Baba, Masaya; Osumi, Hironobu; Terada, Kazutoyo; Araki, Kimi; Takai, Toshiyuki; Kamba, Tomomi; Linehan, W Marston; Moroishi, Toshiro; Oike, Yuichi.

Genes Dev ; 33(23-24): 1641-1656, 2019 12 01.

Article in English | MEDLINE | ID: mdl-31727773

4.

Improvement of the Nuclease Resistance and Immunostimulatory Activity of CpG Oligodeoxynucleotides by Conjugation to Sugar-Immobilized Gold Nanoparticles.

Murata, Koki; Harayama, Kai; Shimoda, Mayuko; Niimura, Mayumi; Wakao, Masahiro; Suda, Yasuo; Moroishi, Toshiro; Shinchi, Hiroyuki.

Bioconjug Chem ; 2024 May 08.

Article in English | MEDLINE | ID: mdl-38718344

5.

RAP2 mediates mechanoresponses of the Hippo pathway.

Meng, Zhipeng; Qiu, Yunjiang; Lin, Kimberly C; Kumar, Aditya; Placone, Jesse K; Fang, Cao; Wang, Kuei-Chun; Lu, Shicong; Pan, Margaret; Hong, Audrey W; Moroishi, Toshiro; Luo, Min; Plouffe, Steven W; Diao, Yarui; Ye, Zhen; Park, Hyun Woo; Wang, Xiaoqiong; Yu, Fa-Xing; Chien, Shu; Wang, Cun-Yu; Ren, Bing; Engler, Adam J; Guan, Kun-Liang.

Nature ; 560(7720): 655-660, 2018 08.

Article in English | MEDLINE | ID: mdl-30135582

6.

Mechanisms of Hippo pathway regulation.

Meng, Zhipeng; Moroishi, Toshiro; Guan, Kun-Liang.

Genes Dev ; 30(1): 1-17, 2016 Jan 01.

Article in English | MEDLINE | ID: mdl-26728553

7.

Distinct functions between ferrous and ferric iron in lung cancer cell growth.

Hinokuma, Hironori; Kanamori, Yohei; Ikeda, Koei; Hao, Li; Maruno, Masataka; Yamane, Taishi; Maeda, Ayato; Nita, Akihiro; Shimoda, Mayuko; Niimura, Mayumi; Takeshima, Yuki; Li, Shuran; Suzuki, Makoto; Moroishi, Toshiro.

Cancer Sci ; 114(11): 4355-4364, 2023 Nov.

Article in English | MEDLINE | ID: mdl-37688294

8.

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.

Moroishi, Toshiro; Park, Hyun Woo; Qin, Baodong; Chen, Qian; Meng, Zhipeng; Plouffe, Steven W; Taniguchi, Koji; Yu, Fa-Xing; Karin, Michael; Pan, Duojia; Guan, Kun-Liang.

Genes Dev ; 29(12): 1271-84, 2015 Jun 15.

Article in English | MEDLINE | ID: mdl-26109050

9.

Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer.

Bu, Luke; Yonemura, Atsuko; Yasuda-Yoshihara, Noriko; Uchihara, Tomoyuki; Ismagulov, Galym; Takasugi, Sanae; Yasuda, Tadahito; Okamoto, Yuya; Kitamura, Fumimasa; Akiyama, Takahiko; Arima, Kota; Itoyama, Rumi; Zhang, Jun; Fu, Lingfeng; Hu, Xichen; Wei, Feng; Arima, Yuichiro; Moroishi, Toshiro; Nishiyama, Koichi; Sheng, Guojun; Mukunoki, Toshifumi; Otani, Jun; Baba, Hideo; Ishimoto, Takatsugu.

Cancer Sci ; 113(10): 3579-3592, 2022 Oct.

Article in English | MEDLINE | ID: mdl-35848891

10.

BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling.

Verma, Sachin; Yeddula, Narayana; Soda, Yasushi; Zhu, Quan; Pao, Gerald; Moresco, James; Diedrich, Jolene K; Hong, Audrey; Plouffe, Steve; Moroishi, Toshiro; Guan, Kun-Liang; Verma, Inder M.

Proc Natl Acad Sci U S A ; 116(15): 7363-7370, 2019 04 09.

Article in English | MEDLINE | ID: mdl-30918126

11.

The Emerging Link between the Hippo Pathway and Non-coding RNA.

Shimoda, Mayuko; Moroishi, Toshiro.

Biol Pharm Bull ; 43(1): 1-10, 2020.

Article in English | MEDLINE | ID: mdl-31902912

12.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Taniguchi, Koji; Moroishi, Toshiro; de Jong, Petrus R; Krawczyk, Michal; Grebbin, Britta Moyo; Luo, Huiyan; Xu, Rui-Hua; Golob-Schwarzl, Nicole; Schweiger, Caroline; Wang, Kepeng; Di Caro, Giuseppe; Feng, Ying; Fearon, Eric R; Raz, Eyal; Kenner, Lukas; Farin, Henner F; Guan, Kun-Liang; Haybaeck, Johannes; Datz, Christian; Zhang, Kang; Karin, Michael.

Proc Natl Acad Sci U S A ; 114(7): 1643-1648, 2017 02 14.

Article in English | MEDLINE | ID: mdl-28130546

13.

Gold Nanoparticles Coimmobilized with Small Molecule Toll-Like Receptor 7 Ligand and α-Mannose as Adjuvants.

Shinchi, Hiroyuki; Yamaguchi, Toru; Moroishi, Toshiro; Yuki, Masaharu; Wakao, Masahiro; Cottam, Howard B; Hayashi, Tomoko; Carson, Dennis A; Suda, Yasuo.

Bioconjug Chem ; 30(11): 2811-2821, 2019 11 20.

Article in English | MEDLINE | ID: mdl-31560198

14.

ANXious for YAP.

Moroishi, Toshiro.

Nat Chem Biol ; 17(7): 750-751, 2021 07.

Article in English | MEDLINE | ID: mdl-33723430

15.

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.

Moroishi, Toshiro; Yamauchi, Takayoshi; Nishiyama, Masaaki; Nakayama, Keiichi I.

J Biol Chem ; 289(23): 16430-41, 2014 Jun 06.

Article in English | MEDLINE | ID: mdl-24778179

16.

Hippo pathway in cell-cell communication: emerging roles in development and regeneration.

Nita, Akihiro; Moroishi, Toshiro.

Inflamm Regen ; 44(1): 18, 2024 Apr 02.

Article in English | MEDLINE | ID: mdl-38566194

17.

Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy.

Horiguchi, Haruki; Kadomatsu, Tsuyoshi; Yamashita, Tomoya; Yumoto, Shinsei; Horino, Taichi; Sato, Michio; Terada, Kazutoyo; Miyata, Keishi; Ichigozaki, Yuki; Kimura, Toshihiro; Fukushima, Satoshi; Moroishi, Toshiro; Oike, Yuichi.

Cancer Gene Ther ; 2024 Mar 11.

Article in English | MEDLINE | ID: mdl-38467764

18.

Comprehensive identification of substrates for F-box proteins by differential proteomics analysis.

Yumimoto, Kanae; Matsumoto, Masaki; Oyamada, Koji; Moroishi, Toshiro; Nakayama, Keiichi I.

J Proteome Res ; 11(6): 3175-85, 2012 Jun 01.

Article in English | MEDLINE | ID: mdl-22524983

19.

Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.

Yu, Le; Zhou, Dan; Zhang, Guiming; Ren, Zhonglu; Luo, Xin; Liu, Peng; Plouffe, Steven W; Meng, Zhipeng; Moroishi, Toshiro; Li, Yilei; Zhang, Yiyue; Brown, Joan Heller; Liu, Shuwen; Guan, Kun-Liang.

Mol Oncol ; 16(3): 607-629, 2022 02.

Article in English | MEDLINE | ID: mdl-34706158

20.

Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects.

Shinchi, Hiroyuki; Komaki, Fumikazu; Yuki, Masaharu; Ohara, Haruka; Hayakawa, Naohiro; Wakao, Masahiro; Cottam, Howard B; Hayashi, Tomoko; Carson, Dennis A; Moroishi, Toshiro; Suda, Yasuo.

ACS Chem Biol ; 17(4): 957-968, 2022 04 15.

Article in English | MEDLINE | ID: mdl-35353497

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