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Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase.
Kikuchi, Takashi; Motoyashiki, Naoki; Yamada, Takeshi; Shibatani, Kanae; Ninomiya, Kiyofumi; Morikawa, Toshio; Tanaka, Reiko.
Int J Mol Sci ; 18(11)2017 Nov 21.
Article in English | MEDLINE | ID: mdl-29160820

ABSTRACT

Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3ß,7ß-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3ß,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.


Subject(s)
Agaricales/chemistry , Aromatase Inhibitors/pharmacology , Biological Products/pharmacology , Ergosterol/analogs & derivatives , Aromatase/metabolism , Aromatase Inhibitors/chemistry , Aromatase Inhibitors/isolation & purification , Biological Products/chemistry , Biological Products/isolation & purification , Enzyme Activation/drug effects , Ergosterol/chemistry , Ergosterol/isolation & purification , Ergosterol/pharmacology , Humans , Magnetic Resonance Spectroscopy , Models, Molecular , Molecular Conformation , Molecular Structure
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