Search | Virtual Health Library

1.

Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington's disease.

Vidas-Guscic, Nicholas; van Rijswijk, Joëlle; Van Audekerke, Johan; Jeurissen, Ben; Nnah, Israel; Tang, Haiying; Muñoz-Sanjuan, Ignacio; Pustina, Dorian; Cachope, Roger; Van der Linden, Annemie; Bertoglio, Daniele; Verhoye, Marleen.

Neurobiol Dis ; 193: 106438, 2024 Apr.

Article in English | MEDLINE | ID: mdl-38365045

2.

Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington's disease.

Vasilkovska, Tamara; Salajeghe, Somaie; Vanreusel, Verdi; Van Audekerke, Johan; Verschuuren, Marlies; Hirschler, Lydiane; Warnking, Jan; Pintelon, Isabel; Pustina, Dorian; Cachope, Roger; Mrzljak, Ladislav; Muñoz-Sanjuan, Ignacio; Barbier, Emmanuel L; De Vos, Winnok H; Van der Linden, Annemie; Verhoye, Marleen.

J Biomed Sci ; 31(1): 37, 2024 Apr 16.

Article in English | MEDLINE | ID: mdl-38627751

3.

Resting-state fMRI reveals longitudinal alterations in brain network connectivity in the zQ175DN mouse model of Huntington's disease.

Vasilkovska, Tamara; Adhikari, Mohit H; Van Audekerke, Johan; Salajeghe, Somaie; Pustina, Dorian; Cachope, Roger; Tang, Haiying; Liu, Longbin; Muñoz-Sanjuán, Ignacio; Van der Linden, Annemie; Verhoye, Marleen.

Neurobiol Dis ; 181: 106095, 2023 06 01.

Article in English | MEDLINE | ID: mdl-36963694

4.

Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington's disease.

Bertoglio, Daniele; Verhaeghe, Jeroen; Miranda, Alan; Wyffels, Leonie; Stroobants, Sigrid; Mrzljak, Ladislav; Khetarpal, Vinod; Skinbjerg, Mette; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Staelens, Steven.

Eur J Nucl Med Mol Imaging ; 49(4): 1166-1175, 2022 03.

Article in English | MEDLINE | ID: mdl-34651228

5.

Biodistribution and dosimetry in human healthy volunteers of the PET radioligands [¹¹C]CHDI-00485180-R and [¹¹C]CHDI-00485626, designed for quantification of cerebral aggregated mutant huntingtin.

Delva, Aline; Koole, Michel; Serdons, Kim; Bormans, Guy; Liu, Longbin; Bard, Jonathan; Khetarpal, Vinod; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Wood, Andrew; Skinbjerg, Mette; Wang, Yuchuan; Vandenberghe, Wim; Van Laere, Koen.

Eur J Nucl Med Mol Imaging ; 50(1): 48-60, 2022 Dec.

Article in English | MEDLINE | ID: mdl-36001116

6.

Modelling the Human Blood-Brain Barrier in Huntington Disease.

Vignone, Domenico; Gonzalez Paz, Odalys; Fini, Ivan; Cellucci, Antonella; Auciello, Giulio; Battista, Maria Rosaria; Gloaguen, Isabelle; Fortuni, Silvia; Cariulo, Cristina; Khetarpal, Vinod; Dominguez, Celia; Muñoz-Sanjuán, Ignacio; Di Marco, Annalise.

Int J Mol Sci ; 23(14)2022 Jul 15.

Article in English | MEDLINE | ID: mdl-35887162

7.

Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4⁺ T Cell Counts and Body Weight.

Swainson, Louise A; Ahn, Haelee; Pajanirassa, Priya; Khetarpal, Vinod; Deleage, Claire; Estes, Jacob D; Hunt, Peter W; Munoz-Sanjuan, Ignacio; McCune, Joseph M.

J Immunol ; 203(4): 899-910, 2019 08 15.

Article in English | MEDLINE | ID: mdl-31285277

8.

Pharmacokinetics and metabolic disposition of a potent and selective kynurenine monooxygenase inhibitor, CHDI-340246, in laboratory animals.

Khetarpal, Vinod; Herbst, Todd; Shefchek, Diana; Ash, Steven; Fitzsimmons, Michael; Gohdes, Mark; Munoz-Sanjuan, Ignacio; Dominguez, Celia.

Xenobiotica ; 51(10): 1155-1180, 2021 Oct.

Article in English | MEDLINE | ID: mdl-34496722

9.

Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin.

Ko, Jan; Isas, J Mario; Sabbaugh, Adam; Yoo, Jung Hyun; Pandey, Nitin K; Chongtham, Anjalika; Ladinsky, Mark; Wu, Wei-Li; Rohweder, Heike; Weiss, Andreas; Macdonald, Douglas; Munoz-Sanjuan, Ignacio; Langen, Ralf; Patterson, Paul H; Khoshnan, Ali.

Hum Mol Genet ; 27(13): 2330-2343, 2018 07 01.

Article in English | MEDLINE | ID: mdl-29912367

10.

Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.

Colarusso, Stefania; De Simone, Daniele; Frattarelli, Tommaso; Andreini, Matteo; Cerretani, Mauro; Missineo, Antonino; Moretti, Daniele; Tambone, Sara; Kempf, Georg; Augustin, Martin; Steinbacher, Stefan; Munoz-Sanjuan, Ignacio; Park, Larry; Summa, Vincenzo; Tomei, Licia; Bresciani, Alberto; Dominguez, Celia; Toledo-Sherman, Leticia; Bianchi, Elisabetta.

Bioorg Med Chem ; 28(21): 115738, 2020 11 01.

Article in English | MEDLINE | ID: mdl-33065433

11.

Application of an in Vitro Blood-Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington's Disease.

Di Marco, Annalise; Gonzalez Paz, Odalys; Fini, Ivan; Vignone, Domenico; Cellucci, Antonella; Battista, Maria Rosaria; Auciello, Giulio; Orsatti, Laura; Zini, Matteo; Monteagudo, Edith; Khetarpal, Vinod; Rose, Mark; Dominguez, Celia; Herbst, Todd; Toledo-Sherman, Leticia; Summa, Vincenzo; Muñoz-Sanjuán, Ignacio.

Mol Pharm ; 16(5): 2069-2082, 2019 05 06.

Article in English | MEDLINE | ID: mdl-30916978

12.

Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.

Luckhurst, Christopher A; Aziz, Omar; Beaumont, Vahri; Bürli, Roland W; Breccia, Perla; Maillard, Michel C; Haughan, Alan F; Lamers, Marieke; Leonard, Phil; Matthews, Kim L; Raphy, Gilles; Stott, Andrew J; Munoz-Sanjuan, Ignacio; Thomas, Beth; Wall, Michael; Wishart, Grant; Yates, Dawn; Dominguez, Celia.

Bioorg Med Chem Lett ; 29(1): 83-88, 2019 01 01.

Article in English | MEDLINE | ID: mdl-30463802

13.

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).

Bresciani, Alberto; Missineo, Antonino; Gallo, Mariana; Cerretani, Mauro; Fezzardi, Paola; Tomei, Licia; Cicero, Daniel Oscar; Altamura, Sergio; Santoprete, Alessia; Ingenito, Raffaele; Bianchi, Elisabetta; Pacifici, Robert; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Harper, Steven; Toledo-Sherman, Leticia; Park, Larry C.

Arch Biochem Biophys ; 631: 31-41, 2017 10 01.

Article in English | MEDLINE | ID: mdl-28801166

14.

Support communities involved in disease studies.

Muñoz-Sanjuan, Ignacio.

Nature ; 531(7593): 141, 2016 Mar 10.

Article in English | MEDLINE | ID: mdl-26961621

15.

Mind the gap: models in multiple species needed for therapeutic development in Huntington's disease.

Howland, David S; Munoz-Sanjuan, Ignacio.

Mov Disord ; 29(11): 1397-403, 2014 Sep 15.

Article in English | MEDLINE | ID: mdl-25155258

16.

Subtyping monogenic disorders: Huntington disease.

Sturchio, Andrea; Duker, Andrew P; Muñoz-Sanjuan, Ignacio; Espay, Alberto J.

Handb Clin Neurol ; 193: 171-184, 2023.

Article in English | MEDLINE | ID: mdl-36803810

17.

In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates Using ¹¹C-CHDI-180R PET in a Nonhuman Primate Model of Huntington Disease.

Bertoglio, Daniele; Weiss, Alison R; Liguore, William; Martin, Lauren Drew; Hobbs, Theodore; Templon, John; Srinivasan, Sathya; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Khetarpal, Vinod; Verhaeghe, Jeroen; Staelens, Steven; Link, Jeanne; Liu, Longbin; Bard, Jonathan A; McBride, Jodi L.

J Nucl Med ; 64(10): 1581-1587, 2023 10.

Article in English | MEDLINE | ID: mdl-37591545

18.

Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington's disease.

Adhikari, Mohit H; Vasilkovska, Tamara; Cachope, Roger; Tang, Haiying; Liu, Longbin; Keliris, Georgios A; Munoz-Sanjuan, Ignacio; Pustina, Dorian; Van der Linden, Annemie; Verhoye, Marleen.

Sci Rep ; 13(1): 10194, 2023 06 23.

Article in English | MEDLINE | ID: mdl-37353500

19.

Design and Evaluation of [¹⁸F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.

Liu, Longbin; Johnson, Peter D; Prime, Michael E; Khetarpal, Vinod; Brown, Christopher J; Anzillotti, Luca; Bertoglio, Daniele; Chen, Xuemei; Coe, Samuel; Davis, Randall; Dickie, Anthony P; Esposito, Simone; Gadouleau, Elise; Giles, Paul R; Greenaway, Catherine; Haber, James; Halldin, Christer; Haller, Scott; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Heßmann, Manuela; Hsai, Ming Min; Khani, Yaser; Kotey, Adrian; Lembo, Angelo; Mangette, John E; Marriner, Gwendolyn A; Marston, Richard W; Mills, Matthew R; Monteagudo, Edith; Forsberg-Morén, Anton; Nag, Sangram; Orsatti, Laura; Sandiego, Christine; Schaertl, Sabine; Sproston, Joanne; Staelens, Steven; Tookey, Jack; Turner, Penelope A; Vecchi, Andrea; Veneziano, Maria; Muñoz-Sanjuan, Ignacio; Bard, Jonathan; Dominguez, Celia.

J Med Chem ; 66(1): 641-656, 2023 01 12.

Article in English | MEDLINE | ID: mdl-36548390

20.

Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease.

Liu, Longbin; Malagu, Karine; Haughan, Alan F; Khetarpal, Vinod; Stott, Andrew J; Esmieu, William; Vater, Huw D; Webster, Stephen J; Van de Poël, Amanda J; Clissold, Cole; Cosgrove, Brett; Sutton, Benjamin; Spencer, Jonathan A; Breccia, Perla; Gancia, Emanuela; Bonomo, Silvia; Ladduwahetty, Tammy; Lazari, Ovadia; Patel, Hiral; Atton, Helen C; Clifton, Steve; Mota, Daniel M; Magnani, Dario; O'Neill, Amy; Stebbeds, Marta; Macabuag, Natsuko; Todd, Daniel; Herva, Maria E; Mitchell, Philip; Visser, Mijke; Compte Sancerni, Sara; Grand Moursel, Laure; da Silva, Marta; Kritikou, Eva; Heikkinen, Taneli T; Bolkvadze, Tamuna; Fodale, Valentina; Spadafora, Debora; Daldin, Manuel; Bresciani, Alberto; Mangette, John E; Doherty, Elizabeth M; Lee, Matthew R; Herbst, Todd; Monteagudo, Edith; Macdonald, Douglas; Plotnikov, Nikolay V; Chambers, Mark; McAllister, George; Munoz-Sanjuan, Ignacio.

J Med Chem ; 66(18): 13205-13246, 2023 Sep 28.

Article in English | MEDLINE | ID: mdl-37712656

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