Hemodynamic effects of intramyometrial epinephrine injection for blood loss reduction in laparoscopic myomectomy.

PURPOSE: To evaluate changes in hemodynamic effects of intramyometrial epinephrine injection for blood loss reduction in laparoscopic myomectomy. METHODS: A total of 185 women with symptomatic uterine fibroids who underwent laparoscopic myomectomy were enrolled in this study. Eighty-six women (study collective) received an intramyometrial injection of epinephrine and were compared to ninety-nine women (control collective) who underwent laparoscopic myomectomy without an intramyometrial epinephrine injection. Demographic parameters, change of hemodynamic parameters during surgery as well as hemoglobin drop after surgery were analyzed. RESULTS: In the study collective maximum systolic blood pressure (p < 0.001), maximum increase of the systolic blood pressure within 5 min (p = 0.003), duration of hypertension (p = 0.012), maximal (p < 0.001) and mean heart rate (p = 0.005), maximal increase of heart rate within 5 min (p = 0.003) and difference of mean to maximal heart rate (p < 0.001) were higher compared to the control collective. There was no difference in pre- and postoperative hemoglobin levels in both collectives and no intraoperative clinically relevant complication occurred due to intramyometrial epinephrine injection. CONCLUSION: The intramyometrial application of epinephrine seems to be safe but leads to significant alterations of hemodynamic parameters without a significant change in postoperative hemoglobin levels.

Dilatation or no dilatation of the cervix during cesarean section (Dondi Trial): a randomized controlled trial.

PURPOSE: To assess the effects of mechanical dilatation of the cervix during cesarean section on postoperative morbidity. METHODS: A total of 447 women with elective cesarean section were included in the Dondi trial (Dilatation or no dilatation of the cervix during cesarean section). The primary outcome measure of this randomized controlled trial was postpartum hemorrhage (PPH) within 6 weeks. Infectious morbidity (puerperal fever, endometritis, wound infection, and urinary tract infection), blood loss (need for blood transfusion or change in hemoglobin levels), and operating time were also evaluated. RESULTS: The rate of PPH within 6 weeks was not different between the two groups [dilatation group: 5 (2.4 %), no dilatation group: 3 (1.2 %), p = 0.479]. Infectious morbidity, blood loss, and operating time were not diverse as well. The only significant difference between the two groups was the rate of retained products of conception with fewer cases after cervical dilatation (0 versus 6.2 %, p < 0.001). CONCLUSIONS: Dilatation of the cervix during cesarean section compared with no dilatation of the cervix did not influence the risk of postpartum hemorrhage. However, there were fewer cases with retained products of conception after dilatation.

Emergency caesarean section: risk factors for adverse neonatal outcome.

OBJECTIVE: Primary aim of the study was to identify risk factors for an adverse neonatal outcome in emergency caesarean deliveries (ECD). Secondary, the influence of the decision-to-delivery interval (DDI) on neonatal outcome was evaluated. METHODS: Study period of this retrospective investigation was 2001-2011, in which 336 ECD were evaluated. Main outcome measures were risk factors associated with an adverse neonatal outcome (umbilical cord arterial pH < 7.05, umbilical cord arterial base excess (BE) < -12, Apgar score at 5 min <5 and the combination of umbilical cord arterial pH < 7.0, and umbilical cord arterial BE < -12). Secondary, the influence of the DDI on neonatal outcome was assessed. These parameters were tested in univariate and multivariate analyses. RESULTS: Prematurity (<37 + 0 weeks of gestation) and silent cardiotocography (CTG) were identified as the major risk factors for an adverse neonatal outcome. Statistical analyses of the influence of the DDI on umbilical cord arterial pH and BE as well as the Apgar score at 5 min revealed no significant results. CONCLUSION: Our results emphasize the necessity of attendance in a level-3 department of obstetrics in case of conceivable compromised neonatal conditions. Prematurity and silent CTG were identified as the major risk factors for an adverse neonatal outcome. As long as the DDI is under 20 min, it did not have an impact on neonatal outcome.

Cervical dilatation and curettage in elective caesarean section. A retrospective analysis.

BACKGROUND/AIM: To analyze the influence of intraoperative cervical dilatation and curettage during elective Caesarean section (CS) on maternal morbidity. PATIENTS AND METHODS: A total of 1,003 elective CS were retrospectively evaluated. Primary outcome measure was the influence of cervical dilatation and curettage on postpartum haemorrhage (PPH). Several subgroup analyses were performed and a multiple logistic regression model was used in order to identify risk factors affecting PPH. RESULTS: Multiple pregnancy (p=0.0025) and body mass index (p=0.0251) were identified as risk factors for PPH. Curettage, cervical dilatation, prior CS, age, and duration of pregnancy were statistically not significant at a level of α=0.10. There was a significantly higher proportion of women suffering from uterine sub-involution when the cervix was dilated (p=0.0482). The operating time was significantly longer when curettage and/or dilatation were performed (p<0.0001). CONCLUSION: Routine cervical dilatation and/or curettage in elective Caesarean section are not beneficial. Accomplishment of either or both of these measures led to a prolonged operating time, without improving the postoperative outcome.