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1.

A Compendium of Mutational Signatures of Environmental Agents.

Kucab, Jill E; Zou, Xueqing; Morganella, Sandro; Joel, Madeleine; Nanda, A Scott; Nagy, Eszter; Gomez, Celine; Degasperi, Andrea; Harris, Rebecca; Jackson, Stephen P; Arlt, Volker M; Phillips, David H; Nik-Zainal, Serena.

Cell ; 177(4): 821-836.e16, 2019 05 02.

Article in English | MEDLINE | ID: mdl-30982602

2.

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

Petljak, Mia; Alexandrov, Ludmil B; Brammeld, Jonathan S; Price, Stacey; Wedge, David C; Grossmann, Sebastian; Dawson, Kevin J; Ju, Young Seok; Iorio, Francesco; Tubio, Jose M C; Koh, Ching Chiek; Georgakopoulos-Soares, Ilias; Rodríguez-Martín, Bernardo; Otlu, Burçak; O'Meara, Sarah; Butler, Adam P; Menzies, Andrew; Bhosle, Shriram G; Raine, Keiran; Jones, David R; Teague, Jon W; Beal, Kathryn; Latimer, Calli; O'Neill, Laura; Zamora, Jorge; Anderson, Elizabeth; Patel, Nikita; Maddison, Mark; Ng, Bee Ling; Graham, Jennifer; Garnett, Mathew J; McDermott, Ultan; Nik-Zainal, Serena; Campbell, Peter J; Stratton, Michael R.

Cell ; 176(6): 1282-1294.e20, 2019 03 07.

Article in English | MEDLINE | ID: mdl-30849372

3.

The life history of 21 breast cancers.

Nik-Zainal, Serena; Van Loo, Peter; Wedge, David C; Alexandrov, Ludmil B; Greenman, Christopher D; Lau, King Wai; Raine, Keiran; Jones, David; Marshall, John; Ramakrishna, Manasa; Shlien, Adam; Cooke, Susanna L; Hinton, Jonathan; Menzies, Andrew; Stebbings, Lucy A; Leroy, Catherine; Jia, Mingming; Rance, Richard; Mudie, Laura J; Gamble, Stephen J; Stephens, Philip J; McLaren, Stuart; Tarpey, Patrick S; Papaemmanuil, Elli; Davies, Helen R; Varela, Ignacio; McBride, David J; Bignell, Graham R; Leung, Kenric; Butler, Adam P; Teague, Jon W; Martin, Sancha; Jönsson, Goran; Mariani, Odette; Boyault, Sandrine; Miron, Penelope; Fatima, Aquila; Langerød, Anita; Aparicio, Samuel A J R; Tutt, Andrew; Sieuwerts, Anieta M; Borg, Åke; Thomas, Gilles; Salomon, Anne Vincent; Richardson, Andrea L; Børresen-Dale, Anne-Lise; Futreal, P Andrew; Stratton, Michael R; Campbell, Peter J.

Cell ; 149(5): 994-1007, 2012 May 25.

Article in English | MEDLINE | ID: mdl-22608083

4.

Mutational processes molding the genomes of 21 breast cancers.

Nik-Zainal, Serena; Alexandrov, Ludmil B; Wedge, David C; Van Loo, Peter; Greenman, Christopher D; Raine, Keiran; Jones, David; Hinton, Jonathan; Marshall, John; Stebbings, Lucy A; Menzies, Andrew; Martin, Sancha; Leung, Kenric; Chen, Lina; Leroy, Catherine; Ramakrishna, Manasa; Rance, Richard; Lau, King Wai; Mudie, Laura J; Varela, Ignacio; McBride, David J; Bignell, Graham R; Cooke, Susanna L; Shlien, Adam; Gamble, John; Whitmore, Ian; Maddison, Mark; Tarpey, Patrick S; Davies, Helen R; Papaemmanuil, Elli; Stephens, Philip J; McLaren, Stuart; Butler, Adam P; Teague, Jon W; Jönsson, Göran; Garber, Judy E; Silver, Daniel; Miron, Penelope; Fatima, Aquila; Boyault, Sandrine; Langerød, Anita; Tutt, Andrew; Martens, John W M; Aparicio, Samuel A J R; Borg, Åke; Salomon, Anne Vincent; Thomas, Gilles; Børresen-Dale, Anne-Lise; Richardson, Andrea L; Neuberger, Michael S.

Cell ; 149(5): 979-93, 2012 May 25.

Article in English | MEDLINE | ID: mdl-22608084

5.

Massive genomic rearrangement acquired in a single catastrophic event during cancer development.

Stephens, Philip J; Greenman, Chris D; Fu, Beiyuan; Yang, Fengtang; Bignell, Graham R; Mudie, Laura J; Pleasance, Erin D; Lau, King Wai; Beare, David; Stebbings, Lucy A; McLaren, Stuart; Lin, Meng-Lay; McBride, David J; Varela, Ignacio; Nik-Zainal, Serena; Leroy, Catherine; Jia, Mingming; Menzies, Andrew; Butler, Adam P; Teague, Jon W; Quail, Michael A; Burton, John; Swerdlow, Harold; Carter, Nigel P; Morsberger, Laura A; Iacobuzio-Donahue, Christine; Follows, George A; Green, Anthony R; Flanagan, Adrienne M; Stratton, Michael R; Futreal, P Andrew; Campbell, Peter J.

Cell ; 144(1): 27-40, 2011 Jan 07.

Article in English | MEDLINE | ID: mdl-21215367

6.

Prevalence and significance of DDX41 gene variants in the general population.

Cheloor Kovilakam, Sruthi; Gu, Muxin; Dunn, William G; Marando, Ludovica; Barcena, Clea; Nik-Zainal, Serena; Mohorianu, Irina; Kar, Siddhartha P; Fabre, Margarete A; Quiros, Pedro M; Vassiliou, George S.

Blood ; 142(14): 1185-1192, 2023 10 05.

Article in English | MEDLINE | ID: mdl-37506341

7.

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nik-Zainal, Serena; Davies, Helen; Staaf, Johan; Ramakrishna, Manasa; Glodzik, Dominik; Zou, Xueqing; Martincorena, Inigo; Alexandrov, Ludmil B; Martin, Sancha; Wedge, David C; Van Loo, Peter; Ju, Young Seok; Smid, Marcel; Brinkman, Arie B; Morganella, Sandro; Aure, Miriam R; Lingjærde, Ole Christian; Langerød, Anita; Ringnér, Markus; Ahn, Sung-Min; Boyault, Sandrine; Brock, Jane E; Broeks, Annegien; Butler, Adam; Desmedt, Christine; Dirix, Luc; Dronov, Serge; Fatima, Aquila; Foekens, John A; Gerstung, Moritz; Hooijer, Gerrit K J; Jang, Se Jin; Jones, David R; Kim, Hyung-Yong; King, Tari A; Krishnamurthy, Savitri; Lee, Hee Jin; Lee, Jeong-Yeon; Li, Yilong; McLaren, Stuart; Menzies, Andrew; Mustonen, Ville; O'Meara, Sarah; Pauporté, Iris; Pivot, Xavier; Purdie, Colin A; Raine, Keiran; Ramakrishnan, Kamna; Rodríguez-González, F Germán; Romieu, Gilles.

Nature ; 566(7742): E1, 2019 02.

Article in English | MEDLINE | ID: mdl-30659290

8.

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Garaycoechea, Juan I; Crossan, Gerry P; Langevin, Frédéric; Mulderrig, Lee; Louzada, Sandra; Yang, Fentang; Guilbaud, Guillaume; Park, Naomi; Roerink, Sophie; Nik-Zainal, Serena; Stratton, Michael R; Patel, Ketan J.

Nature ; 553(7687): 171-177, 2018 01 11.

Article in English | MEDLINE | ID: mdl-29323295

9.

Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness.

Andersen, Lars V B; Larsen, Martin J; Davies, Helen; Degasperi, Andrea; Nielsen, Henriette Roed; Jensen, Louise A; Kroeldrup, Lone; Gerdes, Anne-Marie; Lænkholm, Anne-Vibeke; Kruse, Torben A; Nik-Zainal, Serena; Thomassen, Mads.

Breast Cancer Res ; 25(1): 69, 2023 06 14.

Article in English | MEDLINE | ID: mdl-37316882

10.

Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.

Ju, Young Seok; Martincorena, Inigo; Gerstung, Moritz; Petljak, Mia; Alexandrov, Ludmil B; Rahbari, Raheleh; Wedge, David C; Davies, Helen R; Ramakrishna, Manasa; Fullam, Anthony; Martin, Sancha; Alder, Christopher; Patel, Nikita; Gamble, Steve; O'Meara, Sarah; Giri, Dilip D; Sauer, Torril; Pinder, Sarah E; Purdie, Colin A; Borg, Åke; Stunnenberg, Henk; van de Vijver, Marc; Tan, Benita K T; Caldas, Carlos; Tutt, Andrew; Ueno, Naoto T; van 't Veer, Laura J; Martens, John W M; Sotiriou, Christos; Knappskog, Stian; Span, Paul N; Lakhani, Sunil R; Eyfjörd, Jórunn Erla; Børresen-Dale, Anne-Lise; Richardson, Andrea; Thompson, Alastair M; Viari, Alain; Hurles, Matthew E; Nik-Zainal, Serena; Campbell, Peter J; Stratton, Michael R.

Nature ; 543(7647): 714-718, 2017 03 30.

Article in English | MEDLINE | ID: mdl-28329761

11.

The circular RNome of primary breast cancer.

Smid, Marcel; Wilting, Saskia M; Uhr, Katharina; Rodríguez-González, F Germán; de Weerd, Vanja; Prager-Van der Smissen, Wendy J C; van der Vlugt-Daane, Michelle; van Galen, Anne; Nik-Zainal, Serena; Butler, Adam; Martin, Sancha; Davies, Helen R; Staaf, Johan; van de Vijver, Marc J; Richardson, Andrea L; MacGrogan, Gaëten; Salgado, Roberto; van den Eynden, Gert G G M; Purdie, Colin A; Thompson, Alastair M; Caldas, Carlos; Span, Paul N; Sweep, Fred C G J; Simpson, Peter T; Lakhani, Sunil R; Van Laere, Steven; Desmedt, Christine; Paradiso, Angelo; Eyfjord, Jorunn; Broeks, Annegien; Vincent-Salomon, Anne; Futreal, Andrew P; Knappskog, Stian; King, Tari; Viari, Alain; Børresen-Dale, Anne-Lise; Stunnenberg, Hendrik G; Stratton, Mike; Foekens, John A; Sieuwerts, Anieta M; Martens, John W M.

Genome Res ; 29(3): 356-366, 2019 03.

Article in English | MEDLINE | ID: mdl-30692147

12.

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nik-Zainal, Serena; Davies, Helen; Staaf, Johan; Ramakrishna, Manasa; Glodzik, Dominik; Zou, Xueqing; Martincorena, Inigo; Alexandrov, Ludmil B; Martin, Sancha; Wedge, David C; Van Loo, Peter; Ju, Young Seok; Smid, Marcel; Brinkman, Arie B; Morganella, Sandro; Aure, Miriam R; Lingjærde, Ole Christian; Langerød, Anita; Ringnér, Markus; Ahn, Sung-Min; Boyault, Sandrine; Brock, Jane E; Broeks, Annegien; Butler, Adam; Desmedt, Christine; Dirix, Luc; Dronov, Serge; Fatima, Aquila; Foekens, John A; Gerstung, Moritz; Hooijer, Gerrit K J; Jang, Se Jin; Jones, David R; Kim, Hyung-Yong; King, Tari A; Krishnamurthy, Savitri; Lee, Hee Jin; Lee, Jeong-Yeon; Li, Yilong; McLaren, Stuart; Menzies, Andrew; Mustonen, Ville; O'Meara, Sarah; Pauporté, Iris; Pivot, Xavier; Purdie, Colin A; Raine, Keiran; Ramakrishnan, Kamna; Rodríguez-González, F Germán; Romieu, Gilles.

Nature ; 534(7605): 47-54, 2016 06 02.

Article in English | MEDLINE | ID: mdl-27135926

13.

Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis.

Georgakopoulos-Soares, Ilias; Morganella, Sandro; Jain, Naman; Hemberg, Martin; Nik-Zainal, Serena.

Genome Res ; 28(9): 1264-1271, 2018 09.

Article in English | MEDLINE | ID: mdl-30104284

14.

Mechanisms underlying mutational signatures in human cancers.

Helleday, Thomas; Eshtad, Saeed; Nik-Zainal, Serena.

Nat Rev Genet ; 15(9): 585-98, 2014 Sep.

Article in English | MEDLINE | ID: mdl-24981601

15.

Research culture must be kinder for all, not just royalty.

Nik-Zainal, Serena.

Nature ; 575(7782): 287, 2019 11.

Article in English | MEDLINE | ID: mdl-31719696

16.

Bullying investigations need a code of conduct.

Nik-Zainal, Serena; Barroso, Inês.

Nature ; 565(7740): 429, 2019 01.

Article in English | MEDLINE | ID: mdl-30675047

17.

Genome sequencing of normal cells reveals developmental lineages and mutational processes.

Behjati, Sam; Huch, Meritxell; van Boxtel, Ruben; Karthaus, Wouter; Wedge, David C; Tamuri, Asif U; Martincorena, Inigo; Petljak, Mia; Alexandrov, Ludmil B; Gundem, Gunes; Tarpey, Patrick S; Roerink, Sophie; Blokker, Joyce; Maddison, Mark; Mudie, Laura; Robinson, Ben; Nik-Zainal, Serena; Campbell, Peter; Goldman, Nick; van de Wetering, Marc; Cuppen, Edwin; Clevers, Hans; Stratton, Michael R.

Nature ; 513(7518): 422-425, 2014 Sep 18.

Article in English | MEDLINE | ID: mdl-25043003

18.

Ductal carcinoma in situ: to treat or not to treat, that is the question.

van Seijen, Maartje; Lips, Esther H; Thompson, Alastair M; Nik-Zainal, Serena; Futreal, Andrew; Hwang, E Shelley; Verschuur, Ellen; Lane, Joanna; Jonkers, Jos; Rea, Daniel W; Wesseling, Jelle.

Br J Cancer ; 121(4): 285-292, 2019 08.

Article in English | MEDLINE | ID: mdl-31285590

19.

Signatures of mutational processes in human cancer.

Alexandrov, Ludmil B; Nik-Zainal, Serena; Wedge, David C; Aparicio, Samuel A J R; Behjati, Sam; Biankin, Andrew V; Bignell, Graham R; Bolli, Niccolò; Borg, Ake; Børresen-Dale, Anne-Lise; Boyault, Sandrine; Burkhardt, Birgit; Butler, Adam P; Caldas, Carlos; Davies, Helen R; Desmedt, Christine; Eils, Roland; Eyfjörd, Jórunn Erla; Foekens, John A; Greaves, Mel; Hosoda, Fumie; Hutter, Barbara; Ilicic, Tomislav; Imbeaud, Sandrine; Imielinski, Marcin; Imielinsk, Marcin; Jäger, Natalie; Jones, David T W; Jones, David; Knappskog, Stian; Kool, Marcel; Lakhani, Sunil R; López-Otín, Carlos; Martin, Sancha; Munshi, Nikhil C; Nakamura, Hiromi; Northcott, Paul A; Pajic, Marina; Papaemmanuil, Elli; Paradiso, Angelo; Pearson, John V; Puente, Xose S; Raine, Keiran; Ramakrishna, Manasa; Richardson, Andrea L; Richter, Julia; Rosenstiel, Philip; Schlesner, Matthias; Schumacher, Ton N; Span, Paul N.

Nature ; 500(7463): 415-21, 2013 Aug 22.

Article in English | MEDLINE | ID: mdl-23945592

20.

Short inverted repeats contribute to localized mutability in human somatic cells.

Zou, Xueqing; Morganella, Sandro; Glodzik, Dominik; Davies, Helen; Li, Yilin; Stratton, Michael R; Nik-Zainal, Serena.

Nucleic Acids Res ; 45(19): 11213-11221, 2017 Nov 02.

Article in English | MEDLINE | ID: mdl-28977645

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