ABSTRACT
A new polycarbonate urethane (PCU-I) was synthesized from aliphatic monomers, i.e. polyhexamethylene carbonate diol and 4,4'-methylene-bis cyclohexane diisocyanate, a mixture of low molecular diols, and castor oil (containing mainly the triglyceride of 12-hydroxyoleic acid). The second synthesized polymer (PCU-II) did not contain castor oil. Both PCUs had good tensile strength, i.e. 32.5 and 27.8 MPa for PCU-I and PCU-II, respectively. Modification by castor oil led to a decrease in glass transition temperature (T(g) = -14 degrees C for PCU-I and -6 degrees C for PCU-II) and an increase in the softening temperature (135 and 125 degrees C for PCU-I and PCU-II, respectively). Partial crosslinking of PCU-I increased the storage modulus of elasticity and provided better resistance to sterilization by ETO and gamma radiation. Both PCUs displayed good stability when subjected to sterilization by hydrogen peroxide plasma. Neither PCU caused cytotoxic effect in mouse fibroblasts (3T3 Balb C). They also had no toxic effects on the morphotic components and did not influence changes in the hematologic parameters or plasmatic coagulation system of human blood.
Subject(s)
Biocompatible Materials/chemistry , Biocompatible Materials/chemical synthesis , Polycarboxylate Cement/chemistry , Polycarboxylate Cement/chemical synthesis , Polyurethanes/chemistry , Polyurethanes/chemical synthesis , Animals , BALB 3T3 Cells , Biocompatible Materials/toxicity , Blood Coagulation/drug effects , Drug Stability , Hemolysis/drug effects , Humans , In Vitro Techniques , Materials Testing , Mice , Polycarboxylate Cement/toxicity , Polyurethanes/toxicity , Sterilization , Tensile Strength , ThermodynamicsABSTRACT
Hydrogel Geliperm dressings of BYK Goldbin - Konstanz and Geistlich Sons Ldt. firms were used in patients in case of skin burns and some traumatic wounds. During a four-year observation it was discovered that those materials are safe for the patient, their removing is painless and their are fully useful in the treatment of burns and traumatic wounds in surgical departments and in the ambulatory treatment. Geliperm does not have allergic action. Because of its physicochemical and biological properties Geliperm may have also usage for example in the treatment of leg ulcerations, of bed-sores and of radiation skin defect.
Subject(s)
Bandages , Burns/therapy , Polyethylene Glycols , Wounds, Penetrating/therapy , Adolescent , Adult , Aged , Child , Humans , Hydrogel, Polyethylene Glycol Dimethacrylate , Middle AgedABSTRACT
In this paper we presented the evaluation and assessment of the influence of the knitted polyester materials with the different hydrophobic properties of theirs surfaces on the blood coagulation and fibrinolysis investigated on dynamic "in vitro" model. On the basis of the received results we can stated that the material with hydrophobic surface do not change the coagulation time in the internal-factors model nor in the external-factor model. It also has no influence for the concentration of fibrinogen, activity of the factors XII and VIII, antithrombin III, protein C nor for plasminogen. The knitted material with the hydrophilic surface increased the coagulation time while use in internal-factors model but do not change the coagulation time in the model with external-factors. It also has the influence in decreasing the activity of the factors XII and VIII. The activity of blood coagulations' inhibitors and plasminogen remained not changed.
Subject(s)
Biocompatible Materials , Blood Coagulation/physiology , Hydrophobic and Hydrophilic Interactions , Materials Testing , Polyesters , Fibrinolysis , Humans , In Vitro Techniques , Surface PropertiesABSTRACT
A new procedure in the surgical treatment of large incisional ventral hernias is described. It is based on the use of enlarged relaxation incisions of the abdominal fascia on both sides of the hernia to perform a direct suture of the posterior and superficial fascial layer of the hernia defect without tension. Extensive fascial defects after enlarged side relaxation incisions should be reinforced to prevent a weakness of the ventral abdominal wall. The best material may be a resorbable knitted mesh.
Subject(s)
Abdominal Muscles/surgery , Hernia, Ventral/surgery , Peptic Ulcer Perforation/surgery , Stomach Ulcer/complications , Surgical Mesh , Surgical Wound Dehiscence/complications , Abdominal Muscles/pathology , Adult , England , Hernia, Ventral/etiology , Hernia, Ventral/pathology , Humans , Male , Suture Techniques , Wound HealingSubject(s)
Brachial Plexus/pathology , Neurofibroma, Plexiform/pathology , Peripheral Nervous System Neoplasms/pathology , Brachial Plexus/surgery , Child , Humans , Male , Myelography , Neurofibroma, Plexiform/diagnosis , Neurofibroma, Plexiform/surgery , Peripheral Nervous System Neoplasms/diagnosis , Peripheral Nervous System Neoplasms/surgery , Tomography, X-Ray ComputedSubject(s)
Goiter, Substernal/surgery , Age Factors , Aged , Diagnosis, Differential , Goiter, Substernal/diagnosis , Humans , Middle AgedSubject(s)
Goiter/surgery , Age Factors , Aged , Evaluation Studies as Topic , Humans , Middle Aged , Preoperative CareABSTRACT
Fifty-six patients (45 males and 11 females) aged 19-65 (mean 37.3) were treated on outpatient basis between 1990 and 1994 because of hand injuries sustained at work. An analysis included age and profession of the patient, type of injury, sick leave time, and functional result of treatment. Clinical assessment at follow-up (range 6 months to 5 years) revealed poor results and the authors conclude, that surgical treatment should be used more often.