[Dosage of serum folates by a radio-assay. Comparison of the results obtained by this method and by microbiological method (author's transl)]. / Dosage par radio-essai des folates sériques. Etude méthodologique et comparaison des résultats avec ceux obtenus par la méthode microbiologique

A radio-assay, using a lactoglobulin fraction of milk proteins as a folate binder and 125-I pteroyl glutamate as a competitor, has been studied in 130 cases. The results have been compared to those obtained with microbiological methods. A good correlation has been observed. The radio-assay allows the measurement of folate in the presence of agents inhibiting the bacterial growth (methotrexate, trimethoprime). It can be used for assay in the cerebro-spinal fluid. This method appears to be useful for clinical investigations.