Search | Virtual Health Library

1.

SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans.

Mudd, Philip A; Minervina, Anastasia A; Pogorelyy, Mikhail V; Turner, Jackson S; Kim, Wooseob; Kalaidina, Elizaveta; Petersen, Jan; Schmitz, Aaron J; Lei, Tingting; Haile, Alem; Kirk, Allison M; Mettelman, Robert C; Crawford, Jeremy Chase; Nguyen, Thi H O; Rowntree, Louise C; Rosati, Elisa; Richards, Katherine A; Sant, Andrea J; Klebert, Michael K; Suessen, Teresa; Middleton, William D; Wolf, Joshua; Teefey, Sharlene A; O'Halloran, Jane A; Presti, Rachel M; Kedzierska, Katherine; Rossjohn, Jamie; Thomas, Paul G; Ellebedy, Ali H.

Cell ; 185(4): 603-613.e15, 2022 02 17.

Article in English | MEDLINE | ID: mdl-35026152

2.

Learning from our differences.

Sant, Andrea J; Wilson, Patrick C.

Nat Immunol ; 23(10): 1403-1404, 2022 Oct.

Article in English | MEDLINE | ID: mdl-36168064

3.

The Negative Effect of Preexisting Immunity on Influenza Vaccine Responses Transcends the Impact of Vaccine Formulation Type and Vaccination History.

Moritzky, Savannah A; Richards, Katherine A; Glover, Maryah A; Krammer, Florian; Chaves, Francisco A; Topham, David J; Branche, Angela; Nayak, Jennifer L; Sant, Andrea J.

J Infect Dis ; 227(3): 381-390, 2023 02 01.

Article in English | MEDLINE | ID: mdl-35199825

4.

Intranasal Nanoparticle Vaccination Elicits a Persistent, Polyfunctional CD4 T Cell Response in the Murine Lung Specific for a Highly Conserved Influenza Virus Antigen That Is Sufficient To Mediate Protection from Influenza Virus Challenge.

Nelson, Sean A; Dileepan, Thamotharampillai; Rasley, Amy; Jenkins, Marc K; Fischer, Nicholas O; Sant, Andrea J.

J Virol ; 95(16): e0084121, 2021 07 26.

Article in English | MEDLINE | ID: mdl-34076479

5.

CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential.

Sant, Andrea J; DiPiazza, Anthony T; Nayak, Jennifer L; Rattan, Ajitanuj; Richards, Katherine A.

Immunol Rev ; 284(1): 91-105, 2018 07.

Article in English | MEDLINE | ID: mdl-29944766

6.

Circulating CD4 T Cells Elicited by Endemic Coronaviruses Display Vast Disparities in Abundance and Functional Potential Linked to Antigen Specificity and Age.

Richards, Katherine A; Glover, Maryah; Crawford, Jeremy C; Thomas, Paul G; White, Chantelle; Sant, Andrea J.

J Infect Dis ; 223(9): 1555-1563, 2021 05 20.

Article in English | MEDLINE | ID: mdl-33556959

7.

A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza.

DiPiazza, Anthony T; Fan, Shufang; Rattan, Ajitanuj; DeDiego, Marta L; Chaves, Francisco; Neumann, Gabriele; Kawaoka, Yoshihiro; Sant, Andrea J.

J Immunol ; 203(6): 1502-1508, 2019 09 15.

Article in English | MEDLINE | ID: mdl-31399519

8.

Evidence That Blunted CD4 T-Cell Responses Underlie Deficient Protective Antibody Responses to Influenza Vaccines in Repeatedly Vaccinated Human Subjects.

Richards, Katherine A; Shannon, Ian; Treanor, John J; Yang, Hongmei; Nayak, Jennifer L; Sant, Andrea J.

J Infect Dis ; 222(2): 273-277, 2020 06 29.

Article in English | MEDLINE | ID: mdl-31504634

9.

Protein Vaccination Directs the CD4⁺ T Cell Response toward Shared Protective Epitopes That Can Be Recalled after Influenza Virus Infection.

Rattan, Ajitanuj; Richards, Katherine A; Knowlden, Zackery A G; Sant, Andrea J.

J Virol ; 93(20)2019 10 15.

Article in English | MEDLINE | ID: mdl-31341045

10.

Monoclonal Antibody Responses after Recombinant Hemagglutinin Vaccine versus Subunit Inactivated Influenza Virus Vaccine: a Comparative Study.

Henry, Carole; Palm, Anna-Karin E; Utset, Henry A; Huang, Min; Ho, Irvin Y; Zheng, Nai-Ying; Fitzgerald, Theresa; Neu, Karlynn E; Chen, Yao-Qing; Krammer, Florian; Treanor, John J; Sant, Andrea J; Topham, David J; Wilson, Patrick C.

J Virol ; 93(21)2019 11 01.

Article in English | MEDLINE | ID: mdl-31434733

11.

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.

Zost, Seth J; Parkhouse, Kaela; Gumina, Megan E; Kim, Kangchon; Diaz Perez, Sebastian; Wilson, Patrick C; Treanor, John J; Sant, Andrea J; Cobey, Sarah; Hensley, Scott E.

Proc Natl Acad Sci U S A ; 114(47): 12578-12583, 2017 11 21.

Article in English | MEDLINE | ID: mdl-29109276

12.

The Way Forward: Potentiating Protective Immunity to Novel and Pandemic Influenza Through Engagement of Memory CD4 T Cells.

Sant, Andrea J.

J Infect Dis ; 219(Suppl_1): S30-S37, 2019 04 08.

Article in English | MEDLINE | ID: mdl-30715376

13.

CD4 T Cell Epitope Specificity and Cytokine Potential Are Preserved as Cells Transition from the Lung Vasculature to Lung Tissue following Influenza Virus Infection.

DiPiazza, Anthony; Laniewski, Nathan; Rattan, Ajitanuj; Topham, David J; Miller, Jim; Sant, Andrea J.

J Virol ; 92(13)2018 07 01.

Article in English | MEDLINE | ID: mdl-29669836

14.

Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell Repertoire.

Richards, Katherine A; Treanor, John J; Nayak, Jennifer L; Sant, Andrea J.

J Infect Dis ; 218(7): 1169-1174, 2018 08 24.

Article in English | MEDLINE | ID: mdl-29762692

15.

Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii.

Tesini, Brenda L; Wright, Terry W; Malone, Jane E; Haidaris, Constantine G; Harber, Martha; Sant, Andrea J; Nayak, Jennifer L; Gigliotti, Francis.

Infect Immun ; 85(4)2017 04.

Article in English | MEDLINE | ID: mdl-28031260

16.

Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection.

DiPiazza, Anthony; Richards, Katherine; Batarse, Frances; Lockard, Laura; Zeng, Hui; García-Sastre, Adolfo; Albrecht, Randy A; Sant, Andrea J.

J Virol ; 90(17): 7991-8004, 2016 09 01.

Article in English | MEDLINE | ID: mdl-27356897

17.

Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses.

Nayak, Jennifer L; Richards, Katherine A; Yang, Hongmei; Treanor, John J; Sant, Andrea J.

J Infect Dis ; 211(9): 1408-17, 2015 May 01.

Article in English | MEDLINE | ID: mdl-25378637

18.

Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza.

Richards, Katherine A; Nayak, Jennifer; Chaves, Francisco A; DiPiazza, Anthony; Knowlden, Zackery A G; Alam, Shabnam; Treanor, John J; Sant, Andrea J.

J Infect Dis ; 212(1): 86-94, 2015 Jul 01.

Article in English | MEDLINE | ID: mdl-25492919

19.

Abundance and specificity of influenza reactive circulating memory follicular helper and non-follicular helper CD4 T cells in healthy adults.

Leddon, Scott A; Richards, Katherine A; Treanor, John J; Sant, Andrea J.

Immunology ; 146(1): 157-62, 2015 Sep.

Article in English | MEDLINE | ID: mdl-26094691

20.

CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection.

Alam, Shabnam; Knowlden, Zackery A G; Sangster, Mark Y; Sant, Andrea J.

J Virol ; 88(1): 314-24, 2014 Jan.

Article in English | MEDLINE | ID: mdl-24155379

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