Search | Virtual Health Library

1.

Phase and context shape the function of composite oncogenic mutations.

Gorelick, Alexander N; Sánchez-Rivera, Francisco J; Cai, Yanyan; Bielski, Craig M; Biederstedt, Evan; Jonsson, Philip; Richards, Allison L; Vasan, Neil; Penson, Alexander V; Friedman, Noah D; Ho, Yu-Jui; Baslan, Timour; Bandlamudi, Chaitanya; Scaltriti, Maurizio; Schultz, Nikolaus; Lowe, Scott W; Reznik, Ed; Taylor, Barry S.

Nature ; 582(7810): 100-103, 2020 06.

Article in English | MEDLINE | ID: mdl-32461694

2.

Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman, David M; Piha-Paul, Sarina A; Won, Helen; Rodon, Jordi; Saura, Cristina; Shapiro, Geoffrey I; Juric, Dejan; Quinn, David I; Moreno, Victor; Doger, Bernard; Mayer, Ingrid A; Boni, Valentina; Calvo, Emiliano; Loi, Sherene; Lockhart, Albert C; Erinjeri, Joseph P; Scaltriti, Maurizio; Ulaner, Gary A; Patel, Juber; Tang, Jiabin; Beer, Hannah; Selcuklu, S Duygu; Hanrahan, Aphrothiti J; Bouvier, Nancy; Melcer, Myra; Murali, Rajmohan; Schram, Alison M; Smyth, Lillian M; Jhaveri, Komal; Li, Bob T; Drilon, Alexander; Harding, James J; Iyer, Gopa; Taylor, Barry S; Berger, Michael F; Cutler, Richard E; Xu, Feng; Butturini, Anna; Eli, Lisa D; Mann, Grace; Farrell, Cynthia; Lalani, Alshad S; Bryce, Richard P; Arteaga, Carlos L; Meric-Bernstam, Funda; Baselga, José; Solit, David B.

Nature ; 566(7745): E11-E12, 2019 02.

Article in English | MEDLINE | ID: mdl-30755741

3.

HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman, David M; Piha-Paul, Sarina A; Won, Helen; Rodon, Jordi; Saura, Cristina; Shapiro, Geoffrey I; Juric, Dejan; Quinn, David I; Moreno, Victor; Doger, Bernard; Mayer, Ingrid A; Boni, Valentina; Calvo, Emiliano; Loi, Sherene; Lockhart, Albert C; Erinjeri, Joseph P; Scaltriti, Maurizio; Ulaner, Gary A; Patel, Juber; Tang, Jiabin; Beer, Hannah; Selcuklu, S Duygu; Hanrahan, Aphrothiti J; Bouvier, Nancy; Melcer, Myra; Murali, Rajmohan; Schram, Alison M; Smyth, Lillian M; Jhaveri, Komal; Li, Bob T; Drilon, Alexander; Harding, James J; Iyer, Gopa; Taylor, Barry S; Berger, Michael F; Cutler, Richard E; Xu, Feng; Butturini, Anna; Eli, Lisa D; Mann, Grace; Farrell, Cynthia; Lalani, Alshad S; Bryce, Richard P; Arteaga, Carlos L; Meric-Bernstam, Funda; Baselga, José; Solit, David B.

Nature ; 554(7691): 189-194, 2018 02 08.

Article in English | MEDLINE | ID: mdl-29420467

4.

Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.

Xie, Wei; Wang, Shengliu; Wang, Juncheng; de la Cruz, M Jason; Xu, Guotai; Scaltriti, Maurizio; Patel, Dinshaw J.

Proc Natl Acad Sci U S A ; 118(8)2021 02 23.

Article in English | MEDLINE | ID: mdl-33597306

5.

UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth.

Wolfe, Andrew L; Zhou, Qingwen; Toska, Eneda; Galeas, Jacqueline; Ku, Angel A; Koche, Richard P; Bandyopadhyay, Sourav; Scaltriti, Maurizio; Lebrilla, Carlito B; McCormick, Frank; Kim, Sung Eun.

Proc Natl Acad Sci U S A ; 118(31)2021 08 03.

Article in English | MEDLINE | ID: mdl-34330832

6.

Antitumor activity of the PI3K Î´-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2 + breast cancer.

Fiascarelli, Alessio; Merlino, Giuseppe; Capano, Stefania; Talucci, Simone; Bisignano, Diego; Bressan, Alessandro; Bellarosa, Daniela; Carrisi, Corrado; Paoli, Alessandro; Bigioni, Mario; Tunici, Patrizia; Irrissuto, Clelia; Salerno, Massimiliano; Arribas, Joaquin; de Stanchina, Elisa; Scaltriti, Maurizio; Binaschi, Monica.

Breast Cancer Res Treat ; 199(1): 13-23, 2023 May.

Article in English | MEDLINE | ID: mdl-36913051

7.

Pancreatoblastomas and mixed and pure acinar cell carcinomas share epigenetic signatures distinct from other neoplasms of the pancreas.

Benhamida, Jamal K; Vyas, Monika; Tanaka, Atsushi; Wang, Lu; Bahrami, Armita; Ozcan, Kerem; Basturk, Olca; Villafania, Liliana; Mata, Douglas A; El Jabbour, Tony; Selenica, Pier; Roehrl, Michael H A; Weigelt, Britta; Reis-Filho, Jorge S; Scaltriti, Maurizio; Klimstra, David S.

Mod Pathol ; 35(7): 956-961, 2022 07.

Article in English | MEDLINE | ID: mdl-34969956

8.

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.

Juric, Dejan; Castel, Pau; Griffith, Malachi; Griffith, Obi L; Won, Helen H; Ellis, Haley; Ebbesen, Saya H; Ainscough, Benjamin J; Ramu, Avinash; Iyer, Gopa; Shah, Ronak H; Huynh, Tiffany; Mino-Kenudson, Mari; Sgroi, Dennis; Isakoff, Steven; Thabet, Ashraf; Elamine, Leila; Solit, David B; Lowe, Scott W; Quadt, Cornelia; Peters, Malte; Derti, Adnan; Schegel, Robert; Huang, Alan; Mardis, Elaine R; Berger, Michael F; Baselga, José; Scaltriti, Maurizio.

Nature ; 518(7538): 240-4, 2015 Feb 12.

Article in English | MEDLINE | ID: mdl-25409150

9.

Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy.

Floros, Konstantinos V; Lochmann, Timothy L; Hu, Bin; Monterrubio, Carles; Hughes, Mark T; Wells, Jason D; Morales, Cristina Bernadó; Ghotra, Maninderjit S; Costa, Carlotta; Souers, Andrew J; Boikos, Sosipatros A; Leverson, Joel D; Tan, Ming; Serra, Violeta; Koblinski, Jennifer E; Arribas, Joaquin; Prat, Aleix; Paré, Laia; Miller, Todd W; Dozmorov, Mikhail G; Harada, Hisashi; Windle, Brad E; Scaltriti, Maurizio; Faber, Anthony C.

Proc Natl Acad Sci U S A ; 115(11): E2594-E2603, 2018 03 13.

Article in English | MEDLINE | ID: mdl-29476008

10.

MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer.

Novoplansky, Ofra; Fury, Matthew; Prasad, Manu; Yegodayev, Ksenia; Zorea, Jonathan; Cohen, Limor; Pelossof, Raphael; Cohen, Liz; Katabi, Nora; Cecchi, Fabiola; Joshua, Ben-Zion; Popovtzer, Aron; Baselga, Jose; Scaltriti, Maurizio; Elkabets, Moshe.

Int J Cancer ; 145(3): 748-762, 2019 08 01.

Article in English | MEDLINE | ID: mdl-30694565

11.

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas.

Ebbesen, Saya H; Scaltriti, Maurizio; Bialucha, Carl U; Morse, Natasha; Kastenhuber, Edward R; Wen, Hannah Y; Dow, Lukas E; Baselga, José; Lowe, Scott W.

Proc Natl Acad Sci U S A ; 113(11): 3030-5, 2016 Mar 15.

Article in English | MEDLINE | ID: mdl-26929372

12.

The prognostic value of PI3K mutational status in breast cancer: A meta-analysis.

Sobhani, Navid; Roviello, Giandomenico; Corona, Silvia P; Scaltriti, Maurizio; Ianza, Anna; Bortul, Marina; Zanconati, Fabrizio; Generali, Daniele.

J Cell Biochem ; 119(6): 4287-4292, 2018 06.

Article in English | MEDLINE | ID: mdl-29345357

13.

How a new drug is born.

Caporali, Andrea; Fawell, Steven; Scaltriti, Maurizio.

Eur Heart J ; 42(32): 3039-3041, 2021 08 21.

Article in English | MEDLINE | ID: mdl-33718951

14.

Quantification of HER family receptors in breast cancer.

Nuciforo, Paolo; Radosevic-Robin, Nina; Ng, Tony; Scaltriti, Maurizio.

Breast Cancer Res ; 17: 53, 2015 Apr 09.

Article in English | MEDLINE | ID: mdl-25887735

15.

Biomarkers of drugs targeting HER-family signalling in cancer.

Montemurro, Filippo; Scaltriti, Maurizio.

J Pathol ; 232(2): 219-29, 2014 Jan.

Article in English | MEDLINE | ID: mdl-24105684

16.

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients.

Scaltriti, Maurizio; Eichhorn, Pieter J; Cortés, Javier; Prudkin, Ludmila; Aura, Claudia; Jiménez, José; Chandarlapaty, Sarat; Serra, Violeta; Prat, Aleix; Ibrahim, Yasir H; Guzmán, Marta; Gili, Magui; Rodríguez, Olga; Rodríguez, Sonia; Pérez, José; Green, Simon R; Mai, Sabine; Rosen, Neal; Hudis, Clifford; Baselga, José.

Proc Natl Acad Sci U S A ; 108(9): 3761-6, 2011 Mar 01.

Article in English | MEDLINE | ID: mdl-21321214

17.

Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer.

Blawski, Ryan; Vokshi, Bujamin H; Guo, Xinyu; Kittane, Srushti; Sallaku, Mirna; Chen, Wanlu; Gjyzari, Martina; Cheung, Tony; Zhang, Yuhan; Simpkins, Christopher; Zhou, Weiqiang; Kulick, Amanda; Zhao, Peihua; Wei, Meihan; Shivashankar, Pranavkrishna; Prioleau, Tatiana; Razavi, Pedram; Koche, Richard; Rebecca, Vito W; de Stanchina, Elisa; Castel, Pau; Chan, Ho Man; Scaltriti, Maurizio; Cocco, Emiliano; Ji, Hongkai; Luo, Minkui; Toska, Eneda.

Cell Rep ; 43(5): 114174, 2024 May 28.

Article in English | MEDLINE | ID: mdl-38700982

18.

Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations.

Sivakumar, Smruthy; Jin, Dexter X; Rathod, Ruchita; Ross, Jeffrey; Cantley, Lewis C; Scaltriti, Maurizio; Chen, Jessica W; Hutchinson, Katherine E; Wilson, Timothy R; Sokol, Ethan S; Vasan, Neil.

Clin Cancer Res ; 29(6): 1125-1136, 2023 03 14.

Article in English | MEDLINE | ID: mdl-36595567

19.

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation.

Ladewig, Erik; Michelini, Flavia; Jhaveri, Komal; Castel, Pau; Carmona, Javier; Fairchild, Lauren; Zuniga, Adler G; Arruabarrena-Aristorena, Amaia; Cocco, Emiliano; Blawski, Ryan; Kittane, Srushti; Zhang, Yuhan; Sallaku, Mirna; Baldino, Laura; Hristidis, Vasilis; Chandarlapaty, Sarat; Abdel-Wahab, Omar; Leslie, Christina; Scaltriti, Maurizio; Toska, Eneda.

Cancer Res ; 82(12): 2269-2280, 2022 06 15.

Article in English | MEDLINE | ID: mdl-35442400

20.

High FGFR1-4 mRNA Expression Levels Correlate with Response to Selective FGFR Inhibitors in Breast Cancer.

Sánchez-Guixé, Mònica; Hierro, Cinta; Jiménez, José; Viaplana, Cristina; Villacampa, Guillermo; Monelli, Erika; Brasó-Maristany, Fara; Ogbah, Zighereda; Parés, Mireia; Guzmán, Marta; Grueso, Judit; Rodríguez, Olga; Oliveira, Mafalda; Azaro, Analía; Garralda, Elena; Tabernero, Josep; Casanovas, Oriol; Scaltriti, Maurizio; Prat, Aleix; Dienstmann, Rodrigo; Nuciforo, Paolo; Saura, Cristina; Graupera, Mariona; Vivancos, Ana; Rodon, Jordi; Serra, Violeta.

Clin Cancer Res ; 28(1): 137-149, 2022 01 01.

Article in English | MEDLINE | ID: mdl-34593528

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