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1.
MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Blood
; 133(13): 1507-1516, 2019 03 28.
Article
in English
| MEDLINE | ID: mdl-30692123
2.
Trypsin inhibitors for the treatment of pancreatitis.
Bioorg Med Chem Lett
; 26(17): 4340-4, 2016 09 01.
Article
in English
| MEDLINE | ID: mdl-27476144
3.
A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target.
Proc Natl Acad Sci U S A
; 108(52): 21052-6, 2011 Dec 27.
Article
in English
| MEDLINE | ID: mdl-22160684
4.
Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19 F NMR Binding Assay with Predicted 19 F NMR Chemical Shifts.
ChemMedChem
; 17(13): e202200163, 2022 07 05.
Article
in English
| MEDLINE | ID: mdl-35475323
5.
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat Struct Mol Biol
; 13(4): 372-3, 2006 Apr.
Article
in English
| MEDLINE | ID: mdl-16532006
6.
Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments.
Proteins
; 78(16): 3281-91, 2010 Dec.
Article
in English
| MEDLINE | ID: mdl-20886466
7.
Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
ACS Med Chem Lett
; 11(2): 188-194, 2020 Feb 13.
Article
in English
| MEDLINE | ID: mdl-32071687
8.
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J Med Chem
; 63(15): 8088-8113, 2020 08 13.
Article
in English
| MEDLINE | ID: mdl-32551603
9.
Purification and crystallization of dengue and West Nile virus NS2B-NS3 complexes.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 62(Pt 2): 157-62, 2006 Feb 01.
Article
in English
| MEDLINE | ID: mdl-16511290
10.
Structure of neprilysin in complex with the active metabolite of sacubitril.
Sci Rep
; 6: 27909, 2016 06 15.
Article
in English
| MEDLINE | ID: mdl-27302413
11.
Fluorescence Lifetime-Based Competitive Binding Assays for Measuring the Binding Potency of Protease Inhibitors In Vitro.
J Biomol Screen
; 19(6): 870-7, 2014 Jul.
Article
in English
| MEDLINE | ID: mdl-24487225
12.
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
ACS Med Chem Lett
; 5(7): 787-92, 2014 Jul 10.
Article
in English
| MEDLINE | ID: mdl-25050166
13.
Fragment-based screening by biochemical assays: Systematic feasibility studies with trypsin and MMP12.
J Biomol Screen
; 15(9): 1029-41, 2010 Oct.
Article
in English
| MEDLINE | ID: mdl-20855559
14.
Differential inhibition sensitivities of MET mutants to the small molecule inhibitor SU11274.
Cancer Lett
; 289(2): 228-36, 2010 Mar 28.
Article
in English
| MEDLINE | ID: mdl-19783361
15.
Direct renin inhibitors as a new therapy for hypertension.
J Med Chem
; 53(21): 7490-520, 2010 Nov 11.
Article
in English
| MEDLINE | ID: mdl-20731374
16.
Regulation of the wild-type and Y1235D mutant Met kinase activation.
Biochemistry
; 44(43): 14110-9, 2005 Nov 01.
Article
in English
| MEDLINE | ID: mdl-16245927
17.
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.
Proc Natl Acad Sci U S A
; 100(22): 12654-9, 2003 Oct 28.
Article
in English
| MEDLINE | ID: mdl-14559966
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