Lymphocyte Subset Ratio Cannot Diagnose Immune Failure of a TKA.

BACKGROUND: Up to 20% of patients are dissatisfied following total knee arthroplasty (TKA), most often due to pain and/or stiffness. The differential diagnosis includes immune reaction to the prosthesis. However, there is no consensus on diagnostic criteria for immune failure, an allergic reaction, to a TKA. Histologic evaluation could provide evidence as to whether an allergic reaction caused TKA failure. A recent study showed an increase in CD4+ lymphocytes compared to CD8+ lymphocytes in patients lymphocyte transformation testing (LTT) + for Ni. This finding is consistent with Ni sensitization, but can lymphocyte subsets be used to diagnose immune failure on a case-by-case basis? METHODS: Periprosthetic tissues from 18 revision cases of well-fixed, aseptic, but painful and/or stiff primary TKAs were analyzed. Six patients LTT- for Ni were matched as a cohort for age, sex, and body mass index (BMI), to 12 patients LTT + for Ni. Periprosthetic tissue biopsies underwent immunohistochemical IHC staining for CD4+ and CD8+ lymphocyte subsets and were compared by LTT status. The immunohistochemicalIHC results were also compared with periprosthetic histology. RESULTS: There was no relationship between LTT status and mean CD4+ cells/hpf or CD4+:CD8+ lymphocyte ratio. No relationship was found between LTT stimulation index (continuous or categorical) and CD4+:CD8+ ratio or aseptic lymphocyte-dominant vasculitis-associated lesion ALVAL score. CONCLUSION: Lymphocytes in periprosthetic tissue are highly variable in number, subtype ratio, and location, and have no relationship to LTT result or ALVAL score on a case-by-case basis. Based on these results, lymphocyte subsets cannot diagnose immune failure. Further work is needed to determine criteria for the diagnosis of immune failure of a TKA.

Periprosthetic Tissue Reaction Independent of LTT Result and Implanted Materials in Total Knee Arthroplasty.

BACKGROUND: An allergic reaction may rarely cause a painful or stiff total knee arthroplasty (TKA). However, no consensus diagnostic criteria for TKA immune failure exist. Lymphocyte transformation testing (LTT) measures immune sensitivity to various materials, but its role in diagnosing an allergic reaction to a TKA has not been established. This study compares TKA periprosthetic tissues in a) LTT-positive versus -negative patients and b) patients with conventional CoCrNi versus hypoallergenic implants. METHODS: Periprosthetic tissues from 26 revision cases of well-fixed, aseptic, but painful or stiff TKAs were analyzed. Twelve patients LTT positive for nickel (Ni) were matched as a cohort to 6 LTT-negative patients. In 4 patients LTT positive for Ni, tissue from first revision of CoCrNi implants was compared with tissue from subsequent revision of hypoallergenic implants. Histology was evaluated using the aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) score. RESULTS: No correlation was found between LTT and any ALVAL score component. The mean total ALVAL score was 3.8 ± 1.5 for LTT-negative patients and 3.3 ± 1.2 for LTT-positive patients (P = .44). The mean total ALVAL score at revision of CoCrNi implants was 3.0 ± 1.8 compared with 5.8 ± 0.5 at rerevision of hypoallergenic implants (P = .053). CONCLUSION: Periprosthetic TKA tissue reactions were indistinguishable between LTT-positive and -negative patients. LTT does not predict the periprosthetic tissue response. ALVAL scores of hypoallergenic revision implant tissue trended higher than primary CoCrNi implant tissue. A positive LTT may not indicate that a periprosthetic immune reaction is the cause of pain and stiffness after TKA. LEVEL OF EVIDENCE: 3, retrospective cohort study.

Femoral-Acetabular Mating: The Effect of Femoral and Combined Anteversion on Cross-Linked Polyethylene Wear.

BACKGROUND: Cross-linked polyethylene (XLPE) has generally low rates of wear and osteolysis at 10 years, but component position may become important with longer follow-up. At 5-13 years, neither acetabular component lateral opening angle nor version were significantly correlated to wear. In the present study, we analyzed the effects of femoral anteversion and combined anteversion on XLPE wear. METHODS: Forty-two well-functioning primary total hip arthroplasties in 36 patients, performed by a single surgeon via a posterior approach, were followed for a minimum of 5 years (mean, 7.1 years; range, 5.0-10.3). All hips had a modular, XLPE liner with a ≥36-mm bearing. Femoral anteversion was measured on the modified Budin view. Wear was measured on radiographs using a validated, computer-assisted, edge-detection-based algorithm. The mean lateral opening angle was 40.4° (range, 22.6°-50.3°). The mean acetabular version was 19.1° (range, 11.3°-27.5°). Neither of these variables was significantly correlated to wear. Effects of femoral anteversion and combined anteversion on XLPE wear were assessed using linear and polynomial regression analysis. RESULTS: Femoral anteversion (mean, 18.4°; range, 6.8°-30.7°) was significantly correlated to linear wear (mean, 0.06 mm/y; range, 0-0.16), showing an inverse parabolic relationship with the least wear occurring at 18.2° (P = .02). Combined anteversion (mean, 37.2°; range, 21.8°-54.3°) showed a similar significant relationship with the least wear at 38.1° (P < .001). Based on regression, combined anteversion between 24.6° and 50.4° resulted in linear wear rates less than 0.1 mm/y. CONCLUSION: To the authors' knowledge, this is the first study to identify femoral anteversion as an independent factor influencing XLPE wear, with least wear occurring around 18°. At 5-10 years, average linear wear of XLPE is below 0.1 mm/y over a 25°-50° range of combined anteversion, with the least wear around 38°. Femoral-acetabular mating is a product of both components. Femoral component version and combined anteversion had a greater effect on wear than acetabular component lateral opening angle. Additional studies are warranted, but these results indicate that the sensitivity of wear studies is increased with version assessments.

Wear Rates of Larger-Diameter Cross-Linked Polyethylene at 5 to 13 Years: Does Liner Thickness or Component Position Matter?

BACKGROUND: Cross-linked polyethylene (XLPE) has demonstrated significantly reduced wear and osteolysis into the second decade for total hip arthroplasty. There is a relative paucity of data with ≥36-mm bearings. Issues include potential effects of reduced liner thickness and component position on wear, osteolysis, and mechanical failure of the bearing. METHODS: Radiographs of 48 primary total hip arthroplasties with ≥36-mm modular XLPE bearings were analyzed at a minimum 5 years postoperative on serial radiographs using a validated, edge-detection-based algorithm. Subgroups were examined to assess the effect of bearing diameter, liner thickness, acetabular abduction angle, and acetabular anteversion on XLPE wear. RESULTS: There was no significant difference in volumetric wear when subgroups were stratified by component factors: liner thickness (<6.5 mm vs ≥6.5 mm) 40.69 mm3/y vs 24.47 mm3/y, respectively (P = .315); acetabular component abduction angle (<45° vs ≥45°): 38.68 mm3/y vs 27.8 mm3/y, respectively (P = .522); acetabular anteversion (<20° vs ≥20°): 41.32 mm3/y vs 31.79 mm3/y, respectively (P = .521). There were no dislocations, mechanical failures, or revisions. There were 7 hips with volumetric wear rates ≥80 mm3/y; 1 had possible osteolysis. CONCLUSION: Larger-diameter XLPE wear was not measurably affected by liner thickness, acetabular abduction angle, or acetabular anteversion. However, there is a trend for increasing volumetric wear with increasing bearing size. Wear outliers do occur, and continued follow-up of larger-diameter XLPE bearings is warranted.

Examining the "revisability" benefit of hip resurfacing arthroplasty.

BACKGROUND: Hip resurfacing arthroplasty (HRA) is an alternative to total hip arthroplasty (THA) that is typically reserved for young active patients because it preserves bone. However, the benefits of HRA only hold true if conversion THA after failed HRA provides acceptable outcomes. AIM: To compare patient reported outcomes for conversion THA after HRA failure to primary THA. METHODS: A retrospective review of 36 patients (37 hips) that underwent conversion THA for failed HRA between October 2006 and May 2019 by a single surgeon was performed. Patient reported outcomes [modified Harris Hip Score (mHHS), University of California Los Angeles (UCLA) activity score] were obtained via an email-based responder-anonymous survey. Outcomes were compared to normative data of a primary THA cohort with similar demographics. Subgroup analysis was performed comparing outcomes of conversion THA for adverse local tissue reaction (ALTR) vs all other causes for failure. RESULTS: The study group had a lower mHHS than the control group (81.7 ± 13.8 vs 90.2 ± 11.6, P < 0.01); however, both groups had similar UCLA activity levels (7.5 ± 2.3 vs 7.2 ± 1.6, P = 0.51). Patients that underwent conversion for non-ATLR causes had similar mHHS (85.2 ± 11.5 vs 90.2 ± 11.6, P = 0.11) and higher UCLA activity levels (8.5 ± 1.8 vs 7.2 ± 1.6, P < 0.01) compared to the control group. Patients that underwent conversion for ATLR had worse mHHS (77.1 ± 14.5 vs 90.2 ± 11.6, P < 0.01) and UCLA activity levels (6.1 ± 2.3 vs 7.2 ± 1.6, P = 0.05) when compared to the control group. CONCLUSION: Patient outcomes equivalent to primary THA can be achieved following HRA conversion to THA. However, inferior outcomes were demonstrated for ALTR-related HRA failure. Patient selection and perhaps further studies examining alternative HRA bearing surfaces should be considered.

The 2012 Frank Stinchfield Award: Decreasing patient activity with aging: implications for crosslinked polyethylene wear.

BACKGROUND: Patient activity influences polyethylene wear. However, it is unclear how individual activity changes with patient aging after THA. QUESTIONS/PURPOSES: We quantified changes in individual gait cycles and gait speed, assessed age-related differences in these parameters, and determined their relationship to polyethylene wear. METHODS: A microprocessor was worn on the ankle to quantify the activity of 14 healthy patients with a well-functioning THA at two time periods: early (within 3.5 years of implantation) and late (10-13 postoperative years). Wear was measured on serial radiographs using edge detection-based software. RESULTS: Mean activity decreased by 16% from the early to the late period: 2.04 million gait cycles/year to 1.71 million gait cycles/year. Mean gait speed decreased by 9%: 15.4 cycles/minute to 14.0 cycles/minute. The activity of the 10 patients who were younger than 65 years at surgery decreased by 14% (2.34 million gait cycles/year to 2.02 million gait cycles/year), while the four patients 65 years or older at surgery decreased by 28% (1.29 million gait cycles/year to 0.94 million gait cycles/year). Gait speed was 26% slower for patients 65 years or older than for patients younger than 65 years. The mean linear penetration rate decreased by 42% from the first 5 years (early wear rate) to the next 8 years (late wear rate, 5-13 years): 0.043 mm/year to 0.025 mm/year. CONCLUSIONS: The greatest patient activity and wear occurred during the first 5 years. Walking speed and gait cycles both decreased with aging, resulting in deceasing wear over time.

What is the upper limit of cement penetration for different femoral hip resurfacing components?

We used a validated femoral resurfacing model to obtain measurements of pressure and temperature and quantify cement distribution as a function of inner geometry and cementing technique of five different femoral hip resurfacing components. The purpose was to investigate if manufacture cementing recommendations are reliable. ASR showed only with the recommended manual cementing technique low cement pressures of 58.0±50.2kPa and low interface temperatures of 33.3±4.1°C. BHR had large cement defects of 10.4±1.1mm. Conserve Plus caused the smallest cement penetration depths of 2.9±0.6mm. Durom was tolerant against changes of the cementing technique but showed the widest spread of temperature data 42.8±7.0°C. ReCap showed the highest risk for incomplete seating with a cement mantle thickness of 4.3±0.9mm. Polymerization heat did not exceed the threshold of 45°C with a cement penetration depth of less than 4.2mm in any circumstances of this study.

A more reliable method to assess acetabular component position.

BACKGROUND: Acetabular component position is associated with joint function and bearing wear. Current techniques for determining acetabular component version on standard radiographs lack reliability. Other, more consistent techniques are time-consuming and require additional equipment or software. QUESTIONS/PURPOSES: We compared three methods of acetabular component position assessment: (1) Einzel-Bild-Roentgen-Analyse (EBRA), (2) Woo and Morrey, and (3) the new ischiolateral method. PATIENTS AND METHODS: We assessed axial component position for 52 hips, with at least three radiographic series, using EBRA, and on true lateral radiographs using the Woo and Morrey method and a new method that uses the ischium as a skeletal landmark, the ischiolateral method. RESULTS: The mean SDs of the ischiolateral (2.15°) and EBRA (2.06°) methods were lower than that of the Woo and Morrey method (3.65°) but were not different from one another. We observed a SD of greater than 4° in 19 (36.5%) hip series using the Woo and Morrey method, compared to six series (11.5%) for both the ischiolateral and EBRA methods. Twenty-four (12.6%) Woo and Morrey measurements were greater than 4° from the mean for the hip series, compared to seven (3.8%) for ischiolateral and nine (4.7%) for EBRA. The intraclass correlation coefficients for intra- and interobserver reliability for the ischiolateral method and EBRA were the same (0.9). CONCLUSIONS: Referencing the ischium standardizes pelvic position on each lateral radiograph and provides a simple and reliable means to assess axial component position, which is a surrogate for the planar anteversion measured by EBRA.

Survival of hard-on-hard bearings in total hip arthroplasty: a systematic review.

BACKGROUND: Improvements in prosthetic materials, designs, and implant fixation for THA have led to bearing surface wear being the limitation of this technology. Hard-on-hard bearings promise decreased wear rates and increased survival. However, there may be different survival rates based on bearing materials, manufacturing technologies, and femoral component designs. Additionally, survival rate variability may be based on study design. QUESTIONS/PURPOSES: We determined survival rates and study levels of evidence and quality for the following bearings: stemmed metal-on-metal THA, metal-on-metal hip resurfacing, ceramic-on-ceramic THA, and ceramic-on-metal THA. METHODS: We performed a systematic review of the peer-reviewed literature addressing THA hard-on-hard bearings. Quality for Level I and II studies was assessed. RESULTS: The four Level I or II second-generation stemmed metal-on-metal THA studies reported between 96% and 100% mean survival at 38 to 60 months. The two Level I hip resurfacing studies reported 94% and 98% mean survival at 56 and 33 months. The four Level I studies of ceramic-on-ceramic THA reported survival from 100% at mean 51 months to 96% at 8 years. CONCLUSIONS: While hard-on-hard bearing survival rates have generally been variable with earlier designs, contemporary implants have demonstrated survival of 95% or greater at followup of between 3 and 10 years. Some variability in survival may be due to differences in surgical technique, component positioning, and implant designs. As bearing designs continue to improve with modified materials and manufacturing techniques, use will increase, especially in young and active patients, though concerns remain about the increased reports of adverse events after metal-on-metal bearings.

Fracture of a cross-linked polyethylene liner: a multifactorial issue.

A limited number of reports have detailed the cause of fracture of a highly cross-linked polyethylene liner. Typically, the fractures have occurred in a region of thin and/or unsupported polyethylene, in association with superiorly directed edge loading conditions secondary to an excessively inclinated acetabular component. This case report details an unusual fracture mechanism of a 5-mrad cross-linked liner caused by horizontal loading conditions. The report details several factors that were felt to be etiologic including the specific liner locking mechanism. The treatment options are discussed.

Cementing techniques for hip resurfacing arthroplasty: in vitro study of pressure and temperature.

Cementing irregularities have been associated with femoral failures of resurfacing arthroplasties in retrieval studies. We used an in vitro model to measure pressure, temperatures, and cement penetration as a function of 6 different cementing techniques. Filling the component with cement can lead to overpenetration or increase the resistance to component seating with resultant polar cement mass. Both conditions result in high and long-lasting cement pressures, cement defects, as well as peak temperatures higher than 50°C. Manual application of cement provides complete penetration of the available fixation area with the lowest cement pressures, the smallest total cement mass, and a peak temperature of 36.0°C ± 4.1°C. Application of the principles elucidated by this study may reduce the risk of cement overpenetration and incomplete seating.

Fixed versus rotating platform total knee arthroplasty: a prospective, randomized, single-blind study.

The purpose of this randomized, single-blind clinical trial was to compare a rotating platform (RP) total knee arthroplasty to a fixed-bearing (FB) total knee arthroplasty. Ninety-five knees in 69 patients were implanted by 2 surgeons. There were no significant differences in the preoperative demographics. At a minimum of 2-year follow-up, clinical outcomes and complication rates were similar, with the exception that the RP group had significantly better stair-climbing scores (P = .04). Postoperative range of motion was equally good in both groups (FB knees, 1°-125°; RP knees, 1-126°). There were no bearing dislocations in the RP group. In conclusion, this RP design performs at least as well as the FB version, and the RP patients reported better stair-climbing ability. Enthusiasm for this finding should be tempered by the relatively small sample size.

The influence of cementing technique in hip resurfacing arthroplasty on the initial stability of the femoral component.

PURPOSE: In clinical and retrieval analyses, over-penetration of cement, incomplete seating of the prosthesis with a resultant polar cement mass, or both, have been associated with early femoral failures of resurfacing arthroplasties. We used human bone specimens to experimentally compare the initial stability of different cementing techniques. METHODS: Twenty-six pairs of fresh frozen femora were prepared for resurfacing using original instruments (DePuy ASR). ASR femoral resurfacing prostheses were implanted using two different cementing techniques: (1) component filling and (2) cement applicator. Real-time measurements of pressure and temperature during implantation, analyses of cement penetration and micro motions under torque application were performed. RESULTS: Applicator use reduced significantly the cement penetration depth (9.2 mm vs 5.3 mm with the applicator, p = 0.001), polar mantle (8.1 mm vs 2.6 mm, p = 0.008), cement defects (3.7 mm vs 0.1 mm, p = 0.008) and interface temperatures (40.3°C vs 33.1°C, p < 0.001 ). Initial rotational stability showed statistically significant less extreme values with the cement applicator technique (range 3.4-51.7 m°/Nm, 11.0-29.7 m°/Nm, p = 0.024). CONCLUSIONS: The cement applicator technique significantly reduces cement defects, incomplete seating, over-penetration and interface temperatures with a more consistent initial stability of the ASR femoral resurfacing prostheses.

Suspected Metal Allergy and Femoral Loosening After Total Knee Arthroplasty: A Diagnostic Dilemma.

Metal sensitivity is increasingly prevalent and is associated with negative outcomes after total knee arthroplasty (TKA). Currently, there is no consensus on diagnostic criteria for TKA failure from immune reaction. We present a patient who had pain and aseptic effusion 2 years after TKA. Radiographs were concerning femoral loosening. Lymphocyte transformation testing showed nickel sensitivity. During revision surgery, the femoral component was loose. The histologic aseptic lymphocyte-dominated vasculitis-associated lesion score was 4 with elevated CD4+ lymphocytes, consistent with sensitization. Nickel-free revision implants were used. One year after surgery, the patient is symptom-free. This case has features suggestive of an immune reaction, with femoral loosening, and is illustrative of the diagnostic dilemma. Using a hypoallergenic knee eliminates future concern for nickel sensitivity.

Modern metal-on-metal hip resurfacing.

For this technology overview, the tools of evidence-based medicine were used to summarize information on the indications, effectiveness, and failure rates of modern metal-on-metal hip resurfacing technology. The task was complicated by the fact that resurfacing arthroplasty is commonly offered only to a subset of patients who are candidates for total hip replacement, often prohibiting direct comparisons. Comprehensive literature searches were conducted to address four key questions addressing revision rates, patient characteristics, effectiveness of treatment, and whether improved technique, surgeon experience, and/or patient selection lead to improved outcomes. Despite data limitations, it is apparent that revision rates are higher after resurfacing than after total hip arthroplasty. Potential prognostic indicators did not yield a consistent predictor of patient-oriented outcomes (eg, pain relief) for either resurfacing arthroplasty or total hip replacement. Because of differences between patients who received hip resurfacing and those who received total hip arthroplasty, the results of studies comparing these techniques cannot be interpreted. Finally, changes in technique and increased experience result in a decrease in revision rates and femoral neck fractures and improved pain and hip scores in resurfacing.

Decolonization of drug-resistant organisms before total joint arthroplasty.

Periprosthetic joint infection is now the leading cause of failure after a total knee arthroplasty, and Staphylococcus aureus, most commonly from the patient's own flora, typically is the infective agent. Several preoperative screening tests have been developed to identify patients who are carrying methicillin-resistant S aureus. Testing and decolonization programs have generally been effective in decreasing the incidence of surgical site infections, but the role of such programs in total joint arthroplasty has not been thoroughly investigated. Although recent studies found a tendency toward fewer methicillin-resistant S aureus infections after total joint arthroplasty when a testing and decolonization program was used, most of these studies were underpowered. Larger, randomized, controlled studies are needed.

Resistant organisms in infected total knee arthroplasty: occurrence, prevention, and treatment regimens.

Infection of a primary joint arthroplasty can be a life-changing event for a patient. When the infecting organism demonstrates antibiotic resistance, treatment can be prolonged, and the chances for a successful outcome may be decreased. Antibiotic resistance has been an evolutionary process since the introduction of pharmacologic treatment and until recently has been more problematic with nosocomial types of infections. Methicillin-resistant Staphylococcus aureus skin infections within the community among school or sports teams has been a recent cause for concern. Hospitals have implemented screening and/or isolation procedures to reduce the risk of spreading these resistant organisms and identify patients colonized with resistant organisms. These measures have been successful in patients undergoing total joint arthroplasty. It is important for the orthopaedic surgeon to be knowledgeable about the emergence of resistant bacteria, preoperative and intraoperative screening guidelines, and postoperative considerations to prevent resistant organism infections in total joint arthroplasty patients.

Activity recommendations after total hip and knee arthroplasty: a survey of the American Association for Hip and Knee Surgeons.

There are limited data to guide surgeon recommendations regarding activities after total joint arthroplasty. The present study aims to better clarify the current community standards. A questionnaire was distributed to the members of the American Association for Hip and Knee Surgeons attending the 2007 annual meeting inquiring about recommendations for 15 activities for patients with total hip arthroplasty or total knee arthroplasty. One hundred thirty-nine surveys were returned. Spearman rank correlation was used to analyze the data. More than 95% of the responses placed no limitations on low-impact activities including level surface walking, stair climbing, level surface bicycling, swimming, and golf. Higher-impact activities were more commonly discouraged, although there was considerable variability. Recommendations after total hip arthroplasty were more liberal compared to those after total knee arthroplasty. Higher-volume surgeons tended to be more liberal in their recommendations. No responder indicated that there was strong scientific evidence for their recommendations. Investigations are needed to elucidate the long-term effects of higher load and/or higher cycle activities on total joint arthroplasty.

Lymphocyte Transformation Testing (LTT) in Cases of Pain Following Total Knee Arthroplasty: Little Relationship to Histopathologic Findings and Revision Outcomes.

BACKGROUND: The utilization of lymphocyte transformation testing (LTT) has increased for diagnosing metal sensitivity associated with total knee arthroplasty (TKA), but its validity for the diagnosis of TKA failure due to an immune reaction has not been established. In this study, we sought to characterize the relationship of a positive LTT result to histopathologic findings and clinical and functional outcomes. METHODS: This was a retrospective study of 27 well-fixed, aseptic, primary TKA cases in which the patient had persistent pain and/or stiffness and underwent revision due to a suspected metal allergy to nickel, as determined on the basis of positive LTT. Revision procedures were performed by a single experienced arthroplasty surgeon. Periprosthetic tissue samples obtained at the time of revision surgery were scored using the aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) scoring system. RESULTS: Eight patients were categorized as mildly reactive; 8 patients, moderately reactive; and 11 patients, highly reactive to nickel by LTT. The predominant findings on routine histopathologic analysis were fibrosis and varying degrees of lymphocytic infiltration in 17 (63%) of the 27 cases. The average ALVAL score of the cohort was 3.1 ± 1.9, of a maximum score of 10. Average Knee Society Score (KSS) values improved post-revision, as did range of motion (all p < 0.01). Neither LTT stimulation index as a continuous variable nor as a categorical variable (mildly reactive, moderately reactive, highly reactive) was correlated with ALVAL score, pre-revision function (as assessed by KSS-clinical, KSS-functional, and range of motion), or change in function at the most recent follow-up (0.015 < r < 0.30, 0.13 < p < 0.95). In addition, the ALVAL score did not correlate significantly with either pre-revision or post-revision KSS or range of motion (0.061 < r < 0.365, 0.09 < p < 0.88). CONCLUSIONS: On the basis of this analysis, including histopathologic assessment, LTT results alone were insufficient for the diagnosis of TKA failure due to an immune reaction. A positive LTT may not indicate that an immune reaction is the cause of pain and stiffness post-TKA. The role of LTT in assessing TKA failure from an immune reaction needs further investigation. Diagnostic criteria for such TKA failure need to be established. LEVEL OF EVIDENCE: Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Infection in primary total knee arthroplasty: contributing factors.

Infection after a total knee arthroplasty is an infrequent but serious complication that can have devastating consequences. Infection carries a risk of significant morbidity, and the cost of treatment can be a substantial burden to the health care system. Eradication of infection can be very difficult. Prevention of infection remains the ultimate goal. Identification of host risk factors, careful patient selection, and optimization of the wound environment and the operating room remain some of the core fundamental steps that help minimize the overall incidence of infection. Although the exact role of each of these risk factors in a clinical setting can be debatable, a multidisciplinary approach incorporating all known and established methods of infection control can help to minimize the incidence of infection following total knee arthroplasty.