ABSTRACT
BACKGROUND: Personal history of autoimmune rheumatic diseases has been implicated in the development of malignant neoplasms. Our aim was to assess the risk of head and neck (H&N) cancers in patients with autoimmune rheumatic diseases. METHODS: The articles search included PubMed, EMBASE, LILACS, The Cochrane Library, CINAHL, Scopus, Web of Science, and Google Scholar with no language restrictions for studies published from inception of the databases to August 20, 2022, assessing the risk of H&N cancer in patients with autoimmune rheumatic diseases. Studies were included if they reported the standardized incidence ratio (SIR) with corresponding 95% confidence intervals (CIs). The primary outcome was risk of H&N cancers in patients with autoimmune rheumatic diseases compared with the general population. Pooled summary estimates were calculated using a random-effects model, and subgroup analyses were done to establish whether risk of H&N cancers varied according to study site. RESULTS: Our search identified 5378 records, of which 32 cohort studies were eligible for systematic review and 24 for meta-analysis (including 273 613 patients). A significant association was found between H&N cancer and autoimmune rheumatic diseases (SIR = 2.35; 95% CI: 1.57-3.50; p < 0.01, I2 = 94%). CONCLUSION: Our study suggests that patients with autoimmune rheumatic diseases had a significantly increased risk of H&N cancer compared with the general population, including thyroid, oral, and nasopharyngeal cancers. These findings have implications for the individualized screening of these patients and the planning of oncology units. The protocol is registered with PROSPERO, number CRD42020197827.
Subject(s)
Autoimmune Diseases , Head and Neck Neoplasms , Nasopharyngeal Neoplasms , Rheumatic Diseases , Humans , Head and Neck Neoplasms/complications , Autoimmune Diseases/complications , Cohort Studies , Rheumatic Diseases/complicationsABSTRACT
The styloid process is a bony projection that arises from the tympanic portion of the temporal bone, and its elongation is considered an anomaly that may be related to calcification of the stylohyoid and stylomandibular ligaments, which can trigger a series of symptoms that characterize the Eagle's syndrome. The objective of this study was to report three cases of elongated styloid process seen in human skulls, trying to alert the dentists in the knowledge of this disease in order to include it in their diagnosis, associated with atypical facial pain or in the oral cavity of to facilitate better treatment for these cases.
El proceso estiloides es una proyección ósea que tiene su origen en la porción timpánica del hueso temporal y su elongación es considerado una anomalía que puede relacionarse con la calcificación de los ligamentos estilohioídeo y estilomandibular, y de esta forma desarrollar una serie de síntomas que caracterizan al Síndrome de Eagle. El objetivo de este trabajo fue describir en tres cráneos humanos la elongación del proceso estiloides y dar a conocer al cirujano dentista esta anomalía, para que la incluya en su diagnóstico, cuando se éste presenta dolores atípicos de la cara o de la cavidad oral, y así facilitar el mejor tratamiento en estos casos.