ABSTRACT
Co-infections with human immunodeficiency virus (HIV) and Mycobacterium leprae represent unique opportunities to investigate the interaction of both pathogens. We determined the immunologic, virologic, and histopathologic characteristics of 22 co-infected Brazilian patients (median age = 38 years, 81.8% males, 72.2% with paucibacillary leprosy, and 95.4% with acquired immunodeficiency syndrome). The HIV-1 subtypes B and BF predominated in envelope and gag heteroduplex mobility analysis. Borderline tuberculoid (BT), tuberculoid, lepromatous, and indeterminate morphology with CD3+, CD8+, and CD68+ cell distributions compatible with leprosy patients not infected with HIV were observed. Histologic evidence of nerve damage was observed in BT lesions. IgM antibody to M. leprae-specific phenolic glycolipid I was not detected. Two of six co-infected patients monitored during highly active antiretroviral therapy (HAART) developed a leprosy type 1 reaction after an increase in CD4+ cells, suggesting an immune restoration phenomenon. Clinical, immunologic, histopathologic, and virologic features among these HIV-leprosy co-infected patients indicate that each disease progressed as in single infection. However, HAART immune reconstitution may trigger potential adverse effects, such as leprosy acute inflammatory episodes.
Subject(s)
HIV Infections/epidemiology , Leprosy/epidemiology , Adult , Antibodies, Bacterial/analysis , Brazil/epidemiology , CD4 Lymphocyte Count , Cohort Studies , Comorbidity , DNA, Viral/analysis , Female , HIV Infections/blood , HIV Infections/complications , HIV-1/genetics , HIV-1/isolation & purification , Humans , Leprosy/blood , Leprosy/complications , Male , Mycobacterium leprae/immunology , Mycobacterium leprae/isolation & purificationABSTRACT
Ovos uterinos de fêmeas L. minor, obtidos por eliminaçäo espontânea de abscessos cervicais da paciente W. M. R. (Pequizeiro- GO) - foram postos em contato com soluçäo de Ivermectin nas concentraçöes de 50, 100, 150, 200 e 250 microgramas. Os resultados demonstraram que a droga em todas as concentraçöes utilizadas näo impediu o desenvolvimento larvário. Entretanto, decorrida a embriogênese houve um processo de desvitalizaçäo da larva no interior do ovo caracterizado pela liberaçäo de uma massa amorfa a partir do ovo embrionado. Em ovos do grupo controle houve eclosäo de uma larva integra com todas as características estruturais de larva de Lagochilascaris
Subject(s)
Humans , Female , Ascaris/drug effects , Ivermectin/pharmacology , Abscess/drug therapy , Genital Diseases, Female/drug therapy , Ivermectin/therapeutic useABSTRACT
Temos , até o presente momento, 10 casos de lagochilascaríase humana diagnosticados em Goiás. Os autores chamam atençäo para a freqüência e distribuiçäo geográfica do parasito na área compreendida entr o norte do Estado e a regiäo sul do Pará (Amazônia Legal). Foram realizadas tentativas de reproduçäo experimental do ciclo evolutivo do verme com resultados infrutíferos