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1.
BMC Pediatr ; 22(1): 195, 2022 04 11.
Article in English | MEDLINE | ID: mdl-35410322

ABSTRACT

BACKGROUND: Literature on factors influencing medication adherence within paediatric clinical trials is sparse. The Paracetamol and Ibuprofen in the Primary Prevention of Asthma in Tamariki (PIPPA Tamariki) trial is an open-label, randomised controlled trial aiming to determine whether paracetamol treatment, compared with ibuprofen treatment, as required for fever and pain in the first year of life, increases the risk of asthma at age six years. To inform strategies for reducing trial medication crossovers, understanding factors influencing the observed ibuprofen-to-paracetamol crossovers (non-protocol adherence) is vital. The aim of this study was to investigate the factors influencing the decision-making process when administering or prescribing ibuprofen to infants that may contribute to the crossover events in the PIPPA Tamariki trial. METHODS: Constructivist grounded theory methods were employed. We conducted semi-structured interviews of caregivers of enrolled PIPPA Tamariki infants and healthcare professionals in various healthcare settings. Increasing theoretical sensitivity of the interviewers led to theoretical sampling of participants who could expand on the teams' early constructed codes. Transcribed interviews were coded and analysed using the constant comparative method of concurrent data collection and analysis. RESULTS: Between September and December 2020, 20 participants (12 caregivers; 8 healthcare professionals) were interviewed. We constructed a grounded theory of prioritising infant welfare that represents a basic social process when caregivers and healthcare professionals medicate feverish infants. This process comprises three categories: historical, trusting relationships and being discerning; and is modified by one condition: being conflicted. Participants bring with them historical ideas. Trusting relationships with researchers, treating clinicians and family play a central role in enabling participants to challenge historical ideas and be discerning. Trial medication crossovers occur when participants become conflicted, and they revert to historical practices that feel familiar and safer. CONCLUSIONS: We identified factors and a basic social process influencing ibuprofen use in infants and trial medication crossover events, which can inform strategies for promoting adherence in the PIPPA Tamariki trial. Future studies should explore the role of trusting relationships between researchers and treating clinicians when conducting research.


Subject(s)
Asthma , Ibuprofen , Acetaminophen/therapeutic use , Asthma/drug therapy , Fever/drug therapy , Grounded Theory , Humans , Ibuprofen/therapeutic use , Infant , Infant Welfare
2.
J Paediatr Child Health ; 58(10): 1847-1854, 2022 10.
Article in English | MEDLINE | ID: mdl-35869746

ABSTRACT

AIM: To explore factors influencing fever management practices and antipyretic use among New Zealand Emergency Department (ED) doctors and nurses using the Theoretical Domains Framework (TDF). METHODS: Cross-sectional survey of doctors and nurses across 11 New Zealand EDs. The questionnaire examined eight of 12 TDF domains, based on a generic questionnaire validated to assess TDF-based determinants of health-care professional behaviour. Relevant domains were identified by the frequency of beliefs; the presence of conflicting beliefs within a domain; and the likely strength of impact of a belief on paediatric fever management in the ED. RESULTS: About 602 participants (243 doctors, 353 nurses and 6 unknown) completed the survey (response rate 47.5%). Over half (351/591, 59.6%, 95% confidence interval (CI) 55.5-63.5%) knew the content of clinical practice guidelines regarding antipyretic use in febrile children (TDF Domain Knowledge), or had been trained to ensure antipyretics are given to febrile children only if they appear distressed (347/592, 58.6%, 95% CI 54.5-62.6%) (Skills). Over 40% (246/590, 95% CI 37.7-45.8%) aim to reduce the fever before discharge (Goals). Most (444/591, 75.1%, 95% CI 71.4-78.6%) participants felt capable of explaining appropriate antipyretic use to parents/care givers (Beliefs about Capabilities). Only a minority (155/584, 26.5%, 95% CI 23.0-30.3%) thought that they can ensure antipyretics are given to febrile children only if they appear distressed when the ED is busy (Environmental Context and Resources). CONCLUSIONS: Using the TDF, we identified factors influencing fever management practices and antipyretic use in the ED. These factors can guide the design of targeted, theory-informed knowledge translation strategies.


Subject(s)
Antipyretics , Antipyretics/therapeutic use , Child , Cross-Sectional Studies , Emergency Service, Hospital , Fever/drug therapy , Health Knowledge, Attitudes, Practice , Humans , New Zealand
3.
Emerg Med Australas ; 36(3): 421-428, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38311398

ABSTRACT

OBJECTIVE: To determine the prevalence of food insecurity (FI) among patients in a regional New Zealand ED, factors associated with FI and feasibility of an ED-based FI screening programme with voluntary social work (SW) follow up. METHODS: Cross-sectional study of patients presenting to the Whangarei Hospital ED, using the validated two-item Hunger Vital Sign screening tool to assess for FI. Participants were offered SW follow up to discuss community food resources. RESULTS: Of the 300 participants who completed the questionnaire, 111 (37.0%, 95% confidence interval [CI] 32.0-43.0) were food insecure. Factors associated with FI include Maori ethnicity (odds ratio [OR] 2.12 [95% CI 1.19-3.80], P = 0.011), household crowding (OR 1.19 [95% CI 1.02-1.39], P = 0.024) and lower socioeconomic status (OR 1.13 [95% CI 1.00-1.27], P = 0.048). There was no statistically significant association between FI and number of comorbidities or the primary reason for ED attendance. Of participants who were food insecure, only half reported being aware of (n = 56/111, 50.5%) or had used (n = 60/111, 54.1%) food resources. Participants who were food insecure were more likely to have utilised resources, either currently or in the past (OR 8.50 [95% CI 4.46-16.18], P < 0.001). Forty (13.3%) participants requested SW follow up and of those, most (n = 31/40, 77.5%) were successfully contacted. FI was associated with interest in SW follow up (OR 16.95 [95% CI 5.81-49.42], P < 0.001). At follow up, the majority (n = 24/31, 77.4%) of participants requested further information regarding food resources. CONCLUSION: FI was prevalent among patients in a regional NZ ED. An ED-based FI screening programme with voluntary SW follow up was feasible and acceptable to ED patients.


Subject(s)
Emergency Service, Hospital , Food Insecurity , Humans , Cross-Sectional Studies , New Zealand , Male , Female , Emergency Service, Hospital/statistics & numerical data , Middle Aged , Adult , Surveys and Questionnaires , Prevalence , Aged
4.
Emerg Med Australas ; 36(3): 436-442, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38403429

ABSTRACT

OBJECTIVE: Clinical practice guidelines (CPGs) are an important tool for the management of children with sepsis. The quality, consistency and concordance of Australian and New Zealand (ANZ) childhood sepsis CPGs with the Australian Commission on Safety and Quality in Healthcare (ACSQHC) sepsis clinical care standards and international sepsis guidelines is unclear. METHODS: We accessed childhood sepsis CPGs for all ANZ states and territories through Paediatric Research in Emergency Departments International Collaborative members. The guidelines were assessed for quality using the AGREE-II instrument. Consistency between CPG treatment recommendations was assessed, as was concordance with the ACSQHC sepsis clinical care standards and international sepsis guidelines. RESULTS: Overall, eight CPGs were identified and assessed. CPGs used a narrative and pathway format, with those using both having the highest quality overall. CPG quality was highest for description of scope and clarity of presentation, and lowest for editorial independence. Consistency between guidelines for initial treatment recommendations was poor, with substantial variation in the choice and urgency of empiric antimicrobial administration; the choice, volume and urgency of fluid resuscitation; and the choice of first-line vasoactive agent. Most CPGs were concordant with time-critical components of the ACSQHC sepsis clinical care standard, although few addressed post-acute care. Concordance with international sepsis guidelines was poor. CONCLUSION: Childhood sepsis CPGs in current use in ANZ are of variable quality and lack consistency with key treatment recommendations. CPGs are concordant with the ACSQHC care standard, but not with international sepsis guidelines. A bi-national sepsis CPG may reduce unnecessary variation in care.


Subject(s)
Practice Guidelines as Topic , Sepsis , Humans , New Zealand , Sepsis/therapy , Australia , Child
5.
BMJ Open ; 14(1): e077471, 2024 01 12.
Article in English | MEDLINE | ID: mdl-38216206

ABSTRACT

INTRODUCTION: Sepsis affects 25.2 million children per year globally and causes 3.4 million deaths, with an annual cost of hospitalisation in the USA of US$7.3 billion. Despite being common, severe and expensive, therapies and outcomes from sepsis have not substantially changed in decades. Variable case definitions, lack of a reference standard for diagnosis and broad spectrum of disease hamper efforts to evaluate therapies that may improve sepsis outcomes. This landscape analysis of community-acquired childhood sepsis in Australia and New Zealand will characterise the burden of disease, including incidence, severity, outcomes and cost. Sepsis diagnostic criteria and risk stratification tools will be prospectively evaluated. Sepsis therapies, quality of care, parental awareness and understanding of sepsis and parent-reported outcome measures will be described. Understanding these aspects of sepsis care is fundamental for the design and conduct of interventional trials to improve childhood sepsis outcomes. METHODS AND ANALYSIS: This prospective observational study will include children up to 18 years of age presenting to 12 emergency departments with suspected sepsis within the Paediatric Research in Emergency Departments International Collaborative network in Australia and New Zealand. Presenting characteristics, management and outcomes will be collected. These will include vital signs, serum biomarkers, clinician assessment of severity of disease, intravenous fluid administration for the first 24 hours of hospitalisation, organ support therapies delivered, antimicrobial use, microbiological diagnoses, hospital and intensive care unit length-of-stay, mortality censored at hospital discharge or 30 days from enrolment (whichever comes first) and parent-reported outcomes 90 days from enrolment. We will use these data to determine sepsis epidemiology based on existing and novel diagnostic criteria. We will also validate existing and novel sepsis risk stratification criteria, characterise antimicrobial stewardship, guideline adherence, cost and report parental awareness and understanding of sepsis and parent-reported outcome measures. ETHICS AND DISSEMINATION: Ethics approval was received from the Royal Children's Hospital of Melbourne, Australia Human Research Ethics Committee (HREC/69948/RCHM-2021). This included incorporated informed consent for follow-up. The findings will be disseminated in a peer-reviewed journal and at academic conferences. TRIAL REGISTRATION NUMBER: ACTRN12621000920897; Pre-results.


Subject(s)
Sepsis , Child , Humans , Australia/epidemiology , New Zealand/epidemiology , Sepsis/diagnosis , Sepsis/epidemiology , Sepsis/therapy , Research Design , Hospitalization , Observational Studies as Topic
6.
N Z Med J ; 135(1566): 22-35, 2022 12 02.
Article in English | MEDLINE | ID: mdl-36455177

ABSTRACT

AIMS: The purpose of our current study was to analyse demographic and presenting characteristics of COVID-19 patients, including assigning clinical severity scores, and analyse with respect to oxygen utilisation and hospital course. METHODS: This was a retrospective observational study of COVID-positive patients presenting to the Emergency Department at Middlemore Hospital in Auckland, New Zealand. Data were collected between 1 August 2021 and 1 November 2021. They were followed through 20 December 2021. Data were obtained from both the EMR system and paper charts for all eligible patients during the study period. RESULTS: There were 171 patients included, with 187 patient presentations. Oxygen data were collected on 123 admitted patients and showed that 47% of admission time was spent off oxygen. Of the total presentations, the median length of stay (LOS) was 4 days. The severity of presenting illness was associated with disposition and predictive of LOS. CONCLUSIONS: Approximately half of the admitted patient's hospital time involved no oxygen use, which suggests that we may be able to further risk stratify in order to decrease the number and duration of hospital admissions going forward. As expected, clinical severity scores were associated with oxygen utilisation, disposition and LOS.


Subject(s)
COVID-19 , Humans , Tertiary Care Centers , Length of Stay , Retrospective Studies , COVID-19/epidemiology , COVID-19/therapy , Oxygen/therapeutic use , New Zealand/epidemiology
7.
Emerg Med Australas ; 34(6): 943-953, 2022 12.
Article in English | MEDLINE | ID: mdl-35644989

ABSTRACT

OBJECTIVES: To assess (i) paediatric fever management practices among New Zealand ED doctors and nurses, including adherence to best practice guidelines; and (ii) the acceptability of a randomised controlled trial (RCT) of antipyretics for relief of discomfort in young children. METHODS: A cross-sectional survey of doctors and nurses across 11 New Zealand EDs. The primary outcome of adherence to paediatric fever management best practice guidelines was assessed with clinical vignettes and defined as single antipyretic use for the relief of fever-related discomfort. RESULTS: Out of 602 participants (243 doctors, 353 nurses and six unknown; response rate 47.5%), only 64 (10.6%, 95% confidence interval [CI] 8.3-13.4%) demonstrated adherence to best practice guidelines. In a febrile settled child with normal fluid intake, the percentage of participants that would use antipyretics doubled with abnormal vital signs (33.7% vs 72.9%, difference -39.2%, 95% CI -44.4% to -34.0%). Most participants would use antipyretics for reduced fluid intake (n = 494, 82.1%, 95% CI 78.8-85.0%) in a febrile settled child. Over half (n = 339, 57.1%, 95% CI 53.0-61.1%) would advise giving antipyretics to prevent febrile convulsions. Most (n = 467, 80.0%, 95% CI 76.5-83.1%) participants agreed that a RCT of antipyretics in febrile children <2 years of age with relief of discomfort as a primary outcome is needed. CONCLUSIONS: Just over 10% of New Zealand ED doctors and nurses demonstrated adherence to paediatric fever management best practice guidelines. A RCT of antipyretics in febrile children <2 years of age specifically addressing relief of discomfort as a primary outcome is strongly supported.


Subject(s)
Antipyretics , Physicians , Child , Humans , Child, Preschool , Antipyretics/therapeutic use , New Zealand , Fever/drug therapy , Emergency Service, Hospital
8.
Emerg Med Australas ; 33(6): 1074-1081, 2021 12.
Article in English | MEDLINE | ID: mdl-34142439

ABSTRACT

OBJECTIVE: To determine the prevalence of fever phobia among caregivers of children presenting to New Zealand EDs. METHODS: A cross-sectional survey was administered to caregivers of children <5 years of age presenting to three New Zealand EDs. We defined fever phobia as caregivers having a high level of concern regarding fever or having incorrect beliefs regarding the consequences of fever. RESULTS: A total of 502 caregivers completed the survey. Fever phobia was present in 365 (74.3% [95% confidence interval, CI 70.3-78.0%]) respondents, with 242 (49.3% [95% CI 44.9-53.7%]) caregivers reporting a high level of concern regarding fever, and 288 (61.8% [95% CI 57.3-66.1%]) caregivers reporting at least one incorrect belief regarding the consequences of fever. Majority of caregivers (n = 383, 87.6% [95% CI 84.2-90.4%]) knew the correct dosing interval for paracetamol, compared to less than half of caregivers (n = 179, 42.5% [95% CI 37.9-47.3%]) for ibuprofen. Caregivers reported non-evidence-based fever management practices such as sponging, always giving paracetamol and/or ibuprofen for fever, and waking children from sleep to give antipyretics. Over one-third of caregivers identified ED doctors (n = 195, 40.2% [95% CI 34.7-43.2%]) and ED nurses (n = 173, 35.7% [95% CI 31.5-40.0%]) as sources of information regarding fever management. A higher level of education was associated with fever phobia (odds ratio 1.68 [95% CI 1.04-2.72], P = 0.04). CONCLUSIONS: Fever phobia is prevalent among caregivers of children presenting to New Zealand EDs. Opportunistic caregiver education in the ED in conjunction with public health strategies are needed to dispel undue fears and misconceptions about fever.


Subject(s)
Caregivers , Phobic Disorders , Child , Cross-Sectional Studies , Emergency Service, Hospital , Humans , New Zealand/epidemiology , Phobic Disorders/epidemiology
9.
Emerg Med Australas ; 33(5): 841-847, 2021 10.
Article in English | MEDLINE | ID: mdl-33599054

ABSTRACT

OBJECTIVE: To assess validity of the STUMBL score in New Zealand for complications of blunt chest trauma without multi-trauma and immediate life-threatening injuries. METHODS: A multi-centre, retrospective observational study was carried out in five EDs. Area under the receiver operating characteristic curve (AUROC) was calculated for all, early and late complications and ethnic sub-groups. Youden Index generated for each ROC was used to indicate cut scores for risks of complication, ICU admission, prolonged length of stay (LOS) and mortality. RESULTS: A total of 445 patients were included. AUROC for all complications composite were (0.73, 95% confidence interval [CI] 0.68-0.77), mortality (0.92, 95% CI 0.89-0.94), ICU admissions (0.78, 95% CI 0.73-0.81) and prolonged LOS (0.80, 95% CI 0.76-0.83) were calculated. The score performed better in the New Zealand European (Pakeha) sub-group compared to Maori and Pasifika (AUROC [95% CI]: 0.80 [0.73-0.85], 0.69 [0.56-0.79], 0.66 [0.46-0.82], respectively). Patients with scores >12 were at risk of complications from blunt chest trauma, >15 at risk of prolonged LOS and >18 at risk of ICU admission and mortality. CONCLUSIONS: The STUMBL score at a cut-off of <12 did not predict all complications sufficiently well to recommend for general use in our population. However, a score >15 predicted prolonged LOS and a score >18 predicted mortality sufficiently to be clinically useful for these outcomes. The score is more accurate in New Zealand Pakeha and needs to be used with caution in Maori and Pasifika populations. A larger prospective validation is required to further assess the score.


Subject(s)
Thoracic Injuries , Wounds, Nonpenetrating , Humans , ROC Curve , Retrospective Studies , Risk Assessment , Thoracic Injuries/diagnosis , Thoracic Injuries/epidemiology , Thoracic Injuries/therapy , Wounds, Nonpenetrating/complications , Wounds, Nonpenetrating/diagnosis , Wounds, Nonpenetrating/therapy
10.
Arch Dis Child ; 106(4): 339-344, 2021 04.
Article in English | MEDLINE | ID: mdl-33067310

ABSTRACT

OBJECTIVE: To determine if administration of oral prednisolone to preschool children with acute wheeze alters respiratory outcomes. DESIGN: Double-blind, randomised, placebo-controlled equivalence trial. SETTING: Three hospitals in New Zealand. PATIENTS: 477 children aged 24-59 months with acute wheeze associated with respiratory illness. INTERVENTIONS: 2 mg/kg (maximum 40 mg) oral prednisolone or similar placebo, once daily for 3 days. MAIN OUTCOME MEASURES: Primary outcome was change in Preschool Respiratory Assessment Measure (PRAM) score 24 hours after intervention. Secondary outcomes included PRAM score at 4 hours, length of emergency department and inpatient stays, admission and representation rates, time to return to normal activities and use of additional oral prednisolone or intravenous medications. Analysis was by intention-to-treat. RESULTS: There was no difference between groups for change in PRAM score at 24 hours (difference between means -0.39, 95% CI -0.84 to 0.06, p=0.09). Absolute PRAM score was lower in the prednisolone group at 4 hours (median (IQR) 1 (0-2) vs 2 (0-3), p=0.01) and 24 hours (0 (0-1) vs 0 (0-1), p=0.01), when symptoms had resolved for most children regardless of initial treatment. Admission rate, requirement for additional oral prednisolone and use of intravenous medication were lower in the prednisolone group, although there were no differences between groups for time taken to return to normal activities or rates of representation within 7 days. CONCLUSION: Oral prednisolone does not alter respiratory outcomes at 24 hours or beyond in preschool children presenting with acute wheeze.


Subject(s)
Adrenal Cortex Hormones/therapeutic use , Prednisolone/therapeutic use , Respiratory Sounds/drug effects , Respiratory Tract Diseases/complications , Acute Disease , Administration, Oral , Adrenal Cortex Hormones/administration & dosage , Case-Control Studies , Child, Preschool , Double-Blind Method , Emergency Service, Hospital/statistics & numerical data , Female , Hospitalization/statistics & numerical data , Humans , Male , New Zealand/epidemiology , Outcome Assessment, Health Care , Placebos/administration & dosage , Prednisolone/administration & dosage , Respiratory Sounds/physiopathology
11.
Int Emerg Nurs ; 57: 101046, 2021 07.
Article in English | MEDLINE | ID: mdl-34243105

ABSTRACT

INTRODUCTION: Emergency department (ED) staff face daily exposure to the illness, injury, intoxication, violence and distress of others. Rates of clinician burnout are high and associated with poor patient outcomes. This study sought to measure the prevalence of burnout in ED personnel as well as determine the important facilitators of and barriers to workplace wellbeing. METHOD: An anonymous online survey including six open-ended questions on workplace wellbeing was completed by 1372 volunteer participants employed as nurses, doctors, allied health or nonclinical roles at 22 EDs in Aotearoa, New Zealand in 2020. Responses to the questions were analysed using a general inductive approach. RESULTS: The three key themes that characterise what matters most to participants' workplace wellbeing are: (1) Supportive team culture (2) Delivering excellent patient-centred care and (3) Professional development opportunities. Opportunities to improve wellbeing also focused on enhancements in these three areas. CONCLUSION: In order to optimise workplace wellbeing, emergency departments staff value adequate resourcing for high-quality patient care, supportive and cohesive teams and professional development opportunities. Initiatives in these areas may facilitate staff wellbeing as well as improving safety and quality of patient care.


Subject(s)
Burnout, Professional , Workplace Violence , Emergency Service, Hospital , Humans , New Zealand , Surveys and Questionnaires , Workplace
12.
N Z Med J ; 134(1541): 96-110, 2021 09 03.
Article in English | MEDLINE | ID: mdl-34531600

ABSTRACT

AIM: To quantify staff burnout and wellbeing in emergency departments (EDs) throughout New Zealand (NZ). METHODS: A national cross sectional electronic survey of New Zealand clinical and non-clinical ED staff was conducted between 9 March and 3 April 2020. Burnout and wellbeing were assessed using the Copenhagen Burnout Inventory (CBI) and a variety of quantitative measures. Differences between measures were assessed by demography and work role using univariate analyses. Multivariate analyses assessed associations between burnout and wellbeing. RESULTS: 1,372 staff responded from 22 EDs around New Zealand (response rate 43%). Most were female (n=678, 63%), NZ European (n=799, 59%), aged 20-39 years (n=743, 54%) and nurses (n=711, 52%). The overall prevalence of personal burnout was 60%, work-related burnout 55% and patient-related burnout 19%. There was a wide variation of burnout across all EDs. Females and nurses showed the highest degree of burnout by gender and role, respectively. Measures of wellbeing with significant negative correlations with burnout were work-related happiness, work-life balance, job satisfaction and perceived workplace excellence. Work stress had significant positive correlation with burnout. CONCLUSION: New Zealand ED staff have a high degree of burnout. Safety, financial sustainability and quality of care are likely being adversely affected. Stakeholders can be informed by findings from this study to inspire meaningful interventions in EDs and throughout the New Zealand healthcare system.


Subject(s)
Burnout, Professional/epidemiology , Emergency Service, Hospital , Health Personnel , Mental Health , Administrative Personnel , Adult , Allied Health Personnel , Burnout, Psychological/epidemiology , Emergency Medicine , Emergency Nursing , Female , Humans , Male , Middle Aged , New Zealand/epidemiology , Nurses , Physicians , Pilot Projects , Prevalence , Workplace , Young Adult
13.
JAMA Netw Open ; 3(10): e2022398, 2020 10 01.
Article in English | MEDLINE | ID: mdl-33125495

ABSTRACT

Importance: Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children. Despite the common use of these medications, treatment recommendations for young children remain divergent. Objective: To compare acetaminophen with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years. Data Sources: Systematic search of the databases MEDLINE, Embase, CINAHL, and the Cochrane Central Register of Controlled Trials and the trial registers ClinicalTrials.gov and the Australian New Zealand Clinical Trials Registry from inception to March 2019, with no language limits. Study Selection: Studies of any design that included children younger than 2 years and directly compared acetaminophen with ibuprofen, reporting antipyretic, analgesic, and/or safety outcomes were considered. There were no limits on length of follow-up. Data Extraction and Synthesis: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline, 2 authors independently extracted data and assessed quality. Data were pooled using a fixed-effects method if I2 was less than 50% and using a random-effects method if I2 was 50% or greater. Main Outcomes and Measures: The primary outcomes were fever or pain within 4 hours of treatment onset. Safety outcomes included serious adverse events, kidney impairment, gastrointestinal bleeding, hepatotoxicity, severe soft tissue infection, empyema, and asthma and/or wheeze. Results: Overall, 19 studies (11 randomized; 8 nonrandomized) of 241 138 participants from 7 countries and various health care settings (hospital-based and community-based) were included. Compared with acetaminophen, ibuprofen resulted in reduced temperature at less than 4 hours (4 studies with 435 participants; standardized mean difference [SMD], 0.38; 95% CI, 0.08-0.67; P = .01; I2 = 49%; moderate quality evidence) and at 4 to 24 hours (5 studies with 879 participants; SMD, 0.24; 95% CI, 0.03-0.45; P = .03; I2 = 57%; moderate-quality evidence) and less pain at 4 to 24 hours (2 studies with 535 participants; SMD, 0.20; 95% CI, 0.03-0.37; P = .02; I2 = 25%; moderate-quality evidence). Adverse events were uncommon. Acetaminophen and ibuprofen appeared to have similar serious adverse event profiles (7 studies with 27 932 participants; ibuprofen vs aceteminophen: odds ratio, 1.08; 95% CI, 0.87-1.33; P = .50, I2 = 0%; moderate-quality evidence). Conclusions and Relevance: In this study, use of ibuprofen vs acetaminophen for the treatment of fever or pain in children younger than 2 years was associated with reduced temperature and less pain within the first 24 hours of treatment, with equivalent safety.


Subject(s)
Acetaminophen/standards , Fever/drug therapy , Ibuprofen/standards , Pain/drug therapy , Acetaminophen/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/standards , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Child, Preschool , Female , Humans , Ibuprofen/therapeutic use , Infant , Male
14.
BMJ Open ; 10(12): e038296, 2020 12 10.
Article in English | MEDLINE | ID: mdl-33303437

ABSTRACT

INTRODUCTION: Asthma is one of the most common diseases in the world and is a global public health burden. There is an urgent need for research that leads to evidenced-based primary prevention strategies to reduce the prevalence of asthma. One novel risk factor that might have a role in the pathogenesis of asthma is the use of paracetamol in early life. This trial aims to determine if paracetamol, compared with ibuprofen use, as required for fever and pain in the first year of life, increases the risk of asthma at age 6 years. METHODS AND ANALYSIS: The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial. 3922 infants born at ≥32 weeks' gestation will be randomly allocated to receive only paracetamol or only ibuprofen for treatment of fever and pain, if required in the first year of life. The primary outcome is asthma at 6 years of age, defined as the presence of wheeze in the preceding 12 months. Secondary outcomes include hospital admissions for bronchiolitis, wheeze or asthma in the first year of life, and within the first 6 years of life; wheeze at 3 years of age; eczema within the first year and at 3 and 6 years of age; atopy at 3 and 6 years of age. ETHICS AND DISSEMINATION: The trial has been approved by the Northern A Health and Disability Ethics Committee of New Zealand (17/NTA/233). Dissemination plans include publication in international peer-reviewed journals, and presentation at national and international scientific meetings, assimilation into national and international guidelines, and presentation of findings to lay audiences through established media links. TRIAL REGISTRATION NUMBER: ACTRN12618000303246; Pre-results.


Subject(s)
Acetaminophen , Asthma , Acetaminophen/therapeutic use , Asthma/drug therapy , Asthma/prevention & control , Child , Child, Preschool , Humans , Ibuprofen/therapeutic use , Infant , Infant, Newborn , Multicenter Studies as Topic , New Zealand , Pain , Primary Prevention , Randomized Controlled Trials as Topic
15.
Emerg Med Australas ; 19(6): 515-22, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18021103

ABSTRACT

OBJECTIVES: To determine previous computer training and current computer confidence of emergency medicine (EM) specialists and trainees, and to determine the accessibility of computer and Internet resources in New Zealand ED. METHODS: A prospective, cross-sectional study of all New Zealand EM specialists and trainees between July 2005 and October 2005, using a 47-item postal questionnaire. Descriptive statistics with 95% confidence intervals were compiled. Fisher's exact test was used to compare proportions, with t-test and Mann-Whitney U-test to compare continuous variables. RESULTS: A total of 226 EM specialists and trainees were sent questionnaires. In total, 144 (62 specialists and 82 trainees) out of 224 were analysed (response rate 64.3%). The majority of respondents (136, 94.4% (95% CI 89.4-97.6)) had access to a computer at home. Almost all respondents (143, 99.3% (95% CI 96.2-100.0)) also had computer access in the ED 24 h/day. The vast majority (140, 97.2% (95% CI 93.0-99.2)) had access to medical educational materials via the Internet in the ED 24 h/day. Most respondents had limited prior computer training. Respondents felt most confident using word processing and e-mail/communications applications, and least confident using statistical and graphics programs. Compared with specialists, trainees were significantly less confident with spreadsheets (P = 0.002), literature searching (P = 0.034), and e-mail/communications (P = 0.040). CONCLUSIONS: Increased access to computer technology has not been parallelled by increased confidence in the use of computers among EM specialists and trainees. Training must address gaps in computer literacy if computer technology is to be used to its full potential.


Subject(s)
Computer Literacy , Emergency Medicine , Emergency Service, Hospital/organization & administration , Hospital Information Systems/statistics & numerical data , Internet/statistics & numerical data , Adult , Cross-Sectional Studies , Emergency Medicine/education , Female , Humans , Male , Middle Aged , New Zealand , Professional Competence , Prospective Studies
16.
Emerg Med Australas ; 27(5): 453-9, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26235786

ABSTRACT

OBJECTIVE: To evaluate the relative acceptability of the flipped classroom approach compared with traditional didactics for in-house teaching in emergency medicine. METHODS: Our department changed its learning model from a 'standard' lecture-based model to a 'flipped classroom' model. The 'flipped classroom' included provided pre-session learning objectives and resources before each 2 h weekly session. In-session activities emphasised active learning strategies and knowledge application. Feedback was sought from all medical staff regarding the acceptability of the new approach using an online anonymous cross-sectional qualitative survey. RESULTS: Feedback was received from 49/57 (86%) medical staff. Ninety-eight per cent (48/49) of respondents preferred the flipped classroom over the traditional approach. Aspects of the flipped classroom learners liked most included case-based discussion, interaction with peers, application of knowledge, self-directed learning and small-group learning. Barriers to pre-session learning include work commitments, 'life', perceived lack of time, family commitments, exam preparation and high volume of learning materials. Reported motivational factors promoting pre-session learning include formal assessment, participation requirements, more time, less material, more clinical relevance and/or more interesting material. Case studies and 'hands-on' activities were perceived to be the most useful in-session activities. CONCLUSION: The flipped classroom shows promise as an acceptable approach to in-house emergency medicine teaching.


Subject(s)
Emergency Medicine/education , Teaching/methods , Humans , Internship and Residency/methods , Surveys and Questionnaires , Teaching Materials
17.
J Paediatr Child Health ; 43(7-8): 560-3, 2007.
Article in English | MEDLINE | ID: mdl-17635687

ABSTRACT

AIM: International guidelines recommend that children who are managed at home with mechanical respiratory support (RS) should have sleep studies performed every 6-12 months. This recommendation is based on expert opinion, with little evidence to support it. No studies have been undertaken to examine the utility of sleep studies in children on RS. METHODS: A retrospective review of sleep studies performed over a 12-month period was undertaken at a New Zealand paediatric sleep medicine referral centre, to determine changes made to RS following sleep studies. RESULTS: Sixty-one sleep studies were performed for assessment of RS in 45 children (27 boys; median age 8.3 years; range 0.4-18.6 years). Twenty-nine (64%) children were on continuous positive airway pressure, 14 (31%) on bi-level non-invasive ventilation, and two (4%) on tracheostomy ventilation. A change was made to RS settings after 66% of studies. No clinical parameters predicted which children would require a change in settings. CONCLUSIONS: Although sleep studies are expensive and time-consuming, follow-up studies of children on RS provide important information for optimising management into the long term.


Subject(s)
Polysomnography , Respiration, Artificial/standards , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , New Zealand , Positive-Pressure Respiration/standards , Positive-Pressure Respiration/statistics & numerical data , Respiration, Artificial/methods , Respiration, Artificial/statistics & numerical data , Sleep/physiology , Tracheostomy/standards , Tracheostomy/statistics & numerical data
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