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1.
Morpholine containing CB2 selective agonists.
Zindell, Renée; Riether, Doris; Bosanac, Todd; Berry, Angela; Gemkow, Mark J; Ebneth, Andreas; Löbbe, Sabine; Raymond, Ernest L; Thome, Diane; Shih, Daw-Tsun; Thomson, David.
Bioorg Med Chem Lett ; 19(6): 1604-9, 2009 Mar 15.
Article in English | MEDLINE | ID: mdl-19243942

ABSTRACT

Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing.


Subject(s)
Morpholines/chemical synthesis , Receptor, Cannabinoid, CB2/agonists , Analgesics/chemical synthesis , Analgesics/pharmacology , Animals , Anti-Inflammatory Agents/pharmacology , Cell Line , Chemistry, Pharmaceutical/methods , Drug Design , Humans , Inflammation , Mice , Models, Chemical , Molecular Structure , Morpholines/pharmacology , Receptor, Cannabinoid, CB2/chemistry , Stereoisomerism
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