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1.
ORL J Otorhinolaryngol Relat Spec ; 84(3): 211-218, 2022.
Article in English | MEDLINE | ID: mdl-34500448

ABSTRACT

INTRODUCTION: There are particular challenges in the implantation of malformed cochleae, such as in cases of facial nerve anomalies, cerebrospinal fluid (CSF) leaks, erroneous electrode insertion, or facial stimulation, and the outcomes may differ depending on the severity of the malformation. The aim of this study was to assess the impact of inner ear malformations (IEMs) on surgical complications and outcomes of cochlear implantation. METHODS: In order to assess the impact of IEMs on cochlear implant (CI) outcomes, 2 groups of patients with similar epidemiological parameters were selected from among 863 patients. Both the study group (patients with an IEM) and control group (patients with a normal inner ear) included 25 patients who received a CI and completed at least 1 year of follow-up. Auditory performance, receptive and expressive language skills, and production and use of speech were evaluated preoperatively and at least 1 year after implantation. Types of surgical complications and rates of revision surgeries were determined in each group. RESULTS: In the study group, the most common malformation was an isolated enlarged vestibular aqueduct (EVA) (44.8%). Overall, the patients with IEMs showed significant improvement in auditory-verbal skills. In general, the patients who had normal cochleae scored significantly better compared to patients with IEMs (p < 0.05). The complication rate was significantly lower in the control group compared to the study group (p = 0.001), but the rate of revision surgeries did not differ significantly (p = 0.637). CONCLUSION: It is possible to improve communication skills with CIs in patients with IEMs despite the variations in postoperative performances. Patients with EVA, incomplete partition type 2, and cochlear hypoplasia type 2 were the best performers in terms of auditory-verbal skills. Patients with IEMs scored poorly compared to patients with normal cochleae. CSF leak (gusher or oozing) was the most common complication during surgery, which is highly likely in cases of incomplete partition type 3.


Subject(s)
Cochlear Implantation , Cochlear Implants , Ear, Inner , Cochlear Implantation/adverse effects , Communication , Ear, Inner/surgery , Hearing Loss, Sensorineural , Humans , Retrospective Studies , Vestibular Aqueduct/abnormalities
2.
ORL J Otorhinolaryngol Relat Spec ; 83(4): 280-285, 2021.
Article in English | MEDLINE | ID: mdl-33784673

ABSTRACT

INTRODUCTION: Cochlear implant (CI) surgery is a safe and standardized procedure in the presence of normal temporal bone anatomy. However, in the surgery of patients with chronic otitis media (COM), the surgeon may encounter several problems. The aim of this study was to evaluate the impact of COM with and without cholesteatoma on surgical and auditory outcomes of CIs. METHODS: The study group consisted of 39 patients with COM who received CIs. Age- and gender-matched 38 standard CI patients served as controls. The surgical techniques and complications, pure tone audiometry (PTA) scores, speech discrimination scores (SDS), and the International Outcome Inventory for Hearing Aids (IOI-HA) questionnaire results of the groups were compared. RESULTS: The presence of COM was associated with a higher rate of complication than controls. Staging the surgeries, presence or absence of cholesteatoma, and type of surgical technique were not associated with surgical outcomes and complications (p > 0.05). There was no significant difference between the groups in terms of postoperative PTA scores, SDS, and IOI-HA scores (p > 0.05). CONCLUSION: Postoperative complications like device failure and skin breakdown are increased in cases of COM compared to standard CI surgeries. However, that increase is not associated with staging the surgeries, presence or absence of cholesteatoma, and type of ear surgery performed. It is advocated to close the external ear canal and eustachian tube without mastoid obliteration in the presence of a radical mastoidectomy cavity, which will decrease the postoperative complication rates and allow for radiological follow-up with computed tomography for the possibility of cholesteatoma recurrence. The auditory benefits of CI in patients with and without COM are comparable.


Subject(s)
Cholesteatoma, Middle Ear , Cholesteatoma , Cochlear Implantation , Otitis Media , Audiometry, Pure-Tone , Cholesteatoma, Middle Ear/complications , Cholesteatoma, Middle Ear/surgery , Chronic Disease , Humans , Mastoid/surgery , Otitis Media/complications , Otitis Media/surgery , Retrospective Studies , Treatment Outcome
3.
Turk J Med Sci ; 51(5): 2584-2591, 2021 Oct.
Article in English | MEDLINE | ID: mdl-34174800

ABSTRACT

BACKGROUND: The study aims to evaluate the usage of gold weight implants and monitor complaints and comfort of patients. METHODS: A hundred and ninety-one implantations performed between January 2009 and January 2019 were analyzed. Seventy-eight patients included in this study The average age of the patients was 51.3 ± 14.5 years. Forty-five (57.7%) of them were male and 33 (42.3%) female. Patient satisfaction was measured with a questionnaire containing the most common complaints related to gold weight in the literature through telephone surveys. RESULTS: The average follow-up time was 74.5 months. Ninety-three-point-five percent of subjects had operational causes, among which the most widespread was acoustic neuroma (44.9%). The average time between facial paralysis and implantation was 141.1 days. Implantation was performed 26.6 days on average after acoustic neuroma surgery and 3.2 days on average after temporal zone malignancy surgery. Thirty-eight patients had their implants removed over either complication (n = 14) or recovery (n = 24). Recovery was the fastest after facial nerve decompression (mean= 4.75 ± 3.6 (2-10) months) and the slowest after 7-12 cranial nerve transfer (mean= 18.3 ± 8.2 (3-31) months). Twenty-six-point-nine percent (n = 21) of patients had complications, of which the most common was extrusion (n = 10). The overall satisfaction rate was 88.5% with the highest in visual acuity and the lowest in continuous requirement for artificial tear. DISCUSSION: The gold weight implantation is an effective, reversible, and easy procedure significantly reducing complaints regarding paralytic lagophthalmos. Early implementation may be beneficial for ocular complications. A dynamic facial reanimation could terminate need of implant.


Subject(s)
Facial Paralysis , Neuroma, Acoustic , Humans , Female , Male , Adult , Middle Aged , Aged , Neuroma, Acoustic/complications , Neuroma, Acoustic/surgery , Prostheses and Implants , Facial Paralysis/etiology , Facial Paralysis/surgery , Eye , Gold
4.
Turk J Med Sci ; 49(5): 1426-1432, 2019 Oct 24.
Article in English | MEDLINE | ID: mdl-31651106

ABSTRACT

Background/aim: To compare outcomes of canal wall up (CWU) and canal wall down (CWD) techniques in the treatment of middle ear cholesteatoma. Materials and methods: Medical records of 76 patients who had a primary surgery due to middle ear cholesteatoma between July 2015 and November 2017 were reviewed retrospectively. Hearing thresholds, speech discrimination scores (SDS), recurrences, and revision surgeries of CWU and CWD surgeries were compared. Results: Of 76 cholesteatoma cases, 40 (52.6%) had a CWU and 36 (47.4%) had a CWD operation. Postoperatively, the mean air conduction thresholds were significantly better in CWU compared to CWD surgeries (P = 0.016). The presence of the stapes and the type of reconstruction material used did not have a significant effect on auditory success rates (P = 0.342 and P = 0.905, respectively). Auditory success was affected by the status of the middle ear mucosa as well. The recurrence and revision rates did not differ between the surgical techniques (P > 0.05). Conclusion: Status of the middle ear mucosa and external auditory canal are important factors affecting the outcomes in cholesteatoma. Instead of a CWD surgery, a CWU surgery seems applicable in cases of cholesteatoma when the bone in the external auditory canal is not eroded by the disease.


Subject(s)
Cholesteatoma, Middle Ear/surgery , Otologic Surgical Procedures/methods , Adolescent , Adult , Child , Female , Hearing Tests , Humans , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Young Adult
5.
J Craniofac Surg ; 27(1): 51-5, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26703033

ABSTRACT

OBJECTIVE: To investigate the effect of septal deviation severity on the dimensions of the lateral lamina of the cribriform plate (LLCP), middle turbinate length (MTL), and the angle of the lateral lamella of the cribriform plate (ALLCP). METHODS: Paranasal computed tomography (CT) scans of 148 patients with septum deviation (102 males, 46 females; age range 18-63 years) were retrospectively evaluated. The patients were divided into 3 groups according to the measured angle of nasal septal deviation as mild (<9°), moderate (9-15°), or severe (>15°). Height and width of LLCP, MTL, and ALLCP on both sides were measured and these parameters were compared between the groups according to the septal deviation side. RESULTS: The nasal septum was deviated to the right in 73 patients (49.3%) and to the left in 75 patients (50.7%). The LLCP dimensions, MTL, and ALLCP between the groups at the contralateral side were not statistically different (P > 0.05). The LLCP height, ALLCP between the groups at the ipsilateral side were not statistically different (P > 0.05). There was a significant difference in the LLCP width at the ipsilateral side between the groups (P = 0.039). The MTL at the ipsilateral side was significantly different between the groups (P = 0.003). CONCLUSION: The severity of nasal septum deviation in patients with nasal septum deviation affects the ipsilateral LLCP width and the ipsilateral MTL. These findings suggest that the increase in the severity of septum deviation in patients undergoing endoscopic sinus surgery does not increase the risk of possible damages that may occur in LLCP.


Subject(s)
Ethmoid Bone/diagnostic imaging , Nasal Septum/abnormalities , Turbinates/diagnostic imaging , Adolescent , Adult , Cephalometry/methods , Endoscopy/methods , Ethmoid Sinus/diagnostic imaging , Female , Frontal Bone/diagnostic imaging , Humans , Male , Middle Aged , Nasal Septum/diagnostic imaging , Retrospective Studies , Tomography, X-Ray Computed/methods , Young Adult
6.
Tuberk Toraks ; 64(4): 283-288, 2016 Dec.
Article in English | MEDLINE | ID: mdl-28393717

ABSTRACT

INTRODUCTION: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. PATIENTS AND METHODS: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of ≥ 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group. RESULT: 47 children (51% male and 49% female; mean age 7.8 ± 2.6 years) were recruited. Twenty seven participants were diagnosed with moderate-to-severe OSAS, and twenty children who had AHI < 5 were included in the mild OSAS/primary snoring. The two groups did not differ regarding age, gender and body mass index z score (p> 0.05). Furthermore there were no differences in log serum leptin levels (p= 0.749). Log serum leptin levels correlated with the BMI z score in the whole study group (p= 0.001; r= 0.499) but they were not associated with apnea-hypopnea index, mean and lowest oxygen saturation during sleep. CONCLUSIONS: Serum leptin levels are affected by adiposity but not by OSAS severity among children with habitual snoring.


Subject(s)
Biomarkers/blood , Leptin/blood , Pediatric Obesity , Sleep Apnea, Obstructive/blood , Adolescent , Body Mass Index , Child , Female , Humans , Infant , Male , Polysomnography , Severity of Illness Index , Sleep Apnea, Obstructive/complications , Snoring/etiology
7.
Eur Arch Otorhinolaryngol ; 272(5): 1091-7, 2015 May.
Article in English | MEDLINE | ID: mdl-24504490

ABSTRACT

Our aim was to assess the effects of polylactic acid (PLA) on middle ear mucosa and cochlea, to be used as a film barrier for postoperative adhesion prevention in the middle ear. Twenty-one albino Guinea pigs were included in the study. A window was opened on both tympanic bulla and on one side PLA material was placed in the middle ear and on the other side only fenestration was performed and used as a control. All Guinea pigs underwent evaluation of tympanic membranes microscopically; functional hearing was analyzed by auditory brainstem responses preoperatively, in the first and the sixth month. All Guinea pigs were killed on the sixth month for histopathologic evaluation of their temporal bones. There was no statistical difference between both groups regarding hearing thresholds, interpeak wave latencies preoperatively and on first and the sixth months postoperatively. Histopathological evaluation revealed no specific changes. There was a mild local inflammation both in the PLA implanted and control ears. PLA film barrier most likely has no toxic effects on Guinea pig middle ear and does not show any ototoxic side effects.


Subject(s)
Cochlea/drug effects , Ear, Middle/drug effects , Lactic Acid/adverse effects , Membranes, Artificial , Polymers/adverse effects , Tissue Adhesions/prevention & control , Animals , Cochlea/physiopathology , Ear, Middle/pathology , Ear, Middle/surgery , Evoked Potentials, Auditory, Brain Stem/drug effects , Guinea Pigs , Lactic Acid/therapeutic use , Male , Mucous Membrane/drug effects , Mucous Membrane/pathology , Otitis Media/surgery , Polyesters , Polymers/therapeutic use , Random Allocation , Treatment Outcome , Tympanic Membrane/drug effects , Tympanic Membrane/physiopathology
8.
J Pak Med Assoc ; 64(4): 468-70, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24864648

ABSTRACT

The incidence of numerous head and neck tumours is a known issue though bilateral synchronous tonsillar carcinoma reports are so uncommon that only 20 cases were found in a literature review. Most of these patients were treated with bilateral tonsillectomy followed by adjuvant radiotherapy. We report, to our knowledge, the first case of bilateral synchronous tonsillar squamous cell carcinoma treated only with chemoradiotherapy without tonsillectomy.


Subject(s)
Carcinoma, Squamous Cell/therapy , Chemoradiotherapy , Head and Neck Neoplasms/therapy , Neoplasms, Multiple Primary/therapy , Tonsillar Neoplasms/therapy , Carcinoma, Squamous Cell/pathology , Head and Neck Neoplasms/pathology , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasms, Multiple Primary/pathology , Squamous Cell Carcinoma of Head and Neck , Tonsillar Neoplasms/pathology
9.
Ear Nose Throat J ; 100(6): NP299-NP307, 2021 Jul.
Article in English | MEDLINE | ID: mdl-31581828

ABSTRACT

The relationship between objective vestibular tests and subjective vestibular tests is a controversial topic. In this study, to contribute to this issue, the vestibulo-ocular reflex features and their relationship with balance perception at long-term follow-up in vestibular neurectomy (VN) and total labyrentectomy patients were evaluated. Prospectively, 19 VN and 18 labyrinthectomy patients were enrolled in this study. Patients underwent video head impulse test (VHIT) as objective vestibular test and dizziness handicap inventory (DHI) as subjective vestibular test when they attended to their control visit follow-up between March and September 2017. Lateral canal corrective saccades were classified as organized pattern and deorganized (scattered) pattern. In our results, the saccade pattern analysis (between organized and deorganized saccades) regarding the DHI scores gave P value as .039 for covert saccade pattern and .050 for overt saccade pattern. Therefore, we conclude that the presence of saccades, their patterns, and amplitudes provide extra information at assessing the results of the VHIT test, and the organized pattern of saccades is related to a stable vestibular system and better balance perception.


Subject(s)
Diagnostic Self Evaluation , Disability Evaluation , Dizziness/diagnosis , Reflex, Vestibulo-Ocular , Vestibular Diseases/physiopathology , Adolescent , Adult , Aged , Dizziness/etiology , Female , Head Impulse Test , Humans , Male , Middle Aged , Postoperative Period , Prospective Studies , Reproducibility of Results , Saccades , Vestibular Diseases/complications , Vestibular Diseases/surgery , Vestibular Nerve/surgery , Vestibule, Labyrinth/surgery , Young Adult
10.
Turk Arch Otorhinolaryngol ; 59(1): 14-19, 2021 Mar.
Article in English | MEDLINE | ID: mdl-33912856

ABSTRACT

OBJECTIVE: To evaluate the long-term balance outcomes of vestibular nerve section (VNS) and labyrinthectomy (L) operations. The indirect outcomes will be the correlation of objective and subjective test results and an analysis of anterior-posterior versus medial-lateral computerized posturography (CP) scores. METHODS: This retrospective study evaluated objective CP and subjective Dizziness Handicap Inventory (DHI) results of patients who underwent VNS and L surgeries for Ménière's disease. RESULTS: A total of 55 (31 VNS and 24 L) patients were included in the study. The two operation groups were similar in terms of age, and mean time between surgery and the tests (p=0.465 and p=0.616) respectively. The vestibular and global scores at anterior-posterior CP showed statistically significant differences between the groups (p=0.000 and p=0.007) respectively in favor of the VNS group. In addition, the comparison of the vestibular CP scores of anterior-posterior and medial-lateral evaluations of the entire study population was lower in the medial-lateral evaluation (p=0.000). The mean DHI scores did not show statistically significant differences (p=0.359) between operation groups, nor did the correlation analysis between CP and DHI scores reveal statistical significance (p values >0.05). CONCLUSION: In the long term, objective balance outcomes are better for VNS patients than for L patients. Additionally, medial-lateral balance outcomes are more affected than anterior-posterior balance outcomes from unilateral ablative surgeries. Subjective balance perception is not different between the two surgery groups, and DHI scores do not show a correlation with CP scores.

11.
Otol Neurotol ; 40(4): 464-470, 2019 04.
Article in English | MEDLINE | ID: mdl-30870356

ABSTRACT

OBJECTIVE: To assess the etiology, demographics, rates and outcomes of revision surgeries, and device survival rates after cochlear implantation. STUDY DESIGN: Retrospective case review. SETTING: Tertiary Otology & Neurotology center. PATIENTS: Cochlear implantees who received revision surgeries after implantation INTERVENTIONS:: Any surgical intervention, performed due to device failure or the major complications of cochlear implantation. MAIN OUTCOME MEASURE: Medical records of the patients who received cochlear implants (CIs) between July 2002 and March 2018 were reviewed retrospectively regarding postoperative complications. Demographic data, device survival rates, and causes of revisions were recorded. RESULTS: Totally, 924 implantations were performed in 802 patients. Eighty one (8.7%) of them underwent 102 revision surgeries. The most common causes of revision surgeries were device failures and flap related problems which were seen in 28 and 18 patients, respectively.Overall CI survival rate was 91.9% in a 10 years period, which remained almost stable after 10 years. Although age was not found to be related with device failure (p = 0.693), device loss rates were significantly higher in adult implantees than children (p = 0.006). CONCLUSION: Device failure seems the most common cause of revision. The revision surgeries are usually safe and help to resolve the problem although flap problems are the most difficult to treat and may necessitate multiple revision surgeries. The device failure rate may reach to a plateau after 6 years. Overall CI survival rate exceeds 90% in 10 years period, and then remains stable.


Subject(s)
Cochlear Implantation , Cochlear Implants , Equipment Failure , Postoperative Complications/surgery , Reoperation , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Cochlear Implantation/adverse effects , Cochlear Implants/adverse effects , Female , Humans , Infant , Male , Middle Aged , Postoperative Complications/etiology , Retrospective Studies , Surgical Flaps , Young Adult
12.
Otolaryngol Head Neck Surg ; 138(2): 162-5, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18241709

ABSTRACT

OBJECTIVE: To determine the reliability of medial canthus as a surface landmark to locate supratrochlear vascular pedicle. STUDY DESIGN AND SETTING: The distance from medial canthal line to supratrochlear vascular pedicle was measured in 57 healthy volunteers (Doppler imaging study) and also in 15 fresh cadavers. RESULTS: In the Doppler study, the pedicle was found at most 3 mm lateral or medial to medial canthus (mean +/- SD, 0.8 +/- 0.7 mm). SVP mark tended to be medial to the medial canthus mark in females (males, 6; females, 42), whereas it was lateral to it in males (males, 20; females, 5). In the cadaver study, the pedicle was found 0.7 mm away from medial canthus on average. CONCLUSION: Medial canthus can be used as a reliable landmark for paramedian forehead flaps. When Doppler examination fails, pedicle may be found at most 3 mm away from medial canthus. SVP is more commonly located lateral to medial canthus in males and medial to it in females.


Subject(s)
Arteries/anatomy & histology , Forehead/blood supply , Adolescent , Adult , Arteries/diagnostic imaging , Cadaver , Female , Forehead/diagnostic imaging , Humans , Male , Middle Aged , Plastic Surgery Procedures/methods , Surgical Flaps/blood supply , Ultrasonography, Doppler/methods
13.
Int J Pediatr Otorhinolaryngol ; 72(2): 241-8, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18079005

ABSTRACT

BACKGROUND/AIMS: Our objective was to investigate the efficacy of intramuscular injection and peritonsillar infiltration of tramadol to prevent pain in children undergoing tonsillectomy. METHODS: In a double-blinded trial, 45 children were randomized into three groups: infiltration anesthesia with tramadol (2 mgkg(-1)) to the peritonsillar area (INF group, n=15), intramuscular analgesia with tramadol (2 mgkg(-1)) (IM group, n=15), and the placebo controls (PL group, n=15). Visual analog scale (VAS) scores for pain assessment, heart rate (HR) and mean arterial pressure (MAP) during and after anesthesia were recorded. RESULTS: Mean HR values were higher in INF than PL group at 10th, 20th, and 30th minutes of operation (P<0.05). Nine children required analgesics within the first hour after surgery in PL compared to 1 child in INF group (P=0.036). VAS scores on awakening were significantly better in INF than PL group (P=0.015). The difference between IM and PL groups was not significant for any of the parameters. CONCLUSION: Peritonsillar infiltration with tramadol provided good intraoperative analgesia, less postoperative pain on awakening and lower analgesic requirement within the first hour after surgery.


Subject(s)
Analgesics, Opioid/administration & dosage , Pain, Postoperative/prevention & control , Premedication , Tonsillectomy , Tramadol/administration & dosage , Adolescent , Child , Double-Blind Method , Female , Heart Rate , Humans , Injections , Injections, Intramuscular , Male , Pain Measurement , Palatine Tonsil , Treatment Outcome
14.
Article in English | MEDLINE | ID: mdl-18391580

ABSTRACT

BACKGROUND/AIMS: We aimed to determine the effects of adenoidectomy and/or tonsillectomy (AT) on cardiac functions in children with adenoid and/or tonsillary hypertrophy and obstructive sleep apnea syndrome (OSAS) by using echocardiography with tissue Doppler imaging facility (TDI). METHODS: Twenty-nine children with adenoid and/or tonsillary hypertrophy and OSAS and 26 children with primary snoring entered the study. Cardiac functions were assessed by echocardiography with TDI in both groups. Tests were repeated in the OSAS group 6 months after treatment with AT. RESULTS: Echocardiography showed a decrease in estimated pulmonary artery systolic pressure from 31 +/- 4.2 to 13.1 +/- 2.3 (p < 0.001). In TDI, tricuspid E(m) and E(m)/A(m) increased from 11.0 +/- 2.7 to 13.5 +/- 2.7 cm/s (p < 0.001), and 1.46 +/- 0.52 to 1.82 +/- 0.53 (p = 0.004), respectively, following AT, indicating improvement in right ventricular diastolic dysfunction. Similarly, mitral E(m) and E(m)/A(m) increased from 12.3 +/- 2.1 to 16.3 +/- 2.7 cm/s, and from 1.65 +/- 0.51 to 2.30 +/- 0.54, respectively (p < 0.001). There was no significant difference between postoperative values and control group values. CONCLUSION: TDI is a technique able to detect diastolic dysfunction unnoticeable by conventional echocardiography. Following AT, we observed improvement in both left and right ventricular diastolic functions using TDI.


Subject(s)
Adenoidectomy , Heart/physiopathology , Sleep Apnea, Obstructive/complications , Sleep Apnea, Obstructive/surgery , Tonsillectomy , Ventricular Dysfunction, Right/physiopathology , Blood Pressure , Child , Child, Preschool , Diastole , Echocardiography , Female , Humans , Male , Postoperative Period , Pulmonary Artery/physiopathology , Systole , Treatment Outcome , Tricuspid Valve/physiopathology , Ventricular Dysfunction, Right/diagnostic imaging , Ventricular Dysfunction, Right/etiology
15.
J Clin Anesth ; 20(6): 437-41, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18929284

ABSTRACT

STUDY OBJECTIVE: To determine the effect of dexmedetomidine on intraoperative bleeding during septoplasty and tympanoplasty operations. DESIGN: Randomized, placebo-controlled study. SETTING: Univesity medical center. PATIENTS: 80 ASA physical status I and II patients, aged 18 to 65 years, 40 of whom were scheduled for septoplasty and 40 to undergo tympanoplasty operations. INTERVENTIONS: Patients undergoing septoplasty (S) and tympanoplasty (T) operations were randomly divided into 4 groups. Dexmedetomidine (D) was administered to Group SD and Group TD first as a bolus dose of one microg kg(-1), then intraoperative maintenance was supplied with dexmedetomidine 0.7 microg kg(-1) hour(-1). Groups S and T (controls) were given identical amounts of saline. If systolic blood pressure measurements are greater than 20% preoperative values, then fentanyl one microg kg(-1) was given. MEASUREMENTS: Intraoperative blood loss was determined with suction volumes and gauze counting. Bleeding was rated according to a 6-point scale. Hemodynamic parameters and fentanyl administration were recorded. MAIN RESULTS: Group SD had less bleeding and lower bleeding scores (P < 0.05). In addition, this group received less intraoperative fentanyl (P < 0.05). The only significant difference between Groups TD and T was the amount of intraoperative fentanyl given (35.4 +/- 58.8 vs 110.0 +/- 81.0 microg) (P < 0.05). CONCLUSION: Dexmedetomidine reduces bleeding, bleeding scores, and intraoperative fentanyl consumption during general anesthesia in septoplasty operations.


Subject(s)
Adrenergic alpha-Agonists/pharmacology , Blood Loss, Surgical/prevention & control , Dexmedetomidine/pharmacology , Nasal Septum/surgery , Tympanoplasty , Adolescent , Adult , Aged , Analgesics, Opioid/therapeutic use , Blood Pressure/drug effects , Double-Blind Method , Female , Fentanyl/therapeutic use , Hematocrit , Humans , Male , Middle Aged
16.
Gen Hosp Psychiatry ; 28(2): 174-7, 2006.
Article in English | MEDLINE | ID: mdl-16516069

ABSTRACT

Olfactory reference syndrome (ORS) is a rare psychiatric condition with an unclear etiology showing great interindividual variance in its course and treatment response. Although the core symptom of the disease is preoccupation with imagined body odor that persists despite reassurance, clinical presentations mimic various psychiatric illnesses. There have been several case reports of underlying general medical conditions related to ORS, such as epilepsy, arteriovenous malformation and substance abuse. However, to our knowledge, there has been no report on regional blood flow changes detected in patients with ORS. In this brief report, we present the case of a patient with ORS who underwent unnecessary surgery and was referred twice by surgeons. The phenomenology, nosological features and differential diagnosis of ORS are also discussed with regard to its relationship with affective disorders.


Subject(s)
Brain/blood supply , Delusions , Odorants , Technetium Tc 99m Exametazime , Tomography, Emission-Computed, Single-Photon , Adult , Humans , Male , Smell , Turkey
17.
Jpn J Infect Dis ; 59(4): 229-34, 2006 Aug.
Article in English | MEDLINE | ID: mdl-16936340

ABSTRACT

An outbreak of tularemia occurred in three provinces in Turkey in February 2004 and reemerged in the same provinces in February 2005. A total of 61 cases, 54 of which were confirmed with the micro-agglutination test, were diagnosed with oropharyngeal tularemia. No culture for Francisella tularensis was attempted, but PCR for F. tularensis was positive in aspiration material of suppurated lymphadenitis of 7 patients. F. tularensis detection with PCR was negative in water samples, but epidemiologic and environmental findings suggested that contaminated water or food was the cause of the outbreaks. Late initiation antibiotic therapy could not prevent suppuration and draining of the involved lymph nodes.


Subject(s)
Francisella tularensis/growth & development , Tularemia/drug therapy , Tularemia/epidemiology , Adolescent , Adult , Aged , Agglutination Tests/methods , Child , Ciprofloxacin/administration & dosage , Disease Outbreaks , Doxycycline/administration & dosage , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Pharyngeal Diseases/drug therapy , Pharyngeal Diseases/epidemiology , Pharyngeal Diseases/microbiology , Polymerase Chain Reaction/methods , Streptomycin/administration & dosage , Tularemia/microbiology , Turkey/epidemiology
18.
Turk Arch Otorhinolaryngol ; 54(2): 63-68, 2016 Jun.
Article in English | MEDLINE | ID: mdl-29392019

ABSTRACT

OBJECTIVE: To compare the histopathological effects of fibrin glue (FbGl) and cyanoacrylate (CyAc) on the maxillary sinus mucosa. METHODS: Twenty rabbits were divided into two groups of 10, and surgical defects were created in the maxillary sinuses. The right maxillary sinus was treated with FbGl in one group and with CyAc in the other group. As a control, the left maxillary sinuses of all rabbits were treated with sterile saline solution. One rabbit treated with CyAc died during the study and was excluded. On postoperative day 21, all animals were sacrificed. Maxillary sinus mucosa samples were studied to determine the extent of inflammation and fibrosis, foreign body reaction, cilia loss, increased osteogenesis in bony structures under the mucosa, and loss of serous glands. RESULTS: The FbGl group differed significantly from the CyAc and control groups in terms of a high degree of inflammation (p<0.001), fibrosis (p<0.001), foreign body reaction (p<0.001), cilia loss (p<0.001), and serous gland loss (p<0.001). In terms of osteogenesis, there were no significant differences between the FbGl and CyAc groups (p=0.650), while there was a significant (p=0.002) difference between these two groups and the control group. CONCLUSION: Histopathologically, CyAc had fewer side effects than FbGl. Further clinical studies are needed to demonstrate the validity of these results in humans.

19.
Article in English | MEDLINE | ID: mdl-28011121

ABSTRACT

INTRODUCTION: Temporal bone paragangliomas (TBPs) are benign tumors arising from neural crest cells located along the jugular bulbus and the tympanic plexus. In general surgical excision, radiotherapy and wait-and-scan protocols are the main management modalities for TBPs. OBJECTIVE: In this paper we aim to present our clinical experience with TBPs and to review literature data. METHODS: The patients who were operated for tympanomastoid paraganglioma (TMP) or tympanojugular paraganglioma (TJP) in our clinic in the last 15 years were enrolled in the study. A detailed patient's charts review was performed retrospectively. RESULTS: There were 18 (52.9%) cases with TMPs and 16 (47.1%) cases with TJPs, a total of 34 patients operated for TBPs in this time period. The mean age was 50.3± 11.7 (range 25-71 years). The most common presenting symptoms were tinnitus and hearing loss for both TMPs and TJPs. Gross total tumor resection was achieved in 17 (94.4%) and 10 (62.5%) cases for TMPs and TJPs, respectively. Five patients (31.2%) with TJP experienced facial palsy following the operation. For all the patients the mean follow-up period was 25.8 months (range 4-108 months). CONCLUSION: In conclusion, based on our findings and literature review, total surgical excision alone or with preoperative embolization is the main treatment modality for TBPs. However radiotherapy, observation protocol and subtotal resection must be considered in cases of preoperative functioning cranial nerves, large tumors and advanced age.

20.
Pediatr Pulmonol ; 39(3): 251-6, 2005 Mar.
Article in English | MEDLINE | ID: mdl-15668932

ABSTRACT

Our objective was to investigate the prevalence of sleep-disordered breathing (SDB) and obstructive sleep apnea syndrome (OSAS) in 3-11-year-old Turkish children. A cross-sectional study was conducted in Zonguldak, northwestern Turkey. Symptomatic children were identified by using a self-administered questionnaire and were classified into three groups: nonsnorers, occasional snorers, and habitual snorers. All habitual snoring children were invited to undergo polysomnography (PSG). Nine hundred fifty-four children (79.5%) were nonsnorers, 205 (17.2%) were occasional snorers, and 39 (3.3%) were habitual snorers. There was no significant relationship between gender and habitual snoring (male, 3.4%; female, 3.1%; P > 0.05; odds ratio (OR), 1.13; 95% confidence interval (CI), 0.59-2.14). There was a statistically significant relationship between habitual snoring and allergic rhinitis (OR, 4.23; 95% CI, 2.14-8.35). Four children who snored every night, and who had apnea spells and/or troubled sleep, underwent adenoidectomy and/or tonsillectomy before polysomnographic evaluation because of clinical detoriation. Twenty-eight of 39 children with habitual snoring participated in PSG evaluation. PSG revealed that 11 children (0.9% of the total population) had OSAS. When 4 operated children were added to these 28 children, we found the minimum prevalence of OSAS to be 1.3% in our study group. There was a significant correlation between OSAS and troubled sleeping (P <0.001; OR, 4.37; 95% CI, 1.33-14.3). We found the prevalence of habitual snoring to be 3.3% in Turkish children by using self-administered questionnaires. Allergic rhinitis was significantly correlated with habitual snoring. Minimum estimated prevalence of OSAS was found to be 1.3%.


Subject(s)
Sleep Apnea, Obstructive/epidemiology , Age Distribution , Causality , Child , Child, Preschool , Comorbidity , Cross-Sectional Studies , Female , Health Surveys , Humans , Logistic Models , Male , Mouth Breathing/epidemiology , Obesity/epidemiology , Odds Ratio , Polysomnography , Prevalence , Rhinitis, Allergic, Perennial/epidemiology , Sex Distribution , Sleep Apnea, Obstructive/diagnosis , Snoring/epidemiology , Turkey/epidemiology
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